-
1
-
-
0029076794
-
Alzheimer’s disease: It’s irreversible but not untreatable
-
Filley, C.M. Alzheimer’s disease: It’s irreversible but not untreatable. Geriatrics 1995, 50, 18–23.
-
(1995)
Geriatrics
, vol.50
, pp. 18-23
-
-
Filley, C.M.1
-
2
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (Tau) in alzheimer cytoskeletal pathology
-
Grundke-Iqbal, I.; Iqbal, K.; Tung, Y.C.; Quinlan, M.; Wisniewski, H.M.; Binder, L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA 1986, 83, 4913–4917.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
3
-
-
0012510759
-
Amyloid plaque core protein in alzheimer disease and down syndrome
-
Masters, C.L.; Simms, G.; Weinman, N.A.; Multhaup, G.; McDonald, B.L.; Beyreuther, K. Amyloid plaque core protein in alzheimer disease and down syndrome. Proc. Natl. Acad. Sci. USA 1985, 82, 4245–4249.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
4
-
-
0037135111
-
The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics
-
Hardy, J.; Selkoe, D.J. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science 2002, 297, 353–356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
5
-
-
0031583947
-
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer’s disease
-
Tapiola, T.; Overmyer M.; Lehtovirta, M.; Helisalmi, S.; Ramberg, J.; Alafuzoff, I.; Riekkinen, P., Sr.; Soininen, H. The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer’s disease. Neuroreport 1997, 8, 3961–3963.
-
(1997)
Neuroreport
, vol.8
, pp. 3961-3963
-
-
Tapiola, T.1
Overmyer, M.2
Lehtovirta, M.3
Helisalmi, S.4
Ramberg, J.5
Alafuzoff, I.6
Riekkinen, P.7
Soininen, H.8
-
6
-
-
32044436030
-
Csf biomarkers for Alzheimer’s disease: Levels of β-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival
-
Wallin, A.K.; Blennow, K.; Andreasen, N.; Minthon, L. Csf biomarkers for Alzheimer’s disease: Levels of β-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dement. Geriatr. Cogn. Disord. 2006, 21, 131–138.
-
(2006)
Dement. Geriatr. Cogn. Disord
, vol.21
, pp. 131-138
-
-
Wallin, A.K.1
Blennow, K.2
Andreasen, N.3
Minthon, L.4
-
7
-
-
84923043770
-
Prion-like transmission and spreading of tau pathology
-
Clavaguera, F.; Hench, J.; Goedert, M.; Tolnay, M.: Prion-like transmission and spreading of tau pathology. Neuropathol. Appl. Neurobiol. 2015, 41, 47–58.
-
(2015)
Neuropathol. Appl. Neurobiol
, vol.41
, pp. 47-58
-
-
Clavaguera, F.1
Hench, J.2
Goedert, M.3
Tolnay, M.4
-
8
-
-
77949848854
-
Prion-like transmission of protein aggregates in neurodegenerative diseases
-
Brundin, P.; Melki, R.; Kopito, R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat. Rev. Mol. Cell Biol. 2010, 11, 301–307.
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 301-307
-
-
Brundin, P.1
Melki, R.2
Kopito, R.3
-
9
-
-
84863762839
-
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
-
Nussbaum, J.M.; Schilling, S.; Cynis, H.; Silva, A.; Swanson, E, Wangsanut, T.; Tayler, K.; Wiltgen, B.; Hatami, A.; Rönicke, R. et al.: Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nat. Cell. Biol. 2012, 485, 651–655.
-
(2012)
Nat. Cell. Biol
, vol.485
, pp. 651-655
-
-
Nussbaum, J.M.1
Schilling, S.2
Cynis, H.3
Silva, A.4
Swanson, E.5
Wangsanut, T.6
Tayler, K.7
Wiltgen, B.8
Hatami, A.9
Rönicke, R.10
-
10
-
-
84863595757
-
Purified and synthetic Alzheimer’s amyloid β (Aβ) prions
-
Stöhr, J.; Watts, J.C.; Mensinger, Z.L.; Oehler, A.; Grillo, S.K.; DeArmond, S.J.; Prusiner, S.B.; Gilesa, K.: Purified and synthetic Alzheimer’s amyloid β (aβ) prions. Proc. Natl. Acad. Sci. USA 2012, 109, 11025–11030.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 11025-11030
-
-
Stöhr, J.1
Watts, J.C.2
Mensinger, Z.L.3
Oehler, A.4
Grillo, S.K.5
Dearmond, S.J.6
Prusiner, S.B.7
Gilesa, K.8
-
11
-
-
84901791625
-
Sources of extracellular tau and its signaling
-
Avila, J.; Simón, D.; Díaz-Hernández, M.; Pintor, J.; Hernández, F. Sources of extracellular tau and its signaling. J. Alzheimers Dis. 2014, 40, S7–S15.
