Mitochondrial function in pluripotent stem cells and cellular reprogramming

Gerontology

Volumn 60, Issue 2, 2014, Pages 174-182

  Bukowiecki, Raul ^a   Adjaye, James ^a,b   Prigione, Alessandro ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

iPS cells; Metabolism; Mitochondria; mtDNA; Reprogramming; Stem cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; RIBOSOME RNA; TRANSFER RNA;

BIOGENESIS; CANCER CELL; CELL AGING; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DAMAGE; CELL FATE; CELL FUNCTION; CELL ORGANELLE; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSFORMATION; CELL TYPE; CYTOLOGY; EMBRYONIC STEM CELL; ENERGY METABOLISM; GENE EXPRESSION; GLYCOLYSIS; HEMATOPOIETIC STEM CELL; HUMAN; MEDICAL RESEARCH; MESENCHYMAL STEM CELL; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENOME; MITOCHONDRION; MITOPHAGY; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REJUVENATION; REVIEW; SELECTIVE AUTOPHAGY; SOMATIC CELL; AGING; AUTOPHAGY; CELL ENERGY; DNA DAMAGE; MITOCHONDRIAL GENETICS; PLASTICITY; POINT MUTATION;

AGING; ANIMALS; CELL DIFFERENTIATION; CELL TRANSDIFFERENTIATION; DNA, MITOCHONDRIAL; ENERGY METABOLISM; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MITOCHONDRIA; OXIDATION-REDUCTION; PLURIPOTENT STEM CELLS; REJUVENATION;

EID: 84896306292     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000355050     Document Type: Review

References (38)

1. Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676
2. Sancho-Martinez I, Baek SH, Izpisua Belmonte JC: Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol 2012; 14: 892-899
3. Cho YM, et al: Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells. Biochem Biophys Res Commun 2006; 348: 1472-1478
4. St John JC, et al: The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells. Cloning Stem Cells 2005; 7: 141-153
5. Facucho-Oliveira JM, et al: Mitochondrial DNA replication during differentiation of murine embryonic stem cells. J Cell Sci 2007; 120(Pt 22):4025-4034
6. Todd LR, et al: Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. Mol Biol Cell 2010; 21: 1225-1236
7. Prigione A, et al: The senescence-related mitochondrial/ oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 2010; 28: 721-733
8. Suhr ST, et al: Mitochondrial rejuvenation after induced pluripotency. PLoS One 2010; 5:e14095
9. Varum S, et al: Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One 2011; 6:e20914
10. Folmes CD, et al: Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab 2011; 14: 264-271
11. Armstrong L, et al: Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells 2010; 28: 661-673
12. Chen T, et al: Rapamycin and other longevitypromoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 2011; 10: 908-911
13. Menendez JA, et al: MTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: A roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 2011; 10: 3658-3677
14. Prigione A, Adjaye J: Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells. Int J Dev Biol 2010; 54: 1729-1741
15. Mandal S, et al: Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells 2011; 29: 486-495
16. Vander Heiden MG, Cantley LC, Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033
17. Zhang J, et al: UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J 2011; 30: 4860-4873
18. Panopoulos AD, et al: The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res 2011; 22: 168-177
19. Prigione A, et al: Mitochondrial-Associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS One 2011; 6:e27352
20. Prigione A, et al: Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming. Stem Cells 2011; 29: 1338-1348
21. Zhu S, et al: Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010; 7: 651-655
22. Chen CT, et al: Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 2008; 26: 960-968
23. Baris OR, et al: The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells 2011; 29: 1459-1468
24. Suda T, Takubo K, Semenza GL: Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 2011; 9: 298-310
25. Prigione A, et al: HIF1a modulates cell fate reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2. Stem Cells 2013, DOI: 10.1002/stem.1552
26. Yanes O, et al: Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol 2010; 6: 411-417
27. Ralser M, et al: Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. J Biol 2007; 6: 10
28. Kazak L, Reyes A, Holt IJ: Minimizing the damage: Repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol 2012; 13: 659-671
29. Prigione A, Cortopassi G: Mitochondrial DNA deletions induce the adenosine monophosphate-Activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell 2007; 6: 619-630
30. Van Haute L, et al: Human embryonic stem cells commonly display large mitochondrial DNA deletions. Nat Biotechnol 2013; 31: 20-23
31. Kelly RD, et al: Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells 2012; 31: 703-716
32. Cheng L, et al: Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression. Cell Stem Cell 2012; 10: 337-344
33. Cherry AB, et al: Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion. Stem Cells 2013;31:1287-1297
34. Fujikura J, et al: Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation. Diabetologia 2012; 55: 1689-1698
35. Folmes CD, et al: Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS. Stem Cells 2013; 31: 1298-1308
36. Mahmoudi S, Brunet A: Aging and reprogramming: A two-way street. Curr Opin Cell Biol 2012; 24: 744-756
37. Parker GC, Acsadi G, Brenner CA: Mitochondria: Determinants of stem cell fate?. Stem Cells Dev 2009; 18: 803-806
38. Birket MJ, et al: A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci 2011; 124(Pt 3):348-358