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Volumn 3, Issue 4, 2013, Pages 1051-1075

Metformin: On ongoing journey across diabetes, cancer therapy and prevention

Author keywords

Cancer; Chemoprevention; Diabetes; Meta analysis; Metabolism; microRNA; Therapy

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; CARBOPLATIN; CHOLESTEROL; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GLIBENCLAMIDE; GLUCOSE TRANSPORTER 1; HEXOKINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; HYPOXIA INDUCIBLE FACTOR 1; INITIATION FACTOR 4E BINDING PROTEIN 1; LACTATE DEHYDROGENASE; LUTEINIZING HORMONE; METFORMIN; MICRORNA; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; PROTEIN P53; PYRUVATE DEHYDROGENASE KINASE; ROSIGLITAZONE; SOMATOMEDIN BINDING PROTEIN 1; SULFONYLUREA; TRANSCRIPTION FACTOR NANOG; TRICARBOXYLIC ACID;

EID: 84984937251     PISSN: None     EISSN: 22181989     Source Type: Journal    
DOI: 10.3390/metabo3041051     Document Type: Review
Times cited : (28)

References (136)
  • 1
    • 0024330279 scopus 로고
    • Traditional plant medicines as treatments for diabetes
    • Bailey, C.J.; Day, C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989, 12, 553-564.
    • (1989) Diabetes Care , vol.12 , pp. 553-564
    • Bailey, C.J.1    Day, C.2
  • 2
    • 0034783579 scopus 로고    scopus 로고
    • The blooming of the french lilac
    • Witters, L.A. The blooming of the french lilac. J. Clin. Invest. 2001, 108, 1105-1107.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1105-1107
    • Witters, L.A.1
  • 4
    • 0000149388 scopus 로고
    • Studies in the metabolic changes induced by administration of guanidine bases
    • Watanabe, C. Studies in the metabolic changes induced by administration of guanidine bases. J. Biol. Chem. 1918, 33, 253-265.
    • (1918) J. Biol. Chem. , vol.33 , pp. 253-265
    • Watanabe, C.1
  • 6
    • 0005915684 scopus 로고
    • Die wirkung des biguanids und seiner derivate aud den zuckerstoffwechsel (in German)
    • Hesse, G.; Taubmann, G. Die wirkung des biguanids und seiner derivate aud den zuckerstoffwechsel (in German). Arch. Exp. Path. Pharmacol. 1929, 142, 290-308.
    • (1929) Arch. Exp. Path. Pharmacol. , vol.142 , pp. 290-308
    • Hesse, G.1    Taubmann, G.2
  • 7
    • 2342424434 scopus 로고    scopus 로고
    • Metformin: Its botanical background
    • Bailey, C.J.; Day, C. Metformin: Its botanical background. Pract. Diab. Int. 2004, 21, 115-117.
    • (2004) Pract. Diab. Int. , vol.21 , pp. 115-117
    • Bailey, C.J.1    Day, C.2
  • 10
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
    • El-Mir, M.Y.; Nogueira, V.; Fontaine, E.; Averet, N.; Rigoulet, M.; Leverve, X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i. J. Biol. Chem. 2000, 275, 223-228.
    • (2000) J. Biol. Chem. , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 11
    • 84873412963 scopus 로고    scopus 로고
    • Metformin and cancer: From the old medicine cabinet to pharmacological pitfalls and prospects
    • Emami Riedmaier, A.; Fisel, P.; Nies, A.T.; Schaeffeler, E.; Schwab, M. Metformin and cancer: From the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol. Sci. 2013, 34, 126-135.
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 126-135
    • Emami Riedmaier, A.1    Fisel, P.2    Nies, A.T.3    Schaeffeler, E.4    Schwab, M.5
  • 12
    • 3543140227 scopus 로고    scopus 로고
    • Amp-activated protein kinase: A master switch in glucose and lipid metabolism
    • Hardie, D.G. Amp-activated protein kinase: A master switch in glucose and lipid metabolism. Rev. Endocr. Metab. Disord. 2004, 5, 119-125.
    • (2004) Rev. Endocr. Metab. Disord. , vol.5 , pp. 119-125
    • Hardie, D.G.1
  • 14
    • 82455209029 scopus 로고    scopus 로고
    • Metformin activates amp-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
    • Stephenne, X.; Foretz, M.; Taleux, N.; van der Zon, G.C.; Sokal, E.; Hue, L.; Viollet, B.; Guigas, B. Metformin activates amp-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 2011, 54, 3101-3110.
