메뉴 건너뛰기




Volumn 2016, Issue , 2016, Pages

Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CARDIOLOGY; CELL DEATH; CELL MEMBRANES; HEART; MAMMALS; METABOLISM; MITOCHONDRIA; NUTRITION; TISSUE;

EID: 84985952051     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/9340654     Document Type: Review
Times cited : (44)

References (116)
  • 1
    • 33751546348 scopus 로고    scopus 로고
    • Myocardial triglyceride content and epicardial fat mass in human obesity: Relationship to left ventricular function and serumfree fatty acid levels
    • M. Kankaanpää, H.-R. Lehto, J. P. Pärkkä et al., "Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serumfree fatty acid levels, "The Journal of Clinical Endocrinology &Metabolism, vol. 91, no. 11, pp. 4689-4695, 2006.
    • (2006) The Journal of Clinical Endocrinology &metabolism , vol.91 , Issue.11 , pp. 4689-4695
    • Kankaanpää, M.1    Lehto, H.-R.2    Pärkkä, J.P.3
  • 2
    • 84930665631 scopus 로고    scopus 로고
    • The mitochondria in diabetic heart failure: From pathogenesis to therapeutic promise schilling
    • D. Joel, "The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise schilling, " Antioxidants & Redox Signaling, vol. 22, no. 17, pp. 1515-1526, 2015.
    • (2015) Antioxidants & Redox Signaling , vol.22 , Issue.17 , pp. 1515-1526
    • Joel, D.1
  • 3
  • 6
    • 25844520458 scopus 로고    scopus 로고
    • Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
    • P. Ježek and L. Hlavatá, "Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism, " International Journal of Biochemistry and Cell Biology, vol. 37, no. 12, pp. 2478-2503, 2005.
    • (2005) International Journal of Biochemistry and Cell Biology , vol.37 , Issue.12 , pp. 2478-2503
    • Ježek, P.1    Hlavatá, L.2
  • 8
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • E. Cadenas and K. J. A. Davies, "Mitochondrial free radical generation, oxidative stress, and aging, " Free Radical Biology and Medicine, vol. 29, no. 3-4, pp. 222-230, 2000.
    • (2000) Free Radical Biology and Medicine , vol.29 , Issue.3-4 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.A.2
  • 9
    • 84929074460 scopus 로고    scopus 로고
    • Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction
    • S. Liu, B. Geng, L. Zou et al., "Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction, " Cardiovascular Research, vol. 105, no. 1, pp. 20-30, 2015.
    • (2015) Cardiovascular Research , vol.105 , Issue.1 , pp. 20-30
    • Liu, S.1    Geng, B.2    Zou, L.3
  • 12
    • 84939999016 scopus 로고    scopus 로고
    • Post-translational modifications disclose a dual role for redox stress in cardiovascular pathophysiology
    • V. J. Victorino, A. L. Mencalha, and C. Panis, "Post-translational modifications disclose a dual role for redox stress in cardiovascular pathophysiology, " Life Sciences, vol. 129, pp. 42-47, 2015.
    • (2015) Life Sciences , vol.129 , pp. 42-47
    • Victorino, V.J.1    Mencalha, A.L.2    Panis, C.3
  • 13
    • 84922536968 scopus 로고    scopus 로고
    • Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
    • S. Cardoso, S. Correia, C. Carvalho et al., "Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection, " Journal of Bioenergetics and Biomembranes, vol. 47, no. 1-2, pp. 119-131, 2014.
    • (2014) Journal of Bioenergetics and Biomembranes , vol.47 , Issue.1-2 , pp. 119-131
    • Cardoso, S.1    Correia, S.2    Carvalho, C.3
  • 14
    • 84865434841 scopus 로고    scopus 로고
    • Mitochondrial proticity and ROS signaling: Lessons fromthe uncoupling proteins
    • R. J. Mailloux and M.-E. Harper, "Mitochondrial proticity and ROS signaling: lessons fromthe uncoupling proteins, " Trends in Endocrinology andMetabolism, vol. 23, no. 9, pp. 451-458, 2012.
    • (2012) Trends in Endocrinology and Metabolism , vol.23 , Issue.9 , pp. 451-458
    • Mailloux, R.J.1    Harper, M.-E.2
  • 15
    • 84869421018 scopus 로고    scopus 로고
    • Uncoupling and reactive oxygen species (ROS) - A double-edged sword for β-cell function? 'moderation in all things'
    • S. Collins, J. Pi, and E. Yehuda-Shnaidman, "Uncoupling and reactive oxygen species (ROS)-a double-edged sword for β-cell function? 'moderation in all things', " Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 26, no. 6, pp. 753-758, 2012.
    • (2012) Best Practice & Research: Clinical Endocrinology & Metabolism , vol.26 , Issue.6 , pp. 753-758
    • Collins, S.1    Pi, J.2    Yehuda-Shnaidman, E.3
  • 16
    • 20444437554 scopus 로고    scopus 로고
    • Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis
    • K.-U. Lee, I. K. Lee, J. Han et al., "Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis, " Circulation Research, vol. 96, no. 11, pp. 1200-1207, 2005.
    • (2005) Circulation Research , vol.96 , Issue.11 , pp. 1200-1207
    • Lee, K.-U.1    Lee, I.K.2    Han, J.3
  • 17
  • 19
    • 84891410684 scopus 로고    scopus 로고
    • Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
    • C. Perrino, G. G. Schiattarella, A. Sannino et al., "Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure, " Journal of the American Heart Association, vol. 2, no. 3, Article ID e000086, 2013.