-
(2014)
J. Alzheimers Dis
, vol.40
, pp. SS7-S15
-
-
Avila, J.1
Simón, D.2
Díaz-Hernández, M.3
Pintor, J.4
Hernández, F.5
-
12
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
Haass, C.; Schlossmacher, M.G.; Hung, A.Y.; Vigo-Pelfrey, C.; Mellon, A.; Ostaszewski, B.L.; Lieberburg, I.; Koo, E.H.; Schenk, D.; Teplow, D.B. et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 1992, 359, 322–325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
-
13
-
-
0026721943
-
β-amyloid precursor protein cleavage by a membrane-bound protease
-
Sisodia, S.S.: β-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. USA 1992, 89, 6075–6079.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6075-6079
-
-
Sisodia, S.S.1
-
14
-
-
0028855851
-
Dominant and differential deposition of distinct β-amyloid peptide species, aβN3(PE), in senile plaques
-
Saido, T.C.; Iwatsubo, T.; Mann, D.M.; Shimada, H.; Ihara, Y.; Kawashima, S. Dominant and differential deposition of distinct β-amyloid peptide species, aβN3(pE), in senile plaques. Neuron 1995, 14, 457–466.
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
15
-
-
0029849644
-
Full-length amyloid-β (1–42(43)) and amino-terminally modified and truncated amyloid-β 42(43) deposit in diffuse plaques
-
Iwatsubo, T.; Saido, T.C.; Mann, D.M.; Lee, V.M.; Trojanowski, J.Q. Full-length amyloid-β (1–42(43)) and amino-terminally modified and truncated amyloid-β 42(43) deposit in diffuse plaques. Am. J. Pathol. 1996, 149, 1823–1830.
-
(1996)
Am. J. Pathol
, vol.149
, pp. 1823-1830
-
-
Iwatsubo, T.1
Saido, T.C.2
Mann, D.M.3
Lee, V.M.4
Trojanowski, J.Q.5
-
16
-
-
0030742712
-
Heterogeneity of water-soluble amyloid β-peptide in alzheimer's disease and down’s syndrome brains
-
Russo, C.; Saido, T.C.; DeBusk, L.M.; Tabaton, M.; Gambetti, P.; Teller, J.K. Heterogeneity of water-soluble amyloid β-peptide in alzheimer's disease and down’s syndrome brains. FEBS Lett. 1997, 409, 411–416.
-
(1997)
FEBS Lett
, vol.409
, pp. 411-416
-
-
Russo, C.1
Saido, T.C.2
Debusk, L.M.3
Tabaton, M.4
Gambetti, P.5
Teller, J.K.6
-
17
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer’s disease
-
Russo, C.; Schettini, G.; Saido, T.C.; Hulette, C.; Lippa, C.; Lannfelt, L.; Ghetti, B.; Gambetti, P.; Tabaton, M.; Teller, J.K. Presenilin-1 mutations in Alzheimer’s disease. Nature 2000, 405, 531–532.
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
18
-
-
77957279325
-
Mass spectrometric characterization of brain amyloid β isoform signatures in familial and sporadic Alzheimer’s disease
-
Portelius, E.; Bogdanovic, N.; Gustavsson, M.K.; Volkmann, I.; Brinkmalm, G.; Zetterberg, H.; Winblad, B.; Blennow, K. Mass spectrometric characterization of brain amyloid β isoform signatures in familial and sporadic Alzheimer’s disease. Acta Neuropathol. 2010, 120, 185–193.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 185-193
-
-
Portelius, E.1
Bogdanovic, N.2
Gustavsson, M.K.3
Volkmann, I.4
Brinkmalm, G.5
Zetterberg, H.6
Winblad, B.7
Blennow, K.8
-
19
-
-
84455170737
-
Cerebrospinal fluid biomarkers in progranulin mutations carriers
-
Carecchio, M.; Fenoglio, C.; Cortini, F.; Comi, C.; Benussi, L.; Ghidoni, R.; Borroni, B.; de Riz, M.; Serpente, M.; Cantoni, C. et al. Cerebrospinal fluid biomarkers in progranulin mutations carriers. J. Alzheimers Dis. 2011, 27, 781–790.
-
(2011)
J. Alzheimers Dis
, vol.27
, pp. 781-790
-
-
Carecchio, M.1
Fenoglio, C.2
Cortini, F.3
Comi, C.4
Benussi, L.5
Ghidoni, R.6
Borroni, B.7
De Riz, M.8
Serpente, M.9
Cantoni, C.10
-
20
-
-
80053309666
-
Novel aβ isoforms in Alzheimer’s disease—Their role in diagnosis and treatment
-
Portelius, E.; Mattsson, N.; Andreasson, U.; Blennow, K.; Zetterberg, H.: Novel aβ isoforms in Alzheimer’s disease—Their role in diagnosis and treatment. Curr. Pharm. Des. 2011, 17, 2594–2602.
