Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives

Hypertension Research

Volumn 35, Issue 2, 2012, Pages 180-185

  Sun, Wu Ping ^a   Li, Da ^a   Lun, Yong Zhi ^a   Gong, Xiao Jie ^a   Sun, Shen Xia ^a   Guo, Ming ^a   Jing, Li Xin ^a   Zhang, Li Bin ^b   Xiao, Fu Cheng ^a   Zhou, Shi Sheng ^a  

^a DALIAN UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

catecholamines; homocysteine; methylation status; nicotinamide

Indexed keywords

1 METHYLNICOTINAMIDE; ADRENALIN; BETAINE; CATECHOLAMINE; HOMOCYSTEINE; METADRENALIN; N METHYLNICOTINAMIDE; NICOTINAMIDE; NORADRENALIN; NORMETADRENALIN; S ADENOSYLMETHIONINE;

ADRENALIN BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRADATION; DRUG BLOOD LEVEL; HUMAN; HYPERTENSION; LOADING TEST; METHYLATION;

ADULT; BETAINE; BLOOD PRESSURE; CATECHOLAMINES; FEMALE; HOMOCYSTEINE; HUMANS; HYPERTENSION; INDICATORS AND REAGENTS; MALE; METHYLATION; NIACINAMIDE; VITAMINS;

EID: 84863036710     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2011.151     Document Type: Article

References (30)

1. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press: Washington, DC, 1998, pp 123-149.
2. Carmel R, Jacobsen DW. Homocysteine in Health and Disease. Cambridge University Press: Cambridge UK, 2001.
3. McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses 2000; 55: 189-194.
4. McCully KS. Homocysteine and vascular disease. Nat Med 1996; 2: 386-389. (Pubitemid 26191904)
5. Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev 2010; 90: 513-557.
6. Goldstein DS. Plasma catecholamines in clinical studies of cardiovascular diseases. Acta Physiol Scand Suppl 1984; 527: 39-41.
7. Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev 2004; 56: 331-349. (Pubitemid 39096594)
8. Zhou SS, Li D, Sun WP, Guo M, Lun YZ, Zhou YM, Xiao FC, Jing LX, Sun SX, Zhang LB, Luo N, Bian FN, Zou W, Dong LB, Zhao ZG, Li SF, Gong XJ, Yu ZG, Sun CB, Zheng CL, Jiang DJ, Li ZN. Nicotinamide overload may play a role in the development of type 2 diabetes. World J Gastroenterol 2009; 15: 5674-5684.
9. Pfeiffer CM, Huff DL, Gunter EW. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem 1999; 45: 290-292. (Pubitemid 29079132)
10. Laryea MD, Steinhagen F, Pawliczek S, Wendel U. Simple method for the routine determination of betaine and N,N-dimethylglycine in blood and urine. Clin Chem 1998; 44: 1937-1941. (Pubitemid 28405759)
11. Bechgaard H, Jespersen S. GI absorption of niacin in humans. J PharmSci 1977; 66: 871-872. (Pubitemid 8133659)
12. Ueland PM, Holm PI, Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med 2005; 43: 1069-1075. (Pubitemid 41581963)
13. Zhou SS, Li D, Zhou YM, Sun WP, Liu QG. B-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study. BMC Public Health 2010; 10: 746.
14. Ebbing M, Ueland PM. Prevention: B vitamins and CVD-failure to find a simple solution. Nat Rev Cardiol 2010; 7: 608-609.
15. Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 2004; 44: 248-252. (Pubitemid 39167216)
16. Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc Med 2007; 17: 48-54. (Pubitemid 46205327)
17. Fearon IM, Faux SP. Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J Mol Cell Cardiol 2009; 47: 372-381.
18. Greenbaum CJ, Kahn SE, Palmer JP. Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 1996; 45: 1631-1634. (Pubitemid 26357559)
19. Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol 2010; 16: 2378-2387.
20. Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis 2009; 204: 412-417.
21. Kim HC, Mofarrahi M, Vassilakopoulos T, Maltais F, Sigala I, Debigare R, Bellenis I, Hussain SN. Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 181: 797-805.
22. Jang JS, Cho HY, Lee YJ, Ha WS, Kim HW. The differential proteome profile of stomach cancer: identification of the biomarker candidates. Oncol Res 2004; 14: 491-499. (Pubitemid 39551562)
23. Roessler M, Rollinger W, Palme S, Hagmann ML, Berndt P, Engel AM, Schneidinger B, Pfeffer M, Andres H, Karl J, Bodenmüller H, Rüschoff J, Henkel T, Rohr G, Rossol S, Rösch W, Langen H, Zolg W, Tacke M. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin Cancer Res 2005; 11: 6550-6557. (Pubitemid 41338994)
24. Sartini D, Muzzonigro G, Milanese G, Pierella F, Rossi V, Emanuelli M. Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. J Urol 2006; 176: 2248-2254. (Pubitemid 44633146)
25. Xu J, Moatamed F, Caldwell JS, Walker JR, Kraiem Z, Taki K, Brent GA, Hershman JM. Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 2003; 88: 4990-4996. (Pubitemid 37357554)
26. Parsons RB, Smith SW, Waring RH, Williams AC, Ramsden DB. High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease. Neurosci Lett 2003; 342: 13-16. (Pubitemid 36513898)
27. Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. J Psychosom Res 2002; 52: 1-23. (Pubitemid 34130239)
28. Rikans LL, Arata D, Cederquist DC. Fatty livers produced in albino rats by excess niacin in high fat diets. I. Alterations in enzyme and coenzyme systems induced by supplementing 40% fat diets with 0.1% of niacin. J Nutr 1964; 82: 83-87.
29. Kielstein JT, Fliser D, Veldink H. Asymmetric dimethylarginine and symmetric dimethylarginine: axis of evil or useful alliance? Semin Dial 2009; 22: 346-350.
30. Kelly GS. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2. Altern Med Rev 2010; 15: 313-328.