    • (2013) Journal of the American Heart Association , vol.2 , Issue.3
    • Perrino, C.1    Schiattarella, G.G.2    Sannino, A.3
  • 20
    • 0345529917 scopus 로고    scopus 로고
    • Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria
    • G. Petrosillo, F. M. Ruggiero, and G. Paradies, "Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria, " The FASEB Journal, vol. 17, no. 15, pp. 2202-2208, 2003.
    • (2003) The FASEB Journal , vol.17 , Issue.15 , pp. 2202-2208
    • Petrosillo, G.1    Ruggiero, F.M.2    Paradies, G.3
  • 22
    • 84880659584 scopus 로고    scopus 로고
    • Regulation of the intrinsic apoptosis pathway by reactive oxygen species
    • C.-C. Wu and S. B. Bratton, "Regulation of the intrinsic apoptosis pathway by reactive oxygen species, " Antioxidants & Redox Signaling, vol. 19, no. 6, pp. 546-558, 2013.
    • (2013) Antioxidants & Redox Signaling , vol.19 , Issue.6 , pp. 546-558
    • Wu, C.-C.1    Bratton, S.B.2
  • 23
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • D. Ricquier and F. Bouillaud, "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP, " The Biochemical Journal, vol. 345, no. 2, pp. 161-179, 2000.
    • (2000) The Biochemical Journal , vol.345 , Issue.2 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 24
    • 79961168437 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein 2 structure determined by NMRmolecular fragment searching
    • M. J. Berardi, W. M. Shih, S. C. Harrison, and J. J. Chou, "Mitochondrial uncoupling protein 2 structure determined by NMRmolecular fragment searching, " Nature, vol. 476, no. 7358, pp. 109-113, 2011.
    • (2011) Nature , vol.476 , Issue.7358 , pp. 109-113
    • Berardi, M.J.1    Shih, W.M.2    Harrison, S.C.3    Chou, J.J.4
  • 25
    • 84927740393 scopus 로고    scopus 로고
    • Role of positively charged residues of the second transmembrane domain in the ion transport activity and conformation of human uncoupling protein-2
    • T. Hoang, T. Matovic, J. Parker, M. D. Smith, and M. Jelokhani-Niaraki, "Role of positively charged residues of the second transmembrane domain in the ion transport activity and conformation of human uncoupling protein-2, " Biochemistry, vol. 54, no. 14, pp. 2303-2313, 2015.
    • (2015) Biochemistry , vol.54 , Issue.14 , pp. 2303-2313
    • Hoang, T.1    Matovic, T.2    Parker, J.3    Smith, M.D.4    Jelokhani-Niaraki, M.5
  • 26
  • 28
    • 27644448810 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in the CNS: In support of function and survival
    • Z. B. Andrews, S. Diano, and T. L. Horvath, "Mitochondrial uncoupling proteins in the CNS: in support of function and survival, " Nature Reviews Neuroscience, vol. 6, no. 11, pp. 829-840, 2005.
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.11 , pp. 829-840
    • Andrews, Z.B.1    Diano, S.2    Horvath, T.L.3
  • 29
    • 84902595587 scopus 로고    scopus 로고
    • Different effects of guanine nucleotides (GDP and GTP) on proteinmediated mitochondrial proton leak
    • A. M. Woyda-Ploszczyca and W. Jarmuszkiewicz, "Different effects of guanine nucleotides (GDP and GTP) on proteinmediated mitochondrial proton leak, " PLoS ONE, vol. 9, no. 6, Article ID e98969, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.6
    • Woyda-Ploszczyca, A.M.1    Jarmuszkiewicz, W.2
  • 31
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activatesmitochondrial uncoupling protein 2 fromthe matrix side. Studies using targeted antioxidants
    • K. S. Echtay, M. P. Murphy, R.A. J. Smith, D.A. Talbot, and M.D. Brand, "Superoxide activatesmitochondrial uncoupling protein 2 fromthe matrix side. Studies using targeted antioxidants, " The Journal of Biological Chemistry, vol. 277, no.49, pp.47129-47135, 2002.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.49 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.J.3    Talbot, D.A.4    Brand, M.D.5
  • 32
    • 18244379331 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling proteins
    • K. S. Echtay, D. Roussel, J. St-Plerre et al., "Superoxide activates mitochondrial uncoupling proteins, " Nature, vol. 415, no. 6867, pp. 96-99, 2002.
    • (2002) Nature , vol.415 , Issue.6867 , pp. 96-99
    • Echtay, K.S.1    Roussel, D.2    St-Plerre, J.3
  • 33
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • S. Cadenas, J. A. Buckingham, S. Samec et al., "UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged, " The FEBS Letters, vol. 462, no. 3, pp. 257-260, 1999.
    • (1999) The FEBS Letters , vol.462 , Issue.3 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3
  • 34
    • 33846873689 scopus 로고    scopus 로고
    • The dominant negative thyroid hormone receptor β-mutant Δ337T alters PPARΔ signaling in heart
    • N. E. Buroker, M. E. Young, C. Wei et al., "The dominant negative thyroid hormone receptor β-mutant Δ337T alters PPARΔ signaling in heart, " American Journal of Physiology- Endocrinology and Metabolism, vol. 292, no. 2, pp. E453-E460, 2007.
    • (2007) American Journal of Physiology- Endocrinology and Metabolism , vol.292 , Issue.2 , pp. E453-E460
    • Buroker, N.E.1    Young, M.E.2    Wei, C.3
  • 36
    • 33747372618 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes
    • M. Zhang, B. Wang, Y.-H. Ni et al., "Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes, " Life Sciences, vol. 79, no. 15, pp. 1428-1435, 2006.
