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Volumn 24, Issue 1, 2014, Pages 30-37

TERT promoter mutations in cancer development

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 84890636883     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2013.11.005     Document Type: Review
Times cited : (193)

References (107)
  • 1
    • 84880813583 scopus 로고    scopus 로고
    • How will telomeric complex be further contributed to our longevity? The potential novel biomarkers of telomere complex counteracting both aging and cancer
    • Lu Y., Wei B., Zhang T., Chen Z., Ye J. How will telomeric complex be further contributed to our longevity? The potential novel biomarkers of telomere complex counteracting both aging and cancer. Protein Cell 2013, 4:573-581.
    • (2013) Protein Cell , vol.4 , pp. 573-581
    • Lu, Y.1    Wei, B.2    Zhang, T.3    Chen, Z.4    Ye, J.5
  • 2
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange T. How telomeres solve the end-protection problem. Science 2009, 326:948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • de Lange, T.1
  • 3
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 5
    • 84872912456 scopus 로고    scopus 로고
    • Finding the end: recruitment of telomerase to telomeres
    • Nandakumar J., Cech T.R. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol 2013, 14:69-82.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 69-82
    • Nandakumar, J.1    Cech, T.R.2
  • 7
    • 77952240404 scopus 로고    scopus 로고
    • Telomere rejuvenation during nuclear reprogramming
    • Marion R.M., Blasco M.A. Telomere rejuvenation during nuclear reprogramming. Curr Opin Genet Dev 2010, 20:190-196.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 190-196
    • Marion, R.M.1    Blasco, M.A.2
  • 9
    • 84882630671 scopus 로고    scopus 로고
    • Telomerase at the intersection of cancer and aging
    • Bernardes de Jesus B., Blasco M.A. Telomerase at the intersection of cancer and aging. Trends Genet 2013, 29:513-520.
    • (2013) Trends Genet , vol.29 , pp. 513-520
    • Bernardes de Jesus, B.1    Blasco, M.A.2
  • 10
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 84883163849 scopus 로고    scopus 로고
    • Telomerase: central regulator of all of the hallmarks of cancer
    • Low K.C., Tergaonkar V. Telomerase: central regulator of all of the hallmarks of cancer. Trends Biochem Sci 2013, 38:426-434.
    • (2013) Trends Biochem Sci , vol.38 , pp. 426-434
    • Low, K.C.1    Tergaonkar, V.2
  • 14
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: models, mechanisms and implications
    • Cesare A.J., Reddel R.R. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 2010, 11:319-330.
    • (2010) Nat Rev Genet , vol.11 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2
  • 16
    • 84855493135 scopus 로고    scopus 로고
    • It all comes together at the ends: telomerase structure, function, and biogenesis
    • Podlevsky J.D., Chen J.J. It all comes together at the ends: telomerase structure, function, and biogenesis. Mutat Res 2012, 730:3-11.
    • (2012) Mutat Res , vol.730 , pp. 3-11
    • Podlevsky, J.D.1    Chen, J.J.2
  • 18
    • 0034698133 scopus 로고    scopus 로고
    • Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component
    • Masutomi K., Kaneko S., Hayashi N., Yamashita T., Shirota Y., Kobayashi K., Murakami S. Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component. J Biol Chem 2000, 275:22568-22573.
    • (2000) J Biol Chem , vol.275 , pp. 22568-22573
    • Masutomi, K.1    Kaneko, S.2    Hayashi, N.3    Yamashita, T.4    Shirota, Y.5    Kobayashi, K.6    Murakami, S.7
  • 19
    • 84855763327 scopus 로고    scopus 로고
    • Telomerase and telomere-associated proteins: structural insights into mechanism and evolution
    • Lewis K.A., Wuttke D.S. Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure 2012, 20:28-39.
    • (2012) Structure , vol.20 , pp. 28-39
    • Lewis, K.A.1    Wuttke, D.S.2
  • 21
    • 77952604818 scopus 로고    scopus 로고
    • Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
    • Egan E.D., Collins K. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol 2010, 30:2775-2786.
    • (2010) Mol Cell Biol , vol.30 , pp. 2775-2786
    • Egan, E.D.1    Collins, K.2
  • 22
    • 33745862398 scopus 로고    scopus 로고
    • The biogenesis and regulation of telomerase holoenzymes
    • Collins K. The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol 2006, 7:484-494.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 484-494
    • Collins, K.1
  • 23
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay J.W., Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997, 33:787-791.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 25
    • 65949117219 scopus 로고    scopus 로고
    • TCAB1: driving telomerase to Cajal bodies
    • Venteicher A.S., Artandi S.E. TCAB1: driving telomerase to Cajal bodies. Cell Cycle 2009, 8:1329-1331.
