The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B 3 derivative, are elicited by FoxO3 in human gestational tissues: Implications for preterm birth

Journal of Nutritional Biochemistry

Volumn 22, Issue 12, 2011, Pages 1195-1201

  Lappas, Martha ^a,b   Permezel, Michael ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MERCY HOSPITAL FOR WOMEN   (Australia)

Author keywords

Cytokines; FoxO3; Nicotinamide; Oxidative stress; Parturition; Prostaglandins; Vitamin B 3

Indexed keywords

8 ISOPROSTANE; CATALASE; CYCLOOXYGENASE 2; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; NICOTINAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FETUS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; PLACENTA; PREMATURE LABOR; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CYCLOOXYGENASE 2; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NF-KAPPA B; NIACINAMIDE; PLACENTA; PREGNANCY; PREMATURE BIRTH; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052610040     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.10.009     Document Type: Article

References (53)

1. Beck S., Say L., Betran A.P., Merialdi M., Rubens C., Menon R., et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull 31 World Health Organ 2010, 88:31-38.
2. Moster D., Lie R.T., Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med 2008, 359:262-273.
3. Gomez R., Romero R., Edwin S.S., David C. Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. Infect Dis Clin North Am 1997, 11:135-176.
4. Keelan J.A., Blumenstein M., Helliwell R.J.A., Sato T.A., Marvin K.W., Mitchell M.D. Cytokines, prostaglandins and parturition - A review. Placenta 2003, 24:S33-S46.
5. Longini M., Perrone S., Vezzosi P., Marzocchi B., Kenanidis A., Centini G., et al. Association between oxidative stress in pregnancy and preterm premature rupture of membranes. Clin Biochem 2007, 40:793-797.
6. Woods J.R. Reactive oxygen species and preterm premature rupture of membranes-a review. Placenta 2001, 22(Suppl A):S38-S44.
7. Bowen J.M., Chamley L., Keelan J.A., Mitchell M.D. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta 2002, 23:257-273.
8. Vadillo-Ortega F., Estrada-Gutierrez G. Role of matrix metalloproteinases in preterm labour. BJOG-An International Journal of Obstetrics and Gynaecology 2005, 112:19-22.
9. Maiese K., Chong Z.Z., Hou J.L., Shang Y.C. The vitamin nicotinamide: translating nutrition into clinical care. Molecules 2009, 14:3446-3485.
10. Maiese K. Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother 2008, 62:218-232.
11. Moberg L., Olsson A., Berne C., Felldin M., Foss A., Kallen R., et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation 2003, 76:1285-1288.
12. Hiromatsu Y., Sato M., Yamada K., Nonaka K. Inhibitory effects of nicotinamide on recombinant human interferon-gamma-induced intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigen expression on cultured human endothelial cells. Immunol Lett 1992, 31:35-39.
13. Biedron R., Ciszek M., Tokarczyk M., Bobek M., Kurnyta M., Slominska E.M., et al. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp 2008, 56:127-134.
14. Bryniarski K., Biedron R., Jakubowski A., Chlopicki S., Marcinkiewicz J. Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. Eur J Pharmacol 2008, 578:332-338.
15. Reddy S., Young M., Ginn S. Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide. Histochem J 2001, 33:317-327.
16. Fukuzawa M., Satoh J., Muto G., Muto Y., Nishimura S., Miyaguchi S., et al. Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha. Immunol Lett 1997, 59:7-11.
17. Traister A., Breitman I., Bar-Lev E., Zvibel I., Harel A., Halpern Z., et al. Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells. Scand J Gastroenterol 2005, 40:1226-1234.
18. Grange P.A., Raingeaud J., Calvez V., Dupin N. Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappa B and MAPK pathways. J Dermatol Sci 2009, 56:106-112.
19. Ungerstedt J.S., Blomback M., Soderstrom T. Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin Exp Immunol 2003, 131:48-52.
20. Chen C.F., Wang D., Hwang C.P., Liu H.W., Wei J., Lee R.P., et al. The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci 2001, 8:446-452.
21. Kamat J.P., Devasagayam T.P.A. Nicotinamide (vitamin B-3) as an effective antioxidant against oxidative damage in rat brain mitochondria. Redox Rep 1999, 4:179-184.