    • (2011) Diabetologia , vol.54 , pp. 3101-3110
    • Stephenne, X.1    Foretz, M.2    Taleux, N.3    van der Zon, G.C.4    Sokal, E.5    Hue, L.6    Viollet, B.7    Guigas, B.8
  • 15
    • 30544446305 scopus 로고    scopus 로고
    • Impact of metformin therapy in patients with polycystic ovarian syndrome
    • Hasan, J.A.; Memon, G.U. Impact of metformin therapy in patients with polycystic ovarian syndrome. J. Coll. Physicians Surg. Pak. 2005, 15, 712-715.
    • (2005) J. Coll. Physicians Surg. Pak. , vol.15 , pp. 712-715
    • Hasan, J.A.1    Memon, G.U.2
  • 16
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation
    • Moghetti, P.; Castello, R.; Negri, C.; Tosi, F.; Perrone, F.; Caputo, M.; Zanolin, E.; Muggeo, M. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J. Clin. Endocrinol. Metab. 2000, 85, 139-146.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Perrone, F.5    Caputo, M.6    Zanolin, E.7    Muggeo, M.8
  • 18
    • 84864371674 scopus 로고    scopus 로고
    • Metformin and cancer: New applications for an old drug
    • Kourelis, T.V.; Siegel, R.D. Metformin and cancer: New applications for an old drug. Med Oncol 2012, 29, 1314-1327.
    • (2012) Med Oncol , vol.29 , pp. 1314-1327
    • Kourelis, T.V.1    Siegel, R.D.2
  • 20
    • 84866322945 scopus 로고    scopus 로고
    • Investigating metformin for cancer prevention and treatment: The end of the beginning
    • Pollak, M.N. Investigating metformin for cancer prevention and treatment: The end of the beginning. Cancer Discov. 2012, 2, 778-790.
    • (2012) Cancer Discov. , vol.2 , pp. 778-790
    • Pollak, M.N.1
  • 23
    • 79952538201 scopus 로고    scopus 로고
    • Diet and tumor lkb1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    • Algire, C.; Amrein, L.; Bazile, M.; David, S.; Zakikhani, M.; Pollak, M. Diet and tumor lkb1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene 2011, 30, 1174-1182.
    • (2011) Oncogene , vol.30 , pp. 1174-1182
    • Algire, C.1    Amrein, L.2    Bazile, M.3    David, S.4    Zakikhani, M.5    Pollak, M.6
  • 25
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 26
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 27
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's achilles' heel
    • Kroemer, G.; Pouyssegur, J. Tumor cell metabolism: Cancer's achilles' heel. Cancer Cell 2008, 13, 472-482.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 28
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez, J.A.; Lupu, R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat. Rev. Cancer 2007, 7, 763-777.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 29
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G.L.; Roth, P.H.; Fang, H.M.; Wang, G.L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 1994, 269, 23757-23763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 30
    • 33644614520 scopus 로고    scopus 로고
    • Hif-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J.W.; Tchernyshyov, I.; Semenza, G.L.; Dang, C.V. Hif-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3, 177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 31
    • 33644622570 scopus 로고    scopus 로고
    • Hif-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou, I.; Cairns, R.A.; Fontana, L.; Lim, A.L.; Denko, N.C. Hif-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3, 187-197.
    • (2006) Cell Metab. , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 33
    • 39449114808 scopus 로고    scopus 로고
    • Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-ii
    • Miyamoto, S.; Murphy, A.N.; Brown, J.H. Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-ii. Cell Death Differ 2008, 15, 521-529.
    • (2008) Cell Death Differ , vol.15 , pp. 521-529
    • Miyamoto, S.1    Murphy, A.N.2    Brown, J.H.3
  • 34
    • 0030794277 scopus 로고    scopus 로고
    • Identification of putative c-myc-responsive genes: Characterization of rcl, a novel growth-related gene
    • Lewis, B.C.; Shim, H.; Li, Q.; Wu, C.S.; Lee, L.A.; Maity, A.; Dang, C.V. Identification of putative c-myc-responsive genes: Characterization of rcl, a novel growth-related gene. Mol. Cell. Biol. 1997, 17, 4967-4978.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4967-4978
    • Lewis, B.C.1    Shim, H.2    Li, Q.3    Wu, C.S.4    Lee, L.A.5    Maity, A.6    Dang, C.V.7
  • 35
    • 0037197962 scopus 로고    scopus 로고
    • Characterization of the c-myc-regulated transcriptome by sage: Identification and analysis of c-myc target genes
    • Menssen, A.; Hermeking, H. Characterization of the c-myc-regulated transcriptome by sage: Identification and analysis of c-myc target genes. Proc. Natl. Acad. Sci. USA 2002, 99, 6274-6279.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6274-6279
    • Menssen, A.1    Hermeking, H.2
  • 36
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking the warburg effect with myc micromanaging glutamine metabolism
    • Dang, C.V. Rethinking the warburg effect with myc micromanaging glutamine metabolism. Cancer Res. 2010, 70, 859-862.
