메뉴 건너뛰기




Volumn 2, Issue 6, 2010, Pages 345-352

Aging induces a distinct gene expression program in mouse islets

Author keywords

cells; Aging; Gene expression; Islets; Reg genes; Regeneration

Indexed keywords

MESSENGER RNA; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

EID: 78751484975     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.2.6.13376     Document Type: Article
Times cited : (34)

References (47)
  • 1
    • 50449095078 scopus 로고    scopus 로고
    • Minireview: Pancreatic progenitor cells - Recent studies
    • Ku HT. Minireview: pancreatic progenitor cells - recent studies. Endocrinology 2008; 149:4312-6.
    • (2008) Endocrinology , vol.149 , pp. 4312-4316
    • Ku, H.T.1
  • 2
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by selfduplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by selfduplication rather than stem-cell differentiation. Nature 2004; 429:41-6.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 3
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult Beta cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult Beta cells does not involve specialized progenitors. Dev Cell 2007; 12:817-26.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 4
    • 0037677695 scopus 로고    scopus 로고
    • Increased islet volume but unchanged islet number in ob/ob mice
    • Bock T, Pakkenberg B, Buschard K. Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 2003; 52:1716-22. (Pubitemid 36792462)
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1716-1722
    • Bock, T.1    Pakkenberg, B.2    Buschard, K.3
  • 5
    • 0026573783 scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
    • Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 1992; 130:1459-66.
    • (1992) Endocrinology , vol.130 , pp. 1459-1466
    • Parsons, J.A.1    Brelje, T.C.2    Sorenson, R.L.3
  • 6
    • 41149150651 scopus 로고    scopus 로고
    • Expanding human beta cells
    • Scharfmann R. Expanding human beta cells. Diabetologia 2008; 51:692-3.
    • (2008) Diabetologia , vol.51 , pp. 692-693
    • Scharfmann, R.1
  • 7
    • 38449086256 scopus 로고    scopus 로고
    • Partial pancreatectomy in adult humans does not provoke beta-cell regeneration
    • Menge BA, Tannapfel A, Belyaev O, Drescher R, Muller C, Uhl W, et al. Partial pancreatectomy in adult humans does not provoke beta-cell regeneration. Diabetes 2008; 57:142-9.
    • (2008) Diabetes , vol.57 , pp. 142-149
    • Menge, B.A.1    Tannapfel, A.2    Belyaev, O.3    Drescher, R.4    Muller, C.5    Uhl, W.6
  • 8
    • 0028987251 scopus 로고
    • Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995; 44:249-56.
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner Weir, S.3
  • 10
    • 77949289481 scopus 로고    scopus 로고
    • The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
    • Cnop M, Hughes SJ, Igoillo-Esteve M, Hoppa MB, Sayyed F, van de Laar L, et al. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia 53:321-30.
    • Diabetologia , vol.53 , pp. 321-330
    • Cnop, M.1    Hughes, S.J.2    Igoillo-Esteve, M.3    Hoppa, M.B.4    Sayyed, F.5    Van De Laar, L.6
  • 11
    • 77957787230 scopus 로고    scopus 로고
    • Significant human beta-cell turnover is limited to the first three decades of life as determined by in-vivo thymidine analog incorporation and radiocarbon dating
    • Perl SKJ, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in-vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab 2010; 95:E234-9.
    • (2010) J Clin Endocrinol Metab , vol.95
    • Perl, S.K.J.1    Buchholz, B.A.2    Meeker, A.K.3    Stein, G.M.4    Hsieh, M.5    Kirby, M.6
  • 12
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 2009; 58:1365-72.
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 13
    • 66649084335 scopus 로고    scopus 로고
    • Agedependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice
    • Tschen SI, Dhawan S, Gurlo T, Bhushan A. Agedependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes 2009; 58:1312-20.