    • (2006) Life Sciences , vol.79 , Issue.15 , pp. 1428-1435
    • Zhang, M.1    Wang, B.2    Ni, Y.-H.3
  • 37
    • 33845985635 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells
    • S. L. Chan, D. Liu, G. A. Kyriazis, P. Bagsiyao, X. Ouyang, and M. P. Mattson, "Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells, " Journal of Biological Chemistry, vol. 281, no. 49, pp. 37391-37403, 2006.
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.49 , pp. 37391-37403
    • Chan, S.L.1    Liu, D.2    Kyriazis, G.A.3    Bagsiyao, P.4    Ouyang, X.5    Mattson, M.P.6
  • 38
    • 84928391335 scopus 로고    scopus 로고
    • Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart
    • A. T. Akhmedov, V. Rybin, and J. Marín-García, "Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart, " Heart Failure Reviews, vol. 20, no. 2, pp. 227-249, 2015.
    • (2015) Heart Failure Reviews , vol.20 , Issue.2 , pp. 227-249
    • Akhmedov, A.T.1    Rybin, V.2    Marín-García, J.3
  • 39
    • 84911413325 scopus 로고    scopus 로고
    • Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator
    • S. J. F. Chong, I. C. C. Low, and S. Pervaiz, "Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator, " Mitochondrion, vol. 19, pp. 39-48, 2014.
    • (2014) Mitochondrion , vol.19 , pp. 39-48
    • Chong, S.J.F.1    Low, I.C.C.2    Pervaiz, S.3
  • 41
    • 38049120264 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
    • C. Pecqueur, T. Bui, C. Gelly et al., "Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization, " The FASEB Journal, vol. 22, no. 1, pp. 9-18, 2008.
    • (2008) The FASEB Journal , vol.22 , Issue.1 , pp. 9-18
    • Pecqueur, C.1    Bui, T.2    Gelly, C.3
  • 42
    • 25844519056 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia
    • C. J. McLeod, A. Aziz, R. F. Hoyt Jr., J. P. McCoy Jr., and M. N. Sack, "Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia, " Journal of Biological Chemistry, vol. 280, no. 39, pp. 33470-33476, 2005.
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33470-33476
    • McLeod, C.J.1    Aziz, A.2    Hoyt, R.F.3    McCoy, J.P.4    Sack, M.N.5
  • 43
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibitsmitochondrial death pathway in cardiomyocytes
    • Y. Teshima, M. Akao, S. P. Jones, and E. Marbán, "Uncoupling protein-2 overexpression inhibitsmitochondrial death pathway in cardiomyocytes, " Circulation Research, vol. 93, no. 3, pp. 192-200, 2003.
    • (2003) Circulation Research , vol.93 , Issue.3 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3    Marbán, E.4
  • 44
    • 84937787836 scopus 로고    scopus 로고
    • Inhibition of uncoupling protein 2 attenuates cardiac hypertrophy induced by transverse aortic constriction in mice
    • X.-B. Ji, X.-R. Li, D. Hao et al., "Inhibition of uncoupling protein 2 attenuates cardiac hypertrophy induced by transverse aortic constriction in mice, " Cellular Physiology and Biochemistry, vol. 36, no. 5, pp. 1688-1698, 2015.
    • (2015) Cellular Physiology and Biochemistry , vol.36 , Issue.5 , pp. 1688-1698
    • Ji, X.-B.1    Li, X.-R.2    Hao, D.3
  • 45
    • 0035920122 scopus 로고    scopus 로고
    • β-Adrenergic activation of p38 MAP kinase in adipocytes: CAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
    • W. Cao, A. V. Medvedev, K. W. Daniel, and S. Collins, "β-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase, " The Journal of Biological Chemistry, vol. 276, no. 29, pp. 27077-27082, 2001.
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.29 , pp. 27077-27082
    • Cao, W.1    Medvedev, A.V.2    Daniel, K.W.3    Collins, S.4
  • 46
    • 42749100308 scopus 로고    scopus 로고
    • PPARs in the control of uncoupling proteins gene expression
    • F. Villarroya, R. Iglesias, and M. Giralt, "PPARs in the control of uncoupling proteins gene expression, " PPAR Research, vol. 2007, Article ID 74364, 12 pages, 2007.
    • (2007) PPAR Research , vol.2007 , pp. 12
    • Villarroya, F.1    Iglesias, R.2    Giralt, M.3
  • 47
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • M. J. Barberá, A. Schlüter, N. Pedraza, R. Iglesias, F. Villarroya, and M. Giralt, "Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell, " The Journal of Biological Chemistry, vol. 276, no. 2, pp. 1486-1493, 2001.
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 1486-1493
    • Barberá, M.J.1    Schlüter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 48
    • 33748752704 scopus 로고    scopus 로고
    • Developmental and tissue-specific involvement of peroxisome proliferatoractivated receptor-α in the control of mouse uncoupling protein-3 gene expression
    • N. Pedraza, M. Rosell, J. Villarroya et al., "Developmental and tissue-specific involvement of peroxisome proliferatoractivated receptor-α in the control of mouse uncoupling protein-3 gene expression, " Endocrinology, vol. 147, no. 10, pp. 4695-4704, 2006.
