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Volumn 8, Issue 7, 2016, Pages 1330-1352

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

Author keywords

Cancer; Epigenetics; Mitochondria; Mitophagy; Pluripotency; Stem cells

Indexed keywords

PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE;

EID: 84981488617     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100976     Document Type: Article
Times cited : (72)

References (103)
  • 1
    • 84867773087 scopus 로고    scopus 로고
    • Mitophagy: mechanisms, pathophysiological roles, and analysis
    • Ding WX, Yin XM. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem. 2012; 393: 547-64.
    • (2012) Biol Chem , vol.393 , pp. 547-564
    • Ding, W.X.1    Yin, X.M.2
  • 3
    • 84863430453 scopus 로고    scopus 로고
    • Mitophagy: a complex mechanism of mitochondrial removal
    • Novak I. Mitophagy: a complex mechanism of mitochondrial removal. Antioxid Redox Signal. 2012; 17: 794-802.
    • (2012) Antioxid Redox Signal , vol.17 , pp. 794-802
    • Novak, I.1
  • 5
    • 84871005673 scopus 로고    scopus 로고
    • The pathways of mitophagy for quality control and clearance of mitochondria
    • Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 2013; 20: 31-42.
    • (2013) Cell Death Differ , vol.20 , pp. 31-42
    • Ashrafi, G.1    Schwarz, T.L.2
  • 6
    • 84879606527 scopus 로고    scopus 로고
    • Molecular signaling toward mitophagy and its physiological significance
    • Feng D, Liu L, Zhu Y, Chen Q. Molecular signaling toward mitophagy and its physiological significance. Exp Cell Res. 2013; 319: 1697-1705.
    • (2013) Exp Cell Res , vol.319 , pp. 1697-1705
    • Feng, D.1    Liu, L.2    Zhu, Y.3    Chen, Q.4
  • 7
    • 84871749760 scopus 로고    scopus 로고
    • Mitochondrial morphology in mitophagy and macroautophagy
    • Gomes LC, Scorrano L. Mitochondrial morphology in mitophagy and macroautophagy. Biochim Biophys Acta. 2013; 1833: 205-12.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 205-212
    • Gomes, L.C.1    Scorrano, L.2
  • 8
    • 84910141948 scopus 로고    scopus 로고
    • Mitochondrial dynamics and inheritance during cell division, development and disease
    • Mishra P, Chan DC. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat Rev Mol Cell Biol. 2014; 15: 634-46.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 634-646
    • Mishra, P.1    Chan, D.C.2
  • 9
    • 84940722108 scopus 로고    scopus 로고
    • Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses
    • Wei H, Liu L, Chen Q. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Biochim Biophys Acta. 2015; 1853: 2784-90.
    • (2015) Biochim Biophys Acta , vol.1853 , pp. 2784-2790
    • Wei, H.1    Liu, L.2    Chen, Q.3
  • 10
    • 84897048042 scopus 로고    scopus 로고
    • Mitochondrial quality control in neurodegenerative diseases
    • Dupuis L. Mitochondrial quality control in neurodegenerative diseases. Biochimie. 2014; 100: 177-83.
    • (2014) Biochimie , vol.100 , pp. 177-183
    • Dupuis, L.1
  • 12
    • 84885653993 scopus 로고    scopus 로고
    • Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases
    • Osellame LD, Duchen MR. Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases. Autophagy. 2013; 9: 1633-35.
    • (2013) Autophagy , vol.9 , pp. 1633-1635
    • Osellame, L.D.1    Duchen, M.R.2
  • 13
    • 84897454469 scopus 로고    scopus 로고
    • Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration
    • Osellame LD, Duchen MR. Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration. Br J Pharmacol. 2014; 171: 1958-1972.
    • (2014) Br J Pharmacol , vol.171 , pp. 1958-1972
    • Osellame, L.D.1    Duchen, M.R.2
  • 14
    • 84921369563 scopus 로고    scopus 로고
    • The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease
    • Pickrell AM, Youle RJ. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron. 2015; 85: 257-73.
