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Volumn 32, Issue 8, 2011, Pages 1452-1465

Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease

Author keywords

AD; Afterhyperpolarization; Aging; AHP; Alzheimer's disease; CA1; Fear conditioning; Hippocampus; Intrinsic excitability; Intrinsic plasticity; Trace fear conditioning

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CALCIUM ION; PRESENILIN 1;

EID: 79959581845     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.09.003     Document Type: Article
Times cited : (82)

References (85)
  • 1
    • 0028670272 scopus 로고
    • Beta-amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease
    • Arispe N., Pollard H.B., Rojas E. Beta-amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease. Mol. Cell. Biochem. 1994, 140(2):119-125.
    • (1994) Mol. Cell. Biochem. , vol.140 , Issue.2 , pp. 119-125
    • Arispe, N.1    Pollard, H.B.2    Rojas, E.3
  • 3
    • 0034087948 scopus 로고    scopus 로고
    • Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity
    • Bhatia R., Lin H., Lal R. Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity. FASEB J. 2000, 14(9):1233-1243.
    • (2000) FASEB J. , vol.14 , Issue.9 , pp. 1233-1243
    • Bhatia, R.1    Lin, H.2    Lal, R.3
  • 7
    • 27744546317 scopus 로고    scopus 로고
    • Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice
    • Chowdhury N., Quinn J.J., Fanselow M.S. Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice. Behav. Neurosci. 2005, 119(5):1396-1402.
    • (2005) Behav. Neurosci. , vol.119 , Issue.5 , pp. 1396-1402
    • Chowdhury, N.1    Quinn, J.J.2    Fanselow, M.S.3
  • 8
    • 16544394140 scopus 로고    scopus 로고
    • Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation
    • Craft J.M., Van Eldik L.J., Zasadzki M., Hu W., Watterson D.M. Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. J. Mol. Neurosci. 2004, 24(1):115-122.
    • (2004) J. Mol. Neurosci. , vol.24 , Issue.1 , pp. 115-122
    • Craft, J.M.1    Van Eldik, L.J.2    Zasadzki, M.3    Hu, W.4    Watterson, D.M.5
  • 9
    • 33645034092 scopus 로고    scopus 로고
    • Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease
    • Disterhoft J.F., Oh M.M. Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease. J. Physiol. Paris 2006, 99(2-3):180-192.
    • (2006) J. Physiol. Paris , vol.99 , Issue.2-3 , pp. 180-192
    • Disterhoft, J.F.1    Oh, M.M.2
  • 12
    • 0035399822 scopus 로고    scopus 로고
    • Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
    • Fitzjohn S.M., Morton R.A., Kuenzi F., Rosahl T.W., Shearman M., Lewis H., Smith D., Reynolds D.S., Davies C.H., Collingridge G.L., Seabrook G.R. Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J. Neurosci. 2001, 21(13):4691-4698.
    • (2001) J. Neurosci. , vol.21 , Issue.13 , pp. 4691-4698
    • Fitzjohn, S.M.1    Morton, R.A.2    Kuenzi, F.3    Rosahl, T.W.4    Shearman, M.5    Lewis, H.6    Smith, D.7    Reynolds, D.S.8    Davies, C.H.9    Collingridge, G.L.10    Seabrook, G.R.11
  • 13
    • 0035211539 scopus 로고    scopus 로고
    • Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites
    • Golding N.L., Kath W.L., Spruston N. Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. J. Neurophysiol. 2001, 86(6):2998-3010.
    • (2001) J. Neurophysiol. , vol.86 , Issue.6 , pp. 2998-3010
    • Golding, N.L.1    Kath, W.L.2    Spruston, N.3
  • 14
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y., Chang L., Viola K.L., Lacor P.N., Lambert M.P., Finch C.E., Krafft G.A., Klein W.L. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(18):10417-10422.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , Issue.18 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6    Krafft, G.A.7    Klein, W.L.8
  • 15
    • 0028169905 scopus 로고
    • Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
    • Goodman Y., Mattson M.P. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp. Neurol. 1994, 128(1):1-12.
    • (1994) Exp. Neurol. , vol.128 , Issue.1 , pp. 1-12
    • Goodman, Y.1    Mattson, M.P.2
  • 16
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297(5580):353-356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 17
    • 0033570337 scopus 로고    scopus 로고
    • Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
    • Hartley D.M., Walsh D.M., Ye C.P., Diehl T., Vasquez S., Vassilev P.M., Teplow D.B., Selkoe D.J. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J. Neurosci. 1999, 19(20):8876-8884.