    • (2006) Endocrinology , vol.147 , Issue.10 , pp. 4695-4704
    • Pedraza, N.1    Rosell, M.2    Villarroya, J.3
  • 49
    • 77952921211 scopus 로고    scopus 로고
    • A novel intronic peroxisome proliferatoractivated receptor γ enhancer in the Uncoupling Protein (UCP) 3 gene as a regulator of both UCP2 and-3 expression in adipocytes
    • A. Bugge, M. Siersbæk, M. S. Madsen, A. Göndör, C. Rougier, and S. Mandrup, "A novel intronic peroxisome proliferatoractivated receptor γ enhancer in the Uncoupling Protein (UCP) 3 gene as a regulator of both UCP2 and-3 expression in adipocytes, " Journal of Biological Chemistry, vol. 285, no. 23, pp. 17310-17317, 2010.
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.23 , pp. 17310-17317
    • Bugge, A.1    Siersbæk, M.2    Madsen, M.S.3    Göndör, A.4    Rougier, C.5    Mandrup, S.6
  • 50
    • 84992329222 scopus 로고    scopus 로고
    • Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid
    • F. Baraldi, F. Dalalio, B. Teodoro, I. Prado, C. Curti, and L. Alberici, "Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid, " Free Radical Biology and Medicine, vol. 75, supplement 1, p. S21, 2014.
    • (2014) Free Radical Biology and Medicine , vol.75 , pp. S21
    • Baraldi, F.1    Dalalio, F.2    Teodoro, B.3    Prado, I.4    Curti, C.5    Alberici, L.6
  • 51
    • 0142120289 scopus 로고    scopus 로고
    • Functional relationship between myod and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription
    • G. Solanes, N. Pedraza, R. Iglesias, M. Giralt, and F. Villarroya, "Functional relationship between myod and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription, " Molecular Endocrinology, vol. 17, no. 10, pp. 1944-1958, 2003.
    • (2003) Molecular Endocrinology , vol.17 , Issue.10 , pp. 1944-1958
    • Solanes, G.1    Pedraza, N.2    Iglesias, R.3    Giralt, M.4    Villarroya, F.5
  • 52
    • 0034012778 scopus 로고    scopus 로고
    • Effects of fatty acids on uncoupling protein-2 expression in the rat heart
    • K. A. J. M. VanDer Lee, P. H. M. Willemsen, G. J. VanDerVusse, and M. Van Bilsen, "Effects of fatty acids on uncoupling protein-2 expression in the rat heart, " The FASEB Journal, vol. 14, no. 3, pp. 495-502, 2000.
    • (2000) The FASEB Journal , vol.14 , Issue.3 , pp. 495-502
    • VanDer Lee, K.A.J.M.1    Willemsen, P.H.M.2    VanDerVusse, G.J.3    Van Bilsen, M.4
  • 53
    • 84926631640 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 protects the heart from oxidative stress
    • A. Planavila, I. Redondo-Angulo, F. Ribas et al., "Fibroblast growth factor 21 protects the heart from oxidative stress, " Cardiovascular Research, vol. 106, no. 1, pp. 19-31, 2015.
    • (2015) Cardiovascular Research , vol.106 , Issue.1 , pp. 19-31
    • Planavila, A.1    Redondo-Angulo, I.2    Ribas, F.3
  • 54
    • 84891410684 scopus 로고    scopus 로고
    • Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
    • C. Perrino, G. G. Schiattarella, A. Sannino et al., "Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure, " Journal of the American Heart Association, vol. 2, no. 3, Article ID e000086, 2013.
    • (2013) Journal of the American Heart Association , vol.2 , Issue.3
    • Perrino, C.1    Schiattarella, G.G.2    Sannino, A.3
  • 55
    • 84935472432 scopus 로고    scopus 로고
    • Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels
    • A. Koziel, I. Sobieraj, and W. Jarmuszkiewicz, "Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 309, no. 1, pp. H147-H156, 2015.
    • (2015) American Journal of Physiology-Heart and Circulatory Physiology , vol.309 , Issue.1 , pp. H147-H156
    • Koziel, A.1    Sobieraj, I.2    Jarmuszkiewicz, W.3
  • 56
    • 84922435398 scopus 로고    scopus 로고
    • Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening
    • Y. Chen, J. Liu, Y. Zheng et al., "Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening, " Cardiovascular Research, vol. 105, no. 2, pp. 192-202, 2015.
    • (2015) Cardiovascular Research , vol.105 , Issue.2 , pp. 192-202
    • Chen, Y.1    Liu, J.2    Zheng, Y.3
  • 57
    • 0038061012 scopus 로고    scopus 로고
    • A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
    • A. Nègre-Salvayre, C. Hirtz, G. Carrera et al., "A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation, "TheFASEB Journal, vol. 11, no. 10, pp. 809-815, 1997.
    • (1997) The FASEB Journal , vol.11 , Issue.10 , pp. 809-815
    • Nègre-Salvayre, A.1    Hirtz, C.2    Carrera, G.3
  • 59
    • 23644434842 scopus 로고    scopus 로고
    • Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
    • J. D. MacLellan, M. F. Gerrits, A. Gowing, P. J. S. Smith, M. B. Wheeler, and M.-E. Harper, "Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells, " Diabetes, vol. 54, no. 8, pp. 2343-2350, 2005.
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2343-2350
    • MacLellan, J.D.1    Gerrits, M.F.2    Gowing, A.3    Smith, P.J.S.4    Wheeler, M.B.5    Harper, M.-E.6
  • 60
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • S. Boudina, S. Sena, H. Theobald et al., "Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins, " Diabetes, vol. 56, no. 10, pp. 2457-2466, 2007.
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3
  • 61
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology ofmitochondrial superoxide production
    • M. D. Brand, "The sites and topology ofmitochondrial superoxide production, " Experimental Gerontology, vol. 45, no. 7-8, pp. 466-472, 2010.
