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Volumn 21, Issue 8, 2015, Pages 813-826

Nicotinamide: A vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features

Author keywords

Inflammation; LPS; macrophages; NF B; nicotinamide

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOCHROME P450; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ICOSANOID; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; NICOTINAMIDE; TUMOR NECROSIS FACTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; VITAMIN B COMPLEX;

EID: 84945191473     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425915602545     Document Type: Article
Times cited : (35)

References (49)
  • 2
    • 15244355745 scopus 로고    scopus 로고
    • Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
    • Avalos JL, Bever KM, Wolberger C,. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 2005; 17: 855-868.
    • (2005) Mol Cell , vol.17 , pp. 855-868
    • Avalos, J.L.1    Bever, K.M.2    Wolberger, C.3
  • 4
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander G, Guarente L,. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004; 73: 417-435.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 5
    • 38449088040 scopus 로고    scopus 로고
    • The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
    • Hassa PO, Hottiger MO,. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci 2008; 13: 3046-3082.
    • (2008) Front Biosci , vol.13 , pp. 3046-3082
    • Hassa, P.O.1    Hottiger, M.O.2
  • 6
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • Michan S, Sinclair D,. Sirtuins in mammals: insights into their biological function. Biochem J 2007; 404: 1-13.
    • (2007) Biochem J , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 7
    • 0031665078 scopus 로고    scopus 로고
    • Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: The experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer
    • Bernier J, Stratford MR, Denekamp J, Dennis MF, Bieri S, Hagen F, et al. Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer. Radiother Oncol 1998; 48: 123-133.
    • (1998) Radiother Oncol , vol.48 , pp. 123-133
    • Bernier, J.1    Stratford, M.R.2    Denekamp, J.3    Dennis, M.F.4    Bieri, S.5    Hagen, F.6
  • 8
    • 0028802880 scopus 로고
    • Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation
    • Heine H, Ulmer AJ, Flad HD, Hauschildt S,. Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation. J Immunol 1995; 155: 4899-4908.
    • (1995) J Immunol , vol.155 , pp. 4899-4908
    • Heine, H.1    Ulmer, A.J.2    Flad, H.D.3    Hauschildt, S.4
  • 9
    • 31944451377 scopus 로고    scopus 로고
    • Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: A review
    • Niren NM,. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis 2006; 77: 11-16.
    • (2006) Cutis , vol.77 , pp. 11-16
    • Niren, N.M.1
  • 10
    • 59649125761 scopus 로고    scopus 로고
    • NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
    • Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, et al. NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med 2009; 15: 151-158.
    • (2009) Nat Med , vol.15 , pp. 151-158
    • Skokowa, J.1    Lan, D.2    Thakur, B.K.3    Wang, F.4    Gupta, K.5    Cario, G.6
  • 11
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez FO, Gordon S,. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 2014; 6: 13-13.
    • (2014) F1000Prime Rep , vol.6 , pp. 13-13
    • Martinez, F.O.1    Gordon, S.2
  • 12
    • 34247124840 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: Implications for CSF blockade in inflammation
    • Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD,. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007; 178: 5245-5252.
    • (2007) J Immunol , vol.178 , pp. 5245-5252
    • Fleetwood, A.J.1    Lawrence, T.2    Hamilton, J.A.3    Cook, A.D.4
  • 13
    • 12144288237 scopus 로고    scopus 로고
    • Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    • Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, Vaisberg E, et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci U S A 2004; 101: 4560-4565.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4560-4565
    • Verreck, F.A.1    De Boer, T.2    Langenberg, D.M.3    Hoeve, M.A.4    Kramer, M.5    Vaisberg, E.6