    • (2010) Cancer Res. , vol.70 , pp. 859-862
    • Dang, C.V.1
  • 40
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum, L.Z.; Witters, L.A.; Pasternack, G.R.; Kuhajda, F.P. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res. 1997, 3, 2115-2120.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 41
    • 0030063936 scopus 로고    scopus 로고
    • Expression of fatty acid synthase (fas) as a predictor of recurrence in stage i breast carcinoma patients
    • Alo, P.L.; Visca, P.; Marci, A.; Mangoni, A.; Botti, C.; Di Tondo, U. Expression of fatty acid synthase (fas) as a predictor of recurrence in stage i breast carcinoma patients. Cancer 1996, 77, 474-482.
    • (1996) Cancer , vol.77 , pp. 474-482
    • Alo, P.L.1    Visca, P.2    Marci, A.3    Mangoni, A.4    Botti, C.5    Di Tondo, U.6
  • 45
    • 0031007392 scopus 로고    scopus 로고
    • Increased expression of fatty acid synthase (oa-519) in ovarian neoplasms predicts shorter survival
    • Gansler, T.S.; Hardman, W., III; Hunt, D.A.; Schaffel, S.; Hennigar, R.A. Increased expression of fatty acid synthase (oa-519) in ovarian neoplasms predicts shorter survival. Hum. Pathol. 1997, 28, 686-692.
    • (1997) Hum. Pathol. , vol.28 , pp. 686-692
    • Gansler, T.S.1    Hardman III, W.2    Hunt, D.A.3    Schaffel, S.4    Hennigar, R.A.5
  • 46
    • 65549096661 scopus 로고    scopus 로고
    • De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
    • Mashima, T.; Seimiya, H.; Tsuruo, T. De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br. J. Cancer 2009, 100, 1369-1372.
    • (2009) Br. J. Cancer , vol.100 , pp. 1369-1372
    • Mashima, T.1    Seimiya, H.2    Tsuruo, T.3
  • 53
    • 77955456415 scopus 로고    scopus 로고
    • Mir-33 links srebp-2 induction to repression of sterol transporters
    • Marquart, T.J.; Allen, R.M.; Ory, D.S.; Baldan, A. Mir-33 links srebp-2 induction to repression of sterol transporters. Proc. Natl. Acad. Sci. USA 2010, 107, 12228-12232.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12228-12232
    • Marquart, T.J.1    Allen, R.M.2    Ory, D.S.3    Baldan, A.4
  • 60
    • 77956315551 scopus 로고    scopus 로고
    • Hepatic-specific disruption of sirt6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    • Kim, H.S.; Xiao, C.; Wang, R.H.; Lahusen, T.; Xu, X.; Vassilopoulos, A.; Vazquez-Ortiz, G.; Jeong, W.I.; Park, O.; Ki, S.H.; et al. Hepatic-specific disruption of sirt6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010, 12, 224-236.
    • (2010) Cell Metab. , vol.12 , pp. 224-236
    • Kim, H.S.1    Xiao, C.2    Wang, R.H.3    Lahusen, T.4    Xu, X.5    Vassilopoulos, A.6    Vazquez-Ortiz, G.7    Jeong, W.I.8    Park, O.9    Ki, S.H.10
  • 62
    • 75349099919 scopus 로고    scopus 로고
    • Development of protein kinase activators: Ampk as a target in metabolic disorders and cancer
    • Fogarty, S.; Hardie, D.G. Development of protein kinase activators: Ampk as a target in metabolic disorders and cancer. Biochim. Biophys. Acta 2010, 1804, 581-591.
    • (2010) Biochim. Biophys. Acta , vol.1804 , pp. 581-591
    • Fogarty, S.1    Hardie, D.G.2
  • 64
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen, M.R.; Doran, E.; Halestrap, A.P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 2000, 348, 607-614.
    • (2000) Biochem. J. , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 66
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for amp activation of the amp-activated protein kinase cascade
    • Sanders, M.J.; Grondin, P.O.; Hegarty, B.D.; Snowden, M.A.; Carling, D. Investigating the mechanism for amp activation of the amp-activated protein kinase cascade. Biochem. J. 2007, 403, 139-148.