    • (2010) Experimental Gerontology , vol.45 , Issue.7-8 , pp. 466-472
    • Brand, M.D.1
  • 63
    • 80052160109 scopus 로고    scopus 로고
    • New aspects of mitochondrial uncoupling proteins (UCPs) and their roles in tumorigenesis
    • D. Robbins and Y. Zhao, "New aspects of mitochondrial uncoupling proteins (UCPs) and their roles in tumorigenesis, " International Journal of Molecular Sciences, vol. 12, no. 8, pp. 5285-5293, 2011.
    • (2011) International Journal of Molecular Sciences , vol.12 , Issue.8 , pp. 5285-5293
    • Robbins, D.1    Zhao, Y.2
  • 64
    • 84877922143 scopus 로고    scopus 로고
    • The role of mitochondrial DNAmutations and free radicals in disease and ageing
    • M. Lagouge and N.-G. Larsson, "The role of mitochondrial DNAmutations and free radicals in disease and ageing, " Journal of Internal Medicine, vol. 273, no. 6, pp. 529-543, 2013.
    • (2013) Journal of Internal Medicine , vol.273 , Issue.6 , pp. 529-543
    • Lagouge, M.1    Larsson, N.-G.2
  • 66
    • 84861212393 scopus 로고    scopus 로고
    • Mitochondria and cell signalling
    • S. W. G. Tait and D. R. Green, "Mitochondria and cell signalling, " Journal of Cell Science, vol. 125, no. 4, pp. 807-815, 2012.
    • (2012) Journal of Cell Science , vol.125 , Issue.4 , pp. 807-815
    • Tait, S.W.G.1    Green, D.R.2
  • 68
    • 84997770282 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species mediate cardiac structural, functional, and mitochondrial consequences of diet-induced metabolic heart disease
    • A. L. Sverdlov, A. Elezaby, F. Qin et al., "Mitochondrial reactive oxygen species mediate cardiac structural, functional, and mitochondrial consequences of diet-induced metabolic heart disease, " Journal of the American Heart Association, vol. 5, no. 1, Article ID e002555, 2016.
    • (2016) Journal of the American Heart Association , vol.5 , Issue.1
    • Sverdlov, A.L.1    Elezaby, A.2    Qin, F.3
  • 69
    • 84894165975 scopus 로고    scopus 로고
    • Cardiacmitochondria and reactive oxygen species generation
    • Y.-R. Chen and J. L. Zweier, "Cardiacmitochondria and reactive oxygen species generation, " Circulation Research, vol. 114, no. 3, pp. 524-537, 2014.
    • (2014) Circulation Research , vol.114 , Issue.3 , pp. 524-537
    • Chen, Y.-R.1    Zweier, J.L.2
  • 71
    • 84906937056 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure
    • M. Schwarzer, M. Osterholt, A. Lunkenbein, A. Schrepper, P. Amorim, and T. Doenst, "Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure, " Journal of Physiology, vol. 592, no. 17, pp. 3767-3782, 2014.
    • (2014) Journal of Physiology , vol.592 , Issue.17 , pp. 3767-3782
    • Schwarzer, M.1    Osterholt, M.2    Lunkenbein, A.3    Schrepper, A.4    Amorim, P.5    Doenst, T.6
  • 72
    • 33744497609 scopus 로고    scopus 로고
    • Apoptosis in pressure overload-induced cardiac hypertrophy is mediated, in part, by adenine nucleotide translocator-1
    • T. Hang, Z. Huang, S. Jiang et al., "Apoptosis in pressure overload-induced cardiac hypertrophy is mediated, in part, by adenine nucleotide translocator-1, " Annals of Clinical and Laboratory Science, vol. 36, no. 1, pp. 88-95, 2006.
    • (2006) Annals of Clinical and Laboratory Science , vol.36 , Issue.1 , pp. 88-95
    • Hang, T.1    Huang, Z.2    Jiang, S.3
  • 73
    • 0033564419 scopus 로고    scopus 로고
    • Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat
    • G. Condorelli, C. Morisco, G. Stassi et al., "Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat, " Circulation, vol. 99, no. 23, pp. 3071-3078, 1999.
    • (1999) Circulation , vol.99 , Issue.23 , pp. 3071-3078
    • Condorelli, G.1    Morisco, C.2    Stassi, G.3
  • 74
    • 80053355508 scopus 로고    scopus 로고
    • Mitochondrial ('mild') uncoupling and ROS production: Physiologically relevant or not?
    • I. G. Shabalina and J. Nedergaard, "Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?" Biochemical Society Transactions, vol. 39, no. 5, pp. 1305-1309, 2011.
    • (2011) Biochemical Society Transactions , vol.39 , Issue.5 , pp. 1305-1309
    • Shabalina, I.G.1    Nedergaard, J.2
  • 75
    • 84924778498 scopus 로고    scopus 로고
    • Controlled-releasemitochondrial protonophore reverses diabetes and protonophore reverses diabetes and steatohepatitis in rats
    • R. J. Perry, D. Zhang, X.-M. Zhang, J. L. Boyer, and G. I. Shulman, "Controlled-releasemitochondrial protonophore reverses diabetes and protonophore reverses diabetes and steatohepatitis in rats, " Science, vol. 347, no. 6227, pp. 1253-1256, 2015.
    • (2015) Science , vol.347 , Issue.6227 , pp. 1253-1256
    • Perry, R.J.1    Zhang, D.2    Zhang, X.-M.3    Boyer, J.L.4    Shulman, G.I.5
  • 76
    • 84859882241 scopus 로고    scopus 로고
    • Uncoupling proteins: Molecular, functional, regulatory, physiological and pathological aspects
    • F. E. Sluse, "Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects, " Advances in Experimental Medicine and Biology, vol. 942, pp. 137-156, 2012.
