Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency

Cell Death and Differentiation

Volumn 22, Issue 12, 2015, Pages 1957-1969

  Son, M J ^a,b   Kwon, Y ^a,b   Son, M Y ^a   Seol, B ^a   Choi, H S ^a   Ryu, S W ^c   Choi, C ^c   Cho, Y S ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOFUSIN 1; MITOFUSIN 2; PROTEIN P21; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTOME; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GUANOSINE TRIPHOSPHATASE; MFN1 PROTEIN, MOUSE; MFN2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL FATE; CELL FUSION; CELL GROWTH; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENERGY METABOLISM; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE SILENCING; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; MASS SPECTROMETRY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL METABOLIC REPROGRAMMING; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA SPLICING; SIGNAL TRANSDUCTION; SOMATIC CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DEFICIENCY; GENETICS; INDUCED PLURIPOTENT STEM CELL; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MOUSE EMBRYONIC STEM CELL; RNA INTERFERENCE;

ANIMALS; CELL LINE; CELLULAR REPROGRAMMING; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GTP PHOSPHOHYDROLASES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MOUSE EMBRYONIC STEM CELLS; RAF KINASES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84947488862     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.43     Document Type: Article

References (30)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
2. Theunissen TW, Jaenisch R. Molecular Control of Induced Pluripotency. Cell Stem Cell 2014; 14: 720-734.
3. Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, Ganz K et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012; 150: 1209-1222.
4. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460: 1140-1144.
5. Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009; 460: 1145-1148.
6. Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460: 1132-1135.
7. Guo S, Zi X, Schulz VP, Cheng J, Zhong M, Koochaki SH et al. Nonstochastic reprogramming from a privileged somatic cell state. Cell 2014; 156: 649-662.
8. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005; 7: 165-171.
9. Brosh R, Assia-Alroy Y, Molchadsky A, Bornstein C, Dekel E, Madar S et al. p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition. Cell Death Differ 2013; 20: 312-320.
10. Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer 2014; 14: 359-370.
11. Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP et al. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprog ramming. Cell Metab 2011; 14: 264-271.
12. Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J. The senescence-related mitochondrial/ oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 2010; 28: 721-733.
13. Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010; 11: 872-884.
14. Son MY, Choi H, Han YM, Cho YS. Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency. Stem Cells 2013; 31: 2374-2387.
15. Vazquez-Martin A, Cufi S, Corominas-Faja B, Oliveras-Ferraros C, Vellon L, Menendez JA. Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness. Aging 2012; 4: 393-401.
16. Wang W, Cheng X, Lu J, Wei J, Fu G, Zhu F et al. Mitofusin-2 is a novel direct target of p53. Biochem Biophys Res Commun 2010; 400: 587-592.
17. Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D et al. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol 2004; 6: 872-883.
18. Chen KH, Dasgupta A, Ding J, Indig FE, Ghosh P, Longo DL. Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J 2014; 28: 382-394.
19. Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R et al. HIF1alpha modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells 2014; 32: 364-376.
20. Mathieu J, Zhou W, Xing Y, Sperber H, Ferreccio A, Agoston Z et al. Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency. Cell Stem Cell 2014; 14: 592-605.
21. Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005; 2005: re12.
22. Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM et al. Reactive oxygen species genera ted at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 2000; 275: 25130-25138.
23. Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 2009; 5: 237-241.
24. Son MJ, Jeong BR, Kwon Y, Cho YS. Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition. Int J Biochem Cell Biol 2013; 45: 2512-2518.
25. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003; 160: 189-200.
26. Naon D, Scorrano L. At the right distance: ER-mitochondria juxtaposition in cell life and death. Biochim Biophys Acta 2014; 1843: 2184-2194.
27. West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol 2011; 11: 389-402.
28. Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007; 8: 870-879.
29. Farrand L, Byun S, Kim JY, Im-Aram A, Lee J, Lim S et al. Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 2013; 288: 23740-23750.
30. Son MJ, Son MY, Seol B, Kim MJ, Yoo CH, Han MK et al. Nicotinamide overcomes pluripotency deficits and reprogramming barriers. Stem Cells 2013; 31: 1121-1135.