The familial alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Human Molecular Genetics

Volumn 23, Issue 13, 2014, Pages 3523-3536

  Muratore, Christina R ^a   Rice, Heather C ^a   Srikanth, Priya ^a   Callahan, Dana G ^a   Shin, Taehwan ^a   Benjamin, Lawrence N P ^a   Walsh, Dominic M ^a   Selkoe, Dennis J ^a   Young Pearse, Tracy L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 3 (3,4 DICHLOROPHENYL) 1 ISOPROPYL 4 METHYLIMIDAZOLIUM CHLORIDE; ALKALINE PHOSPHATASE; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE INHIBITOR; COMPLEMENT COMPONENT C3; COMPLEMENTARY DNA; CYCLIN D1; DIMETHYL SULFOXIDE; EARLY ENDOSOME ANTIGEN 1; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; KRUPPEL LIKE FACTOR 4; L 685458; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; MYC PROTEIN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; POSTSYNAPTIC DENSITY PROTEIN 95; STAGE SPECIFIC EMBRYO ANTIGEN 3; STAGE SPECIFIC EMBRYO ANTIGEN 4; SYNAPSIN; TAU PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; AMYLOID BETA PROTEIN;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN CELL; CELL FATE; CELL LINEAGE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; CLINICAL ARTICLE; CLONE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DAUGHTER; EMBRYOID BODY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL DISEASE; FATHER; FEMALE; FIBROBLAST; FOREBRAIN; GENE MUTATION; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; KARYOTYPE; KARYOTYPING; MALE; MIDDLE AGED; NERVE CELL; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; PHENOTYPE; PLURIPOTENT STEM CELL LINE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; SKIN BIOPSY; TRANSIENT TRANSFECTION; UNITED KINGDOM; WESTERN BLOTTING; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; METABOLISM; MORTALITY; PHYSIOLOGY; PLURIPOTENT STEM CELL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; CELL DIFFERENTIATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NEURONS; TAU PROTEINS;

EID: 84902303124     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu064     Document Type: Article

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