Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13410-13419

  Rajamäki, Kristiina ^a   Nordström, Tommy ^b   Nurmi, Katariina ^a   Åkerman, Karl E O ^b   Kovanen, Petri T ^a   Öörni, Katariina ^a   Eklund, Kari K ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; DANGER SIGNALS; EXTRACELLULAR; HUMAN MACROPHAGES; INFLAMMASOME; INNATE IMMUNITY; INTERLEUKIN-1; ISCHEMIC TISSUES;

BIOCHEMISTRY; BIOLOGY;

IMMUNE SYSTEM;

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; POTASSIUM;

ACIDIFICATION; ACIDITY; ACIDOSIS; ALKALINITY; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL;

ACIDOSIS; INFLAMMASOME; INFLAMMATION; INNATE IMMUNITY; INTERLEUKIN; MACROPHAGES; NOD-LIKE RECEPTORS (NLR);

ACIDOSIS; ANIMALS; CARRIER PROTEINS; CASPASE 1; CELL HYPOXIA; CELLS, CULTURED; CULTURE MEDIA; CYTOKINES; ENZYME ACTIVATION; EXTRACELLULAR FLUID; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROLIDES; MACROPHAGES; MICE; POTASSIUM; PROTON PUMP INHIBITORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84877705901     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.426254     Document Type: Article

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