Neutral sphingomyelinase-2 deficiency ameliorates Alzheimer’s disease pathology and improves cognition in the 5XFAD mouse

Journal of Neuroscience

Volumn 36, Issue 33, 2016, Pages 8653-8667

  Dinkins, Michael B ^a   Enasko, John ^a   Hernandez, Caterina ^a   Wang, Guanghu ^a   Kong, Jina ^a   Helwa, Inas ^a   Liu, Yutao ^a   Terry, Alvin V ^a   Bieberich, Erhard ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

5XFAD; Alzheimer s; Ceramide; Exosomes; Fear conditioning; Sphingomyelinase

Indexed keywords

CERAMIDE; SPHINGOMYELIN PHOSPHODIESTERASE; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CD11B ANTIGEN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; SMPD3 PROTEIN, MOUSE;

5XFAD MOUSE; ADULT; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL ACTIVATION; CELL CULTURE; COGNITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; FEAR CONDITIONING TEST; FEMALE; GENE SILENCING; GLIA CELL; HIPPOCAMPUS; LEARNING; LIPID ANALYSIS; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; ANIMAL; C57BL MOUSE; COGNITION DISORDERS; COMPLICATION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GLIA; HUMAN; LIPID METABOLISM; METABOLISM; MUTATION; NEWBORN; PATHOLOGY; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD11B; CELLS, CULTURED; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; EXOSOMES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROGLIA; PRESENILIN-1; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84982298737     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1429-16.2016     Document Type: Article

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