Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 34, 2016, Pages E5024-E5033

  Patel, Priyanka L ^a   Suram, Anitha ^a   Mirani, Neena ^a   Bischof, Oliver ^b,c   Herbig, Utz ^a,d  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

^d UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Oncogene induced senescence; Senescence escape; Telomerase; Telomere; TERT

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; BRAF PROTEIN, HUMAN; MYC PROTEIN; MYC PROTEIN, HUMAN; PROTEIN P21; TERT PROTEIN, HUMAN;

ARTICLE; BREAST; CANCER CELL LINE; CELL AGING; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE RESPONSE; DNA REPLICATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE; ONCOGENE C MYC; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN; BREAST TUMOR; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; SKIN TUMOR; TELOMERE; TELOMERE HOMEOSTASIS; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLULAR SENESCENCE; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; ONCOGENE PROTEIN P21(RAS); PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84983607587     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602379113     Document Type: Article

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