The binding of apolipoprotein e to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation

Biochemistry

Volumn 53, Issue 40, 2014, Pages 6323-6331

  Garai, Kanchan ^a,b   Verghese, Philip B ^a,c   Baban, Berevan ^a   Holtzman, David M ^a   Frieden, Carl ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^c Center for Emerging Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEINS; NEURODEGENERATIVE DISEASES; OLIGOMERS; RECOMBINANT PROTEINS; STABILIZATION;

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; APOLIPOPROTEIN E (APOE); CYTOTOXIC; FIBRIL GROWTH; ISOFORMS;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ISOPROTEIN; NONSTOICHIOMETRIC COMPOUND; OLIGOMER; RECOMBINANT PROTEIN; TETRAMETHYLRHODAMINE; AMYLOID; AMYLOID BETA PROTEIN; PEPTIDE FRAGMENT; PROTEIN BINDING;

ARTICLE; ASTROCYTE CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE ANALYSIS; GROWTH RATE; HUMAN; HUMAN CELL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; CHEMISTRY; KINETICS; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; ULTRASTRUCTURE;

AMYLOID; AMYLOID BETA-PEPTIDES; APOLIPOPROTEINS E; HUMANS; KINETICS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY;

EID: 84908032605     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5008172     Document Type: Article

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