Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

EMBO Journal

Volumn 31, Issue 13, 2012, Pages 2839-2851

  Suram, Anitha ^a   Kaplunov, Jessica ^a   Patel, Priyanka L ^a   Ruan, Haihe ^a   Cerutti, Aurora ^b   Boccardi, Virginia ^a   Fumagalli, Marzia ^b,e   Di Micco, Raffaella ^b,f   Mirani, Neena ^a   Gurung, Resham Lal ^c   Hande, Manoor Prakash ^c   D'Adda Di Fagagna, Fabrizio ^b,d   Herbig, Utz ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d CNR   (Italy)

^e TTFactor Srl   (Italy)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cancer progression; cellular senescence; oncogene; telomere dysfunction; tumour suppressing mechanism

Indexed keywords

BETA GALACTOSIDASE; KI 67 ANTIGEN; PROTEIN P16; TELOMERASE;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL AGING; CELL PROLIFERATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVITY; GENE REPLICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TELOMERE; TELOMERE DYSFUNCTION INDUCED SENESCENCE;

CELL AGING; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA REPLICATION; HUMANS; ONCOGENES; PROTEIN SYNTHESIS INHIBITORS; PUROMYCIN; SIGNAL TRANSDUCTION; TELOMERE;

EID: 84863842252     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.132     Document Type: Article

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