    • (2015) Neuron , vol.85 , pp. 257-273
    • Pickrell, A.M.1    Youle, R.J.2
  • 15
    • 84925298301 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
    • Ryan BJ, Hoek S, Fon EA, Wade-Martins R. Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem Sci. 2015; 40: 200-10.
    • (2015) Trends Biochem Sci , vol.40 , pp. 200-210
    • Ryan, B.J.1    Hoek, S.2    Fon, E.A.3    Wade-Martins, R.4
  • 16
    • 84887387419 scopus 로고    scopus 로고
    • After the banquet: mitochondrial biogenesis, mitophagy, and cell survival
    • Zhu J, Wang KZ, Chu CT. After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy. 2013; 9: 1663-76.
    • (2013) Autophagy , vol.9 , pp. 1663-1676
    • Zhu, J.1    Wang, K.Z.2    Chu, C.T.3
  • 18
    • 84887456727 scopus 로고    scopus 로고
    • Mitophagy in hematopoietic stem cells: the case for exploration
    • Joshi A, Kundu M. Mitophagy in hematopoietic stem cells: the case for exploration. Autophagy. 2013; 9: 1737-49.
    • (2013) Autophagy , vol.9 , pp. 1737-1749
    • Joshi, A.1    Kundu, M.2
  • 19
    • 84934434639 scopus 로고    scopus 로고
    • Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer
    • Menendez JA, Joven J. Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer. Adv Exp Med Biol. 2014; 824: 117-40.
    • (2014) Adv Exp Med Biol , vol.824 , pp. 117-140
    • Menendez, J.A.1    Joven, J.2
  • 20
    • 80655140600 scopus 로고    scopus 로고
    • mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging
    • Menendez JA, Vellon L, Oliveras-Ferraros C, Cufí S, Vazquez-Martin A. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle. 2011; 10: 3658-77.
    • (2011) Cell Cycle , vol.10 , pp. 3658-3677
    • Menendez, J.A.1    Vellon, L.2    Oliveras-Ferraros, C.3    Cufí, S.4    Vazquez-Martin, A.5
  • 23
    • 84872340936 scopus 로고    scopus 로고
    • Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging
    • Phadwal K, Watson AS, Simon AK. Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging. Cell Mol Life Sci. 2013; 70: 89-103.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 89-103
    • Phadwal, K.1    Watson, A.S.2    Simon, A.K.3
  • 24
    • 84857489373 scopus 로고    scopus 로고
    • Autophagy in stem cell maintenance and differentiation
    • Vessoni AT, Muotri AR, Okamoto OK. Autophagy in stem cell maintenance and differentiation. Stem Cells Dev. 2012; 21: 513-20.
    • (2012) Stem Cells Dev , vol.21 , pp. 513-520
    • Vessoni, A.T.1    Muotri, A.R.2    Okamoto, O.K.3
  • 25
    • 84859424813 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming
    • Chen CT, Hsu SH, Wei YH. Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming. Biochim Biophys Acta. 2012; 1820: 571-76.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 571-576
    • Chen, C.T.1    Hsu, S.H.2    Wei, Y.H.3
  • 27
    • 82755195582 scopus 로고    scopus 로고
    • Energy metabolism in nuclear reprogramming
    • Folmes CD, Nelson TJ, Terzic A. Energy metabolism in nuclear reprogramming. Biomark Med. 2011; 5: 715-29.
    • (2011) Biomark Med , vol.5 , pp. 715-729
    • Folmes, C.D.1    Nelson, T.J.2    Terzic, A.3
  • 28
    • 84868347607 scopus 로고    scopus 로고
    • Metabolic plasticity in stem cell homeostasis and differentiation
    • Folmes CD, Dzeja PP, Nelson TJ, Terzic, A. Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell. 2012; 11: 596-06.