    • (2012) Advances in Experimental Medicine and Biology , vol.942 , pp. 137-156
    • Sluse, F.E.1
  • 77
    • 84922435398 scopus 로고    scopus 로고
    • Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening
    • Y. Chen, J. Liu, Y. Zheng et al., "Uncoupling protein 3 mediates H2O2 preconditioning-afforded cardioprotection through the inhibition of MPTP opening, " Cardiovascular Research, vol. 105, no. 2, pp. 192-202, 2015.
    • (2015) Cardiovascular Research , vol.105 , Issue.2 , pp. 192-202
    • Chen, Y.1    Liu, J.2    Zheng, Y.3
  • 78
    • 33749440288 scopus 로고    scopus 로고
    • FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation
    • J. P. Brennan, R. G. Berry, M. Baghai, M. R. Duchen, and M. J. Shattock, "FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation, " Cardiovascular Research, vol. 72, no. 2, pp. 322-330, 2006.
    • (2006) Cardiovascular Research , vol.72 , Issue.2 , pp. 322-330
    • Brennan, J.P.1    Berry, R.G.2    Baghai, M.3    Duchen, M.R.4    Shattock, M.J.5
  • 79
    • 84897085790 scopus 로고    scopus 로고
    • Pericardial fat, insulin resistance, and left ventricular structure and function in morbid obesity
    • G. Pucci, F. Battista, S. de Vuono et al., "Pericardial fat, insulin resistance, and left ventricular structure and function in morbid obesity, " Nutrition, Metabolism and Cardiovascular Diseases, vol. 24, no. 4, pp. 440-446, 2014.
    • (2014) Nutrition, Metabolism and Cardiovascular Diseases , vol.24 , Issue.4 , pp. 440-446
    • Pucci, G.1    Battista, F.2    De Vuono, S.3
  • 80
    • 84856400955 scopus 로고    scopus 로고
    • High free fatty acids level related with cardiac dysfunction in obese rats
    • X. Sun, H. Pan, H. Tan, and Y. Yu, "High free fatty acids level related with cardiac dysfunction in obese rats, " Diabetes Research and Clinical Practice, vol. 95, no. 2, pp. 251-259, 2012.
    • (2012) Diabetes Research and Clinical Practice , vol.95 , Issue.2 , pp. 251-259
    • Sun, X.1    Pan, H.2    Tan, H.3    Yu, Y.4
  • 83
    • 84874868379 scopus 로고    scopus 로고
    • Cardiac steatosis associates with visceral obesity in nondiabetic obesemen
    • M. Granér, R. Siren, K. Nyman et al., "Cardiac steatosis associates with visceral obesity in nondiabetic obesemen, " Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 3, pp. 1189-1197, 2013.
    • (2013) Journal of Clinical Endocrinology and Metabolism , vol.98 , Issue.3 , pp. 1189-1197
    • Granér, M.1    Siren, R.2    Nyman, K.3
  • 84
    • 84867147394 scopus 로고    scopus 로고
    • Effects of pioglitazone on high-fat-diet-induced ventricular remodeling and dysfunction in rats
    • Y.-Q. Tian, S.-S. Li, X.-D. Su et al., "Effects of pioglitazone on high-fat-diet-induced ventricular remodeling and dysfunction in rats, " Journal of Cardiovascular Pharmacology andTherapeutics, vol. 17, no. 2, pp. 223-228, 2012.
    • (2012) Journal of Cardiovascular Pharmacology and Therapeutics , vol.17 , Issue.2 , pp. 223-228
    • Tian, Y.-Q.1    Li, S.-S.2    Su, X.-D.3
  • 87
    • 0036326045 scopus 로고    scopus 로고
    • Impaired longchain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart
    • M. E. Young, P. H. Guthrie, P. Razeghi et al., "Impaired longchain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart, " Diabetes, vol. 51, no. 8, pp. 2587-2595, 2002.
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2587-2595
    • Young, M.E.1    Guthrie, P.H.2    Razeghi, P.3
  • 88
    • 84951810549 scopus 로고    scopus 로고
    • Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis
    • L. Martínez, S. Torres, A. Baulies et al., "Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis, " Oncotarget, vol. 6, no. 39, pp. 41479-41496, 2015.
    • (2015) Oncotarget , vol.6 , Issue.39 , pp. 41479-41496
    • Martínez, L.1    Torres, S.2    Baulies, A.3
  • 89
    • 84916899552 scopus 로고    scopus 로고
    • Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides
    • H. Gao, X.-J. Feng, Z.-M. Li et al., "Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides, " Archives of Biochemistry and Biophysics, vol. 565, pp. 76-88, 2015.
    • (2015) Archives of Biochemistry and Biophysics , vol.565 , pp. 76-88
    • Gao, H.1    Feng, X.-J.2    Li, Z.-M.3
  • 90
    • 0141763547 scopus 로고    scopus 로고
    • Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle
    • S. Wang, A. Subramaniam, M. A. Cawthorne, and J. C. Clapham, "Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle, " Diabetes, Obesity and Metabolism, vol. 5, no. 5, pp. 295-301, 2003.
