Uncoupling proteins: Molecular, functional, regulatory, physiological and pathological aspects

Advances in Experimental Medicine and Biology

Volumn 942, Issue , 2012, Pages 137-156

  Sluse, Francis E ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Partitioning of proton electrochemical gradient; Pathological implications of UCPs linked to their physiological roles; Physiological roles of uncoupling proteins (UCP); Reactive oxygen species prevention and energy metabolism balance; Regulation mechanisms of UCP activity; Widespread distribution of UCPs

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; FATTY ACID; GUANOSINE TRIPHOSPHATE; MITOCHONDRIAL ANION CARRIER FAMILY PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ARTICLE; BIOENERGY; BROWN ADIPOSE TISSUE; CITRIC ACID CYCLE; ENZYME ACTIVATION; ENZYME INHIBITION; METABOLIC BALANCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; PROTON MOTIVE FORCE; RESPIRATORY CHAIN; STEADY STATE; THERMOGENESIS; UPREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; HUMANS; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES;

EUKARYOTA;

EID: 84859882241     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-2869-1_6     Document Type: Article

References (88)

1. Avery SV, Harwood JL et al (1994) Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoebacastellanii cultures of different ages. Biochem Soc Trans 22(3):257S
2. Azzu V, Jastroch M et al (2010) The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta 1797(6-7):785-791
3. Barreiro E, Garcia-Martinez C et al (2009) UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes. FEBS Lett 583(2):350-356
4. Bezaire V, Spriet LL et al (2005) Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation. FASEB J 19(8):977-979
5. Borecky J, Maia IG et al (2001) Functional reconstitution of Arabidopsis thalianaplant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichiacoli. FEBS Lett 505(2):240-244
6. Brand MD, Pamplona R et al (2002) Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondriafrom mice underexpressing or overexpressing uncoupling protein 3. Biochem J 368(Pt 2):597-603
7. Breidenbach RW, Saxton MJ et al (1997) Heat generation and dissipation in plants: can the alternative oxidative phosphorylation pathway serve athermoregulatory role in plant tissues other than specialized organs? Plant Physiol 114(4):1137-1140
8. Brookes PS (2005) Mitochondrial H(+) leak and ROS generation: an odd couple. Free Radic Biol Med 38(1):12-23
9. Cadenas S, Buckingham JA et al (1999) UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett 462(3):257-260
10. Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84(1):277-359
11. Chan CB, MacDonald PE et al (1999) Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48(7):1482-1486
12. Chavin KD, Yang S et al (1999) Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem 274(9):5692-5700
13. Considine MJ, Daley DO et al (2001) The expression of alternative oxidase and uncoupling protein during fruit ripening in mango. Plant Physiol 126(4):1619-1629
14. Considine MJ, Goodman M et al (2003) Superoxide stimulates aproton leak in potato mitochondriathat is related to the activity of uncoupling protein. J Biol Chem 278(25):22298-22302
15. Czarna M, Jarmuszkiewicz W (2005) Activation of alternative oxidase and uncoupling protein lowers hydrogen peroxide formation in amoebaAcanthamoebacastellanii mitochondria. FEBS Lett 579(14):3136-3140
16. Derdak Z, Fulop P et al (2006) Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis 27(5):956-961
17. Di Lisa F, Bernardi P (1998) Mitochondrial function as adeterminant of recovery or death in cell response to injury. Mol Cell Biochem 184(1-2):379-391
18. Douette P, Sluse FE (2006) Mitochondrial uncoupling proteins: new insights from functional and proteomic studies. Free Radic Biol Med 40(7):1097-1107
19. Douette P, Navet R et al (2005) Steatosis-induced proteomic changes in liver mitochondriaevidenced by two-dimensional differential in-gel electrophoresis. J Proteome Res 4(6):2024-2031
20. Douette P, Gerkens P et al (2006) Uncoupling protein 1 affects the yeast mitoproteome and oxygen free radical production. Free Radic Biol Med 40(2):303-315
21. Echtay KS (2007) Mitochondrial uncoupling proteins-what is their physiological role? Free Radic Biol Med 43(10):1351-1371
22. Echtay KS, Winkler E et al (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408(6812):609-613
23. Echtay KS, Winkler E et al (2001) Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci USA 98(4):1416-1421
24. Echtay KS, Roussel D et al (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415(6867):96-99