    • (2007) Biochem. J. , vol.403 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 71
    • 35548999608 scopus 로고    scopus 로고
    • Aicar induces phosphorylation of ampk in an atm-dependent, lkb1-independent manner
    • Sun, Y.; Connors, K.E.; Yang, D.Q. Aicar induces phosphorylation of ampk in an atm-dependent, lkb1-independent manner. Mol. Cell. Biochem. 2007, 306, 239-245.
    • (2007) Mol. Cell. Biochem. , vol.306 , pp. 239-245
    • Sun, Y.1    Connors, K.E.2    Yang, D.Q.3
  • 77
    • 33644664085 scopus 로고    scopus 로고
    • Metformin is a superior substrate for renal organic cation transporter oct2 rather than hepatic oct1
    • Kimura, N.; Masuda, S.; Tanihara, Y.; Ueo, H.; Okuda, M.; Katsura, T.; Inui, K. Metformin is a superior substrate for renal organic cation transporter oct2 rather than hepatic oct1. Drug Metab. Pharmacokinet. 2005, 20, 379-386.
    • (2005) Drug Metab. Pharmacokinet. , vol.20 , pp. 379-386
    • Kimura, N.1    Masuda, S.2    Tanihara, Y.3    Ueo, H.4    Okuda, M.5    Katsura, T.6    Inui, K.7
  • 78
    • 34547946755 scopus 로고    scopus 로고
    • Functional involvement of organic cation transporter1 (oct1/oct1) in the hepatic uptake of organic cations in humans and rats
    • Umehara, K.I.; Iwatsubo, T.; Noguchi, K.; Kamimura, H. Functional involvement of organic cation transporter1 (oct1/oct1) in the hepatic uptake of organic cations in humans and rats. Xenobiotica 2007, 37, 818-831.
    • (2007) Xenobiotica , vol.37 , pp. 818-831
    • Umehara, K.I.1    Iwatsubo, T.2    Noguchi, K.3    Kamimura, H.4
  • 80
    • 78649646556 scopus 로고    scopus 로고
    • Organic cation transporters (octs, mates), in vitro and in vivo evidence for the importance in drug therapy
    • Nies, A.T.; Koepsell, H.; Damme, K.; Schwab, M. Organic cation transporters (octs, mates), in vitro and in vivo evidence for the importance in drug therapy. Handb. Exp. Pharmacol. 2011, 201, 105-167.
    • (2011) Handb. Exp. Pharmacol. , vol.201 , pp. 105-167
    • Nies, A.T.1    Koepsell, H.2    Damme, K.3    Schwab, M.4
  • 81
    • 67849116869 scopus 로고    scopus 로고
    • Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus
    • Becker, M.L.; Visser, L.E.; van Schaik, R.H.; Hofman, A.; Uitterlinden, A.G.; Stricker, B.H. Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus. Pharmacogenomics J. 2009, 9, 242-247.
    • (2009) Pharmacogenomics J. , vol.9 , pp. 242-247
    • Becker, M.L.1    Visser, L.E.2    van Schaik, R.H.3    Hofman, A.4    Uitterlinden, A.G.5    Stricker, B.H.6
  • 82
    • 53049095113 scopus 로고    scopus 로고
    • Oct2 polymorphisms and in vivo renal functional consequence: Studies with metformin and cimetidine
    • Wang, Z.J.; Yin, O.Q.; Tomlinson, B.; Chow, M.S. Oct2 polymorphisms and in vivo renal functional consequence: Studies with metformin and cimetidine. Pharmacogenet. Genomics 2008, 18, 637-645.
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 637-645
    • Wang, Z.J.1    Yin, O.Q.2    Tomlinson, B.3    Chow, M.S.4
  • 85
    • 20044370885 scopus 로고    scopus 로고
    • Deficiency of lkb1 in skeletal muscle prevents ampk activation and glucose uptake during contraction
    • Sakamoto, K.; McCarthy, A.; Smith, D.; Green, K.A.; Grahame Hardie, D.; Ashworth, A.; Alessi, D.R. Deficiency of lkb1 in skeletal muscle prevents ampk activation and glucose uptake during contraction. EMBO J. 2005, 24, 1810-1820.
    • (2005) EMBO J. , vol.24 , pp. 1810-1820
    • Sakamoto, K.1    McCarthy, A.2    Smith, D.3    Green, K.A.4    Grahame Hardie, D.5    Ashworth, A.6    Alessi, D.R.7
  • 86
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mtor
    • Hay, N.; Sonenberg, N. Upstream and downstream of mtor. Genes Dev. 2004, 18, 1926-1945.
    • (2004) Genes Dev. , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 87
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • Dowling, R.J.; Zakikhani, M.; Fantus, I.G.; Pollak, M.; Sonenberg, N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007, 67, 10804-10812.