    • (2009) Diabetes , vol.58 , pp. 1312-1320
    • Tschen, S.I.1    Dhawan, S.2    Gurlo, T.3    Bhushan, A.4
  • 16
    • 2442564700 scopus 로고    scopus 로고
    • Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
    • Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, et al. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 2004; 18:1035-46.
    • (2004) Genes Dev , vol.18 , pp. 1035-1046
    • Sun, L.Q.1    Lee, D.W.2    Zhang, Q.3    Xiao, W.4    Raabe, E.H.5    Meeker, A.6
  • 18
    • 61449110966 scopus 로고    scopus 로고
    • Directing cell differentiation with small-molecule histone deacetylase inhibitors: The example of promoting pancreatic endocrine cells
    • Haumaitre C, Lenoir O, Scharfmann R. Directing cell differentiation with small-molecule histone deacetylase inhibitors: the example of promoting pancreatic endocrine cells. Cell Cycle 2009; 8:536-44.
    • (2009) Cell Cycle , vol.8 , pp. 536-544
    • Haumaitre, C.1    Lenoir, O.2    Scharfmann, R.3
  • 20
    • 1842529261 scopus 로고    scopus 로고
    • Identification of two novel components of the human NDC80 kinetochore complex
    • Bharadwaj R, Qi W, Yu H. Identification of two novel components of the human NDC80 kinetochore complex. J Biol Chem 2004; 279:13076-85.
    • (2004) J Biol Chem , vol.279 , pp. 13076-13085
    • Bharadwaj, R.1    Qi, W.2    Yu, H.3
  • 21
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316:1336-41.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5    Lango, H.6
  • 22
    • 0030879478 scopus 로고    scopus 로고
    • DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours
    • Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 1997; 17:32-9.
    • (1997) Nat Genet , vol.17 , pp. 32-39
    • Mollenhauer, J.1    Wiemann, S.2    Scheurlen, W.3    Korn, B.4    Hayashi, Y.5    Wilgenbus, K.K.6
  • 23
    • 0036792510 scopus 로고    scopus 로고
    • Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1
    • Bisgaard HC, Holmskov U, Santoni-Rugiu E, Nagy P, Nielsen O, Ott P, et al. Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Am J Pathol 2002; 161:1187-98.
    • (2002) Am J Pathol , vol.161 , pp. 1187-1198
    • Bisgaard, H.C.1    Holmskov, U.2    Santoni-Rugiu, E.3    Nagy, P.4    Nielsen, O.5    Ott, P.6
  • 29
    • 0036897224 scopus 로고    scopus 로고
    • Recent advances in the Okamoto model: The CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in betacells
    • Okamoto H, Takasawa S. Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in betacells. Diabetes 2002; 51:462-73.
    • (2002) Diabetes , vol.51 , pp. 462-473
    • Okamoto, H.1    Takasawa, S.2
  • 30
    • 0030912531 scopus 로고    scopus 로고
    • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
    • Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997; 99:2100-9.
    • (1997) J Clin Invest , vol.99 , pp. 2100-2109
    • Rafaeloff, R.1    Pittenger, G.L.2    Barlow, S.W.3    Qin, X.F.4    Yan, B.5    Rosenberg, L.6
  • 31
    • 68349097448 scopus 로고    scopus 로고
    • Islet neogenesis-associated protein pentadecapeptide (INGAP-PP): Mechanisms involved in its effect upon beta-cell mass and function
    • Madrid V, Del Zotto H, Maiztegui B, Raschia MA, Alzugaray ME, Boschero AC, et al. Islet neogenesis-associated protein pentadecapeptide (INGAP-PP): mechanisms involved in its effect upon beta-cell mass and function. Regul Pept 2009; 157:25-31.
    • (2009) Regul Pept , vol.157 , pp. 25-31
    • Madrid, V.1    Del Zotto, H.2    Maiztegui, B.3    Raschia, M.A.4    Alzugaray, M.E.5    Boschero, A.C.6
  • 32
    • 33846633796 scopus 로고    scopus 로고
    • FSTL3 deletion reveals roles for TGFbeta family ligands in glucose and fat homeostasis in adults
    • Mukherjee A, Sidis Y, Mahan A, Raher MJ, Xia Y, Rosen ED, et al. FSTL3 deletion reveals roles for TGFbeta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci USA 2007; 104:1348-53.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1348-1353
