Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency

Stem Cells

Volumn 31, Issue 11, 2013, Pages 2374-2387

  Son, Mi Young ^a,b   Choi, Hoonsung ^b   Han, Yong Mahn ^a   Cho, Yee Sook ^b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Cyclin B; Human embryonic stem cell; Human induced pluripotent stem cell; Pluripotency; Reprogramming; REX1

Indexed keywords

CELL MARKER; CYCLIN B; CYCLIN B1; CYCLIN B2; CYCLIN DEPENDENT KINASE 1; DYNAMIN; DYNAMIN I; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; REDUCED EXPRESSION 1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; GLYCOLYSIS; HUMAN; HUMAN CELL; MESODERM; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SOMATIC CELL; TERATOMA; TRANSCRIPTION REGULATION;

CYCLIN B; HUMAN EMBRYONIC STEM CELL; HUMAN INDUCED PLURIPOTENT STEM CELL; PLURIPOTENCY; REPROGRAMMING; REX1;

ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROSCOPY, ELECTRON; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84887987260     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1509     Document Type: Article

References (64)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676. (Pubitemid 44233629)
2. Yu J, Vodyanik MA, Smuga-Otto K et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917-1920.
3. Hosler BA, LaRosa GJ, Grippo JF et al. Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol 1989; 9: 5623-5629. (Pubitemid 20004381)
4. Kimura I, Honda R, Okai H et al. Vascular endothelial growth factor promotes cell-cycle transition from G0 to G1 phase in subcultured endothelial cells of diabetic rat thoracic aorta. Jpn J Pharmacol 2000; 83: 47-55. (Pubitemid 30352656)
5. Beadling C, Cereseto A, Fan W et al. Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival. Oncogene 2001; 20: 1771-1783. (Pubitemid 32368023)
6. Aziz F, van Wijnen AJ, Stein JL et al. HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition. J Cell Physiol 1998; 177: 453-464. (Pubitemid 28524668)
7. Kohn KW. Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition. Oncogene 1998; 16: 1065-1075. (Pubitemid 28107944)
8. Mongan NP, Martin KM, Gudas LJ. The putative human stem cell marker, Rex-1 (Zfp42): Structural classification and expression in normal human epithelial and carcinoma cell cultures. Mol Carcinog 2006; 45: 887-900. (Pubitemid 44907380)
9. Kopper O, Giladi O, Golan-Lev T et al. Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies. Stem Cells 2010; 28: 75-83.
10. Chan EM, Ratanasirintrawoot S, Park IH et al. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol 2009; 27: 1033-1037.
11. Mignotte B, Vayssiere JL. Mitochondria and apoptosis. Eur J Biochem 1998; 252: 1-15. (Pubitemid 28089952)
12. Yu W, Sun Y, Guo S et al. The PINK1/Parkin pathway regulates mito-chondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 2011; 20: 3227-3240.
13. Sanchez Dils E., Lefebvre C, Abeyta K. Teledentistry in the United States: A new horizon of dental care. Int J Dent Hyg 2004; 2: 161-164.
14. Roy SS, Hsu CH, Wen ZH et al. A hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation-bioinformatic and algorithmic approach. Med Hypotheses 2011; 76: 507-511.
15. Toyooka Y, Shimosato D, Murakami K et al. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 2008; 135: 909-918. (Pubitemid 351524145)
16. Hosler BA, Rogers MB, Kozak CA et al. An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells. Mol Cell Biol 1993; 13: 2919-2928. (Pubitemid 23133963)
17. Kim J, Chu J, Shen X et al. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008; 132: 1049-1061. (Pubitemid 351381745)
18. Cavalli LR, Liang BC. Mutagenesis, tumorigenicity, and apoptosis: Are the mitochondria involved? Mutat Res 1998; 398: 19-26.
19. Shi W, Wang H, Pan G et al. Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. J Biol Chem 2006; 281: 23319-23325. (Pubitemid 44274106)
20. Boyer LA, Lee TI, Cole MF et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122: 947-956. (Pubitemid 41345211)
21. Kuroda T, Tada M, Kubota H et al. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 2005; 25: 2475-2485. (Pubitemid 40354640)
22. Hendzel MJ, Wei Y, Mancini MA et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric hetero-chromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997; 106: 348-360. (Pubitemid 27510848)
23. Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 1991; 66: 1197-1206. (Pubitemid 121001409)
24. Kim JD, Faulk C, Kim J. Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1. Nucleic Acids Res 2007; 35: 3442-3452. (Pubitemid 47073605)
25. Berman SB, Pineda FJ, Hardwick JM. Mitochondrial fission and fusion dynamics: The long and short of it. Cell Death Differ 2008; 15: 1147-1152. (Pubitemid 351850967)
26. Su B, Wang X, Zheng L et al. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta 2010; 1802: 135-142.
27. Lonergan T, Bavister B, Brenner C. Mitochondria in stem cells. Mitochondrion 2007; 7: 289-296. (Pubitemid 47300173)
