The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

Science

Volumn 348, Issue 6238, 2015, Pages 1036-1039

  Bell, Robert J A ^a   Rube, H Tomas ^b,c   Kreig, Alex ^b,c   Mancini, Andrew ^a   Fouse, Shaun D ^a   Nagarajan, Raman P ^a   Choi, Serah ^a   Hong, Chibo ^a   He, Daniel ^a   Pekmezci, Melike ^a   Wiencke, John K ^d   Wrensch, Margaret R ^d   Chang, Susan M ^a   Walsh, Kyle M ^d   Myong, Sua ^b,c   Song, Jun S ^a,b,c   Costello, Joseph F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GA BINDING PROTEIN; NUCLEOTIDE; TELOMERASE REVERSE TRANSCRIPTASE; GABPA PROTEIN, HUMAN; PROTEIN BINDING; TELOMERASE; TERT PROTEIN, HUMAN;

APOPTOSIS; CANCER; ENZYME ACTIVITY; MUTATION; PROBA; TRANSFORMATION;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MELANOMA; MULTIPLE CANCER; NEOPLASM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; SENESCENCE; TRANSITIONAL CELL CARCINOMA; WILD TYPE; ALLELE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; TUMOR CELL LINE;

ALLELES; CELL LINE, TUMOR; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN MULTIMERIZATION; TELOMERASE;

EID: 84930677573     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab0015     Document Type: Article

References (29)

1. T. M. Bryan, T. R. Cech, Curr. Opin. Cell Biol. 11, 318-324 (1999).
2. C. W. Greider, E. H. Blackburn, Cell 43, 405-413 (1985).
3. S. L. S. Weinrich et al Nat. Genet 17 498-502 (1997)
4. P. Castelo-Branco et al., Lancet Oncol. 14, 534-542 (2013)
5. N. W. Kim et al., Science 266 2011-2015 (1994)
6. J. W. Shay S. Bacchetti, Eur. J. Cancer 33, 787-791 (1997).
7. S. Horn et al., Science 339, 959-961 (2013).
8. F. W. Huang et al., Science 339, 957-959 (2013).
9. P. J. Killela et al., Proc. Natl. Acad. Sci. U. S. A. 110, 6021-6026 (2013).
10. M. Remke et al., Acta Neuropathol. 126, 917-929 (2013).
11. A. Quaas et al., Virchows Arch. 465, 673-677 (2014).
12. I. Kinde et al., Cancer Res, 73, 7162-7167 (2013).
13. J. Vinagre et al., Nat. Commun. 4, 2185 (2013).
14. P. S. Rachakonda et al., Proc. Natl. Acad. Sci. U. S. A. 110, 17426-17431 (2013).
15. M. Simon et al., Neuro-oncol. 17, 45-52 (2015).
16. S. Spiegl-Kreinecker et al., Neuro-oncol. (2015).
17. G.-H. Wei et al., EMBO J. 29, 2147-2160 (2010).
18. G. W. Klappacher et al., Cell 109. 169-180 (2002).
19. K. C. El Kasmi et al., J. Immunol. 179, 7215-7219 (2007)
20. D. Sawka-Verhelle et al., J. Biol. Chem. 279, 17772-17784 (2004)
21. E. Birney et al., Nature 447, 799-816 (2007).
22. P. C. Hollenhorst et al., Genes Dev. 25, 2147-2157 (2011).
23. R, P. Nagarajan et al., Genome Res. 24, 761-774 (2014).
24. C. C. Thompson, T. A. Brown, S. L. McKnight, Science 253, 762-768 (1991)
25. T. Oikawa, T. Yamada, Gene 303, 11-34 (2003).
26. K. LaMarco C. C. Thompson B. P. Byers E. M. Walton S. L. McKnight Science 253, 789-792 (1991)
27. S. Gugneja J. V. Virbasius R. C. Scarpulla Mol Cell. Biol 15 102-111 (1995)
28. F. C. de la Brousse E. H. Birkenmeier, D. S. King L. B. Rowe S. L. McKnight Genes Dev. 8 1853-1865 (1994)
29. J. Sawada, M. Goto, C. Sawa, H. Watanabe, H. Handa, EMBO J. 13, 1396-1402 (1994).