-
(2011)
Curr. Pharm. Des
, vol.17
, pp. 2594-2602
-
-
Portelius, E.1
Mattsson, N.2
Andreasson, U.3
Blennow, K.4
Zetterberg, H.5
-
21
-
-
79960819248
-
Potent amyloidogenicity and pathogenicity of aβ 43
-
Saito, T.; Suemoto, T.; Brouwers, N.; Sleegers, K.; Funamoto, S.; Mihira, N.; Matsuba, Y.; Yamada, K.; Nilsson, P.; Takano, J. et al. Potent amyloidogenicity and pathogenicity of aβ 43. Nat. Neurosci. 2011, 14, 1023–1032.
-
(2011)
Nat. Neurosci
, vol.14
, pp. 1023-1032
-
-
Saito, T.1
Suemoto, T.2
Brouwers, N.3
Sleegers, K.4
Funamoto, S.5
Mihira, N.6
Matsuba, Y.7
Yamada, K.8
Nilsson, P.9
Takano, J.10
-
22
-
-
84873728856
-
The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease
-
Sandebring, A.; Welander, H.; Winblad, B.; Graff, C.; Tjernberg, L.O. The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease. PLoS One 2013, 8, e55847.
-
(2013)
Plos One
, vol.8
-
-
Sandebring, A.1
Welander, H.2
Winblad, B.3
Graff, C.4
Tjernberg, L.O.5
-
23
-
-
23844551164
-
Amino-terminally truncated aβ peptide species are the main component of cotton wool plaques
-
Miravalle, L.; Calero, M.; Takao, M.; Roher, A.E.; Ghetti, B.; Vidal, R. Amino-terminally truncated aβ peptide species are the main component of cotton wool plaques. Biochemistry 2005, 44, 10810–10821.
-
(2005)
Biochemistry
, vol.44
, pp. 10810-10821
-
-
Miravalle, L.1
Calero, M.2
Takao, M.3
Roher, A.E.4
Ghetti, B.5
Vidal, R.6
-
24
-
-
41649107275
-
Presenilin-1 280Glu → Ala mutation alters C-terminal APP processing yielding longer aβ peptides: Implications for Alzheimer’s disease
-
Van Vickle, G.; Esh, C.L.; Kokjohn, T.A.; Patton, R.L.; Kalback, W.M.; Luehrs, D.C.; Beach, T.G.; Newel, A.J.; Lopera, F.; Ghetti, B. et al.: Presenilin-1 280Glu → Ala mutation alters C-terminal APP processing yielding longer aβ peptides: Implications for Alzheimer’s disease. Mol. Med. 2008, 14, 184–194.
-
(2008)
Mol. Med
, vol.14
, pp. 184-194
-
-
Van Vickle, G.1
Esh, C.L.2
Kokjohn, T.A.3
Patton, R.L.4
Kalback, W.M.5
Luehrs, D.C.6
Beach, T.G.7
Newel, A.J.8
Lopera, F.9
Ghetti, B.10
-
25
-
-
84901399091
-
Truncated and modified amyloid-β species
-
Kummer, M.P.; Heneka, M.T.: Truncated and modified amyloid-β species. Alzheimers Res. Ther. 2014, 6, 28.
-
(2014)
Alzheimers Res. Ther
, vol.6
, pp. 28
-
-
Kummer, M.P.1
Heneka, M.T.2
-
26
-
-
83655184703
-
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils
-
Bieschke, J.; Herbst, M.; Wiglenda, T.; Friedrich, R.P.; Boeddrich, A.; Schiele, F.; Kleckers, D.; Lopez del Amo, J.M.; Gruning, B.A.; Wang, Q. et al.: Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat. Chem. Biol. 2012, 8, 93–101.
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 93-101
-
-
Bieschke, J.1
Herbst, M.2
Wiglenda, T.3
Friedrich, R.P.4
Boeddrich, A.5
Schiele, F.6
Kleckers, D.7
Lopez Del Amo, J.M.8
Gruning, B.A.9
Wang, Q.10
-
27
-
-
0028856460
-
An english translation of Alzheimer’s 1907 paper, “uber eine eigenartige erkankung der hirnrinde”
-
Alzheimer, A.; Stelzmann, R.A.; Schnitzlein, H.N.; Murtagh, F.R. An english translation of Alzheimer’s 1907 paper, “uber eine eigenartige erkankung der hirnrinde”. Clin. Anat. 1995, 8, 429–431.
-
(1995)
Clin. Anat
, vol.8
, pp. 429-431
-
-
Alzheimer, A.1
Stelzmann, R.A.2
Schnitzlein, H.N.3
Murtagh, F.R.4
-
28
-
-
84875655895
-
Inflammation in alzheimer disease—A brief review of the basic science and clinical literature
-
Wyss-Coray, T.; Rogers, T.: Inflammation in alzheimer disease—A brief review of the basic science and clinical literature. Cold Spring Harb. Perspect. Med. 2012, 2, a006346.