    • (2009) Cell Cycle , vol.8 , pp. 1329-1331
    • Venteicher, A.S.1    Artandi, S.E.2
  • 26
    • 0038392866 scopus 로고    scopus 로고
    • Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs
    • Fu D., Collins K. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell 2003, 11:1361-1372.
    • (2003) Mol Cell , vol.11 , pp. 1361-1372
    • Fu, D.1    Collins, K.2
  • 28
    • 33745679352 scopus 로고    scopus 로고
    • Telomerase therapeutics for cancer: challenges and new directions
    • Shay J.W., Wright W.E. Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 2006, 5:577-584.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 577-584
    • Shay, J.W.1    Wright, W.E.2
  • 29
    • 34247188473 scopus 로고    scopus 로고
    • Telomere and telomerase in stem cells
    • Hiyama E., Hiyama K. Telomere and telomerase in stem cells. Br J Cancer 2007, 96:1020-1024.
    • (2007) Br J Cancer , vol.96 , pp. 1020-1024
    • Hiyama, E.1    Hiyama, K.2
  • 30
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., Shay J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996, 18:173-179.
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 31
    • 84875894854 scopus 로고    scopus 로고
    • The role of telomere biology in cancer
    • Xu L., Li S., Stohr B.A. The role of telomere biology in cancer. Annu Rev Pathol 2013, 8:49-78.
    • (2013) Annu Rev Pathol , vol.8 , pp. 49-78
    • Xu, L.1    Li, S.2    Stohr, B.A.3
  • 35
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T., Foster S.A., Koop J.I., McDougall J.K., Galloway D.A., Klingelhutz A.J. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998, 396:84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 36
    • 0035045477 scopus 로고    scopus 로고
    • Telomerase activation, cellular immortalization and cancer
    • Hahn W.C., Meyerson M. Telomerase activation, cellular immortalization and cancer. Ann Med 2001, 33:123-129.
    • (2001) Ann Med , vol.33 , pp. 123-129
    • Hahn, W.C.1    Meyerson, M.2
  • 37
    • 79953142510 scopus 로고    scopus 로고
    • Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene
    • Zhu J., Zhao Y., Wang S. Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell 2010, 1:22-32.
    • (2010) Protein Cell , vol.1 , pp. 22-32
    • Zhu, J.1    Zhao, Y.2    Wang, S.3
  • 39
    • 0032962953 scopus 로고    scopus 로고
    • The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter
    • Cong Y.S., Wen J., Bacchetti S. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet 1999, 8:137-142.
    • (1999) Hum Mol Genet , vol.8 , pp. 137-142
    • Cong, Y.S.1    Wen, J.2    Bacchetti, S.3
  • 40
    • 0035897568 scopus 로고    scopus 로고
    • Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
    • Poole J.C., Andrews L.G., Tollefsbol T.O. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 2001, 269:1-12.
    • (2001) Gene , vol.269 , pp. 1-12
    • Poole, J.C.1    Andrews, L.G.2    Tollefsbol, T.O.3
  • 41
    • 0033558281 scopus 로고    scopus 로고
    • Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
    • Horikawa I., Cable P.L., Afshari C., Barrett J.C. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res 1999, 59:826-830.
    • (1999) Cancer Res , vol.59 , pp. 826-830
    • Horikawa, I.1    Cable, P.L.2    Afshari, C.3    Barrett, J.C.4
  • 42
  • 43
    • 80052434889 scopus 로고    scopus 로고
    • Human telomerase activity regulation
    • Wojtyla A., Gladych M., Rubis B. Human telomerase activity regulation. Mol Biol Rep 2011, 38:3339-3349.
    • (2011) Mol Biol Rep , vol.38 , pp. 3339-3349
    • Wojtyla, A.1    Gladych, M.2    Rubis, B.3
  • 44
    • 53049108799 scopus 로고    scopus 로고
    • Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc
    • Xu D., Dwyer J., Li H., Duan W., Liu J.P. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J Biol Chem 2008, 283:23567-23580.