    • (2007) Cancer Res. , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 88
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the tsc-mtor pathway in human disease
    • Inoki, K.; Corradetti, M.N.; Guan, K.L. Dysregulation of the tsc-mtor pathway in human disease. Nat. Genet. 2005, 37, 19-24.
    • (2005) Nat. Genet. , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 89
    • 0345167800 scopus 로고    scopus 로고
    • Tsc2 mediates cellular energy response to control cell growth and survival
    • Inoki, K.; Zhu, T.; Guan, K.L. Tsc2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115, 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 92
    • 84872294586 scopus 로고    scopus 로고
    • Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of akt
    • Wurth, R.; Pattarozzi, A.; Gatti, M.; Bajetto, A.; Corsaro, A.; Parodi, A.; Sirito, R.; Massollo, M.; Marini, C.; Zona, G.; et al. Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of akt. Cell Cycle 2013, 12, 145-156.
    • (2013) Cell Cycle , vol.12 , pp. 145-156
    • Wurth, R.1    Pattarozzi, A.2    Gatti, M.3    Bajetto, A.4    Corsaro, A.5    Parodi, A.6    Sirito, R.7    Massollo, M.8    Marini, C.9    Zona, G.10
  • 93
    • 84885861971 scopus 로고    scopus 로고
    • Mechanism of metformin: Inhibition of DNA damage and proliferative activity in drosophila midgut stem cell
    • Na, H.J.; Park, J.S.; Pyo, J.H.; Lee, S.H.; Jeon, H.J.; Kim, Y.S.; Yoo, M.A. Mechanism of metformin: Inhibition of DNA damage and proliferative activity in drosophila midgut stem cell. Mech. Ageing Dev. 2013, 9, 381-390.
    • (2013) Mech. Ageing Dev. , vol.9 , pp. 381-390
    • Na, H.J.1    Park, J.S.2    Pyo, J.H.3    Lee, S.H.4    Jeon, H.J.5    Kim, Y.S.6    Yoo, M.A.7
  • 94
    • 79958756136 scopus 로고    scopus 로고
    • Promoter-specific effects of metformin on aromatase transcript expression
    • Samarajeewa, N.U.; Ham, S.; Yang, F.; Simpson, E.R.; Brown, K.A. Promoter-specific effects of metformin on aromatase transcript expression. Steroids 2011, 76, 768-771.
    • (2011) Steroids , vol.76 , pp. 768-771
    • Samarajeewa, N.U.1    Ham, S.2    Yang, F.3    Simpson, E.R.4    Brown, K.A.5
  • 99
    • 84859463669 scopus 로고    scopus 로고
    • Metformin inhibits cell proliferation, migration and invasion by attenuating csc function mediated by deregulating mirnas in pancreatic cancer cells
    • Bao, B.; Wang, Z.; Ali, S.; Ahmad, A.; Azmi, A.S.; Sarkar, S.H.; Banerjee, S.; Kong, D.; Li, Y.; Thakur, S.; et al. Metformin inhibits cell proliferation, migration and invasion by attenuating csc function mediated by deregulating mirnas in pancreatic cancer cells. Cancer Prev. Res. 2012, 5, 355-364.
    • (2012) Cancer Prev. Res. , vol.5 , pp. 355-364
    • Bao, B.1    Wang, Z.2    Ali, S.3    Ahmad, A.4    Azmi, A.S.5    Sarkar, S.H.6    Banerjee, S.7    Kong, D.8    Li, Y.9    Thakur, S.10
  • 100
    • 84862777219 scopus 로고    scopus 로고
    • Metformin alters the expression profiles of micrornas in human pancreatic cancer cells
    • Li, W.; Yuan, Y.; Huang, L.; Qiao, M.; Zhang, Y. Metformin alters the expression profiles of micrornas in human pancreatic cancer cells. Diabetes Res. Clin. Pract. 2012, 96, 187-195.
    • (2012) Diabetes Res. Clin. Pract. , vol.96 , pp. 187-195
    • Li, W.1    Yuan, Y.2    Huang, L.3    Qiao, M.4    Zhang, Y.5
  • 103
    • 84877673227 scopus 로고    scopus 로고
    • Therapeutic potential of an anti-diabetic drug, metformin: Alteration of mirna expression in prostate cancer cells
    • Avci, C.B.; Harman, E.; Dodurga, Y.; Susluer, S.Y.; Gunduz, C. Therapeutic potential of an anti-diabetic drug, metformin: Alteration of mirna expression in prostate cancer cells. Asian Pac. J. Cancer Prev. 2013, 14, 765-768.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 765-768
    • Avci, C.B.1    Harman, E.2    Dodurga, Y.3    Susluer, S.Y.4    Gunduz, C.5
  • 105
    • 1842506719 scopus 로고    scopus 로고
    • Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
    • Pawelczyk, L.; Spaczynski, R.Z.; Banaszewska, B.; Duleba, A.J. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2004, 113, 209-213.