    • (1999) J. Neurosci. , vol.19 , Issue.20 , pp. 8876-8884
    • Hartley, D.M.1    Walsh, D.M.2    Ye, C.P.3    Diehl, T.4    Vasquez, S.5    Vassilev, P.M.6    Teplow, D.B.7    Selkoe, D.J.8
  • 18
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
    • Holcomb L.A., Gordon M.N., Jantzen P., Hsiao K., Duff K., Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav. Genet. 1999, 29(3):177-185.
    • (1999) Behav. Genet. , vol.29 , Issue.3 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 20
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274(5284):99-102.
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 23
    • 79959591854 scopus 로고    scopus 로고
    • Intrinsic plasticity in CA1 pyramidal neurons: role of calcium(2+)- and sodium(+)-activated potassium currents in aging and Alzheimer's disease. Dissertation, 1-291
    • Kaczorowski, C.C., 2006. Intrinsic plasticity in CA1 pyramidal neurons: role of calcium(2+)- and sodium(+)-activated potassium currents in aging and Alzheimer's disease. Dissertation, 1-291.
    • (2006)
    • Kaczorowski, C.C.1
  • 24
    • 66349124196 scopus 로고    scopus 로고
    • Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice
    • Kaczorowski C.C., Disterhoft J.F. Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice. Learn. Mem. 2009, 16(6):362-366.
    • (2009) Learn. Mem. , vol.16 , Issue.6 , pp. 362-366
    • Kaczorowski, C.C.1    Disterhoft, J.F.2
  • 25
    • 33846506678 scopus 로고    scopus 로고
    • Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions
    • Kaczorowski C.C., Disterhoft J., Spruston N. Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions. J. Physiol. 2007, 578(Pt 3):799-818.
    • (2007) J. Physiol. , vol.578 , Issue.PART 3 , pp. 799-818
    • Kaczorowski, C.C.1    Disterhoft, J.2    Spruston, N.3
  • 27
    • 0034319190 scopus 로고    scopus 로고
    • Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis
    • Kawahara M., Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res. Bull. 2000, 53(4):389-397.
    • (2000) Brain Res. Bull. , vol.53 , Issue.4 , pp. 389-397
    • Kawahara, M.1    Kuroda, Y.2
  • 28
    • 0023369739 scopus 로고
    • Hypothesis on the regulation of cytosol calcium concentration and the aging brain
    • Khachaturian Z.S. Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol. Aging 1987, 8(4):345-346.
    • (1987) Neurobiol. Aging , vol.8 , Issue.4 , pp. 345-346
    • Khachaturian, Z.S.1
  • 29
    • 0035807829 scopus 로고    scopus 로고
    • Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques
    • Koistinaho M., Ort M., Cimadevilla J.M., Vondrous R., Cordell B., Koistinaho J., Bures J., Higgins L.S. Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques. Proc. Natl. Acad. Sci. U.S.A. 2001, 98(25):14675-14680.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , Issue.25 , pp. 14675-14680
    • Koistinaho, M.1    Ort, M.2    Cimadevilla, J.M.3    Vondrous, R.4    Cordell, B.5    Koistinaho, J.6    Bures, J.7    Higgins, L.S.8
  • 30
    • 2642546665 scopus 로고    scopus 로고
    • A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor
    • Kramar E.A., Lin B., Lin C.Y., Arai A.C., Gall C.M., Lynch G. A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J. Neurosci. 2004, 24(22):5151-5161.
    • (2004) J. Neurosci. , vol.24 , Issue.22 , pp. 5151-5161
    • Kramar, E.A.1    Lin, B.2    Lin, C.Y.3    Arai, A.C.4    Gall, C.M.5    Lynch, G.6
  • 33
    • 2442489729 scopus 로고    scopus 로고
    • Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores
    • Kumar A., Foster T.C. Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores. J. Neurophysiol. 2004, 91(6):2437-2444.