    • (2003) Diabetes, Obesity and Metabolism , vol.5 , Issue.5 , pp. 295-301
    • Wang, S.1    Subramaniam, A.2    Cawthorne, M.A.3    Clapham, J.C.4
  • 91
    • 6044220129 scopus 로고    scopus 로고
    • Evidence for mitochondrial thioesterase 1 as a peroxisome proliferatoractivated receptor-α-regulated gene in cardiac and skeletal muscle
    • M. A. Stavinoha, J.W. RaySpellicy, M. F. Essop et al., "Evidence for mitochondrial thioesterase 1 as a peroxisome proliferatoractivated receptor-α-regulated gene in cardiac and skeletal muscle, " American Journal of Physiology-Endocrinology and Metabolism, vol. 287, no. 5, pp. E888-E895, 2004.
    • (2004) American Journal of Physiology-Endocrinology and Metabolism , vol.287 , Issue.5 , pp. E888-E895
    • Stavinoha, M.A.1    RaySpellicy, J.W.2    Essop, M.F.3
  • 92
    • 84885168882 scopus 로고    scopus 로고
    • Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart
    • R. Harmancey, H. G. Vasquez, P. H. Guthrie, and H. Taegtmeyer, "Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart, " The FASEB Journal, vol. 27, no. 10, pp. 3966-3978, 2013.
    • (2013) The FASEB Journal , vol.27 , Issue.10 , pp. 3966-3978
    • Harmancey, R.1    Vasquez, H.G.2    Guthrie, P.H.3    Taegtmeyer, H.4
  • 95
    • 4344601004 scopus 로고    scopus 로고
    • Impaired cardiac efficiency and increased fatty acid oxidation in insulinresistant ob/ob mouse hearts
    • P. K. Mazumder, B. T. O'Neill, M. W. Roberts et al., "Impaired cardiac efficiency and increased fatty acid oxidation in insulinresistant ob/ob mouse hearts, " Diabetes, vol. 53, no. 9, pp. 2366-2374, 2004.
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2366-2374
    • Mazumder, P.K.1    O'Neill, B.T.2    Roberts, M.W.3
  • 96
    • 0036084877 scopus 로고    scopus 로고
    • Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin
    • J. Y. Kong and S. W. Rabkin, "Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 282, no. 2, pp. H717-H725, 2002.
    • (2002) American Journal of Physiology-Heart and Circulatory Physiology , vol.282 , Issue.2 , pp. H717-H725
    • Kong, J.Y.1    Rabkin, S.W.2
  • 97
    • 84897406015 scopus 로고    scopus 로고
    • Lipid analogues as potential drugs for the regulation ofmitochondrial cell death
    • M. Murray, H. R. E. Dyari, S. E. Allison, and T. Rawling, "Lipid analogues as potential drugs for the regulation ofmitochondrial cell death, " British Journal of Pharmacology, vol. 171, no. 8, pp. 2051-2066, 2014.
    • (2014) British Journal of Pharmacology , vol.171 , Issue.8 , pp. 2051-2066
    • Murray, M.1    Dyari, H.R.E.2    Allison, S.E.3    Rawling, T.4
  • 99
    • 34547098640 scopus 로고    scopus 로고
    • Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport
    • P. Schönfeld and L. Wojtczak, "Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport, " Biochimica et Biophysica Acta (BBA)-Bioenergetics, vol. 1767, no. 8, pp. 1032-1040, 2007.
    • (2007) Biochimica et Biophysica Acta (BBA)-Bioenergetics , vol.1767 , Issue.8 , pp. 1032-1040
    • Schönfeld, P.1    Wojtczak, L.2
  • 100
    • 54449089267 scopus 로고    scopus 로고
    • Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
    • E. L. Seifert, V. Bézaire, C. Estey, and M.-E. Harper, "Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export, " The Journal of Biological Chemistry, vol. 283, no. 37, pp. 25124-25131, 2008.
    • (2008) The Journal of Biological Chemistry , vol.283 , Issue.37 , pp. 25124-25131
    • Seifert, E.L.1    Bézaire, V.2    Estey, C.3    Harper, M.-E.4
  • 101
    • 0642272500 scopus 로고    scopus 로고
    • Uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    • P. Schrauwen, J. Hoeks, G. Schaart et al., "Uncoupling protein 3 as a mitochondrial fatty acid anion exporter, " The FASEB Journal, vol. 17, no. 15, pp. 2272-2274, 2003.
    • (2003) The FASEB Journal , vol.17 , Issue.15 , pp. 2272-2274
    • Schrauwen, P.1    Hoeks, J.2    Schaart, G.3
  • 102
    • 0041465009 scopus 로고    scopus 로고
    • A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
    • K. S. Echtay, T. C. Esteves, J. L. Pakay et al., "A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling, " The EMBO Journal, vol. 22, no. 16, pp. 4103-4110, 2003.
    • (2003) The EMBO Journal , vol.22 , Issue.16 , pp. 4103-4110
    • Echtay, K.S.1    Esteves, T.C.2    Pakay, J.L.3
  • 103
    • 2242425423 scopus 로고    scopus 로고
    • Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
    • M. D. Brand, R. Pamplona, M. Portero-Otín et al., "Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3, " Biochemical Journal, vol. 368, no. 2, pp. 597-603, 2002.
    • (2002) Biochemical Journal , vol.368 , Issue.2 , pp. 597-603
    • Brand, M.D.1    Pamplona, R.2    Portero-Otín, M.3
  • 104
    • 0035462571 scopus 로고    scopus 로고
    • Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes
    • D. Dyntar, M. Eppenberger-Eberhardt, K. Maedler et al., "Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes, " Diabetes, vol. 50, no. 9, pp. 2105-2113, 2001.
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2105-2113
    • Dyntar, D.1    Eppenberger-Eberhardt, M.2    Maedler, K.3
  • 105
    • 0035851186 scopus 로고    scopus 로고
    • Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis
    • D. B. Ostrander, G. C. Sparagna, A. A. Amoscato, J. B. McMillin, and W. Dowhan, "Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis, " Journal of Biological Chemistry, vol. 276, no. 41, pp. 38061-38067, 2001.