    • (2004) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.113 , pp. 209-213
    • Pawelczyk, L.1    Spaczynski, R.Z.2    Banaszewska, B.3    Duleba, A.J.4
  • 106
    • 0031682742 scopus 로고    scopus 로고
    • The igf family and folliculogenesis
    • Adashi, E.Y. The igf family and folliculogenesis. J. Reprod. Immunol. 1998, 39, 13-19.
    • (1998) J. Reprod. Immunol. , vol.39 , pp. 13-19
    • Adashi, E.Y.1
  • 107
    • 33646029746 scopus 로고    scopus 로고
    • Insulin sensitivity during combined androgen blockade for prostate cancer
    • Smith, M.R.; Lee, H.; Nathan, D.M. Insulin sensitivity during combined androgen blockade for prostate cancer. J. Clin. Endocrinol. Metab. 2006, 91, 1305-1308.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1305-1308
    • Smith, M.R.1    Lee, H.2    Nathan, D.M.3
  • 108
    • 14644433735 scopus 로고    scopus 로고
    • The insulin-like growth factor-i receptor kinase inhibitor, nvp-adw742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
    • Warshamana-Greene, G.S.; Litz, J.; Buchdunger, E.; Garcia-Echeverria, C.; Hofmann, F.; Krystal, G.W. The insulin-like growth factor-i receptor kinase inhibitor, nvp-adw742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin. Cancer Res. 2005, 11, 1563-1571.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1563-1571
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3    Garcia-Echeverria, C.4    Hofmann, F.5    Krystal, G.W.6
  • 109
    • 84883764605 scopus 로고    scopus 로고
    • Inhibition of lung tumorigenesis by metformin is associated with decreased plasma igf-i and diminished receptor tyrosine kinase signaling
    • Quinn, B.J.; Dallos, M.; Kitagawa, H.; Kunnumakkara, A.B.; Memmott, R.M.; Hollander, M.C.; Gills, J.J.; Dennis, P.A. Inhibition of lung tumorigenesis by metformin is associated with decreased plasma igf-i and diminished receptor tyrosine kinase signaling. Cancer Prev. Res. 2013, 6, 801-810.
    • (2013) Cancer Prev. Res. , vol.6 , pp. 801-810
    • Quinn, B.J.1    Dallos, M.2    Kitagawa, H.3    Kunnumakkara, A.B.4    Memmott, R.M.5    Hollander, M.C.6    Gills, J.J.7    Dennis, P.A.8
  • 111
    • 77953739658 scopus 로고    scopus 로고
    • Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro
    • Arai, M.; Uchiba, M.; Komura, H.; Mizuochi, Y.; Harada, N.; Okajima, K. Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro. J. Pharmacol. Exp. Ther. 2010, 334, 206-213.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 206-213
    • Arai, M.1    Uchiba, M.2    Komura, H.3    Mizuochi, Y.4    Harada, N.5    Okajima, K.6
  • 113
    • 83755186557 scopus 로고    scopus 로고
    • Metformin and the atm DNA damage response (ddr): Accelerating the onset of stress-induced senescence to boost protection against cancer
    • Menendez, J.A.; Cufi, S.; Oliveras-Ferraros, C.; Martin-Castillo, B.; Joven, J.; Vellon, L.; Vazquez-Martin, A. Metformin and the atm DNA damage response (ddr): Accelerating the onset of stress-induced senescence to boost protection against cancer. Aging 2011, 3, 1063-1077.
    • (2011) Aging , vol.3 , pp. 1063-1077
    • Menendez, J.A.1    Cufi, S.2    Oliveras-Ferraros, C.3    Martin-Castillo, B.4    Joven, J.5    Vellon, L.6    Vazquez-Martin, A.7
  • 114
    • 79955642725 scopus 로고    scopus 로고
    • Metformin activates an ataxia telangiectasia mutated (atm)/chk2-regulated DNA damage-like response
    • Vazquez-Martin, A.; Oliveras-Ferraros, C.; Cufi, S.; Martin-Castillo, B.; Menendez, J.A. Metformin activates an ataxia telangiectasia mutated (atm)/chk2-regulated DNA damage-like response. Cell Cycle 2011, 10, 1499-1501.