    • (2004) J. Neurophysiol. , vol.91 , Issue.6 , pp. 2437-2444
    • Kumar, A.1    Foster, T.C.2
  • 34
    • 79959600453 scopus 로고    scopus 로고
    • Alteration of sIAHP underlies reduction of AHP in rat CA1 pyramidal neurons after trace eyebink conditioning. Soc. Neurosci. Abst. 741.13
    • Kuo, A.G., Lee, G., Disterhoft, J.F., 2004. Alteration of sIAHP underlies reduction of AHP in rat CA1 pyramidal neurons after trace eyebink conditioning. Soc. Neurosci. Abst. 741.13.
    • (2004)
    • Kuo, A.G.1    Lee, G.2    Disterhoft, J.F.3
  • 35
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
    • LaFerla F.M. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 2002, 3(11):862-872.
    • (2002) Nat. Rev. Neurosci. , vol.3 , Issue.11 , pp. 862-872
    • LaFerla, F.M.1
  • 37
    • 0023159115 scopus 로고
    • Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones
    • Lancaster B., Nicoll R.A. Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J. Physiol. 1987, 389:187-203.
    • (1987) J. Physiol. , vol.389 , pp. 187-203
    • Lancaster, B.1    Nicoll, R.A.2
  • 38
    • 0035498498 scopus 로고    scopus 로고
    • Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells
    • Lancaster B., Hu H., Ramakers G.M., Storm J.F. Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells. J. Physiol. 2001, 536(Pt 3):809-823.
    • (2001) J. Physiol. , vol.536 , Issue.PART 3 , pp. 809-823
    • Lancaster, B.1    Hu, H.2    Ramakers, G.M.3    Storm, J.F.4
  • 39
    • 0021645626 scopus 로고
    • Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats
    • Landfield P.W., Pitler T.A. Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science 1984, 226(4678):1089-1092.
    • (1984) Science , vol.226 , Issue.4678 , pp. 1089-1092
    • Landfield, P.W.1    Pitler, T.A.2
  • 40
    • 11344288961 scopus 로고    scopus 로고
    • Heterosynaptic metaplastic regulation of synaptic efficacy in CA1 pyramidal neurons of rat hippocampus
    • Le Ray D., Fernandez De Sevilla D., Belen Porto A., Fuenzalida M., Buno W. Heterosynaptic metaplastic regulation of synaptic efficacy in CA1 pyramidal neurons of rat hippocampus. Hippocampus 2004, 14(8):1011-1025.
    • (2004) Hippocampus , vol.14 , Issue.8 , pp. 1011-1025
    • Le Ray, D.1    Fernandez De Sevilla, D.2    Belen Porto, A.3    Fuenzalida, M.4    Buno, W.5
  • 41
    • 0021284570 scopus 로고
    • Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro
    • Madison D.V., Nicoll R.A. Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro. J. Physiol. 1984, 354:319-331.
    • (1984) J. Physiol. , vol.354 , pp. 319-331
    • Madison, D.V.1    Nicoll, R.A.2
  • 42
    • 65549089108 scopus 로고    scopus 로고
    • The fast AHP and the slow AHP are differentially modulated in hippocampal neurons by aging and by learning
    • Matthews E., Linardakis J.M., Disterhoft J.F. The fast AHP and the slow AHP are differentially modulated in hippocampal neurons by aging and by learning. J. Neurosci. 2009, 29(15):4750-4755.
    • (2009) J. Neurosci. , vol.29 , Issue.15 , pp. 4750-4755
    • Matthews, E.1    Linardakis, J.M.2    Disterhoft, J.F.3
  • 43
    • 0042536471 scopus 로고    scopus 로고
    • Neuronal and glial calcium signaling in Alzheimer's disease
    • Mattson M.P., Chan S.L. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 2003, 34(4-5):385-397.
    • (2003) Cell Calcium , vol.34 , Issue.4-5 , pp. 385-397
    • Mattson, M.P.1    Chan, S.L.2
  • 44
    • 0026570528 scopus 로고
    • Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R.E. Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 1992, 12(2):376-389.
    • (1992) J. Neurosci. , vol.12 , Issue.2 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 45
    • 0027297138 scopus 로고
    • Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF
    • Mattson M.P., Tomaselli K.J., Rydel R.E. Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF. Brain Res. 1993, 621(1):35-49.
    • (1993) Brain Res. , vol.621 , Issue.1 , pp. 35-49
    • Mattson, M.P.1    Tomaselli, K.J.2    Rydel, R.E.3
  • 46
    • 79959592996 scopus 로고    scopus 로고
    • Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning. J. Neurophysiol., in press.
