Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

Diabetologia

Volumn 59, Issue 3, 2016, Pages 502-511

  Sandovici, Ionel ^a   Hammerle, Constanze M ^a   Cooper, Wendy N ^a   Smith, Noel H ^a   Tarry Adkins, Jane L ^a   Dunmore, Benjamin J ^a   Bauer, Julien ^a   Andrews, Simon R ^b   Yeo, Giles S H ^a,c   Ozanne, Susan E ^a,c   Constância, Miguel ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c University of Cambridge ^*  (United Kingdom)

Author keywords

Ageing; DNA methylation; Epigenetics; Inflammageing; Pancreatic islets; Type 2 diabetes

Indexed keywords

CD68 ANTIGEN; CXCL9 CHEMOKINE; PROTEIN; REG3A PROTEIN; UNCLASSIFIED DRUG; ZEBULARINE; ABCC8 PROTEIN, RAT; COL3A1 PROTEIN, RAT; COLLAGEN TYPE 3; CXCL9 PROTEIN, RAT; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; INORGANIC PYROPHOSPHATASE; PHOSPHODIESTERASE; POTASSIUM CHANNEL KCNQ1; SULFONYLUREA RECEPTOR; TETRASPANIN; TSPAN8 PROTEIN, RAT;

AGE; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DNA METHYLATION; DOWN REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE LOCUS; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MALE; MICROARRAY ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; UPREGULATION; ANIMAL; DIABETES MELLITUS, TYPE 2; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY;

AGING; ANIMALS; CHEMOKINE CXCL9; COLLAGEN TYPE III; DIABETES MELLITUS, TYPE 2; DNA METHYLATION; EPIGENESIS, GENETIC; INFLAMMATION; ISLETS OF LANGERHANS; KCNQ1 POTASSIUM CHANNEL; MALE; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; RATS; SULFONYLUREA RECEPTORS; TETRASPANINS;

EID: 84957437856     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3837-8     Document Type: Article

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