-
(2012)
Cold Spring Harb. Perspect. Med
, vol.2
-
-
Wyss-Coray, T.1
Rogers, T.2
-
29
-
-
84861914969
-
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1–42 oligomers are revealed in vivo by using a novel animal model
-
Brouillette, J.; Caillierez, R.; Zommer, N.; Alves-Pires, C.; Benilova, I.; Blum, D.; de Strooper, B.; Buee, L.: Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1–42 oligomers are revealed in vivo by using a novel animal model. J. Neurosci. 2012, 32, 7852–7861.
-
(2012)
J. Neurosci
, vol.32
, pp. 7852-7861
-
-
Brouillette, J.1
Caillierez, R.2
Zommer, N.3
Alves-Pires, C.4
Benilova, I.5
Blum, D.6
De Strooper, B.7
Buee, L.8
-
30
-
-
44549087765
-
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
-
Selkoe, D.J.: Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior. Behav. Brain Res. 2008, 192, 106–113.
-
(2008)
Behav. Brain Res
, vol.192
, pp. 106-113
-
-
Selkoe, D.J.1
-
31
-
-
79952401018
-
Reduced spine density in specific regions of ca1 pyramidal neurons in two transgenic mouse models of Alzheimer’s disease
-
Perez-Cruz, C.; Nolte, M.W.; van Gaalen, M.M.; Rustay, N.R.; Termont, A.; Tanghe, A.; Kirchhoff, F.; Ebert, U. Reduced spine density in specific regions of ca1 pyramidal neurons in two transgenic mouse models of Alzheimer’s disease. J. Neurosci. 2011, 31, 3926–3934.
-
(2011)
J. Neurosci
, vol.31
, pp. 3926-3934
-
-
Perez-Cruz, C.1
Nolte, M.W.2
Van Gaalen, M.M.3
Rustay, N.R.4
Termont, A.5
Tanghe, A.6
Kirchhoff, F.7
Ebert, U.8
-
32
-
-
0032590054
-
Soluble pool of aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease
-
McLean, C.A.; Cherny, R.A.; Fraser, F.W.; Fuller, S.J.; Smith, M.J.; Beyreuther, K.; Bush, A.I.; Masters, C.L. Soluble pool of aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease. Ann. Neurol. 1999, 46, 860–866.
-
(1999)
Ann. Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
33
-
-
84857642949
-
The toxic aβ oligomer and Alzheimer’s disease: An emperor in need of clothes
-
Benilova, I.; Karran, E.; de Strooper, B. The toxic aβ oligomer and Alzheimer’s disease: An emperor in need of clothes. Nat. Neurosci. 2012, 15, 349–357.
-
(2012)
Nat. Neurosci
, vol.15
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
34
-
-
84860919373
-
Membrane trafficking pathways in Alzheimer’s disease
-
Rajendran, L.; Annaert, W. Membrane trafficking pathways in Alzheimer’s disease. Traffic 2012, 13, 759–770.
-
(2012)
Traffic
, vol.13
, pp. 759-770
-
-
Rajendran, L.1
Annaert, W.2
-
35
-
-
84899068704
-
Soluble aβ oligomers are rapidly sequestered from brain isf in vivo and bind gm1 ganglioside on cellular membranes
-
Hong, S.; Ostaszewski, B.L.; Yang, T.; O’Malley, T.T.; Jin, M.; Yanagisawa, K.; Li, S.; Bartels, T.; Selkoe, D.J. Soluble aβ oligomers are rapidly sequestered from brain isf in vivo and bind gm1 ganglioside on cellular membranes. Neuron 2014, 82, 308–319.
-
(2014)
Neuron
, vol.82
, pp. 308-319
-
-
Hong, S.1
Ostaszewski, B.L.2
Yang, T.3
O’Malley, T.T.4
Jin, M.5
Yanagisawa, K.6
Li, S.7
Bartels, T.8
Selkoe, D.J.9
-
36
-
-
34250819839
-
Intracellular amyloid-β in Alzheimer’s disease
-
LaFerla, F.M.; Green, K.N.; Oddo, S. Intracellular amyloid-β in Alzheimer’s disease. Nat. Rev. Neurosci. 2007, 8, 499–509.
-
(2007)
Nat. Rev. Neurosci
, vol.8
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
37
-
-
84864359816
-
Amyloid precursor protein (App) traffics from the cell surface via endosomes for amyloid β (aβ) production in the trans-golgi network
-
Choy, R.W.; Cheng, Z.; Schekman, R. Amyloid precursor protein (app) traffics from the cell surface via endosomes for amyloid β (aβ) production in the trans-golgi network. Proc. Natl. Acad. Sci. USA 2012, 109, E2077–E2082.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E2077-E2082
-
-
Choy, R.W.1
Cheng, Z.2
Schekman, R.3
-
38
-
-
84901502442
-
Conformational targeting of intracellular aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum
-
Meli, G.; Lecci, A.; Manca, A.; Krako, N.; Albertini, V.; Benussi, L.; Ghidoni, R.; Cattaneo, A. Conformational targeting of intracellular aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nat. Commun. 2014, 5, 3867.