    • McKay, B.M., Matthews, E.A., Oliveira, F.A., Disterhoft, J.F. Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning. J. Neurophysiol., in press.
    • McKay, B.M.1    Matthews, E.A.2    Oliveira, F.A.3    Disterhoft, J.F.4
  • 47
    • 20544443789 scopus 로고    scopus 로고
    • R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons
    • Metz A.E., Jarsky T., Martina M., Spruston N. R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons. J. Neurosci. 2005, 25(24):5763-5773.
    • (2005) J. Neurosci. , vol.25 , Issue.24 , pp. 5763-5773
    • Metz, A.E.1    Jarsky, T.2    Martina, M.3    Spruston, N.4
  • 48
    • 33745883312 scopus 로고    scopus 로고
    • Impaired trace and contextual fear conditioning in aged rats
    • Moyer J.R., Brown T.H. Impaired trace and contextual fear conditioning in aged rats. Behav. Neurosci. 2006, 120(3):612-624.
    • (2006) Behav. Neurosci. , vol.120 , Issue.3 , pp. 612-624
    • Moyer, J.R.1    Brown, T.H.2
  • 49
    • 0027070788 scopus 로고
    • Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner
    • Moyer J.R., Thompson L.T., Black J.P., Disterhoft J.F. Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. J. Neurophysiol. 1992, 68(6):2100-2109.
    • (1992) J. Neurophysiol. , vol.68 , Issue.6 , pp. 2100-2109
    • Moyer, J.R.1    Thompson, L.T.2    Black, J.P.3    Disterhoft, J.F.4
  • 50
    • 0034662335 scopus 로고    scopus 로고
    • Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning
    • Moyer J.R., Power J.M., Thompson L.T., Disterhoft J.F. Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning. J. Neurosci. 2000, 20(14):5476-5482.
    • (2000) J. Neurosci. , vol.20 , Issue.14 , pp. 5476-5482
    • Moyer, J.R.1    Power, J.M.2    Thompson, L.T.3    Disterhoft, J.F.4
  • 51
    • 7944235804 scopus 로고    scopus 로고
    • Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice
    • Murphy G.G., Fedorov N.B., Giese K.P., Ohno M., Friedman E., Chen R., Silva A.J. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Curr. Biol. 2004, 14(21):1907-1915.
    • (2004) Curr. Biol. , vol.14 , Issue.21 , pp. 1907-1915
    • Murphy, G.G.1    Fedorov, N.B.2    Giese, K.P.3    Ohno, M.4    Friedman, E.5    Chen, R.6    Silva, A.J.7
  • 54
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 2006, 26(40):10129-10140.
    • (2006) J. Neurosci. , vol.26 , Issue.40 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 55
    • 0345390977 scopus 로고    scopus 로고
    • Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus
    • Oh M.M., Power J.M., Thompson L.T., Moriearty P.L., Disterhoft J.F. Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. J. Neurosci. 1999, 19(5):1814-1823.
    • (1999) J. Neurosci. , vol.19 , Issue.5 , pp. 1814-1823
    • Oh, M.M.1    Power, J.M.2    Thompson, L.T.3    Moriearty, P.L.4    Disterhoft, J.F.5
  • 56
    • 0142027042 scopus 로고    scopus 로고
    • Watermaze learning enhances excitability of CA1 pyramidal neurons
    • Oh M.M., Kuo A.G., Wu W.W., Sametsky E.A., Disterhoft J.F. Watermaze learning enhances excitability of CA1 pyramidal neurons. J. Neurophysiol. 2003, 90(4):2171-2179.
    • (2003) J. Neurophysiol. , vol.90 , Issue.4 , pp. 2171-2179
    • Oh, M.M.1    Kuo, A.G.2    Wu, W.W.3    Sametsky, E.A.4    Disterhoft, J.F.5
  • 57
    • 0346055155 scopus 로고    scopus 로고
    • BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
    • Ohno M., Sametsky E.A., Younkin L.H., Oakley H., Younkin S.G., Citron M., Vassar R., Disterhoft J.F. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 2004, 41(1):27-33.
