Characterization of an apical ceramide-enriched compartment regulating ciliogenesis

Molecular Biology of the Cell

Volumn 23, Issue 16, 2012, Pages 3156-3166

  He, Qian ^a   Wang, Guanghu ^a   Dasgupta, Somsankar ^a   Dinkins, Michael ^a   Zhu, Gu ^a   Bieberich, Erhard ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; IMIPRAMINE; PROTEIN CDC42; SPHINGOMYELIN; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL STRAIN; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOCYTOSIS; EUKARYOTIC FLAGELLUM; INTRACELLULAR SPACE; MUTANT; NONHUMAN; PRIORITY JOURNAL;

ACETYLATION; ANIMALS; CELL POLARITY; CELLS, CULTURED; CERAMIDES; CILIA; CYTOPLASMIC VESICLES; DOGS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; MICROSCOPY, FLUORESCENCE; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; SPHINGOMYELINS; TUBULIN;

EID: 84865236850     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-02-0079     Document Type: Article

References (42)

1. Albouz S, Le Saux F, Wenger D, Hauw JJ, Baumann N (1986). Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines. Life Sci 38, 357-363.
2. Babbey CM, Bacallao RL, Dunn KW (2010). Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol 299, F495-F506.
3. Bieberich E (2011). Lipid vesicle-mediated affinity chromatography using magnetic activated cell sorting (LIMACS): a novel method to analyze protein-lipid interaction. J Vis Exp 50, e2657, doi: 10.3791/2657.
4. Bieberich E, Hu B, Silva J, MacKinnon S, Yu RK, Fillmore H, Broaddus WC, Ottenbrite RM (2002). Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells. Cancer Lett 181, 55-64.
5. Bieberich E, Kawaguchi T, Yu RK (2000). N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells. J Biol Chem 275, 177-181.
6. Bieberich E, MacKinnon S, Silva J, Noggle S, Condie BG (2003). Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide. J Cell Biol 162, 469-479.
7. Bryant DM, Datta A, Rodriguez-Fraticelli AE, Peranen J, Martin-Belmonte F, Mostov KE (2010). A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol 12, 1035-1045.
8. Casanova JE, Wang X, Kumar R, Bhartur SG, Navarre J, Woodrum JE, Altschuler Y, Ray GS, Goldenring JR (1999). Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell 10, 47-61.
9. Cau J, Hall A (2005). Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways. J Cell Sci 118, 2579-2587.
10. Cohen E, Binet S, Meininger V (1988). Ciliogenesis and centriole formation in the mouse embryonic nervous system. An ultrastructural analysis. Biol Cell 62, 165-169.
11. Das A, Guo W (2011). Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond. Trends Cell Biol 21, 383-386.
12. Eggenschwiler JT, Anderson KV (2007). Cilia and developmental signaling. Annu Rev Cell Dev Biol 23, 345-373.
13. Etienne-Manneville S, Hall A (2003). Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756.
14. Evans RJ, Schwarz N, Nagel-Wolfrum K, Wolfrum U, Hardcastle AJ, pericentriolar vesicle transport between the Golgi and the primary cilium. Hum Mol Genet 19, 1358-1367.
15. Fan S, Hurd TW, Liu CJ, Straight SW, Weimbs T, Hurd EA, Domino SE, Margolis B (2004). Polarity proteins control ciliogenesis via kinesin motor interactions. Curr Biol 14, 1451-1461.
16. Gerdes JM, Davis EE, Katsanis N (2009). The vertebrate primary cilium in development, homeostasis, and disease. Cell 137, 32-45.
17. Hurd T, Zhou W, Jenkins P, Liu CJ, Swaroop A, Khanna H, Martens J, Hildebrandt F, Margolis B (2010). The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hum Mol Genet 19, 4330-4344.
18. Kitatani K, Idkowiak-Baldys J, Hannun YA (2008). The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 20, 1010-1018.
19. Knodler A, Feng S, Zhang J, Zhang X, Das A, Peranen J, Guo W (2010). Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc Natl Acad Sci USA 107, 6346-6351.
20. Krishnamurthy K, Dasgupta S, Bieberich E (2007). Development and characterization of a novel anti-ceramide antibody. J Lipid Res 48, 968-975.
21. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV (2008). A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell 15, 854-865.
22. Michaud EJ, Yoder BK (2006). The primary cilium in cell signaling and cancer. Cancer Res 66, 6463-6467.
23. Nachury MV et al. (2007). A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129, 1201-1213.
24. Nachury MV, Seeley ES, Jin H (2010). Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu Rev Cell Dev Biol 26, 59-87.
25. Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu SC, Goldenring JR, Yeaman C, Apodaca G (2007). Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell 18, 3978-3992.
26. Pan J, Snell W (2007). The primary cilium: keeper of the key to cell division. Cell 129, 1255-1257.
27. Pan J, Wang Q, Snell WJ (2005). Cilium-generated signaling and cilia-related disorders. Lab Invest 85, 452-463.
28. Pruliere G, Cosson J, Chevalier S, Sardet C, Chenevert J (2011). Atypical protein kinase C controls sea urchin ciliogenesis. Mol Biol Cell 22, 2042-2053.
29. Rohatgi R, Milenkovic L, Scott MP (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372-376.
30. Rozenova KA, Deevska GM, Karakashian AA, Nikolova-Karakashian MN (2010). Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages. J Biol Chem 285, 21103-21113.
31. Satir P (2007). Cilia biology: stop overeating now! Curr Biol 17, R963-R965.
32. Satir P, Pedersen LB, Christensen ST (2010). The primary cilium at a glance. J Cell Sci 123, 499-503.
33. Seeley ES, Nachury MV (2010). The perennial organelle: assembly and disassembly of the primary cilium. J Cell Sci 123, 511-518.
34. Singla V, Reiter JF (2006). The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 313, 629-633.
35. Sorokin S (1962). Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol 15, 363-377.
36. Takahashi M, Murate M, Fukuda M, Sato SB, Ohta A, Kobayashi T (2007). Cholesterol controls lipid endocytosis through Rab11. Mol Biol Cell 18, 2667-2677.
37. Wang G, Krishnamurthy K, Bieberich E (2009a). Regulation of primary cilia formation by ceramide. J Lipid Res 50, 2103-2110.
38. Wang G, Krishnamurthy K, Umapathy NS, Verin AD, Bieberich E (2009b). The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells. J Biol Chem 284, 14469-14475.
39. Wang G, Silva J, Krishnamurthy K, Tran E, Condie BG, Bieberich E (2005). Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J Biol Chem 280, 26415-26424.
40. Westlake CJ et al. (2011). Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci USA 108, 2759-2764.
41. Wiens CJ et al. (2010). Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem 285, 16218-16230.
42. Zuo X, Fogelgren B, Lipschutz JH (2011). The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells. J Biol Chem 286, 22469-22477.