25. Echtay KS, Esteves TC et al (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J 22(16):4103-4110
26. el Moualij B, Duyckaerts C et al (1997) Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. Yeast 13(6):573-581
27. Enerback S, Jacobsson A et al (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387(6628):90-94
28. Feldmann HM, Golozoubova V et al (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9(2):203-209
29. Garlid KD, Orosz DE et al (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J Biol Chem 271(5):2615-2620
30. Gong DW, Monemdjou S et al (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 275(21):16251-16257
31. Gonzalez-Barroso MM, Fleury C et al (1996) Activation of the uncoupling protein by fatty acids is modulated by mutations in the C-terminal region of the protein. Eur J Biochem 239(2):445-450
32. Hourton-Cabassa C, Mesneau A et al (2002) Alteration of plant mitochondrial proton conductance by free fatty acids. Uncoupling protein involvement. J Biol Chem 277(44):41533-41538
33. Jaburek M, Varecha M et al (1999) Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J Biol Chem 274(37):26003-26007
34. Jarmuszkiewicz W, Sluse-Goffart C et al (1996) Determination of the respective contributions of the cytochrome and alternative oxidase pathways in Acanthamoebacastellanii mitochondria. Biothermokinetics of the living cell. BioThemoKinetics Press, Amsterdam, pp 31-34
35. Jarmuszkiewicz W, Almeida AM et al (1998) Linoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondriaduring resting, phosphorylating, and progressively uncoupled respiration. J Biol Chem 273(52):34882-34886
36. Jarmuszkiewicz W, Sluse-Goffart CM et al (1999) Identification and characterization of aprotozoan uncoupling protein in Acanthamoebacastellanii. J Biol Chem 274(33):23198-23202
37. Jarmuszkiewicz W, Almeida AM et al (2000a) Proton re-uptake partitioning between uncoupling protein and ATP synthase during benzohydroxamic acid-resistant state 3 respiration in tomato fruit mitochondria. J Biol Chem 275(18):13315-13320
38. Jarmuszkiewicz W, Milani G et al (2000b) First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candidaparapsilosis. FEBS Lett 467(2-3):145-149
39. Jarmuszkiewicz W, Sluse-Goffart CM et al (2001) Alternative oxidase and uncoupling protein: thermogenesis versus cell energy balance. Biosci Rep 21(2):213-222
40. Jarmuszkiewicz W, Antos N et al (2004a) The effect of growth at low temperature on the activity and expression of the uncoupling protein in Acanthamoebacastellanii mitochondria. FEBS Lett 569(1-3):178-184
41. Jarmuszkiewicz W, Navet R et al (2004b) Redox state of endogenous coenzyme q modulates the inhibition of linoleic acid-induced uncoupling by guanosine triphosphate in isolated skeletal muscle mitochondria. J Bioenerg Biomembr 36(5):493-502
42. Jarmuszkiewicz W, Swida A et al (2005) In phosphorylating Acanthamoebacastellanii mitochondriathe sensitivity of uncoupling protein activity to GTP depends on the redox state of quinone. J Bioenerg Biomembr 37(2):97-107
43. Jarmuszkiewicz W, Woyda-Ploszczyca A et al (2009) Mitochondrial uncoupling proteins in unicellular eukaryotes. Biochim Biophys Acta 1797(6-7):792-799
44. Jekabsons MB, Echtay KS et al (2002) Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies. Biochem J 366(Pt 2):565-571
45. Jiang N, Zhang G et al (2009) Upregulation of uncoupling protein-3 in skeletal muscle during exercise: apotential antioxidant function. Free Radic Biol Med 46(2):138-145
46. Klingenberg M (1990) Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci 15(3):108-112
47. Klingenberg M, Echtay KS (2001) Uncoupling proteins: the issues from abiochemist point of view. Biochim Biophys Acta 1504(1):128-143
48. Klingenberg M, Winkler E (1985) The reconstituted isolated uncoupling protein is amembrane potential driven H+ translocator. EMBO J 4(12):3087-3092
49. Korshunov SS, Skulachev VP et al (1997) High protonic potential actuates amechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416(1):15-18
50. Lambert AJ, Boysen HM et al (2007) Low rates of hydrogen peroxide production by isolated heart mitochondriaassociate with long maximum lifespan in vertebrate homeotherms. Aging Cell 6(5):607-618
51. Leloup C, Tourrel-Cuzin C et al (2009) Mitochondrial reactive oxygen species are obligatory signals for glucoseinduced insulin secretion. Diabetes 58(3):673-681
52. MacLellan JD, Gerrits MF et al (2005) Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes 54(8): 2343-2350
53. Mao W, Yu XX et al (1999) UCP4, anovel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett 443(3):326-330