28. Zhang J, Khvorostov I, Hong JS et al. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J 2011; 30: 4860-4873.
29. Folmes CD, Nelson TJ, Martinez-Fernandez A et al. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab 2011; 14: 264-271.
30. Bleazard W, McCaffery JM, King EJ et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat Cell Biol 1999; 1: 298-304. (Pubitemid 129495781)
31. Milone M, Benarroch EE. Mitochondrial dynamics: General concepts and clinical implications. Neurology 2012; 78: 1612-1619.
32. Taguchi N, Ishihara N, Jofuku A et al. Mitotic phosphorylation of dynamin-related GTPase DRP1 participates in mitochondrial fission. J Biol Chem 2007; 282: 11521-11529. (Pubitemid 47100787)
33. Prigione A, Fauler B, Lurz R et al. The senescence-related mitochon-drial/oxidative stress pathway is repressed in human induced pluripo-tent stem cells. Stem Cells 2010; 28: 721-733.
34. Rehman J. Empowering self-renewal and differentiation: The role of mitochondria in stem cells. J Mol Med (Berl) 2010; 88: 981-986.
35. Barzilai A, Yamamoto K. DNA damage responses to oxidative stress. DNA Repair (Amst) 2004; 3: 1109-1115. (Pubitemid 38997954)
36. Vazquez-Martin A., Cufi S, Corominas-Faja B et al. Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: New insight into the role of mitophagy in cell stemness. Aging (Albany Ny) 2012; 4: 393-401.
37. Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006; 38: 431-440.
38. Do JT, Scholer HR. Regulatory circuits underlying pluripotency and reprogramming. Trends Pharmacol Sci 2009; 30: 296-302.
39. Heng JC, Orlov YL, Ng HH. Transcription factors for the modulation of pluripotency and reprogramming. Cold Spring Harb Symp Quant Biol 2010; 75: 237-244.
40. Mandal S, Lindgren AG, Srivastava AS et al. Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells 2011; 29: 486-495.
41. Freije WA, Mandal S, Banerjee U. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. G3 (Bethesda) 2012; 2: 843-851.
42. Scotland KB, Chen S, Sylvester R et al. Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation. Dev Dyn 2009; 238: 1863-1877.
43. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000; 24: 372-376. (Pubitemid 30187435)
44. Campbell PA, Perez-Iratxeta C, Andrade-Navarro MA et al. Oct4 targets regulatory nodes to modulate stem cell function. PLoS One 2007; 2:e553.
45. Banito A, Rashid ST, Acosta JC et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev 2009; 23: 2134-2139.
46. Ruiz S, Panopoulos AD, Herrerias A et al. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol 2011; 21: 45-52.
47. Nagata S, Hirano K, Kanemori M et al. Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells. PLoS One 2012; 7:e48699.
48. Vella P, Barozzi I, Cuomo A et al. Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res 2012; 40: 3403-3418.
49. Onder TT, Kara N, Cherry A et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012; 483: 598-602.
50. Kellner S, Kikyo N. Transcriptional regulation of the Oct4 gene, a master gene for pluripotency. Histol Histopathol 2010; 25: 405-412.
51. Yuan J, Yan R, Kramer A et al. Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene 2004; 23: 5843-5852. (Pubitemid 39093030)
52. Brandeis M, Hunt T. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J 1996; 15: 5280-5289. (Pubitemid 26336211)
53. Krause K, Wasner M, Reinhard W et al. The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res 2000; 28: 4410-4418.
54. Manni I, Mazzaro G, Gurtner A et al. NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest. J Biol Chem 2001; 276: 5570-5576.
55. Wu T, Zhang X, Huang X et al. Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. J Biol Chem 2010; 285: 18291-18300.
56. Yuan J, Kramer A, Matthess Y et al. Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo. Oncogene 2006; 25: 1753-1762.
57. Bhandari DR, Seo KW, Roh KH et al. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS One 2010; 5:e10493.
58. Zhang R, Li X. Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle. Mol Biol Rep 2011; 38: 2179-2184.
59. Wang J, Liu C, Zhao H et al. Association between a 45-bp 3'untranslated insertion/deletion polymorphism in exon 8 of UCP2 gene and neural tube defects in a high-risk area of China. Reprod Sci 2011; 18: 556-560.
60. de Araujo H.W., Fukushima K, Takaki GM. Prodigiosin production by Serratia marcescens UCP 1549 using renewable-resources as a low cost substrate. Molecules 2010; 15: 6931-6940.
61. Rufino RD, Luna JM, Sarubbo LA et al. Antimicrobial and anti-adhesive potential of a biosurfactant Rufisan produced by Candida lip-olytica UCP 0988. Colloids Surf B Biointerfaces 2011; 84: 1-5.
62. Saretzki G, Walter T, Atkinson S et al. Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells 2008; 26: 455-464. (Pubitemid 351413606)
63. Friis RM, Wu BP, Reinke SN et al. A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA. Nucleic Acids Res 2009; 37: 3969-3980.
64. Wellen KE, Hatzivassiliou G, Sachdeva UM et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009; 324: 1076-1080.