Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes

Life Sciences

Volumn 79, Issue 15, 2006, Pages 1428-1435

  Zhang, Min ^a   Wang, Bin ^a   Ni, Yu hui ^a   Liu, Feng ^a   Fei, Li ^a   Pan, Xiao qing ^a   Guo, Mei ^a   Chen, Rong hua ^a   Guo, Xi rong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adipogenesis; Apoptosis; Differentiation; Proliferation; Uncoupling protein 4

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CELL MARKER; FATTY ACID SYNTHASE; LIPID BINDING PROTEIN; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 4;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DIFFERENTIATION; DOWN REGULATION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PROADIPOCYTE; PROTEIN MALNUTRITION; RAT; SERUM;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION REGULATION, DEVELOPMENTAL; ION CHANNELS; MICE; MITOCHONDRIAL PROTEINS; PPAR GAMMA; RATS; TRANS-ACTIVATION (GENETICS);

EID: 33747372618     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.04.012     Document Type: Article

References (36)

1. Ailhaud G. Adipose tissue as an endocrine organ. International Journal of Obesity and Related Metabolic Disorders 24 Suppl. 2 (2000) S1-S3
2. Borecky J., Maria I.G., and Arruda P. Mitochondrial uncoupling proteins in mammals and plants. Bioscience Reports 21 2 (2001) 201-212
3. Chan C.B., MacDonald P.E., Saleh M.C., Johns D.C., Marban E., and Wheeler M.B. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48 7 (1999) 1482-1486
4. Collins P., Jones C., Choudhury S., Damelin L., and Hodgson H. Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis. Liver International 25 4 (2005) 880-887
5. Dowell P., Flexner C., Kwiterovich P.O., and Lane M.D. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. The Journal of Biological Chemistry 275 52 (2000) 41325-41332
6. Dulloo A.G., and Samec S. Uncoupling proteins: do they have a role in body weight regulation?. News in Physiological Sciences 15 6 (2000) 313-318
7. Echtay K.S., Roussel D., St-Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., Clapham J.C., and Brand M.D. Superoxide activates mitochondrial uncoupling proteins. Nature 415 6867 (2002) 96-99
8. Evans M., Geigerman C., Cook J., Curtis L., Kuebler B., and McIntosh M. Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35 8 (2000) 899-910
9. Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M.F., Surwit R.S., Ricquier D., and Warden C.H. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15 3 (1997) 269-272
10. Frayn K.N. Obesity and metabolic disease: is adipose tissue the culprit?. Proceedings of the Nutrition Society 64 1 (2005) 7-13
11. Gregoire F.M., Smas C.M., and Sul H.S. Understanding adipocyte differentiation. Physiological Reviews 78 3 (1998) 783-809
12. Grotendorst G.R., Rahmanie H., and Duncan M.R. Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. The FASEB Journal 18 3 (2004) 469-479
13. Guo X.R., Gong H.X., Fei L., Ni Y.H., and Chen R.H. Study on relationship between expression of UCP4 gene in rat adipose tissue and obesity. Chinese Journal of Child Health Care 12 1 (2004) 58-60
14. Harmon A.W., and Harp J.B. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. American Journal of Physiology. Cell Physiology 280 4 (2001) 807-813
15. Harper M.E., and Gerrits M.F. Mitochondrial uncoupling proteins as potential targets for pharmacological agents. Current Opinion in Pharmacology 4 6 (2004) 603-607
16. Haugk K.L., Wilson H.M., Swisshelm K., and Ouinn L.S. Insulin-like growth factor (IGF)-binding protein-related protein-1: an autocrine/paracrine factor that inhibits skeletal myoblast differentiation but permits proliferation in response to IGF. Endocrinology 141 1 (2000) 100-110