-
(2014)
Nat. Commun
, vol.5
, pp. 3867
-
-
Meli, G.1
Lecci, A.2
Manca, A.3
Krako, N.4
Albertini, V.5
Benussi, L.6
Ghidoni, R.7
Cattaneo, A.8
-
39
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima, N.; Komatsu, M. Autophagy: Renovation of cells and tissues. Cell 2011, 147, 728–741.
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
40
-
-
84885864424
-
Aβ secretion and plaque formation depend on autophagy
-
Nilsson, P.; Loganathan, K.; Sekiguchi, M.; Matsuba, Y.; Hui, K.; Tsubuki, S.; Tanaka, M.; Iwata, N.; Saito, T.; Saido, T.C. Aβ secretion and plaque formation depend on autophagy. Cell Rep. 2013, 5, 61–69.
-
(2013)
Cell Rep
, vol.5
, pp. 61-69
-
-
Nilsson, P.1
Loganathan, K.2
Sekiguchi, M.3
Matsuba, Y.4
Hui, K.5
Tsubuki, S.6
Tanaka, M.7
Iwata, N.8
Saito, T.9
Saido, T.C.10
-
41
-
-
84922276427
-
Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases aβ in the multivesicular bodies and induces aβ accumulation in the golgi
-
Nilsson, P.; Sekiguchi, M.; Akagi, T.; Izumi, S.; Komori, T.; Hui, K.; Sörgjerd, K.; Tanaka, M.; Saito, T.; Iwata, N. et al.: Autophagy-related protein 7 deficiency in amyloid β (aβ) precursor protein transgenic mice decreases aβ in the multivesicular bodies and induces aβ accumulation in the golgi. Am. J. Pathol. 2015, 185, 305–313.
-
(2015)
Am. J. Pathol
, vol.185
, pp. 305-313
-
-
Nilsson, P.1
Sekiguchi, M.2
Akagi, T.3
Izumi, S.4
Komori, T.5
Hui, K.6
Sörgjerd, K.7
Tanaka, M.8
Saito, T.9
Iwata, N.10
-
42
-
-
84884552363
-
Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential
-
Verderio, C.: Extracellular membrane microvesicles and nanotubes in the brain: Understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential. Front. Physiol. 2013, 4, 163.
-
(2013)
Front. Physiol
, vol.4
, pp. 163
-
-
Verderio, C.1
-
43
-
-
84866270576
-
Microvesicles: Novel biomarkers for neurological disorders
-
Colombo, E.; Borgiani, B.; Verderio, C.; Furlan, R. Microvesicles: Novel biomarkers for neurological disorders. Front. Physiol. 2012, 3, 63.
-
(2012)
Front. Physiol
, vol.3
, pp. 63
-
-
Colombo, E.1
Borgiani, B.2
Verderio, C.3
Furlan, R.4
-
44
-
-
84866555624
-
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease
-
Vingtdeux, V.; Sergeant, N.; Buee, L. Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease. Front. Physiol. 2012, 3, 229.
-
(2012)
Front. Physiol
, vol.3
, pp. 229
-
-
Vingtdeux, V.1
Sergeant, N.2
Buee, L.3
-
45
-
-
72149125838
-
The transcellular spread of cytosolic amyloids, prions, and prionoids
-
Aguzzi, A.; Rajendran, L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 2009, 64, 783–790.
-
(2009)
Neuron
, vol.64
, pp. 783-790
-
-
Aguzzi, A.1
Rajendran, L.2
-
46
-
-
84875234646
-
Exosomes: Vesicular carriers for intercellular communication in neurodegenerative disorders
-
Schneider, A.; Simons, M. Exosomes: Vesicular carriers for intercellular communication in neurodegenerative disorders. Cell Tissue Res. 2013, 352, 33–47.
-
(2013)
Cell Tissue Res
, vol.352
, pp. 33-47
-
-
Schneider, A.1
Simons, M.2
-
47
-
-
43249087541
-
Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
-
Sharples, R.A.; Vella, L.J.; Nisbet, R.M.; Naylor, R.; Perez, K.; Barnham, K.J.; Masters, C.L.; Hill, A.F. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. Faseb J. 2008, 22, 1469–1478.