    • (2011) Cell Cycle , vol.10 , pp. 1499-1501
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufi, S.3    Martin-Castillo, B.4    Menendez, J.A.5
  • 115
    • 84881161281 scopus 로고    scopus 로고
    • Kras gene mutation as a predictor of cancer cell responsiveness to metformin
    • Ma, Y.; Guo, F.C.; Wang, W.; Shi, H.S.; Li, D.; Wang, Y.S. Kras gene mutation as a predictor of cancer cell responsiveness to metformin. Mol. Med. Rep. 2013, 8, 763-768.
    • (2013) Mol. Med. Rep. , vol.8 , pp. 763-768
    • Ma, Y.1    Guo, F.C.2    Wang, W.3    Shi, H.S.4    Li, D.5    Wang, Y.S.6
  • 116
    • 84880396632 scopus 로고    scopus 로고
    • Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of raf-erk-nrf2 signaling and ampk-independent pathways
    • Do, M.T.; Kim, H.G.; Khanal, T.; Choi, J.H.; Kim, D.H.; Jeong, T.C.; Jeong, H.G. Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of raf-erk-nrf2 signaling and ampk-independent pathways. Toxicol. Appl. Pharmacol. 2013, 271, 229-238.
    • (2013) Toxicol. Appl. Pharmacol. , vol.271 , pp. 229-238
    • Do, M.T.1    Kim, H.G.2    Khanal, T.3    Choi, J.H.4    Kim, D.H.5    Jeong, T.C.6    Jeong, H.G.7
  • 117
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos, D.; Hirsch, H.A.; Struhl, K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 2011, 71, 3196-3201.
    • (2011) Cancer Res. , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 118
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch, H.A.; Iliopoulos, D.; Tsichlis, P.N.; Struhl, K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009, 69, 7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 119
    • 84875864101 scopus 로고    scopus 로고
    • Therapeutic strategies targeting cancer stem cells
    • Ning, X.; Shu, J.; Du, Y.; Ben, Q.; Li, Z. Therapeutic strategies targeting cancer stem cells. Cancer Biol. Ther. 2013, 14, 295-303.
    • (2013) Cancer Biol. Ther. , vol.14 , pp. 295-303
    • Ning, X.1    Shu, J.2    Du, Y.3    Ben, Q.4    Li, Z.5
  • 122
    • 84860196738 scopus 로고    scopus 로고
    • Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
    • doi:10.1038/srep00362
    • Song, C.W.; Lee, H.; Dings, R.P.; Williams, B.; Powers, J.; Santos, T.D.; Choi, B.H.; Park, H.J. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci. Rep. 2012, 2, doi:10.1038/srep00362.
    • (2012) Sci. Rep. , vol.2
    • Song, C.W.1    Lee, H.2    Dings, R.P.3    Williams, B.4    Powers, J.5    Santos, T.D.6    Choi, B.H.7    Park, H.J.8
  • 124
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival
    • Currie, C.J.; Poole, C.D.; Jenkins-Jones, S.; Gale, E.A.; Johnson, J.A.; Morgan, C.L. Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival. Diabetes Care 2012, 35, 299-304.
    • (2012) Diabetes Care , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3    Gale, E.A.4    Johnson, J.A.5    Morgan, C.L.6
  • 125
    • 77955558076 scopus 로고    scopus 로고
    • Experience of malignancies with oral glucose-lowering drugs in the randomised controlled adopt (a diabetes outcome progression trial) and record (rosiglitazone evaluated for cardiovascular outcomes and regulation of glycaemia in diabetes) clinical trials
    • Home, P.D.; Kahn, S.E.; Jones, N.P.; Noronha, D.; Beck-Nielsen, H.; Viberti, G.; Group, A.S.; Committee, R.S. Experience of malignancies with oral glucose-lowering drugs in the randomised controlled adopt (a diabetes outcome progression trial) and record (rosiglitazone evaluated for cardiovascular outcomes and regulation of glycaemia in diabetes) clinical trials. Diabetologia 2010, 53, 1838-1845.
    • (2010) Diabetologia , vol.53 , pp. 1838-1845
    • Home, P.D.1    Kahn, S.E.2    Jones, N.P.3    Noronha, D.4    Beck-Nielsen, H.5    Viberti, G.6    Group, A.S.7    Committee, R.S.8
  • 127
    • 84879552899 scopus 로고    scopus 로고
    • Metformin and sulfonylureas in relation to cancer risk in type ii diabetes patients: A meta-analysis using primary data of published studies
    • Thakkar, B.; Aronis, K.N.; Vamvini, M.T.; Shields, K.; Mantzoros, C.S. Metformin and sulfonylureas in relation to cancer risk in type ii diabetes patients: A meta-analysis using primary data of published studies. Metabolism 2013, 62, 922-934.
