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Volumn 36, Issue , 2014, Pages 130-139

MTOR and the health benefits of exercise

Author keywords

Amino acids; Cancer; Inactivity; Longevity; Quality of life

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOCHONDRIAL PROTEIN; MUSCLE PROTEIN;

EID: 84912115519     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.08.013     Document Type: Review
Times cited : (83)

References (126)
  • 1
    • 61449092865 scopus 로고    scopus 로고
    • Physical inactivity: the biggest public health problem of the 21st century
    • Blair S.N. Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med 2009, 43:1-2.
    • (2009) Br J Sports Med , vol.43 , pp. 1-2
    • Blair, S.N.1
  • 2
    • 47649097993 scopus 로고    scopus 로고
    • Association between muscular strength and mortality in men: prospective cohort study
    • Ruiz J.R., Sui X., Lobelo F., Morrow J.R., Jackson A.W., Sjostrom M., et al. Association between muscular strength and mortality in men: prospective cohort study. BMJ 2008, 337:a439.
    • (2008) BMJ , vol.337 , pp. a439
    • Ruiz, J.R.1    Sui, X.2    Lobelo, F.3    Morrow, J.R.4    Jackson, A.W.5    Sjostrom, M.6
  • 3
    • 84863715693 scopus 로고    scopus 로고
    • Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort
    • Rantanen T., Masaki K., He Q., Ross G.W., Willcox B.J., White L. Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort. Age (Dordr) 2012, 34:563-570.
    • (2012) Age (Dordr) , vol.34 , pp. 563-570
    • Rantanen, T.1    Masaki, K.2    He, Q.3    Ross, G.W.4    Willcox, B.J.5    White, L.6
  • 4
    • 0033537699 scopus 로고    scopus 로고
    • Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome
    • Belardinelli R., Georgiou D., Cianci G., Purcaro A. Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 1999, 99:1173-1182.
    • (1999) Circulation , vol.99 , pp. 1173-1182
    • Belardinelli, R.1    Georgiou, D.2    Cianci, G.3    Purcaro, A.4
  • 5
    • 0037797282 scopus 로고    scopus 로고
    • Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes
    • Courneya K.S., Mackey J.R., Bell G.J., Jones L.W., Field C.J., Fairey A.S. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol 2003, 21:1660-1668.
    • (2003) J Clin Oncol , vol.21 , pp. 1660-1668
    • Courneya, K.S.1    Mackey, J.R.2    Bell, G.J.3    Jones, L.W.4    Field, C.J.5    Fairey, A.S.6
  • 6
    • 0142096622 scopus 로고    scopus 로고
    • Exercise in cancer survivors: an overview of research
    • Courneya K.S. Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc 2003, 35:1846-1852.
    • (2003) Med Sci Sports Exerc , vol.35 , pp. 1846-1852
    • Courneya, K.S.1
  • 7
    • 0014011201 scopus 로고
    • Incidence and prediction of ischaemic heart-disease in London busmen
    • Morris J.N., Kagan A., Pattison D.C., Gardner M.J. Incidence and prediction of ischaemic heart-disease in London busmen. Lancet 1966, 2:553-559.
    • (1966) Lancet , vol.2 , pp. 553-559
    • Morris, J.N.1    Kagan, A.2    Pattison, D.C.3    Gardner, M.J.4
  • 8
    • 33751366229 scopus 로고    scopus 로고
    • Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
    • Lindstrom J., Ilanne-Parikka P., Peltonen M., Aunola S., Eriksson J.G., Hemio K., et al. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 2006, 368:1673-1679.
    • (2006) Lancet , vol.368 , pp. 1673-1679
    • Lindstrom, J.1    Ilanne-Parikka, P.2    Peltonen, M.3    Aunola, S.4    Eriksson, J.G.5    Hemio, K.6
  • 9
    • 33746041829 scopus 로고    scopus 로고
    • A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise
    • Raguso C.A., Kyle U., Kossovsky M.P., Roynette C., Paoloni-Giacobino A., Hans D., et al. A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise. Clin Nutr 2006, 25:573-580.
    • (2006) Clin Nutr , vol.25 , pp. 573-580
    • Raguso, C.A.1    Kyle, U.2    Kossovsky, M.P.3    Roynette, C.4    Paoloni-Giacobino, A.5    Hans, D.6
  • 10
    • 0030590747 scopus 로고    scopus 로고
    • Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures
    • Heinonen A., Kannus P., Sievanen H., Oja P., Pasanen M., Rinne M., et al. Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures. Lancet 1996, 348:1343-1347.