    • (2004) Neuron , vol.41 , Issue.1 , pp. 27-33
    • Ohno, M.1    Sametsky, E.A.2    Younkin, L.H.3    Oakley, H.4    Younkin, S.G.5    Citron, M.6    Vassar, R.7    Disterhoft, J.F.8
  • 59
    • 33645979005 scopus 로고    scopus 로고
    • Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability
    • Ohno M., Sametsky E.A., Silva A.J., Disterhoft J.F. Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. Eur. J. Neurosci. 2006, 23(8):2235-2240.
    • (2006) Eur. J. Neurosci. , vol.23 , Issue.8 , pp. 2235-2240
    • Ohno, M.1    Sametsky, E.A.2    Silva, A.J.3    Disterhoft, J.F.4
  • 60
    • 0025097883 scopus 로고
    • Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons
    • Pitler T.A., Landfield P.W. Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons. Brain Res. 1990, 508(1):1-6.
    • (1990) Brain Res. , vol.508 , Issue.1 , pp. 1-6
    • Pitler, T.A.1    Landfield, P.W.2
  • 61
    • 0035186354 scopus 로고    scopus 로고
    • Metrifonate decreases sI(AHP) in CA1 pyramidal neurons in vitro
    • Power J.M., Oh M.M., Disterhoft J.F. Metrifonate decreases sI(AHP) in CA1 pyramidal neurons in vitro. J. Neurophysiol. 2001, 85(1):319-322.
    • (2001) J. Neurophysiol. , vol.85 , Issue.1 , pp. 319-322
    • Power, J.M.1    Oh, M.M.2    Disterhoft, J.F.3
  • 62
    • 0037104784 scopus 로고    scopus 로고
    • Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro
    • Power J.M., Wu W.W., Sametsky E., Oh M.M., Disterhoft J.F. Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro. J. Neurosci. 2002, 22(16):7234-7243.
    • (2002) J. Neurosci. , vol.22 , Issue.16 , pp. 7234-7243
    • Power, J.M.1    Wu, W.W.2    Sametsky, E.3    Oh, M.M.4    Disterhoft, J.F.5
  • 63
    • 0035866053 scopus 로고    scopus 로고
    • Long-lasting cholinergic modulation underlies rule learning in rats
    • Saar D., Grossman Y., Barkai E. Long-lasting cholinergic modulation underlies rule learning in rats. J. Neurosci. 2001, 21(4):1385-1392.
    • (2001) J. Neurosci. , vol.21 , Issue.4 , pp. 1385-1392
    • Saar, D.1    Grossman, Y.2    Barkai, E.3
  • 64
    • 0029670122 scopus 로고    scopus 로고
    • Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation
    • Sah P. Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends Neurosci. 1996, 19(4):150-154.
    • (1996) Trends Neurosci. , vol.19 , Issue.4 , pp. 150-154
    • Sah, P.1
  • 65
    • 0027474051 scopus 로고
    • Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration
    • Saito K., Elce J.S., Hamos J.E., Nixon R.A. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc. Natl. Acad. Sci. U.S.A. 1993, 90(7):2628-2632.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , Issue.7 , pp. 2628-2632
    • Saito, K.1    Elce, J.S.2    Hamos, J.E.3    Nixon, R.A.4
  • 67
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81(2):741-766.
    • (2001) Physiol. Rev. , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 68
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics
    • Selkoe D.J., Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 2003, 43:545-584.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 69
    • 0032698746 scopus 로고    scopus 로고
    • Alzheimer's disease: perspectives for the new millennium
    • Sisodia S.S. Alzheimer's disease: perspectives for the new millennium. J. Clin. Invest. 1999, 104(9):1169-1170.
    • (1999) J. Clin. Invest. , vol.104 , Issue.9 , pp. 1169-1170
    • Sisodia, S.S.1
  • 70
    • 0344033599 scopus 로고    scopus 로고
    • Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5
    • Sourdet V., Russier M., Daoudal G., Ankri N., Debanne D. Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5. J. Neurosci. 2003, 23(32):10238-10248.
    • (2003) J. Neurosci. , vol.23 , Issue.32 , pp. 10238-10248
    • Sourdet, V.1    Russier, M.2    Daoudal, G.3    Ankri, N.4    Debanne, D.5
  • 71
    • 0025322605 scopus 로고
    • Potassium currents in hippocampal pyramidal cells
    • Storm J.F. Potassium currents in hippocampal pyramidal cells. Prog. Brain Res. 1990, 83:161-187.
