Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

Journal of Cell Biology

Volumn 211, Issue 6, 2015, Pages 1157-1176

  Chen, Allen C ^a   Kim, Sumin ^a   Shepardson, Nina ^a   Patel, Sarvagna ^a   Hong, Soyon ^b   Selkoe, Dennis J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; AVAGACESTAT; BEGACESTAT; BETA SECRETASE 1; GAMMA SECRETASE; SEMAGACESTAT; TETRASPANIN; SECRETASE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BIOTINYLATION; BRAIN MICROSOME; CELL LYSATE; CELL MEMBRANE; CELL SURFACE; CHO CELL LINE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDBACK SYSTEM; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CRICETULUS; METABOLISM;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CHO CELLS; CRICETULUS; HUMANS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEOLYSIS;

EID: 84979996194     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201502001     Document Type: Article

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