    • (1996) Lancet , vol.348 , pp. 1343-1347
    • Heinonen, A.1    Kannus, P.2    Sievanen, H.3    Oja, P.4    Pasanen, M.5    Rinne, M.6
  • 11
    • 0029809985 scopus 로고    scopus 로고
    • Sports participation and emotional wellbeing in adolescents
    • Steptoe A., Butler N. Sports participation and emotional wellbeing in adolescents. Lancet 1996, 347:1789-1792.
    • (1996) Lancet , vol.347 , pp. 1789-1792
    • Steptoe, A.1    Butler, N.2
  • 12
    • 50949110086 scopus 로고    scopus 로고
    • Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    • Lautenschlager N.T., Cox K.L., Flicker L., Foster J.K., van Bockxmeer F.M., Xiao J., et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. J Am Med Assoc 2008, 300:1027-1037.
    • (2008) J Am Med Assoc , vol.300 , pp. 1027-1037
    • Lautenschlager, N.T.1    Cox, K.L.2    Flicker, L.3    Foster, J.K.4    van Bockxmeer, F.M.5    Xiao, J.6
  • 13
    • 77951093119 scopus 로고    scopus 로고
    • Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus
    • Kim S.E., Ko I.G., Kim B.K., Shin M.S., Cho S., Kim C.J., et al. Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp Gerontol 2010, 45:357-365.
    • (2010) Exp Gerontol , vol.45 , pp. 357-365
    • Kim, S.E.1    Ko, I.G.2    Kim, B.K.3    Shin, M.S.4    Cho, S.5    Kim, C.J.6
  • 14
    • 0032921840 scopus 로고    scopus 로고
    • Postexercise net protein synthesis in human muscle from orally administered amino acids
    • Tipton K.D., Ferrando A.A., Phillips S.M., Doyle D., Wolfe R.R. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol 1999, 276:E628-E634.
    • (1999) Am J Physiol , vol.276 , pp. E628-E634
    • Tipton, K.D.1    Ferrando, A.A.2    Phillips, S.M.3    Doyle, D.4    Wolfe, R.R.5
  • 15
    • 0030822785 scopus 로고    scopus 로고
    • Mixed muscle protein synthesis and breakdown after resistance exercise in humans
    • Phillips S.M., Tipton K.D., Aarsland A., Wolf S.E., Wolfe R.R. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol 1997, 273:E99-E107.
    • (1997) Am J Physiol , vol.273 , pp. E99-E107
    • Phillips, S.M.1    Tipton, K.D.2    Aarsland, A.3    Wolf, S.E.4    Wolfe, R.R.5
  • 16
    • 19444386124 scopus 로고    scopus 로고
    • Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions
    • Moore D.R., Phillips S.M., Babraj J.A., Smith K., Rennie M.J. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am J Physiol Endocrinol Metab 2005, 288:E1153-E1159.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E1153-E1159
    • Moore, D.R.1    Phillips, S.M.2    Babraj, J.A.3    Smith, K.4    Rennie, M.J.5
  • 17
    • 84862580398 scopus 로고    scopus 로고
    • Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men
    • Donges C.E., Burd N.A., Duffield R., Smith G.C., West D.W., Short M.J., et al. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. J Appl Physiol (1985) 2012, 112:1992-2001.
    • (2012) J Appl Physiol (1985) , vol.112 , pp. 1992-2001
    • Donges, C.E.1    Burd, N.A.2    Duffield, R.3    Smith, G.C.4    West, D.W.5    Short, M.J.6
  • 18
    • 84873378527 scopus 로고    scopus 로고
    • Exercise metabolism and the molecular regulation of skeletal muscle adaptation
    • Egan B., Zierath J.R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab 2013, 17:162-184.
    • (2013) Cell Metab , vol.17 , pp. 162-184
    • Egan, B.1    Zierath, J.R.2
  • 19
    • 0032948278 scopus 로고    scopus 로고
    • Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise
    • Baar K., Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol 1999, 276:C120-C127.
    • (1999) Am J Physiol , vol.276 , pp. C120-C127
    • Baar, K.1    Esser, K.2
  • 20
    • 58149307453 scopus 로고    scopus 로고
    • Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men
    • Kumar V., Selby A., Rankin D., Patel R., Atherton P., Hildebrandt W., et al. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 2009, 587:211-217.