    • (2012) Cell Stem Cell , vol.11 , pp. 596-606
    • Folmes, C.D.1    Dzeja, P.P.2    Nelson, T.J.3    Terzic, A.4
  • 32
    • 84896929687 scopus 로고    scopus 로고
    • Metabolic requirements for the maintenance of self-renewing stem cells
    • Ito K, Suda T. Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol. 2014; 15: 243-56.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 243-256
    • Ito, K.1    Suda, T.2
  • 34
    • 84883620045 scopus 로고    scopus 로고
    • Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition
    • Son MJ, Jeong BR, Kwon Y, Cho YS. Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition. Int J Biochem Cell Biol. 2013; 45: 2512-18.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 2512-2518
    • Son, M.J.1    Jeong, B.R.2    Kwon, Y.3    Cho, Y.S.4
  • 35
    • 84921260212 scopus 로고    scopus 로고
    • Pluripotent stem cell energy metabolism: an update
    • Teslaa T, Teitell MA. Pluripotent stem cell energy metabolism: an update. EMBO J. 2015; 34: 138-53.
    • (2015) EMBO J , vol.34 , pp. 138-153
    • Teslaa, T.1    Teitell, M.A.2
  • 36
    • 84896306292 scopus 로고    scopus 로고
    • Mitochondrial function in pluripotent stem cells and cellular reprogramming
    • Bukowiecki R, Adjaye J, Prigione, A. Mitochondrial function in pluripotent stem cells and cellular reprogramming. Gerontology. 2014; 60: 174-82.
    • (2014) Gerontology , vol.60 , pp. 174-182
    • Bukowiecki, R.1    Adjaye, J.2    Prigione, A.3
  • 37
    • 79960012954 scopus 로고    scopus 로고
    • Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
    • Prigione A, Adjaye J. Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells. Int J Dev Bio. 2010; 54: 1729-41.
    • (2010) Int J Dev Bio , vol.54 , pp. 1729-1741
    • Prigione, A.1    Adjaye, J.2
  • 38
    • 84988239965 scopus 로고    scopus 로고
    • A mitochondrial strategy for safeguarding the reprogrammed genome
    • Prigione A, Adjaye J. A mitochondrial strategy for safeguarding the reprogrammed genome. Cell Regen (Lond). 2014; 3: 5.
    • (2014) Cell Regen (Lond) , vol.3 , pp. 5
    • Prigione, A.1    Adjaye, J.2
  • 39
    • 77951002352 scopus 로고    scopus 로고
    • The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    • Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells. 2010; 28: 721-33.
    • (2010) Stem Cells , vol.28 , pp. 721-733
    • Prigione, A.1    Fauler, B.2    Lurz, R.3    Lehrach, H.4    Adjaye, J.5
  • 47
    • 84901349234 scopus 로고    scopus 로고
    • Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency
    • Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013; 13: 617-25.
    • (2013) Cell Stem Cell , vol.13 , pp. 617-625
    • Wang, S.1    Xia, P.2    Ye, B.3    Huang, G.4    Liu, J.5    Fan, Z.6
  • 48
    • 84887987260 scopus 로고    scopus 로고
    • Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency
    • Son MY, Choi H, Han YM, Cho YS. Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency. Stem Cells. 2013; 31: 2374-87.
    • (2013) Stem Cells , vol.31 , pp. 2374-2387
    • Son, M.Y.1    Choi, H.2    Han, Y.M.3    Cho, Y.S.4
  • 50
    • 84865031202 scopus 로고    scopus 로고
    • Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness
    • Vazquez-Martin A, Cufi S, Corominas-Faja B, Oliveras-Ferraros C, Vellon L, Menendez JA. Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness. Aging (Albany NY). 2012; 4: 393-401. doi: 10.18632/aging.100465.
    • (2012) Aging (Albany NY) , vol.4 , pp. 393-401
    • Vazquez-Martin, A.1    Cufi, S.2    Corominas-Faja, B.3    Oliveras-Ferraros, C.4    Vellon, L.5    Menendez, J.A.6
  • 51
    • 84913543630 scopus 로고    scopus 로고
    • Drp1 is dispensable for mitochondria biogenesis in induction to pluripotency but required for differentiation of embryonic stem cells
    • Wang L, Ye X, Zhao Q, Zhou Z, Dan J, Zhu Y, Chen Q, Liu L. Drp1 is dispensable for mitochondria biogenesis in induction to pluripotency but required for differentiation of embryonic stem cells. Stem Cells Dev. 2014; 23: 2422-34.