22. Chen Y.H., Wang M.F., Liao J.W., Chang S.P., Hu M.L. Beneficial effects of nicotinamide on alcohol-induced liver injury in senescence-accelerated mice. Biofactors 2008, 34:97-107.
23. Abdallah D.M. Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent. Eur J Pharmacol 2010, 627:276-280.
24. Feng Y.Z., Paul I.A., LeBlanc M.H. Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat. Brain Res Bull 2006, 69:117-122.
25. Chong Z.Z., Lin S.H., Maiese K. The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab 2004, 24:728-743.
26. Lappas M., Permezel M., Georgiou H.M., Rice G.E. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 2002, 67:668-673.
27. Lappas M., Permezel M., Georgiou H.M., Rice G.E. Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro. J Clin Endocrinol Metab 2004, 89:2365-2372.
28. Lappas M., Permezel M., Rice G.E. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J Clin Endocrinol Metab 2003, 88:1723-1729.
29. Lappas M., Rice G.E. The role and regulation of the nuclear factor kappa B signalling pathway in human labour. Placenta 2007, 28:543-556.
30. Lappas M., Rice G.E. Transcriptional regulation of the processes of human labour and delivery. Placenta 2009, 30(Suppl A):S90-S95.
31. Lappas M., Yee K., Permezel M., Rice G.E. Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cells. Placenta 2006, 27:568-575.
32. Lindstrom T.M., Bennett P.R. The role of nuclear factor kappa B in human labour. Reproduction 2005, 130:569-581.
33. Bennett P.R., Rose M.P., Myatt L., Elder M.G. Preterm labor: stimulation of arachidonic acid metabolism in human amnion cells by bacterial products. Am J Obstet Gynecol 1987, 156:649-655.
34. Morrow J.D., Hill K.E., Burk R.F., Nammour T.M., Badr K.F., Roberts L.J. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A 1990, 87:9383-9387.
35. Awad J.A., Roberts L.J., Burk R.F., Morrow J.D. Isoprostanes-prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol Clin North Am 1996, 25:409-427.
36. Soop A., Albert J., Weitzberg E., Bengtsson A., Nilsson C.G., Sollevi A. Nicotinamide does not influence cytokines or exhaled NO in human experimental endotoxaemia. Clin Exp Immunol 2004, 135:114-118.
37. Patel F.A., Challis J.R. Prostaglandins and uterine activity. Front Horm Res 2001, 27:31-56.
38. Jeyabalan A., Caritis S.N. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002, 45:99-113.
39. Halliwell B. Antioxidants in human health and disease. Annu Rev Nutr 1996, 16:33-50.
40. Huang H.J., Tindall D.J. Dynamic FoxO transcription factors. J Cell Sci 2007, 120:2479-2487.
41. Accili D., Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117:421-426.
42. Birkenkamp K.U., Coffer P.J.F.O.X.O. Transcription factors as regulators of immune homeostasis: molecules to die for?. J Immunol 2003, 171:1623-1629.
43. Lam E.W.F., Francis R.E., Petkovic M. FOXO transcription factors: key regulators of cell fate. Biochem Soc Trans 2006, 34:722-726.
44. van der Horst A., Burgering B.M.T. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007, 8:440-450.
45. Arden K.C. FOXO Animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 2008, 27:2345-2350.
46. Lin L., Hron J.D., Peng S.L. Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 2004, 21:203-213.
47. Snoeks L., Weber C.R., Turner J.R., Bhattacharyya M., Wasland K., Savkovic S.D. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun 2008, 76:4677-4685.
48. Snoeks L., Weber C.R., Wasland K., Turner J.R., Vainder C., Qi W.T., et al. Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest 2009, 89:1053-1062.
49. Kim H.K., Kim Y.K., Song I.H., Baek S.H., Lee S.R., Kim J.H., et al. Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol Ser A-Biol Sci Med Sci 2005, 60:4-9.
50. Potente M., Urbich C., Sasaki K., Hofmann W.K., Heeschen C., Aicher A., et al. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Investig 2005, 115:2382-2392.
51. Tornblom S.A., Maul H., Klimaviciute A., Garfield R.E., Bystrom B., Malmstrom A., et al. mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour. Reprod Biol Endocrinol 2005, 3:33.
52. Gotsch F., Gotsch F., Romero R., Erez O., Vaisbuch E., Kusanovic J.P., et al. The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth. J Matern Fetal Neonatal Med 2009, 22(Suppl 2):5-23.
53. Myatt S.S., Lam E.W.F. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007, 7:847-859.