    • (2009) J Physiol , vol.587 , pp. 211-217
    • Kumar, V.1    Selby, A.2    Rankin, D.3    Patel, R.4    Atherton, P.5    Hildebrandt, W.6
  • 21
    • 36348957870 scopus 로고    scopus 로고
    • Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects
    • Terzis G., Georgiadis G., Stratakos G., Vogiatzis I., Kavouras S., Manta P., et al. Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects. Eur J Appl Physiol 2008, 102:145-152.
    • (2008) Eur J Appl Physiol , vol.102 , pp. 145-152
    • Terzis, G.1    Georgiadis, G.2    Stratakos, G.3    Vogiatzis, I.4    Kavouras, S.5    Manta, P.6
  • 22
    • 63849130621 scopus 로고    scopus 로고
    • Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
    • Drummond M.J., Fry C.S., Glynn E.L., Dreyer H.C., Dhanani S., Timmerman K.L., et al. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol 2009, 587:1535-1546.
    • (2009) J Physiol , vol.587 , pp. 1535-1546
    • Drummond, M.J.1    Fry, C.S.2    Glynn, E.L.3    Dreyer, H.C.4    Dhanani, S.5    Timmerman, K.L.6
  • 23
    • 0035736260 scopus 로고    scopus 로고
    • Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    • Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 2001, 3:1014-1019.
    • (2001) Nat Cell Biol , vol.3 , pp. 1014-1019
    • Bodine, S.C.1    Stitt, T.N.2    Gonzalez, M.3    Kline, W.O.4    Stover, G.L.5    Bauerlein, R.6
  • 24
    • 84878539473 scopus 로고    scopus 로고
    • MTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle
    • Ogasawara R., Kobayashi K., Tsutaki A., Lee K., Abe T., Fujita S., et al. mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle. J Appl Physiol (1985) 2013, 114:934-940.
    • (2013) J Appl Physiol (1985) , vol.114 , pp. 934-940
    • Ogasawara, R.1    Kobayashi, K.2    Tsutaki, A.3    Lee, K.4    Abe, T.5    Fujita, S.6
  • 25
    • 81255169943 scopus 로고    scopus 로고
    • The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth
    • Goodman C.A., Frey J.W., Mabrey D.M., Jacobs B.L., Lincoln H.C., You J.S., et al. The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth. J Physiol 2011, 589:5485-5501.
    • (2011) J Physiol , vol.589 , pp. 5485-5501
    • Goodman, C.A.1    Frey, J.W.2    Mabrey, D.M.3    Jacobs, B.L.4    Lincoln, H.C.5    You, J.S.6
  • 26
    • 84891377667 scopus 로고    scopus 로고
    • Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle
    • Kimball S.R. Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle. Am J Clin Nutr 2014, 99:237S-242S.
    • (2014) Am J Clin Nutr , vol.99 , pp. 237S-242S
    • Kimball, S.R.1
  • 27
    • 3042820402 scopus 로고    scopus 로고
    • Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism
    • Hornberger T.A., Stuppard R., Conley K.E., Fedele M.J., Fiorotto M.L., Chin E.R., et al. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 2004, 380:795-804.
    • (2004) Biochem J , vol.380 , pp. 795-804
    • Hornberger, T.A.1    Stuppard, R.2    Conley, K.E.3    Fedele, M.J.4    Fiorotto, M.L.5    Chin, E.R.6
  • 28
    • 37749027195 scopus 로고    scopus 로고
    • A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
    • Spangenburg E.E., Le Roith D., Ward C.W., Bodine S.C. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol 2008, 586:283-291.
    • (2008) J Physiol , vol.586 , pp. 283-291
    • Spangenburg, E.E.1    Le Roith, D.2    Ward, C.W.3    Bodine, S.C.4
  • 29
    • 77955360284 scopus 로고    scopus 로고
    • A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise
    • Hamilton D.L., Philp A., MacKenzie M.G., Baar K. A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise. PLoS ONE 2010, 5:e11624.
    • (2010) PLoS ONE , vol.5 , pp. e11624
    • Hamilton, D.L.1    Philp, A.2    MacKenzie, M.G.3    Baar, K.4
  • 30
    • 70450210312 scopus 로고    scopus 로고
    • Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men
    • West D.W., Kujbida G.W., Moore D.R., Atherton P., Burd N.A., Padzik J.P., et al. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. J Physiol 2009, 587:5239-5247.