-
(2008)
Faseb J
, vol.22
, pp. 1469-1478
-
-
Sharples, R.A.1
Vella, L.J.2
Nisbet, R.M.3
Naylor, R.4
Perez, K.5
Barnham, K.J.6
Masters, C.L.7
Hill, A.F.8
-
48
-
-
78549284024
-
Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
-
Tamboli, I.Y.; Barth, E.; Christian, L.; Siepmann, M.; Kumar, S.; Singh, S.; Tolksdorf, K.; Heneka, M.T.; Lutjohann, D.; Wunderlich, P. et al.: Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J. Biol. Chem. 2010, 285, 37405–37414.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 37405-37414
-
-
Tamboli, I.Y.1
Barth, E.2
Christian, L.3
Siepmann, M.4
Kumar, S.5
Singh, S.6
Tolksdorf, K.7
Heneka, M.T.8
Lutjohann, D.9
Wunderlich, P.10
-
49
-
-
84887392802
-
Exosomes neutralize synaptic-plasticity-disrupting activity of aβ assemblies in vivo
-
An, K.; Klyubin, I.; Kim, Y.; Jung, J.H.; Mably, A.J.; O’Dowd, S.T.; Lynch, T.; Kanmert, D.; Lemere, C.A.; Finan, G.M. et al. Exosomes neutralize synaptic-plasticity-disrupting activity of aβ assemblies in vivo. Mol. Brain 2013, 6, 47.
-
(2013)
Mol. Brain
, vol.6
, pp. 47
-
-
An, K.1
Klyubin, I.2
Kim, Y.3
Jung, J.H.4
Mably, A.J.5
O’Dowd, S.T.6
Lynch, T.7
Kanmert, D.8
Lemere, C.A.9
Finan, G.M.10
-
50
-
-
84906871864
-
Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in alzheimer model mice
-
Yuyama, K.; Sun, H.; Sakai, S.; Mitsutake, S.; Okada, M.; Tahara, H.; Furukawa, J.; Fujitani, N.; Shinohara, Y.; Igarashi, Y. Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in alzheimer model mice. J. Biol. Chem. 2014, 289, 24488–24498.
-
(2014)
J. Biol. Chem
, vol.289
, pp. 24488-24498
-
-
Yuyama, K.1
Sun, H.2
Sakai, S.3
Mitsutake, S.4
Okada, M.5
Tahara, H.6
Furukawa, J.7
Fujitani, N.8
Shinohara, Y.9
Igarashi, Y.10
-
51
-
-
84899968840
-
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5xfad mouse model of Alzheimer’s disease
-
Dinkins, M.B.; Dasgupta, S.; Wang, G.; Zhu, G.; Bieberich, E. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5xfad mouse model of Alzheimer’s disease. Neurobiol. Aging 2014, 35, 1792–1800.
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 1792-1800
-
-
Dinkins, M.B.1
Dasgupta, S.2
Wang, G.3
Zhu, G.4
Bieberich, E.5
-
52
-
-
33746593662
-
Alzheimer’s disease β-amyloid peptides are released in association with exosomes
-
Rajendran, L.; Honsho, M.; Zahn, T.R.; Keller, P.; Geiger, K.D.; Verkade, P.; Simons, K.: Alzheimer’s disease β-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA 2006, 103, 11172–11177.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
-
53
-
-
33847322057
-
Intracellular ph regulates amyloid precursor protein intracellular domain accumulation
-
Vingtdeux, V.; Hamdane, M.; Begard, S.; Loyens, A.; Delacourte, A.; Beauvillain, J.C.; Buee, L.; Marambaud, P.; Sergeant, N. Intracellular ph regulates amyloid precursor protein intracellular domain accumulation. Neurobiol. Dis. 2007, 25, 686–696.
-
(2007)
Neurobiol. Dis
, vol.25
, pp. 686-696
-
-
Vingtdeux, V.1
Hamdane, M.2
Begard, S.3
Loyens, A.4
Delacourte, A.5
Beauvillain, J.C.6
Buee, L.7
Marambaud, P.8
Sergeant, N.9
-
54
-
-
79959585860
-
Cystatin c is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer’s disease
-
Ghidoni, R.; Paterlini, A.; Albertini, V.; Glionna, M.; Monti, E.; Schiaffonati, L.; Benussi, L.; Levy, E.; Binetti, G.: Cystatin c is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer’s disease. Neurobiol. Aging 2011, 32, 1435–1442.
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 1435-1442
-
-
Ghidoni, R.1
Paterlini, A.2
Albertini, V.3
Glionna, M.4
Monti, E.5
Schiaffonati, L.6
Benussi, L.7
Levy, E.8
Binetti, G.9
-
55
-
-
84871118236
-
The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space
-
Perez-Gonzalez, R.; Gauthier, S.A.; Kumar, A.; Levy, E. The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J. Biol. Chem. 2012, 287, 43108–43115.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 43108-43115
-
-
Perez-Gonzalez, R.1
Gauthier, S.A.2
Kumar, A.3
Levy, E.4
-
56
-
-
84859499570
-
Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia
-
Yuyama, K.; Sun, H.; Mitsutake, S.; Igarashi, Y. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia. J. Biol. Chem. 2012, 287, 10977–10989.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 10977-10989
-
-
Yuyama, K.1
Sun, H.2
Mitsutake, S.3
Igarashi, Y.4
-
57
-
-
84918776208
-
A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide
-
Yuyama, K.; Sun, H.; Usukia, S.; Sakaia, S.; Hanamatsua, H.; Miokaa, T.; Kimurac, N.; Okadad, M.; Taharad, H.; Furukawae, J. et al. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide. FEBS Lett. 2015, 589, 84–88.
