AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

Journal of Physiology

Volumn 565, Issue 2, 2005, Pages 537-546

  Smith, Angela C ^a   Bruce, Clinton R ^a   Dyck, David J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; FATTY ACID; GLUCOSE; PALMITIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX; TRIACYLGLYCEROL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ESTERIFICATION; FATTY ACID OXIDATION; FEMALE; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; LIPID HYDROLYSIS; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE; AEROBIC METABOLISM; ANALYSIS OF VARIANCE; ENERGY YIELD; ENZYME ACTIVITY; FATTY ACID METABOLISM; IMMUNOPRECIPITATION; PROTEIN CONTENT; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; ENERGY METABOLISM; ENZYME ACTIVATION; FATTY ACIDS; FEMALE; GLUCOSE; HYPOGLYCEMIC AGENTS; MUSCLE, SKELETAL; OXIDATION-REDUCTION; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REST; RIBONUCLEOTIDES;

EID: 21044447666     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.081679     Document Type: Article

References (32)

1. Ai H, Ihlemann J, Hellsten Y, Lauritzen HP, Hardie DG, Galbo H & Ploug T (2002). Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle. Am J Physiol Endocrinol Metab 282, E1291-E1300.
2. Alam N & Saggerson ED (1998). Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle. Biochem J 334, 233-241.
3. Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF & Goodyear LJ (2002). Effect of AICAR treatment on glycogen metabolism in skeletal muscle. Diabetes 51, 567-573.
4. Bergeron R, Russell RR III, Young LH, Ren J-M, Marcucci M, Lee A & Shulman GI (1999). Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol Endocrinol Metab 276, E938-E944.
5. Chen Z-P, McConnell GK, Michell BJ, Snow RJ, Canny BJ & Kemp BE (2000). AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab 279, E1202-E1206.
6. Corton JM, Gillespie JG, Hawley SA & Hardie DG (1995). 5-Aminoimidazole-4-carboxamide riboside: a specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229, 558-565.
7. Dagher Z, Ruderman N, Tornheim K & Ido Y (1999). The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun 265, 112-115.
8. Dyck DJ & Bonen A (1998). Muscle contraction increases palmitate esterification and oxidation and triacylglycerol oxidation. Am J Physiol 275, E888-E896.
9. Dyck DJ, Miskovic D, Code L, Luiken JJ & Bonen A (2000). Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus. Am J Physiol Endocrinol Metab 278, E778-E785.
10. Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ & Yeaman SJ (1989). Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. Eur J Biochem 179, 249-254.
11. Hardie DG, Salt IP, Hawley SA & Davies SP (1999). AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem J 338, 717-722.
12. Hayashi T, Hirshman MF, Kurth EJ, Winder WW & Goodyear LJ (1998). Evidence for 5(-AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47, 1369-1373.
13. Ihlemann J, Ploug T, Hellsten Y & Galbo H (2000). Effect of stimulation frequency on contraction-induced glucose transport in rat skeletal muscle. Am J Physiol Endocrinol Metab 279, E862-E867.
14. Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O & Lund S (2003). Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. J Appl Physiol 94, 1373-1379.
15. Kaushik VK, Young ME, Dean DJ, Kurowski TG, Saha AK & Ruderman NB (2001). Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab 281, E335-E340.
16. Langfort J, Ploug T, Ihlemann J, Baranczuk E, Donsmark M, Gorski J & Galbo H (2003). Additivity of adrenaline and contractions on hormone-sensitive lipase, but not on glycogen phosphorylase, in rat muscle. Acta Physiol Scand 178, 51-60.
17. Langfort J, Ploug T, Ihlemann J, Enevoldsen LH, Stallknecht B, Saldo M, Kjaer M, Holm C & Galbo H (1998). Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle. Adv Exp Med Biol 441, 219-228.
18. Merrill GF, Kurth EJ, Hardie DG & Winder WW (1997). AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273, E1107-E1112.
19. Muoio DM, Seefeld K, Witters LA & Coleman RA (1999). AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338, 783-791.
20. Musi N, Hayashi T, Fujii N, Hirshman ME, Witters LA & Goodyear LJ (2001). AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am J Physiol Endocrinol Metab 280, E677-E684.
21. Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB & Saba AK (2002). Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem 277, 32571-32577.
22. Passoneau JV & Lowry OH (1993). Enzymatic Analysis: A Practical Guide. Humana Press, Totawa, NJ, USA.
23. Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM & Brown NF (2004). Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J Biol Chem 279, 27177-27186.
24. Peters SJ, Dyck DJ, Bonen A & Spriet LL (1998). Effects of epinephrine on lipid metabolism in resting skeletal muscle. Am J Physiol Endocrinol Metab 275, E300-E309.
25. Putman CT, Spriet LL, Hultman E, Lindinger MI, Lands LC, McKelvie RS, Cederblad G, Jones NL & Heigenhauser GJ (1993). Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am J Physiol 265, E752-E760.
26. Raney MA, Yee AJ, Todd MK & Turcotte LP (2005). AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low intensity muscle contraction. Am J Physiol Endocrinol Metab 288, E592-E598.
27. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M & Ruderman NB (2000). Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Biol Chem 275, 24279-24283.
28. Spriet LL & Heigenhauser GJ (2002). Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise. Exerc Sport Sci Rev 30, 91-95.
29. Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D & Beri RK (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett 353, 33-36.
30. Watt MJ, Steinberg GR, Chan S, Garnham A, Kemp BE & Febbraio MA (2004). β-Adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. FASEB J 18, 1445-1446.
31. Winder WW, Wilson HA, Hardie DG, Rasmussen BB, Hutber CA, Call GB, Clayton RD, Conley LM, Yoon S & Zhou B (1997). Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J Appl Physiol 82, 219-225.
32. Wojtaszewski JF, Jorgensen SB, Hellsten Y, Hardie DG & Richter EA (2002). Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes 51, 284-292.