    • (2009) J Physiol , vol.587 , pp. 5239-5247
    • West, D.W.1    Kujbida, G.W.2    Moore, D.R.3    Atherton, P.4    Burd, N.A.5    Padzik, J.P.6
  • 31
    • 73949131768 scopus 로고    scopus 로고
    • Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors
    • West D.W., Burd N.A., Tang J.E., Moore D.R., Staples A.W., Holwerda A.M., et al. Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol 2010, 108:60-67.
    • (2010) J Appl Physiol , vol.108 , pp. 60-67
    • West, D.W.1    Burd, N.A.2    Tang, J.E.3    Moore, D.R.4    Staples, A.W.5    Holwerda, A.M.6
  • 32
    • 84884254389 scopus 로고    scopus 로고
    • Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
    • Jacobs B.L., You J.S., Frey J.W., Goodman C.A., Gundermann D.M., Hornberger T.A. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. J Physiol 2013, 591:4611-4620.
    • (2013) J Physiol , vol.591 , pp. 4611-4620
    • Jacobs, B.L.1    You, J.S.2    Frey, J.W.3    Goodman, C.A.4    Gundermann, D.M.5    Hornberger, T.A.6
  • 33
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003, 13:1259-1268.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 34
    • 0032810190 scopus 로고    scopus 로고
    • Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle
    • Fluck M., Carson J.A., Gordon S.E., Ziemiecki A., Booth F.W. Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle. Am J Physiol 1999, 277:C152-C162.
    • (1999) Am J Physiol , vol.277 , pp. C152-C162
    • Fluck, M.1    Carson, J.A.2    Gordon, S.E.3    Ziemiecki, A.4    Booth, F.W.5
  • 35
    • 33845981498 scopus 로고    scopus 로고
    • Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth
    • Gan B., Yoo Y., Guan J.L. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. J Biol Chem 2006, 281:37321-37329.
    • (2006) J Biol Chem , vol.281 , pp. 37321-37329
    • Gan, B.1    Yoo, Y.2    Guan, J.L.3
  • 36
    • 0035955315 scopus 로고    scopus 로고
    • Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation
    • Wang J.G., Miyazu M., Matsushita E., Sokabe M., Naruse K. Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. Biochem Biophys Res Commun 2001, 288:356-361.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 356-361
    • Wang, J.G.1    Miyazu, M.2    Matsushita, E.3    Sokabe, M.4    Naruse, K.5
  • 37
    • 0038719715 scopus 로고    scopus 로고
    • Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A
    • Pankov R., Cukierman E., Clark K., Matsumoto K., Hahn C., Poulin B., et al. Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem 2003, 278:18671-18681.
    • (2003) J Biol Chem , vol.278 , pp. 18671-18681
    • Pankov, R.1    Cukierman, E.2    Clark, K.3    Matsumoto, K.4    Hahn, C.5    Poulin, B.6
  • 38
    • 0038182574 scopus 로고    scopus 로고
    • Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function
    • Michele D.E., Campbell K.P. Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function. J Biol Chem 2003, 278:15457-15460.
    • (2003) J Biol Chem , vol.278 , pp. 15457-15460
    • Michele, D.E.1    Campbell, K.P.2
  • 39
    • 84868147762 scopus 로고    scopus 로고
    • The inside and out of dystroglycan post-translational modification
    • Moore C.J., Winder S.J. The inside and out of dystroglycan post-translational modification. Neuromusc Disorders 2012, 22:959-965.
    • (2012) Neuromusc Disorders , vol.22 , pp. 959-965
    • Moore, C.J.1    Winder, S.J.2
  • 40
    • 0034605070 scopus 로고    scopus 로고
    • The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin
    • Rybakova I.N., Patel J.R., Ervasti J.M. The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. J Cell Biol 2000, 150:1209-1214.
    • (2000) J Cell Biol , vol.150 , pp. 1209-1214
    • Rybakova, I.N.1    Patel, J.R.2    Ervasti, J.M.3
  • 41
    • 33644826679 scopus 로고    scopus 로고
    • Inhibition of stretch-activated channels during eccentric muscle contraction attenuates p70S6K activation
    • Spangenburg E.E., McBride T.A. Inhibition of stretch-activated channels during eccentric muscle contraction attenuates p70S6K activation. J Appl Physiol 2006, 100:129-135.