    • (2008) J Biol Chem , vol.283 , pp. 23567-23580
    • Xu, D.1    Dwyer, J.2    Li, H.3    Duan, W.4    Liu, J.P.5
  • 45
    • 49749139661 scopus 로고    scopus 로고
    • Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
    • Kyo S., Takakura M., Fujiwara T., Inoue M. Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci 2008, 99:1528-1538.
    • (2008) Cancer Sci , vol.99 , pp. 1528-1538
    • Kyo, S.1    Takakura, M.2    Fujiwara, T.3    Inoue, M.4
  • 48
    • 0037087550 scopus 로고    scopus 로고
    • Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT
    • Cerezo A., Kalthoff H., Schuermann M., Schafer B., Boukamp P. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. J Cell Sci 2002, 115:1305-1312.
    • (2002) J Cell Sci , vol.115 , pp. 1305-1312
    • Cerezo, A.1    Kalthoff, H.2    Schuermann, M.3    Schafer, B.4    Boukamp, P.5
  • 49
    • 0037036349 scopus 로고    scopus 로고
    • A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer
    • Li H., Lee T.H., Avraham H. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. J Biol Chem 2002, 277:20965-20973.
    • (2002) J Biol Chem , vol.277 , pp. 20965-20973
    • Li, H.1    Lee, T.H.2    Avraham, H.3
  • 50
    • 0034048726 scopus 로고    scopus 로고
    • Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription
    • Kanaya T., Kyo S., Hamada K., Takakura M., Kitagawa Y., Harada H., Inoue M. Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin Cancer Res 2000, 6:1239-1247.
    • (2000) Clin Cancer Res , vol.6 , pp. 1239-1247
    • Kanaya, T.1    Kyo, S.2    Hamada, K.3    Takakura, M.4    Kitagawa, Y.5    Harada, H.6    Inoue, M.7
  • 51
    • 74049113793 scopus 로고    scopus 로고
    • Ets2 transcription factor, telomerase activity and breast cancer
    • Dwyer J.M., Liu J.P. Ets2 transcription factor, telomerase activity and breast cancer. Clin Exp Pharmacol Physiol 2010, 37:83-87.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 83-87
    • Dwyer, J.M.1    Liu, J.P.2
  • 52
    • 0347624599 scopus 로고    scopus 로고
    • Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf
    • Goueli B.S., Janknecht R. Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol 2004, 24:25-35.
    • (2004) Mol Cell Biol , vol.24 , pp. 25-35
    • Goueli, B.S.1    Janknecht, R.2
  • 53
    • 18444377359 scopus 로고    scopus 로고
    • Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway
    • Maida Y., Kyo S., Kanaya T., Wang Z., Yatabe N., Tanaka M., Nakamura M., Ohmichi M., Gotoh N., Murakami S., et al. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene 2002, 21:4071-4079.
    • (2002) Oncogene , vol.21 , pp. 4071-4079
    • Maida, Y.1    Kyo, S.2    Kanaya, T.3    Wang, Z.4    Yatabe, N.5    Tanaka, M.6    Nakamura, M.7    Ohmichi, M.8    Gotoh, N.9    Murakami, S.10
  • 54
    • 0037821661 scopus 로고    scopus 로고
    • Multiple tumor suppressor pathways negatively regulate telomerase
    • Lin S.Y., Elledge S.J. Multiple tumor suppressor pathways negatively regulate telomerase. Cell 2003, 113:881-889.
    • (2003) Cell , vol.113 , pp. 881-889
    • Lin, S.Y.1    Elledge, S.J.2
  • 55
    • 79959419265 scopus 로고    scopus 로고
    • High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis
    • Li A.Y., Lin H.H., Kuo C.Y., Shih H.M., Wang C.C., Yen Y., Ann D.K. High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol 2011, 31:2605-2617.
    • (2011) Mol Cell Biol , vol.31 , pp. 2605-2617
    • Li, A.Y.1    Lin, H.H.2    Kuo, C.Y.3    Shih, H.M.4    Wang, C.C.5    Yen, Y.6    Ann, D.K.7
  • 62
    • 1442323605 scopus 로고    scopus 로고
    • BRAF mutations are common somatic events in melanocytic nevi
    • Kumar R., Angelini S., Snellman E., Hemminki K. BRAF mutations are common somatic events in melanocytic nevi. J Invest Dermatol 2004, 122:342-348.