    • (2014) Stem Cells Dev , vol.23 , pp. 2422-2434
    • Wang, L.1    Ye, X.2    Zhao, Q.3    Zhou, Z.4    Dan, J.5    Zhu, Y.6    Chen, Q.7    Liu, L.8
  • 54
    • 77953877676 scopus 로고    scopus 로고
    • A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease
    • Chu CT. A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet. 2010; 19: R28-R37.
    • (2010) Hum Mol Genet , vol.19 , pp. R28-R37
    • Chu, C.T.1
  • 56
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • Deng H, Dodson MW, Huang H, Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A. 2008; 105: 14503-508.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 57
    • 84922776083 scopus 로고    scopus 로고
    • PINK1/Parkin-mediated mitophagy in mammalian cells
    • Eiyama A, Okamoto K. PINK1/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol. 2015; 33: 95-101.
    • (2015) Curr Opin Cell Biol , vol.33 , pp. 95-101
    • Eiyama, A.1    Okamoto, K.2
  • 58
    • 49649097747 scopus 로고    scopus 로고
    • Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
    • Gautier CA, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008; 105: 11364-369.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11364-11369
    • Gautier, C.A.1    Kitada, T.2    Shen, J.3
  • 59
    • 78649463381 scopus 로고    scopus 로고
    • Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
    • Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet. 2010; 19: 4861-70.
    • (2010) Hum Mol Genet , vol.19 , pp. 4861-4870
    • Gegg, M.E.1    Cooper, J.M.2    Chau, K.Y.3    Rojo, M.4    Schapira, A.H.5    Taanman, J.W.6
  • 61
    • 77950371695 scopus 로고    scopus 로고
    • PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
    • Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, Hattori N. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 2010; 584: 1073-79.
    • (2010) FEBS Lett , vol.584 , pp. 1073-1079
    • Kawajiri, S.1    Saiki, S.2    Sato, S.3    Sato, F.4    Hatano, T.5    Eguchi, H.6    Hattori, N.7
  • 62
    • 79952324644 scopus 로고    scopus 로고
    • Regulation of PINK1-Parkin-mediated mitophagy
    • Springer W, Kahle PJ. Regulation of PINK1-Parkin-mediated mitophagy. Autophagy. 2011; 7: 266-78.
    • (2011) Autophagy , vol.7 , pp. 266-278
    • Springer, W.1    Kahle, P.J.2
  • 66
    • 78149408058 scopus 로고    scopus 로고
    • Empowering self-renewal and differentiation: the role of mitochondria in stem cells
    • Rehman J. Empowering self-renewal and differentiation: the role of mitochondria in stem cells. J Mol Med (Berl). 2010; 88: 981-86.
    • (2010) J Mol Med (Berl) , vol.88 , pp. 981-986
    • Rehman, J.1
  • 67
    • 33644606491 scopus 로고    scopus 로고
    • Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes
    • Rodriguez-Enriquez S, Kim I, Currin RT, Lemasters JJ. Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy. 2006; 2: 39-46.
    • (2006) Autophagy , vol.2 , pp. 39-46
    • Rodriguez-Enriquez, S.1    Kim, I.2    Currin, R.T.3    Lemasters, J.J.4
  • 69
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
    • Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell. 2002; 9: 1031-44.
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6    Wahl, G.M.7
  • 70
    • 34248223064 scopus 로고    scopus 로고
    • The ever expanding role for c-Myc in promoting genomic instability
    • Prochownik EV, Li Y. The ever expanding role for c-Myc in promoting genomic instability. Cell Cycle. 2007; 6: 1024-29.
    • (2007) Cell Cycle , vol.6 , pp. 1024-1029
    • Prochownik, E.V.1    Li, Y.2
  • 74
    • 84876463939 scopus 로고    scopus 로고
    • Breathing-in epigenetic change with vitamin C
    • Monfort A, Wutz A. Breathing-in epigenetic change with vitamin C. EMBO Rep. 2013; 14: 337-46.
