-
1
-
-
79952451443
-
Obesity, insulin resistance and free fatty acids
-
Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 2011;18:139-143
-
(2011)
Curr Opin Endocrinol Diabetes Obes
, vol.18
, pp. 139-143
-
-
Boden, G.1
-
3
-
-
77950543816
-
Diacylglycerol-mediated insulin resistance
-
Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nat Med 2010;16:400-402
-
(2010)
Nat Med
, vol.16
, pp. 400-402
-
-
Erion, D.M.1
Shulman, G.I.2
-
4
-
-
84860482342
-
A ceramide-centric view of insulin resistance
-
Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell Metab 2012;15:585-594
-
(2012)
Cell Metab
, vol.15
, pp. 585-594
-
-
Chavez, J.A.1
Summers, S.A.2
-
5
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002;277:50230-50236
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
6
-
-
59849098608
-
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
-
Watson ML, Coghlan M, Hundal HS. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem J 2009;417:791-801
-
(2009)
Biochem J
, vol.417
, pp. 791-801
-
-
Watson, M.L.1
Coghlan, M.2
Hundal, H.S.3
-
7
-
-
79959746261
-
Sphingolipids: Agents provocateurs in the pathogenesis of insulin resistance
-
Lipina C, Hundal HS. Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Diabetologia 2011;54:1596-1607
-
(2011)
Diabetologia
, vol.54
, pp. 1596-1607
-
-
Lipina, C.1
Hundal, H.S.2
-
8
-
-
0033668021
-
Lipid oxidation is reduced in obese human skeletal muscle
-
Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 2000;279:E1039-E1044
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Kim, J.Y.1
Hickner, R.C.2
Cortright, R.L.3
Dohm, G.L.4
Houmard, J.A.5
-
9
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002;51:2944-2950
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
10
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003;300:1140-1142
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
-
11
-
-
12144275294
-
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
-
Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005;54:8-14
-
(2005)
Diabetes
, vol.54
, pp. 8-14
-
-
Ritov, V.B.1
Menshikova, E.V.2
He, J.3
Ferrell, R.E.4
Goodpaster, B.H.5
Kelley, D.E.6
-
12
-
-
21344444333
-
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
-
Sparks LM, Xie H, Koza RA, et al. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005;54:1926-1933
-
(2005)
Diabetes
, vol.54
, pp. 1926-1933
-
-
Sparks, L.M.1
Xie, H.2
Koza, R.A.3
-
13
-
-
34147175161
-
Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
-
Heilbronn LK, Gan SK, Turner N, Campbell LV, Chisholm DJ. Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. J Clin Endocrinol Metab 2007;92:1467-1473
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 1467-1473
-
-
Heilbronn, L.K.1
Gan, S.K.2
Turner, N.3
Campbell, L.V.4
Chisholm, D.J.5
-
14
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao Z, Hwang D, Bataille F, et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 2002; 277:48115-48121
-
(2002)
J Biol Chem
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
-
15
-
-
4744344777
-
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B
-
Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 2004;279: 41294-41301
-
(2004)
J Biol Chem
, vol.279
, pp. 41294-41301
-
-
Sinha, S.1
Perdomo, G.2
Brown, N.F.3
O'doherty, R.M.4
-
16
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004;350:664-671
-
(2004)
N Engl J Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
17
-
-
77956342883
-
TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes
-
Chen XH, Zhao YP, Xue M, et al. TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes. Mol Cell Endocrinol 2010;328:63-69
-
(2010)
Mol Cell Endocrinol
, vol.328
, pp. 63-69
-
-
Chen, X.H.1
Zhao, Y.P.2
Xue, M.3
-
18
-
-
58149094542
-
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
-
Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem 2008;283:35375-35382
-
(2008)
J Biol Chem
, vol.283
, pp. 35375-35382
-
-
Zhang, J.1
Gao, Z.2
Yin, J.3
Quon, M.J.4
Ye, J.5
-
19
-
-
79953221811
-
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kB signalling in rat skeletal muscle cells by AMP-activated protein kinase
-
Green CJ, Macrae K, Fogarty S, Hardie DG, Sakamoto K, Hundal HS. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kB signalling in rat skeletal muscle cells by AMP-activated protein kinase. Biochem J 2011;435:463-474
-
(2011)
Biochem J
, vol.435
, pp. 463-474
-
-
Green, C.J.1
Macrae, K.2
Fogarty, S.3
Hardie, D.G.4
Sakamoto, K.5
Hundal, H.S.6
-
20
-
-
2642561229
-
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
-
Weigert C, Brodbeck K, Staiger H, et al. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem 2004;279:23942-23952
-
(2004)
J Biol Chem
, vol.279
, pp. 23942-23952
-
-
Weigert, C.1
Brodbeck, K.2
Staiger, H.3
-
21
-
-
84859233338
-
A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans
-