    • (2004) J Invest Dermatol , vol.122 , pp. 342-348
    • Kumar, R.1    Angelini, S.2    Snellman, E.3    Hemminki, K.4
  • 64
    • 84877967061 scopus 로고    scopus 로고
    • Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma
    • Liu X., Wu G., Shan Y., Hartmann C., von Deimling A., Xing M. Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. Cell Cycle 2013, 12:1637-1638.
    • (2013) Cell Cycle , vol.12 , pp. 1637-1638
    • Liu, X.1    Wu, G.2    Shan, Y.3    Hartmann, C.4    von Deimling, A.5    Xing, M.6
  • 65
    • 84891828969 scopus 로고    scopus 로고
    • Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine
    • Hurst C.D., Platt F.M., Knowles M.A. Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine. Eur Urol 2013, 10.1016/j.eururo.2013.08.057.
    • (2013) Eur Urol
    • Hurst, C.D.1    Platt, F.M.2    Knowles, M.A.3
  • 66
    • 84891835829 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome
    • Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., et al. Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. Eur Urol 2013, 10.1016/j.eururo.2013.08.052.
    • (2013) Eur Urol
    • Allory, Y.1    Beukers, W.2    Sagrera, A.3    Flandez, M.4    Marques, M.5    Marquez, M.6    van der Keur, K.A.7    Dyrskjot, L.8    Lurkin, I.9    Vermeij, M.10
  • 76
    • 84897486638 scopus 로고    scopus 로고
    • Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma
    • Scott G.A., Laughlin T.S., Rothberg P.G. Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma. Mod Pathol 2013, 10.1038/modpathol.2013.167.
    • (2013) Mod Pathol
    • Scott, G.A.1    Laughlin, T.S.2    Rothberg, P.G.3
  • 77
    • 84887503946 scopus 로고    scopus 로고
    • Low frequency of TERT promoter somatic mutation in 313 sporadic esophageal squamous cell carcinomas
    • Zhao Y., Gao Y., Chen Z., Hu X., Zhou F., He J. Low frequency of TERT promoter somatic mutation in 313 sporadic esophageal squamous cell carcinomas. Int J Cancer 2013, 134:493-494.
    • (2013) Int J Cancer , vol.134 , pp. 493-494
    • Zhao, Y.1    Gao, Y.2    Chen, Z.3    Hu, X.4    Zhou, F.5    He, J.6
  • 82
    • 0028356516 scopus 로고
    • Elk-1 proteins interact with MAP kinases
    • Rao V.N., Reddy E.S. elk-1 proteins interact with MAP kinases. Oncogene 1994, 9:1855-1860.
    • (1994) Oncogene , vol.9 , pp. 1855-1860
    • Rao, V.N.1    Reddy, E.S.2
  • 83
    • 84888585803 scopus 로고    scopus 로고
    • Molecular mechanisms of ETS transcription factor-mediated tumorigenesis
    • Kar A., Gutierrez-Hartmann A. Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol 2013, 48:522-543.
    • (2013) Crit Rev Biochem Mol Biol , vol.48 , pp. 522-543
    • Kar, A.1    Gutierrez-Hartmann, A.2
  • 84
    • 0348049997 scopus 로고    scopus 로고
    • Ets ternary complex transcription factors
    • Buchwalter G., Gross C., Wasylyk B. Ets ternary complex transcription factors. Gene 2004, 324:1-14.
    • (2004) Gene , vol.324 , pp. 1-14
    • Buchwalter, G.1    Gross, C.2    Wasylyk, B.3
  • 88
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco M.A. Telomerase beyond telomeres. Nat Rev Cancer 2002, 2:627-633.
    • (2002) Nat Rev Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 89
    • 33644511376 scopus 로고    scopus 로고
    • Telomerase: not just for the elongation of telomeres
    • Calado R.T., Chen J. Telomerase: not just for the elongation of telomeres. Bioessays 2006, 28:109-112.
    • (2006) Bioessays , vol.28 , pp. 109-112
    • Calado, R.T.1    Chen, J.2
  • 90
  • 91
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez P., Blasco M.A. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 2011, 11:161-176.
    • (2011) Nat Rev Cancer , vol.11 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 94
    • 79959919116 scopus 로고    scopus 로고
    • Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression
    • Beck S., Jin X., Sohn Y.W., Kim J.K., Kim S.H., Yin J., Pian X., Kim S.C., Nam D.H., Choi Y.J., et al. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression. Mol Cells 2011, 31:9-15.