  • 14
    • 84919457870 scopus 로고    scopus 로고
    • Myeloid colony-stimulating factors as regulators of macrophage polarization
    • Hamilton TA, Zhao C, Pavicic PG Jr., Datta S,. Myeloid colony-stimulating factors as regulators of macrophage polarization. Front Immunol 2014; 5: 554-554.
    • (2014) Front Immunol , vol.5 , pp. 554-554
    • Hamilton, T.A.1    Zhao, C.2    Pavicic, P.G.3    Datta, S.4
  • 15
    • 84862104611 scopus 로고    scopus 로고
    • Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models
    • Lacey DC, Achuthan A, Fleetwood AJ, Dinh H, Roiniotis J, Scholz GM, et al. Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models. J Immunol 2012; 188: 5752-5765.
    • (2012) J Immunol , vol.188 , pp. 5752-5765
    • Lacey, D.C.1    Achuthan, A.2    Fleetwood, A.J.3    Dinh, H.4    Roiniotis, J.5    Scholz, G.M.6
  • 16
    • 70350435962 scopus 로고    scopus 로고
    • Epigenetic regulation of the alternatively activated macrophage phenotype
    • Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, et al. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 2009; 114: 3244-3254.
    • (2009) Blood , vol.114 , pp. 3244-3254
    • Ishii, M.1    Wen, H.2    Corsa, C.A.3    Liu, T.4    Coelho, A.L.5    Allen, R.M.6
  • 17
    • 84898897839 scopus 로고    scopus 로고
    • An optimized protocol for human M2 macrophages using M-CSF and IL-4/IL-10/TGF-beta yields a dominant immunosuppressive phenotype
    • Mia S, Warnecke A, Zhang XM, Malmstrom V, Harris RA,. An optimized protocol for human M2 macrophages using M-CSF and IL-4/IL-10/TGF-beta yields a dominant immunosuppressive phenotype. Scand J Immunol 2014; 79: 305-314.
    • (2014) Scand J Immunol , vol.79 , pp. 305-314
    • Mia, S.1    Warnecke, A.2    Zhang, X.M.3    Malmstrom, V.4    Harris, R.A.5
  • 18
    • 0027430713 scopus 로고
    • Phenotypical and functional characterization of Fc gamma receptor i (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity
    • Grage-Griebenow E, Lorenzen D, Fetting R, Flad HD, Ernst M,. Phenotypical and functional characterization of Fc gamma receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity. Eur J Immunol 1993; 23: 3126-3135.
    • (1993) Eur J Immunol , vol.23 , pp. 3126-3135
    • Grage-Griebenow, E.1    Lorenzen, D.2    Fetting, R.3    Flad, H.D.4    Ernst, M.5
  • 19
    • 0035145852 scopus 로고    scopus 로고
    • Diverse regulation of microfilament assembly, production of TNF-alpha, and reactive oxygen intermediates by actin modulating substances and inhibitors of ADP-ribosylation in human monocytes stimulated with LPS
    • Rossol M, Gartner D, Hauschildt S,. Diverse regulation of microfilament assembly, production of TNF-alpha, and reactive oxygen intermediates by actin modulating substances and inhibitors of ADP-ribosylation in human monocytes stimulated with LPS. Cell Motil Cytoskeleton 2001; 48: 96-108.
    • (2001) Cell Motil Cytoskeleton , vol.48 , pp. 96-108
    • Rossol, M.1    Gartner, D.2    Hauschildt, S.3
  • 20
    • 84876972697 scopus 로고    scopus 로고
    • Fast liquid chromatography-quadrupole linear ion trap-mass spectrometry analysis of polyunsaturated fatty acids and eicosanoids in human plasma
    • Kortz L, Dorow J, Becker S, Thiery J, Ceglarek U,. Fast liquid chromatography-quadrupole linear ion trap-mass spectrometry analysis of polyunsaturated fatty acids and eicosanoids in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 927: 209-213.
    • (2013) J Chromatogr B Analyt Technol Biomed Life Sci , vol.927 , pp. 209-213
    • Kortz, L.1    Dorow, J.2    Becker, S.3    Thiery, J.4    Ceglarek, U.5
  • 21
    • 0035893037 scopus 로고    scopus 로고
    • Regulation and possible function of beta-catenin in human monocytes
    • Thiele A, Wasner M, Muller C, Engeland K, Hauschildt S,. Regulation and possible function of beta-catenin in human monocytes. J Immunol 2001; 167: 6786-6793.
    • (2001) J Immunol , vol.167 , pp. 6786-6793
    • Thiele, A.1    Wasner, M.2    Muller, C.3    Engeland, K.4    Hauschildt, S.5
  • 23
    • 55349109686 scopus 로고    scopus 로고
    • The orthologue of the 'acatalytic' mammalian ART4 in chicken is an arginine-specific mono-ADP-ribosyltransferase