17. Ho P.W., Chan D.Y., Kwok K.H., Chu A.C., Ho J.W., Kung M.H., Ramsden D.B., and Ho S.L. Methyl-4-phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells. Journal of Neuroscience Research 81 2 (2005) 261-268
18. Jezek P., Zackova M., Ruzicka M., Skobisova E., and Jaburek M. Mitochondrial uncoupling proteins-facts and fantasies. Physiological Research 53 Suppl. 1 (2004) S199-S211
19. Kim M.S., Yoon C.Y., Jang P.G., Park Y.J., Shin C.S., Park H.S., Ryu J.W., Park J.Y., Lee K.U., Kim S.Y., Lee H.K., Kim Y.B., and Park K.S. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Molecular Endocrinology 18 9 (2004) 2291-2301
20. Lameloise N., Muzzin P., Prentki M., and Assimacopoulos-Jeannet F. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?. Diabetes 50 4 (2001) 803-809
21. Lee K.U., Lee I.K., Han J., Song D.K., Kim Y.M., Song H.S., Kim H.S., Lee W.J., Koh E.H., Song K.H., Han S.M., Kim M.S., Park I.S., and Park J.Y. Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circulation Research 96 11 (2005) 1200-1207
22. Longo K.A., Kennell J.A., Ochocinska M.J., Ross S.E., Wright W.S., and MarDougald O.A. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. The Journal of Biological Chemistry 277 41 (2002) 38239-38244
23. MacDougald O.A., and Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annual Review of Biochemistry 64 (1995) 345-373
24. Mao W., Yu X.X., Zhong A., Li W., Brush J., Sherwood S.W., Adams S.H., and Pan G. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Letters 443 3 (1999) 326-330
25. Mattson M.P., and Liu D. Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochemical and Biophysical Research Communications 304 3 (2003) 539-549
26. Moitra J., Mason M.M., Olive M., Krylov D., Gavrilova O., Marcus-Samuels B., Feigenbaum L., Lee E., Aoyama T., Eckhaus M., Reitman M.L., and Vinson C. Life without white fat: a transgenic mouse. Genes & Development 12 20 (1998) 3168-3181
27. Nedergaard J., Golozoubova V., Matthias A., Asadi A., Jacobsson A., and Cannon B. UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochimica et Biophysica Acta 1504 1 (2001) 82-106
28. Negre-Salvayre A., Hirtz C., Carrera G., Cazenave R., Troly M., Salvayre R., Penicaud L., and Casteilla L. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. The FASEB Journal 11 10 (1997) 809-815
29. Rousset S., Alves-Guerra M.C., Mozo J., Miroux B., Cassard-Doulcier A.M., Bouillaud F., and Ricquier D. The biology of mitochondrial uncoupling proteins. Diabetes 53 Suppl. 1 (2004) 130-135
30. Shimba S., Wada T., Hara S., and Tezuka M. EPAS1 promotes adipose differentiation in 3T3-L1 cells. The Journal of Biological Chemistry 279 39 (2004) 40946-40953
31. Teshima Y., Akao Masaharu, Jones S.P., and Marban E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circulation Research 93 3 (2003) 192-200
32. Vankoningsloo S., Piens M., Lecocq C., Gilson A., De Pauw A., Renard P., Demazy C., Houbion A., Raes M., and Arnould T. Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid β-oxidation and glucose. Journal of Lipid Research 46 6 (2005) 1133-1149
33. Vidal-Puig A., Solanes G., Grujic D., Flier J.S., and Lowell B.B. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and Biophysical Research Communications 235 1 (1997) 79-82
34. Vincent A.M., Olzmann J.A., Brownlee M., Sivitz W.I., and Russell J.W. Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes 53 3 (2004) 726-734
35. Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., and Pan G. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. The FASEB Journal 14 11 (2000) 1611-1618
36. Zhang C.Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., Hagen T., Vidal-Puig A.J., Boss O., Kim Y.B., Zheng X.X., Wheeler M.B., Shulman G.I., Chan C.B., and Lowell B.B. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105 6 (2001) 745-755