-
(2015)
FEBS Lett
, vol.589
, pp. 84-88
-
-
Yuyama, K.1
Sun, H.2
Usukia, S.3
Sakaia, S.4
Hanamatsua, H.5
Miokaa, T.6
Kimurac, N.7
Okadad, M.8
Taharad, H.9
Furukawae, J.10
-
58
-
-
61349201380
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
-
Lauren, J.; Gimbel, D.A.; Nygaard, H.B.; Gilbert, J.W.; Strittmatter, S.M. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers. Nature 2009, 457, 1128–1132.
-
(2009)
Nature
, vol.457
, pp. 1128-1132
-
-
Lauren, J.1
Gimbel, D.A.2
Nygaard, H.B.3
Gilbert, J.W.4
Strittmatter, S.M.5
-
59
-
-
64249106591
-
Paracrine diffusion of prp(C) and propagation of prion infectivity by plasma membrane-derived microvesicles
-
Mattei, V.; Barenco, M.G.; Tasciotti, V.; Garofalo, T.; Longo, A.; Boller, K.; Lower, J.; Misasi, R.; Montrasio, F.; Sorice, M. Paracrine diffusion of prp(c) and propagation of prion infectivity by plasma membrane-derived microvesicles. PLoS One 2009, 4, e5057.
-
(2009)
Plos One
, vol.4
-
-
Mattei, V.1
Barenco, M.G.2
Tasciotti, V.3
Garofalo, T.4
Longo, A.5
Boller, K.6
Lower, J.7
Misasi, R.8
Montrasio, F.9
Sorice, M.10
-
60
-
-
84903362492
-
Legname, G.; et al. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
-
Joshi, P.; Turola, E.; Ruiz, A.; Bergami, A.; Libera, D.D.; Benussi, L.; Giussani, P.; Magnani, G.; Comi, G.; Legname, G.; et al. Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. Cell Death Differ. 2014, 21, 582–593.
-
(2014)
Cell Death Differ
, vol.21
, pp. 582-593
-
-
Joshi, P.1
Turola, E.2
Ruiz, A.3
Bergami, A.4
Libera, D.D.5
Benussi, L.6
Giussani, P.7
Magnani, G.8
Comi, G.9
-
61
-
-
23944509766
-
Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
-
Del Conde, I.; Shrimpton, C.N.; Thiagarajan, P.; Lopez, J.A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005, 106, 1604–1611.
-
(2005)
Blood
, vol.106
, pp. 1604-1611
-
-
Del Conde, I.1
Shrimpton, C.N.2
Thiagarajan, P.3
Lopez, J.A.4
-
62
-
-
79954568598
-
Protein targeting to exosomes/microvesicles by plasma membrane anchors
-
Shen, B.; Wu, N.; Yang, J.M.; Gould, S.J. Protein targeting to exosomes/microvesicles by plasma membrane anchors. J. Biol. Chem. 2011, 286, 14383–14395.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 14383-14395
-
-
Shen, B.1
Wu, N.2
Yang, J.M.3
Gould, S.J.4
-
63
-
-
84879586923
-
Classical and unconventional pathways of vesicular release in microglia
-
Prada, I.; Furlan, R.; Matteoli, M.; Verderio, C. Classical and unconventional pathways of vesicular release in microglia. Glia 2013, 61, 1003–1017.
-
(2013)
Glia
, vol.61
, pp. 1003-1017
-
-
Prada, I.1
Furlan, R.2
Matteoli, M.3
Verderio, C.4
-
64
-
-
38049056730
-
Lipids revert inert aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
-
Martins, I.C.; Kuperstein, I.; Wilkinson, H.; Maes, E.; Vanbrabant, M.; Jonckheere, W.; van Gelder, P.; Hartmann, D.; D’Hooge, R.; de Strooper, B.; et al. Lipids revert inert aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice. Embo J. 2008, 27, 224–233.
-
(2008)
Embo J
, vol.27
, pp. 224-233
-
-
Martins, I.C.1
Kuperstein, I.2
Wilkinson, H.3
Maes, E.4
Vanbrabant, M.5
Jonckheere, W.6
Van Gelder, P.7
Hartmann, D.8
D’Hooge, R.9
De Strooper, B.10
-
65
-
-
84866426167
-
Exosomes: Vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front
-
Bellingham, S.A.; Guo, B.B.; Coleman, B.M.; Hill, A.F. Exosomes: Vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front. Physiol. 2012, 3, 124.