54. Meeuse B (1975) Thermogenic respiration in Aroids. Annu Rev Plant Physiol 26:117-126
55. Mitchell P (1961) Coupling of phosphorylation to electron and hydrogen transfer by achemi-osmotic type of mechanism. Nature 191:144-148
56. Mookerjee SA, Divakaruni AS et al (2010) Mitochondrial uncoupling and lifespan. Mech Ageing Dev 131(7-8): 463-472
57. Moukdar F, Robidoux J et al (2009) Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res 50(1):59-70
58. Murphy MP, Echtay KS et al (2003) Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using amitochondria-targeted spin trap derived from alpha-phenyl-N-tertbutylnitrone. J Biol Chem 278(49):48534-48545
59. Nabben M, Hoeks J (2008) Mitochondrial uncoupling protein 3 and its role in cardiac-and skeletal muscle metabolism. Physiol Behav 94(2):259-269
60. Navet R, Douette P et al (2005) Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria. FEBS Lett 579(20):4437-4442
61. Navet R, Mouithys-Mickalad A et al (2006) Proton leak induced by reactive oxygen species produced during in vitro anoxia/reoxygenation in rat skeletal muscle mitochondria. J Bioenerg Biomembr 38(1):23-32
62. Navet R, Mathy G et al (2007) Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation. J Proteome Res 6(1):25-33
63. Negre-Salvayre A, Hirtz C et al (1997) A role for uncoupling protein-2 as aregulator of mitochondrial hydrogen peroxide generation. FASEB J 11(10):809-815
64. Nicholls DG (2006) The physiological regulation of uncoupling proteins. Biochim Biophys Acta 1757(5-6):459-466
65. Nicholls DG, Rial E (1999) A history of the first uncoupling protein, UCP1. J Bioenerg Biomembr 31(5):399-406
66. Pi J, Bai Y et al (2009) Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 150(7):3040-3048
67. Rial E, Gonzalez-Barroso M et al (1999) Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. EMBO J 18(21):5827-5833
68. Ricquier D, Bouillaud F (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J 345(Pt 2):161-179
69. Sanchis D, Busquets S et al (1998) Skeletal muscle UCP2 and UCP3 gene expression in arat cancer cachexiamodel. FEBS Lett 436(3):415-418
70. Saraste M (1999) Oxidative phosphorylation at the fin de siecle. Science 283(5407):1488-1493
71. Shabalina IG, Jacobsson A et al (2004) Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem 279(37):38236-38248
72. Skulachev VP (1991) Fatty acid circuit as aphysiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett 294(3):158-162
73. Sluse FE (1996) Mitochondrial metabolite carrier family, topology, structure and functional properties: an overview. ActaBiochim Pol 43(2):349-360
74. Sluse FE, Jarmuszkiewicz W (2000) Activity and functional interaction of alternative oxidase and uncoupling protein in mitochondriafrom tomato fruit. Braz J Med Biol Res 33(3):259-268
75. Sluse FE, Jarmuszkiewicz W (2002) Uncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects. FEBS Lett 510(3):117-120
76. Sluse FE, Almeida AM et al (1998a) Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria. FEBS Lett 433(3):237-240
77. Sluse FE, Jarmuszkiewicz W et al (1998b) Determination of actual contribution of energy-dissipating pathways to mitochondrial respiration: the ADP/O method. In: Plant mitochondria: from gene to function. Backhuys Publisher, Leiden
78. Sluse FE, Jarmuszkiewicz W et al (2006) Mitochondrial UCPs: new insights into regulation and impact. Biochim Biophys Acta 1757(5-6):480-485
79. Smith AM, Ratcliffe RG et al (2004) Activation and function of mitochondrial uncoupling protein in plants. J Biol Chem 279(50):51944-51952
80. Son C, Hosoda K et al (2004) Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle. Diabetologia47(1):47-54
81. Swida-Barteczka A, Woyda-Ploszczyca A et al (2009) Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state. Biochem J 424(2):297-306
82. Vercesi AE, Martins LS et al (1995) PUMPing plants. Nature 375(6526):24-24
83. Vercesi AE, Borecky J et al (2006) Plant uncoupling mitochondrial proteins. Annu Rev Plant Biol 57:383-404
84. Vidal-Puig AJ, Grujic D et al (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 275(21):16258-16266
85. Yang S, Zhu H et al (2000) Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 378(2):259-268
86. Zackova M, Skobisova E et al (2003) Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3. J Biol Chem 278(23): 20761-20769
87. Zhang CY, Hagen T et al (1999) Assessment of uncoupling activity of uncoupling protein 3 using ayeast heterologous expression system. FEBS Lett 449(2-3):129-134
88. Zhang CY, Baffy G et al (2001) Uncoupling protein-2 negatively regulates insulin secretion and is amajor link between obesity, betacell dysfunction, and type 2 diabetes. Cell 105(6):745-755