Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

Redox Biology

Volumn 3, Issue , 2014, Pages 63-71

  Yang, Sijun ^a   Xia, Chunxiang ^a   Li, Shali ^a   Du, Leilei ^a   Zhang, Lu ^a   Zhou, Ronbin ^a  

^a NANJING NORMAL UNIVERSITY   (China)

Author keywords

KIF5B; Mitophagy; Proinflammatory response; Rheb

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; KINESIN; KINESIN FAMILY MEMBER 5B; NIFEDIPINE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR 3; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; RHEB PROTEIN; UNCLASSIFIED DRUG; CALCIUM; CARRIER PROTEIN; CELL RECEPTOR; GLUCOSE; INSULIN; KIF5B PROTEIN, RAT; LIPOPOLYSACCHARIDE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE; NOD-LIKE RECEPTOR 3, RAT; PALMITIC ACID DERIVATIVE; RHEB PROTEIN, RAT;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SYNTHESIS; INFLAMMATION; INSULIN RESISTANCE; LIPOTOXICITY; MEMBRANE POTENTIAL; MITOCHONDRION; MITOPHAGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; ANIMAL; DRUG EFFECTS; GENE EXPRESSION; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE; PANCREAS ISLET; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SECRETION (PROCESS);

ANIMALS; CALCIUM; CARRIER PROTEINS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; KINESIN; LIPOPOLYSACCHARIDES; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANES; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PALMITATES; PROTEIN TRANSPORT; PROTEOLYSIS; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84913529685     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2014.04.001     Document Type: Article

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