Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16508-16513

  Rahimi, Yasmeen ^a   Camporez, João Paulo G ^a   Petersen, Max C ^a   Pesta, Dominik ^a   Perry, Rachel J ^a   Jurczak, Michael J ^a   Cline, Gary W ^a   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diacylglycerol; Insulin action; Liquid chromatography mass spectrometry; Nuclear magnetic resonance; Protein kinase C theta

Indexed keywords

ACYL COENZYME A; ACYLCARNITINE; CERAMIDE; DIACYLGLYCEROL; GLUCOSE; INSULIN; PROTEIN KINASE C THETA; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVATE DEHYDROGENASE KINASE 4; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; CARNITINE; FAT INTAKE; FATTY ACID; GLYCOGEN; ISOENZYME; MESSENGER RNA; PRKCQ PROTEIN, MOUSE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ESTERIFICATION; FATTY ACID OXIDATION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGEN ANALYSIS; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE METABOLISM; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WAKEFULNESS; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; C57BL MOUSE; CITRIC ACID CYCLE; DEFICIENCY; ENZYME SPECIFICITY; FAT INTAKE; GENETICS; HYPERINSULINISM; KNOCKOUT MOUSE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; OXIDATION REDUCTION REACTION; PHARMACOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; TOXICITY;

MUS;

ANIMALS; CARNITINE; CITRIC ACID CYCLE; DIETARY FATS; ENZYME ACTIVATION; FATTY ACIDS; GLUCOSE; GLYCOGEN; HYPERINSULINISM; INSULIN RESISTANCE; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 84919469789     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419104111     Document Type: Article

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