Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice

Biochemical and Biophysical Research Communications

Volumn 442, Issue 1-2, 2013, Pages 92-98

  Fukaya, Makiko ^a   Tamura, Yoshiaki ^a   Chiba, Yuko ^a   Tanioka, Toshihiro ^a   Mao, Ji ^a   Inoue, Yoko ^a   Yamada, Marina ^a   Waeber, Christian ^a,c   Ido Kitamura, Yukari ^b   Kitamura, Tadahiro ^b   Kaneki, Masao ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GUNMA UNIVERSITY   (Japan)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Diabetes; Isonicotinamide; Pancreatic cells; Streptozotocin

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; ISONICOTINAMIDE; PHOSPHATE BUFFERED SALINE; SIRTUIN 1; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DAMAGE; CONTROLLED STUDY; DIABETES MELLITUS; FOOD INTAKE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; ISOLATED PANCREAS ISLET; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; WEIGHT GAIN;

MUS; RODENTIA;

DIABETES; HD-STZ; HIGH-DOSE STREPTOZOTOCIN; ISONICOTINAMIDE; LD-STZ; LOW-DOSE STREPTOZOTOCIN; MD-STZ; MEDIUM-DOSE STREPTOZOTOCIN; NAD(+); NICOTINAMIDE ADENINE DINUCLEOTIDE; PANCREATIC Β-CELLS; PARP; POLY(ADP-RIBOSE) POLYMERASE; STREPTOZOTOCIN; STZ; TDT-MEDIATED DUTP NICK-END LABELING; TUNEL;

ANIMALS; APOPTOSIS; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; NIACINAMIDE; SIRTUIN 1; STREPTOZOCIN;

EID: 84889683916     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.024     Document Type: Article

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