    • (1990) Prog. Brain Res. , vol.83 , pp. 161-187
    • Storm, J.F.1
  • 72
    • 33646945317 scopus 로고    scopus 로고
    • Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice
    • Stutzmann G.E., Smith I., Caccamo A., Oddo S., Laferla F.M., Parker I. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 2006, 26(19):5180-5189.
    • (2006) J. Neurosci. , vol.26 , Issue.19 , pp. 5180-5189
    • Stutzmann, G.E.1    Smith, I.2    Caccamo, A.3    Oddo, S.4    Laferla, F.M.5    Parker, I.6
  • 73
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30(4):572-580.
    • (1991) Ann. Neurol. , vol.30 , Issue.4 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 74
    • 0035892243 scopus 로고    scopus 로고
    • Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity
    • Thibault O., Hadley R., Landfield P.W. Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. J. Neurosci. 2001, 21(24):9744-9756.
    • (2001) J. Neurosci. , vol.21 , Issue.24 , pp. 9744-9756
    • Thibault, O.1    Hadley, R.2    Landfield, P.W.3
  • 75
    • 33947493213 scopus 로고    scopus 로고
    • Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store
    • Thibault O., Gant J.C., Landfield P.W. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell 2007, 6(3):307-317.
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 307-317
    • Thibault, O.1    Gant, J.C.2    Landfield, P.W.3
  • 76
    • 14944380610 scopus 로고    scopus 로고
    • The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats
    • Tombaugh G.C., Rowe W.B., Rose G.M. The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats. J. Neurosci. 2005, 25(10):2609-2616.
    • (2005) J. Neurosci. , vol.25 , Issue.10 , pp. 2609-2616
    • Tombaugh, G.C.1    Rowe, W.B.2    Rose, G.M.3
  • 78
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • Turner P.R., O'Connor K., Tate W.P., Abraham W.C. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog. Neurobiol. 2003, 70(1):1-32.
    • (2003) Prog. Neurobiol. , vol.70 , Issue.1 , pp. 1-32
    • Turner, P.R.1    O'Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 79
    • 4344630985 scopus 로고    scopus 로고
    • BACE1: the beta-secretase enzyme in Alzheimer's disease
    • Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. J. Mol. Neurosci. 2004, 23(1-2):105-114.
    • (2004) J. Mol. Neurosci. , vol.23 , Issue.1-2 , pp. 105-114
    • Vassar, R.1
  • 80
    • 0034651105 scopus 로고    scopus 로고
    • The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons
    • Weiss C., Preston A.R., Oh M.M., Schwarz R.D., Welty D., Disterhoft J.F. The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons. J. Neurosci. 2000, 20(2):783-790.
    • (2000) J. Neurosci. , vol.20 , Issue.2 , pp. 783-790
    • Weiss, C.1    Preston, A.R.2    Oh, M.M.3    Schwarz, R.D.4    Welty, D.5    Disterhoft, J.F.6
  • 81
    • 25444457995 scopus 로고    scopus 로고
    • Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction
    • Xie C.W. Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction. Neuromol. Med. 2004, 6(1):53-64.
    • (2004) Neuromol. Med. , vol.6 , Issue.1 , pp. 53-64
    • Xie, C.W.1
  • 82
    • 0028537416 scopus 로고
    • The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition
    • Younkin S.G. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition. Tohoku J. Exp. Med. 1994, 174(3):217-223.
    • (1994) Tohoku J. Exp. Med. , vol.174 , Issue.3 , pp. 217-223
    • Younkin, S.G.1
  • 83
    • 0032105394 scopus 로고    scopus 로고
    • The role of A beta 42 in Alzheimer's disease
    • Younkin S.G. The role of A beta 42 in Alzheimer's disease. J. Physiol. Paris 1998, 92(3-4):289-292.
    • (1998) J. Physiol. Paris , vol.92 , Issue.3-4 , pp. 289-292
    • Younkin, S.G.1
  • 85
    • 0242300203 scopus 로고    scopus 로고
    • The other side of the engram: experience-driven changes in neuronal intrinsic excitability
    • Zhang W., Linden D.J. The other side of the engram: experience-driven changes in neuronal intrinsic excitability. Nat. Rev. Neurosci. 2003, 4(11):885-900.
    • (2003) Nat. Rev. Neurosci. , vol.4 , Issue.11 , pp. 885-900
    • Zhang, W.1    Linden, D.J.2


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