Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 476-481

  Teranishi, Yasuhiro ^a,b   Hur, Ji Yeun ^a   Gu, Gucci Jijuan ^c   Kihara, Takahiro ^b   Ishikawa, Taizo ^b   Nishimura, Takeshi ^b   Winblad, Bengt ^a   Behbahani, Homira ^a   Kamali Moghaddam, Masood ^c   Frykman, Susanne ^a   Tjernberg, Lars O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Secretase; Affinity purification; Alzheimer disease; Amyloid peptide; Detergent resistant membranes; Erlin 2

Indexed keywords

AMYLOID BETA PROTEIN; ERLIN 2; GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE SILENCING; HUMAN; HUMAN TISSUE; LIPID RAFT; MICROSOME; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; HUMANS; MEMBRANE PROTEINS; MICE; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

RATTUS;

EID: 84864740457     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.137     Document Type: Article

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