Environmental enrichment potently prevents microglia-mediated neuroinflammation by human amyloid β-protein oligomers

Journal of Neuroscience

Volumn 36, Issue 35, 2016, Pages 9041-9056

  Xu, Huixin ^a   Gelyana, Eilrayna ^a   Rajsombath, Molly ^a   Yang, Ting ^a   Li, Shaomin ^a   Selkoe, Dennis ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Alzheimer s disease; Brain inflammation; Environmental enrichment; Microglia; Oligomeric amyloid beta

Indexed keywords

AMYLOID BETA PROTEIN; CD11B ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MYC PROTEIN; PROSTAGLANDIN E RECEPTOR 3; PROTEIN FOS; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; 5-ETHYNYL-2'-DEOXYURIDINE; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; AMYLOID PRECURSOR PROTEIN; CALCIUM BINDING PROTEIN; CD68 PROTEIN, MOUSE; CYTOKINE; DEOXYURIDINE; DIFFERENTIATION ANTIGEN; DOUBLECORTIN PROTEIN; LEUKOCYTE ANTIGEN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENTATE GYRUS; ELECTROPHYSIOLOGY; ENVIRONMENTAL ENRICHMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MALE; MICRODIALYSIS; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; ENCEPHALITIS; ENVIRONMENT; GENETIC TRANSFECTION; GENETICS; LONG TERM POTENTIATION; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; CHO CELLS; CRICETULUS; CYTOKINES; DENTATE GYRUS; DEOXYURIDINE; ENCEPHALITIS; ENVIRONMENT; HUMANS; LONG-TERM POTENTIATION; MALE; MICE; MICE, INBRED C57BL; MICRODIALYSIS; MICROFILAMENT PROTEINS; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; NEUROPEPTIDES; PHAGOCYTOSIS; RNA, MESSENGER; TRANSFECTION;

EID: 84985034233     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1023-16.2016     Document Type: Article

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