Blachnio-Zabielska AU, Persson XM, Koutsari C, Zabielski P, Jensen MD. A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans. Rapid Commun Mass Spectrom 2012; 26:1134-1140
-
(2012)
Rapid Commun Mass Spectrom
, vol.26
, pp. 1134-1140
-
-
Blachnio-Zabielska, A.U.1
Persson, X.M.2
Koutsari, C.3
Zabielski, P.4
Jensen, M.D.5
-
22
-
-
33750572410
-
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
-
Dimopoulos N, Watson M, Sakamoto K, Hundal HS. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J 2006;399:473-481
-
(2006)
Biochem J
, vol.399
, pp. 473-481
-
-
Dimopoulos, N.1
Watson, M.2
Sakamoto, K.3
Hundal, H.S.4
-
23
-
-
81255144050
-
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: Improved metabolite identification by retention time prediction
-
Creek DJ, Jankevics A, Breitling R, Watson DG, Barrett MP, Burgess KE. Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. Anal Chem 2011;83:8703-8710
-
(2011)
Anal Chem
, vol.83
, pp. 8703-8710
-
-
Creek, D.J.1
Jankevics, A.2
Breitling, R.3
Watson, D.G.4
Barrett, M.P.5
Burgess, K.E.6
-
24
-
-
79953267955
-
PeakML/ mzMatch: A file format, Java library, R library, and tool-chain for mass spectrometry data analysis
-
Scheltema RA, Jankevics A, Jansen RC, Swertz MA, Breitling R. PeakML/ mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis. Anal Chem 2011;83:2786-2793
-
(2011)
Anal Chem
, vol.83
, pp. 2786-2793
-
-
Scheltema, R.A.1
Jankevics, A.2
Jansen, R.C.3
Swertz, M.A.4
Breitling, R.5
-
25
-
-
4544242908
-
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
-
Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS. Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 2004;382:619-629
-
(2004)
Biochem J
, vol.382
, pp. 619-629
-
-
Powell, D.J.1
Turban, S.2
Gray, A.3
Hajduch, E.4
Hundal, H.S.5
-
26
-
-
33646394578
-
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: Role of intramuscular accumulation of lipid metabolites
-
Lee JS, Pinnamaneni SK, Eo SJ, et al. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol 2006;100:1467-1474
-
(2006)
J Appl Physiol
, vol.100
, pp. 1467-1474
-
-
Lee, J.S.1
Pinnamaneni, S.K.2
Eo, S.J.3
-
27
-
-
55349100928
-
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and postreceptor signalling
-
Ruddock MW, Stein A, Landaker E, et al. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and postreceptor signalling. J Biochem 2008;144:599-607
-
(2008)
J Biochem
, vol.144
, pp. 599-607
-
-
Ruddock, M.W.1
Stein, A.2
Landaker, E.3
-
28
-
-
0027727915
-
Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: Differences revealed using aminooxyacetate
-
McKenna MC, Tildon JT, Stevenson JH, Boatright R, Huang S. Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate. Dev Neurosci 1993; 15:320-329
-
(1993)
Dev Neurosci
, vol.15
, pp. 320-329
-
-
McKenna, M.C.1
Tildon, J.T.2
Stevenson, J.H.3
Boatright, R.4
Huang, S.5
-
29
-
-
0038718723
-
Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats
-
Wan R, Camandola S, Mattson MP. Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats. FASEB J 2003;17:1133-1134
-
(2003)
FASEB J
, vol.17
, pp. 1133-1134
-
-
Wan, R.1
Camandola, S.2
Mattson, M.P.3
-
30
-
-
0029948212
-
Mechanism of free fatty acidinduced insulin resistance in humans
-
Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acidinduced insulin resistance in humans. J Clin Invest 1996;97:2859-2865
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
-
31
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland WL, Brozinick JT, Wang LP, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 2007;5:167-179
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
-
32
-
-
84860455885
-
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
-
Farese RV Jr, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab 2012;15:570-573
-
(2012)
Cell Metab
, vol.15
, pp. 570-573
-
-
Farese Jr., R.V.1
Zechner, R.2
Newgard, C.B.3
Walther, T.C.4
-
33
-
-
84868144928
-
Revisiting the diacylglycerol-induced insulin resistance hypothesis
-
Amati F. Revisiting the diacylglycerol-induced insulin resistance hypothesis. Obes Rev 2012;13(Suppl. 2):40-50
-
(2012)
Obes Rev
, vol.13
, Issue.SUPPL. 2
, pp. 40-50
-
-
Amati, F.1
-
34
-
-
84863944529
-
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity
-
Timmers S, Nabben M, Bosma M, et al. Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity. Proc Natl Acad Sci USA 2012;109: 11711-11716
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11711-11716
-
-
Timmers, S.1
Nabben, M.2
Bosma, M.3
-
35
-
-
40449097575
-
Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide
-
Hajduch E, Turban S, Le Liepvre X, et al. Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide. Biochem J 2008;410: 369-379
-
(2008)
Biochem J
, vol.410
, pp. 369-379
-
-
Hajduch, E.1
Turban, S.2
Le Liepvre, X.3
-
36
-
-
53649083550
-
Is mitochondrial dysfunction a cause of insulin resistance?