    • Grahnert A, Richter S, Siegert F, Berndt A, Hauschildt S,. The orthologue of the 'acatalytic' mammalian ART4 in chicken is an arginine-specific mono-ADP-ribosyltransferase. BMC Mol Biol 2008; 9: 86-86.
    • (2008) BMC Mol Biol , vol.9 , pp. 86-86
    • Grahnert, A.1    Richter, S.2    Siegert, F.3    Berndt, A.4    Hauschildt, S.5
  • 25
    • 0025464798 scopus 로고
    • Lipopolysaccharide-induced production of cytokines by bone marrow-derived macrophages: Dissociation between intracellular interleukin 1 production and interleukin 1 release
    • Aznar C, Fitting C, Cavaillon JM,. Lipopolysaccharide-induced production of cytokines by bone marrow-derived macrophages: dissociation between intracellular interleukin 1 production and interleukin 1 release. Cytokine 1990; 2: 259-265.
    • (1990) Cytokine , vol.2 , pp. 259-265
    • Aznar, C.1    Fitting, C.2    Cavaillon, J.M.3
  • 26
    • 0027076645 scopus 로고
    • Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide
    • Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992; 267: 25934-25938.
    • (1992) J Biol Chem , vol.267 , pp. 25934-25938
    • Lee, S.H.1    Soyoola, E.2    Chanmugam, P.3    Hart, S.4    Sun, W.5    Zhong, H.6
  • 27
    • 59649117804 scopus 로고    scopus 로고
    • Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
    • Van Gool F, Galli M, Gueydan C, Kruys V, Prevot PP, Bedalov A, et al. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 2009; 15: 206-210.
    • (2009) Nat Med , vol.15 , pp. 206-210
    • Van Gool, F.1    Galli, M.2    Gueydan, C.3    Kruys, V.4    Prevot, P.P.5    Bedalov, A.6
  • 29
    • 58149090925 scopus 로고    scopus 로고
    • SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    • Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136: 62-74.
    • (2009) Cell , vol.136 , pp. 62-74
    • Kawahara, T.L.1    Michishita, E.2    Adler, A.S.3    Damian, M.4    Berber, E.5    Lin, M.6
  • 30
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: 2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6
  • 31
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-196.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 32
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen LF, Greene WC,. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004; 5: 392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 33
    • 34548803616 scopus 로고    scopus 로고
    • Niacinamide abrogates the organ dysfunction and acute lung injury caused by endotoxin
    • Kao SJ, Liu DD, Su CF, Chen HI,. Niacinamide abrogates the organ dysfunction and acute lung injury caused by endotoxin. J Cardiovasc Pharmacol 2007; 50: 333-342.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 333-342
    • Kao, S.J.1    Liu, D.D.2    Su, C.F.3    Chen, H.I.4
  • 34
    • 0037232298 scopus 로고    scopus 로고
    • Nicotinamide is a potent inhibitor of pro-inflammatory cytokines
    • Ungerstedt JS, Blomback M, Soderstrom T,. Nicotinamide is a potent inhibitor of pro-inflammatory cytokines. Clin Exp Immunol 2003; 131: 48-52.
    • (2003) Clin Exp Immunol , vol.131 , pp. 48-52
    • Ungerstedt, J.S.1    Blomback, M.2    Soderstrom, T.3
  • 35
    • 10944270187 scopus 로고    scopus 로고
    • The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
    • Revollo JR, Grimm AA, Imai S,. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 2004; 279: 50754-50763.
    • (2004) J Biol Chem , vol.279 , pp. 50754-50763
    • Revollo, J.R.1    Grimm, A.A.2    Imai, S.3
  • 36
    • 77952549055 scopus 로고    scopus 로고
    • A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis
    • Imai S,. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res 2010; 62: 42-47.
    • (2010) Pharmacol Res , vol.62 , pp. 42-47
    • Imai, S.1
  • 37
    • 21644459951 scopus 로고    scopus 로고
    • Structure and function of poly(ADP-ribose) polymerase-1: Role in oxidative stress-related pathologies
    • Virag L,. Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. Curr Vasc Pharmacol 2005; 3: 209-214.
    • (2005) Curr Vasc Pharmacol , vol.3 , pp. 209-214
    • Virag, L.1
  • 38
    • 77956213727 scopus 로고    scopus 로고
    • Substrate fate in activated macrophages: A comparison between innate, classic, and alternative activation
    • Rodriguez-Prados JC, Traves PG, Cuenca J, Rico D, Aragones J, Martin-Sanz P, et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol 2010; 185: 605-614.