    • Mukherjee, A.1    Sidis, Y.2    Mahan, A.3    Raher, M.J.4    Xia, Y.5    Rosen, E.D.6
  • 33
    • 77955516799 scopus 로고    scopus 로고
    • Reciprocal modulation of adult beta cell maturity by activin a and follistatin
    • Szabat M, Johnson JD, Piret JM. Reciprocal modulation of adult beta cell maturity by activin A and follistatin. Diabetologia 53:1680-9.
    • Diabetologia , vol.53 , pp. 1680-1689
    • Szabat, M.1    Johnson, J.D.2    Piret, J.M.3
  • 34
    • 33646567450 scopus 로고    scopus 로고
    • Developmental roles of the BMP1/TLD metalloproteinases
    • Ge G, Greenspan DS. Developmental roles of the BMP1/TLD metalloproteinases. Birth Defects Res C Embryo Today 2006; 78:47-68.
    • (2006) Birth Defects Res C Embryo Today , vol.78 , pp. 47-68
    • Ge, G.1    Greenspan, D.S.2
  • 35
    • 0030988472 scopus 로고    scopus 로고
    • Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome
    • Catchpoole D, Lam WW, Valler D, Temple IK, Joyce JA, Reik W, et al. Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome. J Med Genet 1997; 34:353-9.
    • (1997) J Med Genet , vol.34 , pp. 353-359
    • Catchpoole, D.1    Lam, W.W.2    Valler, D.3    Temple, I.K.4    Joyce, J.A.5    Reik, W.6
  • 36
    • 0029558541 scopus 로고
    • A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif
    • Bertolino E, Reimund B, Wildt-Perinic D, Clerc RG. A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J Biol Chem 1995; 270:31178-88.
    • (1995) J Biol Chem , vol.270 , pp. 31178-31188
    • Bertolino, E.1    Reimund, B.2    Wildt-Perinic, D.3    Clerc, R.G.4
  • 37
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton D, Lo RS, Lee S, Massague J. A Smad transcriptional corepressor. Cell 1999; 97:29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massague, J.4
  • 41
    • 70249141961 scopus 로고    scopus 로고
    • Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
    • Anderson RM, Bosch JA, Goll MG, Hesselson D, Dong PD, Shin D, et al. Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol 2009; 334:213-23.
    • (2009) Dev Biol , vol.334 , pp. 213-223
    • Anderson, R.M.1    Bosch, J.A.2    Goll, M.G.3    Hesselson, D.4    Dong, P.D.5    Shin, D.6
  • 42
    • 75149171461 scopus 로고    scopus 로고
    • HOP is a monomer: Investigation of the oligomeric state of the co-chaperone HOP
    • Yi F, Doudevski I, Regan L. HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Protein Sci 19:19-25.
    • Protein Sci , vol.19 , pp. 19-25
    • Yi, F.1    Doudevski, I.2    Regan, L.3
  • 44
    • 33846975788 scopus 로고    scopus 로고
    • Metabolic diapause in pancreatic beta-cells expressing a gain-offunction mutant of the forkhead protein Foxo1
    • Buteau J, Shlien A, Foisy S, Accili D. Metabolic diapause in pancreatic beta-cells expressing a gain-offunction mutant of the forkhead protein Foxo1. J Biol Chem 2007; 282:287-93.
    • (2007) J Biol Chem , vol.282 , pp. 287-293
    • Buteau, J.1    Shlien, A.2    Foisy, S.3    Accili, D.4
  • 45
    • 58149343890 scopus 로고    scopus 로고
    • Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
    • Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC. Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes 2008; 57:2755-61.
    • (2008) Diabetes , vol.57 , pp. 2755-2761
    • Juhl, K.1    Sarkar, S.A.2    Wong, R.3    Jensen, J.4    Hutton, J.C.5
  • 46
    • 73349092420 scopus 로고    scopus 로고
    • Gene expression analysis in diabetes research
    • White P, Kaestner KH. Gene expression analysis in diabetes research. Methods Mol Biol 2009; 560:239-61.
    • (2009) Methods Mol Biol , vol.560 , pp. 239-261
    • White, P.1    Kaestner, K.H.2
  • 47
    • 0036020892 scopus 로고    scopus 로고
    • A direct approach to false discovery rates
    • Storey JD. A direct approach to false discovery rates. J R Statist Soc B 2002; 64:479-98.
    • (2002) J R Statist Soc B , vol.64 , pp. 479-498
    • Storey, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.