-
Turner N, Heilbronn LK. Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol Metab 2008;19:324-330
-
(2008)
Trends Endocrinol Metab
, vol.19
, pp. 324-330
-
-
Turner, N.1
Heilbronn, L.K.2
-
37
-
-
84860430699
-
Lipid-induced mitochondrial stress and insulin action in muscle
-
Muoio DM, Neufer PD. Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab 2012;15:595-605
-
(2012)
Cell Metab
, vol.15
, pp. 595-605
-
-
Muoio, D.M.1
Neufer, P.D.2
-
38
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008;7:45-56
-
(2008)
Cell Metab
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
-
39
-
-
38849199866
-
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulinresistant mice
-
Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulinresistant mice. J Clin Invest 2008;118:789-800
-
(2008)
J Clin Invest
, vol.118
, pp. 789-800
-
-
Bonnard, C.1
Durand, A.2
Peyrol, S.3
-
40
-
-
78649660058
-
Different effects of oleate vs palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: Role of oxidative stress
-
Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab 2010; 299:E1096-E1105
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Yuzefovych, L.1
Wilson, G.2
Rachek, L.3
-
41
-
-
26844558334
-
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
-
Nisoli E, Tonello C, Cardile A, et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005; 310:314-317
-
(2005)
Science
, vol.310
, pp. 314-317
-
-
Nisoli, E.1
Tonello, C.2
Cardile, A.3
-
42
-
-
33947710793
-
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
-
CALERIE Pennington Team
-
Civitarese AE, Carling S, Heilbronn LK, et al.; CALERIE Pennington Team. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 2007;4:e76
-
(2007)
PLoS Med
, vol.4
-
-
Civitarese, A.E.1
Carling, S.2
Heilbronn, L.K.3
-
43
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC- 1alpha
-
Gerhart-Hines Z, Rodgers JT, Bare O, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC- 1alpha. EMBO J 2007;26:1913-1923
-
(2007)
EMBO J
, vol.26
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
Rodgers, J.T.2
Bare, O.3
-
44
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458:1056-1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
-
45
-
-
84860561281
-
Loss of AMP-activated protein kinase-a2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
-
Wang P, Zhang RY, Song J, et al. Loss of AMP-activated protein kinase-a2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 2012;61:1051-1061
-
(2012)
Diabetes
, vol.61
, pp. 1051-1061
-
-
Wang, P.1
Zhang, R.Y.2
Song, J.3
-
46
-
-
84862001123
-
Defining the contribution of AMPactivated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells
-
Turban S, Stretton C, Drouin O, et al. Defining the contribution of AMPactivated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. J Biol Chem 2012; 287:20088-20099
-
(2012)
J Biol Chem
, vol.287
, pp. 20088-20099
-
-
Turban, S.1
Stretton, C.2
Drouin, O.3
-
47
-
-
65249179010
-
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
-
Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein S. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 2009;136:1552-1560
-
(2009)
Gastroenterology
, vol.136
, pp. 1552-1560
-
-
Kirk, E.1
Reeds, D.N.2
Finck, B.N.3
Mayurranjan, S.M.4
Patterson, B.W.5
Klein, S.6
-
48
-
-
78751704506
-
Glycolytic inhibition as a strategy for developing calorie restriction mimetics
-
Ingram DK, Roth GS. Glycolytic inhibition as a strategy for developing calorie restriction mimetics. Exp Gerontol 2011;46:148-154
-
(2011)
Exp Gerontol
, vol.46
, pp. 148-154
-
-
Ingram, D.K.1
Roth, G.S.2
|