    • (2006) J Appl Physiol , vol.100 , pp. 129-135
    • Spangenburg, E.E.1    McBride, T.A.2
  • 42
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang Y., Vilella-Bach M., Bachmann R., Flanigan A., Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001, 294:1942-1945.
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 43
    • 38549134335 scopus 로고    scopus 로고
    • Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
    • Veverka V., Crabbe T., Bird I., Lennie G., Muskett F.W., Taylor R.J., et al. Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 2008, 27:585-595.
    • (2008) Oncogene , vol.27 , pp. 585-595
    • Veverka, V.1    Crabbe, T.2    Bird, I.3    Lennie, G.4    Muskett, F.W.5    Taylor, R.J.6
  • 44
    • 33645241260 scopus 로고    scopus 로고
    • The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    • Hornberger T.A., Chu W.K., Mak Y.W., Hsiung J.W., Huang S.A., Chien S. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci U S A 2006, 103:4741-4746.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4741-4746
    • Hornberger, T.A.1    Chu, W.K.2    Mak, Y.W.3    Hsiung, J.W.4    Huang, S.A.5    Chien, S.6
  • 45
    • 84892657844 scopus 로고    scopus 로고
    • The role of diacylglycerol kinase zeta and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy
    • You J.S., Lincoln H.C., Kim C.R., Frey J.W., Goodman C.A., Zhong X.P., et al. The role of diacylglycerol kinase zeta and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. J Biol Chem 2014, 289:1551-1563.
    • (2014) J Biol Chem , vol.289 , pp. 1551-1563
    • You, J.S.1    Lincoln, H.C.2    Kim, C.R.3    Frey, J.W.4    Goodman, C.A.5    Zhong, X.P.6
  • 47
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    • Crozier S.J., Kimball S.R., Emmert S.W., Anthony J.C., Jefferson L.S. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 2005, 135:376-382.
    • (2005) J Nutr , vol.135 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthony, J.C.4    Jefferson, L.S.5
  • 48
    • 69749123362 scopus 로고    scopus 로고
    • Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
    • Tang J.E., Moore D.R., Kujbida G.W., Tarnopolsky M.A., Phillips S.M. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol (1985) 2009, 107:987-992.
    • (2009) J Appl Physiol (1985) , vol.107 , pp. 987-992
    • Tang, J.E.1    Moore, D.R.2    Kujbida, G.W.3    Tarnopolsky, M.A.4    Phillips, S.M.5
  • 49
    • 84861707373 scopus 로고    scopus 로고
    • Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men
    • Churchward-Venne T.A., Burd N.A., Mitchell C.J., West D.W., Philp A., Marcotte G.R., et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol 2012, 590:2751-2765.
    • (2012) J Physiol , vol.590 , pp. 2751-2765
    • Churchward-Venne, T.A.1    Burd, N.A.2    Mitchell, C.J.3    West, D.W.4    Philp, A.5    Marcotte, G.R.6
  • 50
    • 84893341852 scopus 로고    scopus 로고
    • Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females
    • Moberg M., Apro W., Ohlsson I., Ponten M., Villanueva A., Ekblom B., et al. Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females. Appl Physiol Nutr Metab 2014, 39:183-194.
    • (2014) Appl Physiol Nutr Metab , vol.39 , pp. 183-194
    • Moberg, M.1    Apro, W.2    Ohlsson, I.3    Ponten, M.4    Villanueva, A.5    Ekblom, B.6
  • 53
    • 84878357685 scopus 로고    scopus 로고
    • A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
    • Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 2013, 340:1100-1106.
    • (2013) Science , vol.340 , pp. 1100-1106
    • Bar-Peled, L.1    Chantranupong, L.2    Cherniack, A.D.3    Chen, W.W.4    Ottina, K.A.5    Grabiner, B.C.6
  • 54
    • 84866431363 scopus 로고    scopus 로고
    • Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
    • Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 2012, 150:1196-1208.
    • (2012) Cell , vol.150 , pp. 1196-1208
    • Bar-Peled, L.1    Schweitzer, L.D.2    Zoncu, R.3    Sabatini, D.M.4
  • 55
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149:410-424.
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6
  • 56
    • 84888200442 scopus 로고    scopus 로고
    • The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
    • Tsun Z.Y., Bar-Peled L., Chantranupong L., Zoncu R., Wang T., Kim C., et al. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell 2013, 52:495-505.