    • (2013) Metabolism , vol.62 , pp. 922-934
    • Thakkar, B.1    Aronis, K.N.2    Vamvini, M.T.3    Shields, K.4    Mantzoros, C.S.5
  • 128
    • 84866138849 scopus 로고    scopus 로고
    • Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials
    • Stevens, R.J.; Ali, R.; Bankhead, C.R.; Bethel, M.A.; Cairns, B.J.; Camisasca, R.P.; Crowe, F.L.; Farmer, A.J.; Harrison, S.; Hirst, J.A.; et al. Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials. Diabetologia 2012, 55, 2593-2603.
    • (2012) Diabetologia , vol.55 , pp. 2593-2603
    • Stevens, R.J.1    Ali, R.2    Bankhead, C.R.3    Bethel, M.A.4    Cairns, B.J.5    Camisasca, R.P.6    Crowe, F.L.7    Farmer, A.J.8    Harrison, S.9    Hirst, J.A.10
  • 130
    • 84858695046 scopus 로고    scopus 로고
    • Cancer risk in diabetic patients treated with metformin: A systematic review and meta-analysis
    • Noto, H.; Goto, A.; Tsujimoto, T.; Noda, M. Cancer risk in diabetic patients treated with metformin: A systematic review and meta-analysis. PLoS One 2012, 7, e33411.
    • (2012) PLoS One , vol.7
    • Noto, H.1    Goto, A.2    Tsujimoto, T.3    Noda, M.4
  • 131
    • 84869788946 scopus 로고    scopus 로고
    • Metformin and the risk of cancer: Time-related biases in observational studies
    • Suissa, S.; Azoulay, L. Metformin and the risk of cancer: Time-related biases in observational studies. Diabetes Care 2012, 35, 2665-2673.
    • (2012) Diabetes Care , vol.35 , pp. 2665-2673
    • Suissa, S.1    Azoulay, L.2
  • 132
    • 84858693012 scopus 로고    scopus 로고
    • Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: A meta-analysis
    • Zhang, Z.J.; Zheng, Z.J.; Kan, H.; Song, Y.; Cui, W.; Zhao, G.; Kip, K.E. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: A meta-analysis. Diabetes Care 2011, 34, 2323-2328.
    • (2011) Diabetes Care , vol.34 , pp. 2323-2328
    • Zhang, Z.J.1    Zheng, Z.J.2    Kan, H.3    Song, Y.4    Cui, W.5    Zhao, G.6    Kip, K.E.7
  • 133
    • 84863116107 scopus 로고    scopus 로고
    • Antidiabetes drugs correlate with decreased risk of lung cancer: A population-based observation in taiwan
    • Lai, S.W.; Liao, K.F.; Chen, P.C.; Tsai, P.Y.; Hsieh, D.P.; Chen, C.C. Antidiabetes drugs correlate with decreased risk of lung cancer: A population-based observation in taiwan. Clin. Lung Cancer 2012, 13, 143-148.
    • (2012) Clin. Lung Cancer , vol.13 , pp. 143-148
    • Lai, S.W.1    Liao, K.F.2    Chen, P.C.3    Tsai, P.Y.4    Hsieh, D.P.5    Chen, C.C.6
  • 134
    • 84863601615 scopus 로고    scopus 로고
    • Metformin for liver cancer prevention in patients with type 2 diabetes: A systematic review and meta-analysis
    • Zhang, Z.J.; Zheng, Z.J.; Shi, R.; Su, Q.; Jiang, Q.; Kip, K.E. Metformin for liver cancer prevention in patients with type 2 diabetes: A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2012, 97, 2347-2353.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 2347-2353
    • Zhang, Z.J.1    Zheng, Z.J.2    Shi, R.3    Su, Q.4    Jiang, Q.5    Kip, K.E.6
  • 136
    • 78651415908 scopus 로고    scopus 로고
    • Metformin and incident breast cancer among diabetic women: A population-based case-control study in denmark
    • Bosco, J.L.; Antonsen, S.; Sorensen, H.T.; Pedersen, L.; Lash, T.L. Metformin and incident breast cancer among diabetic women: A population-based case-control study in denmark. Cancer Epidemiol. Biomark. Prev. 2011, 20, 101-111.
    • (2011) Cancer Epidemiol. Biomark. Prev. , vol.20 , pp. 101-111
    • Bosco, J.L.1    Antonsen, S.2    Sorensen, H.T.3    Pedersen, L.4    Lash, T.L.5


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