    • (2010) J Immunol , vol.185 , pp. 605-614
    • Rodriguez-Prados, J.C.1    Traves, P.G.2    Cuenca, J.3    Rico, D.4    Aragones, J.5    Martin-Sanz, P.6
  • 39
    • 84861815123 scopus 로고    scopus 로고
    • Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes
    • Schilling E, Wehrhahn J, Klein C, Raulien N, Ceglarek U, Hauschildt S,. Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes. Innate Immun 2012; 18: 518-530.
    • (2012) Innate Immun , vol.18 , pp. 518-530
    • Schilling, E.1    Wehrhahn, J.2    Klein, C.3    Raulien, N.4    Ceglarek, U.5    Hauschildt, S.6
  • 40
    • 79953230829 scopus 로고    scopus 로고
    • NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
    • Liu TF, Yoza BK, El GM, Vachharajani VT, McCall CE,. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem 2011; 286: 9856-9864.
    • (2011) J Biol Chem , vol.286 , pp. 9856-9864
    • Liu, T.F.1    Yoza, B.K.2    El, G.M.3    Vachharajani, V.T.4    McCall, C.E.5
  • 41
    • 66149115196 scopus 로고    scopus 로고
    • Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines
    • Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, et al. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol Gastrointest Liver Physiol 2009; 296: G1047-G1053.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G1047-G1053
    • Shen, Z.1    Ajmo, J.M.2    Rogers, C.Q.3    Liang, X.4    Le, L.5    Murr, M.M.6
  • 42
    • 0345628001 scopus 로고    scopus 로고
    • Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
    • Le Page C, Sanceau J, Drapier JC, Wietzerbin J,. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation. Biochem Biophys Res Commun 1998; 243: 451-457.
    • (1998) Biochem Biophys Res Commun , vol.243 , pp. 451-457
    • Le Page, C.1    Sanceau, J.2    Drapier, J.C.3    Wietzerbin, J.4
  • 43
    • 0036710459 scopus 로고    scopus 로고
    • The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders
    • Hassa PO, Hottiger MO,. The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci 2002; 59: 1534-1553.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1534-1553
    • Hassa, P.O.1    Hottiger, M.O.2
  • 44
    • 84868155156 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes
    • Bai P, Virag L,. Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes. FEBS Lett 2012; 586: 3771-3777.
    • (2012) FEBS Lett , vol.586 , pp. 3771-3777
    • Bai, P.1    Virag, L.2
  • 45
    • 80052378448 scopus 로고    scopus 로고
    • Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype
    • Norris PC, Reichart D, Dumlao DS, Glass CK, Dennis EA,. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol 2011; 90: 563-574.
    • (2011) J Leukoc Biol , vol.90 , pp. 563-574
    • Norris, P.C.1    Reichart, D.2    Dumlao, D.S.3    Glass, C.K.4    Dennis, E.A.5
  • 46
    • 0034943516 scopus 로고    scopus 로고
    • Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes
    • Tilley SL, Coffman TM, Koller BH,. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 2001; 108: 15-23.
    • (2001) J Clin Invest , vol.108 , pp. 15-23
    • Tilley, S.L.1    Coffman, T.M.2    Koller, B.H.3
  • 47
    • 0032489318 scopus 로고    scopus 로고
    • Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells
    • Inoue H, Tanabe T,. Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 1998; 244: 143-148.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 143-148
    • Inoue, H.1    Tanabe, T.2
  • 48
    • 0034008927 scopus 로고    scopus 로고
    • Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages
    • Wadleigh DJ, Reddy ST, Kopp E, Ghosh S, Herschman HR,. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J Biol Chem 2000; 275: 6259-6266.
    • (2000) J Biol Chem , vol.275 , pp. 6259-6266
    • Wadleigh, D.J.1    Reddy, S.T.2    Kopp, E.3    Ghosh, S.4    Herschman, H.R.5
  • 49
    • 0037490098 scopus 로고    scopus 로고
    • Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia
    • Stehr A, Ploner F, Tugtekin I, Matejovic M, Theisen M, Zulke C, et al. Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia. Intensive Care Med 2003; 29: 995-1002.
    • (2003) Intensive Care Med , vol.29 , pp. 995-1002
    • Stehr, A.1    Ploner, F.2    Tugtekin, I.3    Matejovic, M.4    Theisen, M.5    Zulke, C.6


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