    • (2011) Mol Cells , vol.31 , pp. 9-15
    • Beck, S.1    Jin, X.2    Sohn, Y.W.3    Kim, J.K.4    Kim, S.H.5    Yin, J.6    Pian, X.7    Kim, S.C.8    Nam, D.H.9    Choi, Y.J.10
  • 95
    • 84872022032 scopus 로고    scopus 로고
    • A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells
    • Xie L., Gazin C., Park S.M., Zhu L.J., Debily M.A., Kittler E.L., Zapp M.L., Lapointe D., Gobeil S., Virbasius C.M., et al. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. PLoS Genet 2012, 8:e1003151.
    • (2012) PLoS Genet , vol.8
    • Xie, L.1    Gazin, C.2    Park, S.M.3    Zhu, L.J.4    Debily, M.A.5    Kittler, E.L.6    Zapp, M.L.7    Lapointe, D.8    Gobeil, S.9    Virbasius, C.M.10
  • 97
    • 14844301658 scopus 로고    scopus 로고
    • HTERT antagonizes p53-induced apoptosis independently of telomerase activity
    • Rahman R., Latonen L., Wiman K.G. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 2005, 24:1320-1327.
    • (2005) Oncogene , vol.24 , pp. 1320-1327
    • Rahman, R.1    Latonen, L.2    Wiman, K.G.3
  • 99
    • 77956252000 scopus 로고    scopus 로고
    • Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
    • Lim K.W., Lacroix L., Yue D.J., Lim J.K., Lim J.M., Phan A.T. Coexistence of two distinct G-quadruplex conformations in the hTERT promoter. J Am Chem Soc 2010, 132:12331-12342.
    • (2010) J Am Chem Soc , vol.132 , pp. 12331-12342
    • Lim, K.W.1    Lacroix, L.2    Yue, D.J.3    Lim, J.K.4    Lim, J.M.5    Phan, A.T.6
  • 100
    • 0036597090 scopus 로고    scopus 로고
    • The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo
    • Grand C.L., Han H., Munoz R.M., Weitman S., Von Hoff D.D., Hurley L.H., Bearss D.J. The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. Mol Cancer Ther 2002, 1:565-573.
    • (2002) Mol Cancer Ther , vol.1 , pp. 565-573
    • Grand, C.L.1    Han, H.2    Munoz, R.M.3    Weitman, S.4    Von Hoff, D.D.5    Hurley, L.H.6    Bearss, D.J.7
  • 102
    • 84875290637 scopus 로고    scopus 로고
    • Cancer: trouble upstream
    • Patton E.E., Harrington L. Cancer: trouble upstream. Nature 2013, 495:320-321.
    • (2013) Nature , vol.495 , pp. 320-321
    • Patton, E.E.1    Harrington, L.2
  • 103
    • 84875198920 scopus 로고    scopus 로고
    • Transcriptional regulation and its misregulation in disease
    • Lee T.I., Young R.A. Transcriptional regulation and its misregulation in disease. Cell 2013, 152:1237-1251.
    • (2013) Cell , vol.152 , pp. 1237-1251
    • Lee, T.I.1    Young, R.A.2
  • 104
    • 84855517708 scopus 로고    scopus 로고
    • Telomeres and disease: an overview
    • Armanios M., Price C. Telomeres and disease: an overview. Mutat Res 2012, 730:1-2.
    • (2012) Mutat Res , vol.730 , pp. 1-2
    • Armanios, M.1    Price, C.2
  • 105
    • 84874611617 scopus 로고    scopus 로고
    • Telomeres and age-related disease: how telomere biology informs clinical paradigms
    • Armanios M. Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest 2013, 123:996-1002.
    • (2013) J Clin Invest , vol.123 , pp. 996-1002
    • Armanios, M.1
  • 106
    • 84876976986 scopus 로고    scopus 로고
    • Novel anticancer therapeutics targeting telomerase
    • Ruden M., Puri N. Novel anticancer therapeutics targeting telomerase. Cancer Treat Rev 2013, 39:444-456.
    • (2013) Cancer Treat Rev , vol.39 , pp. 444-456
    • Ruden, M.1    Puri, N.2
  • 107
    • 84875706825 scopus 로고    scopus 로고
    • Resistance to BRAF-targeted therapy in melanoma
    • Sullivan R.J., Flaherty K.T. Resistance to BRAF-targeted therapy in melanoma. Eur J Cancer 2013, 49:1297-1304.
    • (2013) Eur J Cancer , vol.49 , pp. 1297-1304
    • Sullivan, R.J.1    Flaherty, K.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.