-
(2012)
Physiol
, vol.3
, pp. 124
-
-
Bellingham, S.A.1
Guo, B.B.2
Coleman, B.M.3
Hill, A.F.4
-
66
-
-
43049160705
-
Exosomes: The trojan horses of neurodegeneration
-
Ghidoni, R.; Benussi, L.; Binetti, G. Exosomes: The trojan horses of neurodegeneration. Med. Hypotheses 2008, 70, 1226–1227.
-
(2008)
Med. Hypotheses
, vol.70
, pp. 1226-1227
-
-
Ghidoni, R.1
Benussi, L.2
Binetti, G.3
-
67
-
-
84913583564
-
Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and alzheimer disease
-
Agosta, F.; Dalla Libera, D.; Spinelli, E.G.; Finardi, A.; Canu, E.; Bergami, A.; Bocchio Chiavetto, L.; Baronio, M.; Comi, G.; Martino, G. et al. Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and alzheimer disease. Ann. Neurol. 2014, 76, 813-825.
-
(2014)
Ann. Neurol
, vol.76
, pp. 813-825
-
-
Agosta, F.1
Dalla Libera, D.2
Spinelli, E.G.3
Finardi, A.4
Canu, E.5
Bergami, A.6
Bocchio Chiavetto, L.7
Baronio, M.8
Comi, G.9
Martino, G.10
-
68
-
-
79955958446
-
Protective mechanisms by cystatin c in neurodegenerative diseases
-
Gauthier, S.; Kaur, G.; Mi, W.; Tizon, B.; Levy, E. Protective mechanisms by cystatin c in neurodegenerative diseases. Front. Biosci. 2011, 3, 541–554.
-
(2011)
Front. Biosci
, vol.3
, pp. 541-554
-
-
Gauthier, S.1
Kaur, G.2
Mi, W.3
Tizon, B.4
Levy, E.5
-
69
-
-
84873688339
-
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
-
Katsuda, T.; Tsuchiya, R.; Kosaka, N.; Yoshioka, Y.; Takagaki, K.; Oki, K.; Takeshita, F.; Sakai, Y.; Kuroda, M.; Ochiya, T. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci. Rep. 2013, 3, 1197.
-
(2013)
Sci. Rep
, vol.3
, pp. 1197
-
-
Katsuda, T.1
Tsuchiya, R.2
Kosaka, N.3
Yoshioka, Y.4
Takagaki, K.5
Oki, K.6
Takeshita, F.7
Sakai, Y.8
Kuroda, M.9
Ochiya, T.10
-
70
-
-
84898039042
-
Msc-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease
-
Kordelas, L.; Rebmann, V.; Ludwig, A.K.; Radtke, S.; Ruesing, J.; Doeppner, T.R.; Epple, M.; Horn, P.A.; Beelen, D.W.; Giebel, B. Msc-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 2014, 28, 970–973.
-
(2014)
Leukemia
, vol.28
, pp. 970-973
-
-
Kordelas, L.1
Rebmann, V.2
Ludwig, A.K.3
Radtke, S.4
Ruesing, J.5
Doeppner, T.R.6
Epple, M.7
Horn, P.A.8
Beelen, D.W.9
Giebel, B.10
-
71
-
-
77954375412
-
Astrocytic aβ 1–42 uptake is determined by a β-aggregation state and the presence of amyloid-associated proteins
-
Nielsen, H.M.; Mulder, S.D.; Belien, J.A.; Musters, R.J.; Eikelenboom, P.; Veerhuis, R. Astrocytic aβ 1–42 uptake is determined by a β-aggregation state and the presence of amyloid-associated proteins. Glia 2010, 58, 1235–1246.
-
(2010)
Glia
, vol.58
, pp. 1235-1246
-
-
Nielsen, H.M.1
Mulder, S.D.2
Belien, J.A.3
Musters, R.J.4
Eikelenboom, P.5
Veerhuis, R.6
-
72
-
-
84856707794
-
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
-
Saman, S.; Kim, W.; Raya, M.; Visnick, Y.; Miro, S.; Jackson, B.; McKee, A.C.; Alvarez, V.E.; Lee, N.C.; Hall, G.F.: Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J. Biol. Chem. 2012, 287, 3842–3849.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 3842-3849
-
-
Saman, S.1
Kim, W.2
Raya, M.3
Visnick, Y.4
Miro, S.5
Jackson, B.6
McKee, A.C.7
Alvarez, V.E.8
Lee, N.C.9
Hall, G.F.10
-
73
-
-
84655176335
-
Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
-
Simon, D.; Garcia-Garcia, E.; Royo, F.; Falcon-Perez, J.M.; Avila, J. Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles. FEBS Lett. 2012, 586, 47–54.
-
(2012)
FEBS Lett
, vol.586
, pp. 47-54
-
-
Simon, D.1
Garcia-Garcia, E.2
Royo, F.3
Falcon-Perez, J.M.4
Avila, J.5
|