    • (2013) EMBO Rep , vol.14 , pp. 337-346
    • Monfort, A.1    Wutz, A.2
  • 79
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    • Knoepfler PS. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells. 2009; 27: 1050-56.
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 80
    • 77956634610 scopus 로고    scopus 로고
    • A call to standardize teratoma assays used to define human pluripotent cell lines
    • Müller FJ, Goldmann J, Löser P, Loring JF. A call to standardize teratoma assays used to define human pluripotent cell lines. Cell Stem Cell. 2010; 6: 412-14.
    • (2010) Cell Stem Cell , vol.6 , pp. 412-414
    • Müller, F.J.1    Goldmann, J.2    Löser, P.3    Loring, J.F.4
  • 86
    • 77957666255 scopus 로고    scopus 로고
    • Histone methyl transferases and demethylases; can they link metabolism and transcription?
    • Teperino R, Schoonjans K, Auwerx J. Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab. 2010;12:321-27.
    • (2010) Cell Metab , vol.12 , pp. 321-327
    • Teperino, R.1    Schoonjans, K.2    Auwerx, J.3
  • 87
    • 84868593544 scopus 로고    scopus 로고
    • Kinetic analysis of iron-dependent histone demethylases: a-ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells
    • Cascella B, Mirica LM. Kinetic analysis of iron-dependent histone demethylases: a-ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells. Biochemistry. 2012;51:8699-701.
    • (2012) Biochemistry , vol.51 , pp. 8699-8701
    • Cascella, B.1    Mirica, L.M.2
  • 88
    • 84902685602 scopus 로고    scopus 로고
    • Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process
    • Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process. Ageing Res Rev. 2014;16:45-65.
    • (2014) Ageing Res Rev , vol.16 , pp. 45-65
    • Salminen, A.1    Kauppinen, A.2    Hiltunen, M.3    Kaarniranta, K.4
  • 89
    • 84925503908 scopus 로고    scopus 로고
    • Intracellular a-ketoglutarate maintains the pluripotency of embryonic stem cells
    • Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB. Intracellular a-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518:413-16.
    • (2015) Nature , vol.518 , pp. 413-416
    • Carey, B.W.1    Finley, L.W.2    Cross, J.R.3    Allis, C.D.4    Thompson, C.B.5
  • 90
    • 84860586157 scopus 로고    scopus 로고
    • Mitochondrial regulation of epigenetics and its role in human diseases
    • Minocherhomji S, Tollefsbol TO, Singh KK. Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics. 2012;7:326-34.
    • (2012) Epigenetics , vol.7 , pp. 326-334
    • Minocherhomji, S.1    Tollefsbol, T.O.2    Singh, K.K.3
  • 91
    • 84898845550 scopus 로고    scopus 로고
    • Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process
    • Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process. Cell Signal. 2014;26:1598-1603.
    • (2014) Cell Signal , vol.26 , pp. 1598-1603
    • Salminen, A.1    Kaarniranta, K.2    Hiltunen, M.3    Kauppinen, A.4
  • 93
    • 84895484925 scopus 로고    scopus 로고
    • Chemical ablation of tumorinitiating human pluripotent stem cells
    • Ben-David U, Benvenisty N. Chemical ablation of tumorinitiating human pluripotent stem cells. Nat Protoc. 2014; 9: 729-40.
    • (2014) Nat Protoc , vol.9 , pp. 729-740
    • Ben-David, U.1    Benvenisty, N.2
  • 97
    • 84964054269 scopus 로고    scopus 로고
    • Metabolic control of cancer cell stemness: Lessons from iPS cells
    • Menendez JA. Metabolic control of cancer cell stemness: Lessons from iPS cells. Cell Cycle. 2015; 14: 3801-11.
    • (2015) Cell Cycle , vol.14 , pp. 3801-3811
    • Menendez, J.A.1
  • 100
    • 84938739650 scopus 로고    scopus 로고
    • Evolution of Mitochondria as Signaling Organelles
    • Chandel NS. Evolution of Mitochondria as Signaling Organelles. Cell Metab. 2015;22:204-06.
    • (2015) Cell Metab , vol.22 , pp. 204-206
    • Chandel, N.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.