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.41 , pp. 38061-38067
    • Ostrander, D.B.1    Sparagna, G.C.2    Amoscato, A.A.3    McMillin, J.B.4    Dowhan, W.5
  • 106
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibitsmitochondrial death pathway in cardiomyocytes
    • Y. Teshima, M. Akao, S. P. Jones, and E. Marbán, "Uncoupling protein-2 overexpression inhibitsmitochondrial death pathway in cardiomyocytes, " Circulation Research, vol. 93, no. 3, pp. 192-200, 2003.
    • (2003) Circulation Research , vol.93 , Issue.3 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3    Marbán, E.4
  • 107
    • 84908530426 scopus 로고    scopus 로고
    • Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitromodel of cardiomyocyte lipotoxicity
    • M. Bosma, D.H. Dapito, Z. Drosatos-Tampakaki et al., "Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitromodel of cardiomyocyte lipotoxicity, " Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, vol. 1841, no. 12, pp. 1648-1655, 2014.
    • (2014) Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids , vol.1841 , Issue.12 , pp. 1648-1655
    • Bosma, M.1    Dapito, D.H.2    Drosatos-Tampakaki, Z.3
  • 108
    • 0026608979 scopus 로고
    • Molecular basis of inheritedmedium-chain acyl-CoAdehydrogenase deficiency causing sudden child death
    • D. P. Kelly, D. E. Hale, S. L. Rutledge et al., "Molecular basis of inheritedmedium-chain acyl-CoAdehydrogenase deficiency causing sudden child death, " Journal of Inherited Metabolic Disease, vol. 15, no. 2, pp. 171-180, 1992.
    • (1992) Journal of Inherited Metabolic Disease , vol.15 , Issue.2 , pp. 171-180
    • Kelly, D.P.1    Hale, D.E.2    Rutledge, S.L.3
  • 109
    • 13044277575 scopus 로고    scopus 로고
    • Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation
    • D.M. Kurtz, P. Rinaldo, W. J. Rhead et al., "Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 26, pp. 15592-15597, 1998.
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , Issue.26 , pp. 15592-15597
    • Kurtz, D.M.1    Rinaldo, P.2    Rhead, W.J.3
  • 110
    • 40649083566 scopus 로고    scopus 로고
    • Heart lipid accumulation in obese non-diabetic rats: Effect of weight loss
    • C. Pagano, A. Calcagno, M. Granzotto et al., "Heart lipid accumulation in obese non-diabetic rats: effect of weight loss, " Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 3, pp. 189-197, 2008.
    • (2008) Nutrition, Metabolism and Cardiovascular Diseases , vol.18 , Issue.3 , pp. 189-197
    • Pagano, C.1    Calcagno, A.2    Granzotto, M.3
  • 111
    • 84922365747 scopus 로고    scopus 로고
    • Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase
    • J. Roussel, J. Thireau, C. Brenner et al., "Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: role of adenine nucleotide translocase, " Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1852, no. 5, pp. 749-758, 2015.
    • (2015) Biochimica et Biophysica Acta-Molecular Basis of Disease , vol.1852 , Issue.5 , pp. 749-758
    • Roussel, J.1    Thireau, J.2    Brenner, C.3
  • 112
    • 34047176377 scopus 로고    scopus 로고
    • Effects of palmitate on Ca2+ handling in adult control and ob/ob cardiomyocytes: Impact of mitochondrial reactive oxygen species
    • J. Fauconnier, D. C. Andersson, S.-J. Zhang et al., "Effects of palmitate on Ca2+ handling in adult control and ob/ob cardiomyocytes: impact ofmitochondrial reactive oxygen species, " Diabetes, vol. 56, no. 4, pp. 1136-1142, 2007.
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1136-1142
    • Fauconnier, J.1    Andersson, D.C.2    Zhang, S.-J.3
  • 113
    • 84905816041 scopus 로고    scopus 로고
    • Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation
    • O. A. Alrob and G. D. Lopaschuk, "Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation, " Biochemical Society Transactions, vol. 42, no. 4, pp. 1043-1051, 2014.
    • (2014) Biochemical Society Transactions , vol.42 , Issue.4 , pp. 1043-1051
    • Alrob, O.A.1    Lopaschuk, G.D.2
  • 114
    • 82455212901 scopus 로고    scopus 로고
    • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
    • M. D. Hirschey, T. Shimazu, E. Jing et al., "SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome, "Molecular Cell, vol. 44, no. 2, pp. 177-190, 2011.
    • (2011) Molecular Cell , vol.44 , Issue.2 , pp. 177-190
    • Hirschey, M.D.1    Shimazu, T.2    Jing, E.3
  • 115
    • 84888329025 scopus 로고    scopus 로고
    • Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site
    • S. S. Bharathi, Y. Zhang, A.-W. Mohsen et al., "Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site, " The Journal of Biological Chemistry, vol. 288, no. 47, pp. 33837-33847, 2013.
    • (2013) The Journal of Biological Chemistry , vol.288 , Issue.47 , pp. 33837-33847
    • Bharathi, S.S.1    Zhang, Y.2    Mohsen, A.-W.3
  • 116
    • 77950806433 scopus 로고    scopus 로고
    • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    • M. D. Hirschey, T. Shimazu, E. Goetzman et al., "SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation, " Nature, vol. 464, no. 7285, pp. 121-125, 2010.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 121-125
    • Hirschey, M.D.1    Shimazu, T.2    Goetzman, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.