    • (2013) Mol Cell , vol.52 , pp. 495-505
    • Tsun, Z.Y.1    Bar-Peled, L.2    Chantranupong, L.3    Zoncu, R.4    Wang, T.5    Kim, C.6
  • 57
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 58
    • 79960254595 scopus 로고    scopus 로고
    • Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise
    • Drummond M.J., Fry C.S., Glynn E.L., Timmerman K.L., Dickinson J.M., Walker D.K., et al. Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise. J Appl Physiol (1985) 2011, 111:135-142.
    • (2011) J Appl Physiol (1985) , vol.111 , pp. 135-142
    • Drummond, M.J.1    Fry, C.S.2    Glynn, E.L.3    Timmerman, K.L.4    Dickinson, J.M.5    Walker, D.K.6
  • 59
    • 0025292876 scopus 로고
    • Relationship of resting metabolic rate to body composition and protein turnover
    • Welle S., Nair K.S. Relationship of resting metabolic rate to body composition and protein turnover. Am J Physiol 1990, 258:E990-E998.
    • (1990) Am J Physiol , vol.258 , pp. E990-E998
    • Welle, S.1    Nair, K.S.2
  • 60
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
    • Cunningham J.T., Rodgers J.T., Arlow D.H., Vazquez F., Mootha V.K., Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 2007, 450:736-740.
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 61
    • 0036903174 scopus 로고    scopus 로고
    • Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    • Baar K., Wende A.R., Jones T.E., Marison M., Nolte L.A., Chen M., et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 2002, 16:1879-1886.
    • (2002) FASEB J , vol.16 , pp. 1879-1886
    • Baar, K.1    Wende, A.R.2    Jones, T.E.3    Marison, M.4    Nolte, L.A.5    Chen, M.6
  • 62
    • 0014198263 scopus 로고
    • Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle
    • Holloszy J.O. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem 1967, 242:2278-2282.
    • (1967) J Biol Chem , vol.242 , pp. 2278-2282
    • Holloszy, J.O.1
  • 63
    • 84865742594 scopus 로고    scopus 로고
    • Contractile activity-induced mitochondrial biogenesis and mTORC1
    • Carter H.N., Hood D.A. Contractile activity-induced mitochondrial biogenesis and mTORC1. Am J Physiol Cell Physiol 2012, 303:C540-C547.
    • (2012) Am J Physiol Cell Physiol , vol.303 , pp. C540-C547
    • Carter, H.N.1    Hood, D.A.2
  • 64
    • 80051642419 scopus 로고    scopus 로고
    • The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis
    • Breen L., Philp A., Witard O.C., Jackman S.R., Selby A., Smith K., et al. The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis. J Physiol 2011, 589:4011-4025.
    • (2011) J Physiol , vol.589 , pp. 4011-4025
    • Breen, L.1    Philp, A.2    Witard, O.C.3    Jackman, S.R.4    Selby, A.5    Smith, K.6
  • 65
    • 85029461897 scopus 로고    scopus 로고
    • Differential regulation of myofibrillar and mitochondrial protein synthesis following acute endurance exercise (702.3)
    • Philp A., Schenk S., Breen L., Hamilton L., Scott F., Laverone E., et al. Differential regulation of myofibrillar and mitochondrial protein synthesis following acute endurance exercise (702.3). FASEB J 2014, 28.
    • (2014) FASEB J , pp. 28
    • Philp, A.1    Schenk, S.2    Breen, L.3    Hamilton, L.4    Scott, F.5    Laverone, E.6
  • 66
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo A.Y., Yoon S.O., Kim S.G., Roux P.P., Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 2008, 105:17414-17419.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 67
    • 84887415150 scopus 로고    scopus 로고
    • MTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
    • Morita M., Gravel S.P., Chenard V., Sikstrom K., Zheng L., Alain T., et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab 2013, 18:698-711.
    • (2013) Cell Metab , vol.18 , pp. 698-711
    • Morita, M.1    Gravel, S.P.2    Chenard, V.3    Sikstrom, K.4    Zheng, L.5    Alain, T.6
  • 68
    • 0037444470 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle
    • Williamson D., Gallagher P., Harber M., Hollon C., Trappe S. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol 2003, 547:977-987.
    • (2003) J Physiol , vol.547 , pp. 977-987
    • Williamson, D.1    Gallagher, P.2    Harber, M.3    Hollon, C.4    Trappe, S.5
  • 70
    • 0029978799 scopus 로고    scopus 로고
    • Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    • Winder W.W., Hardie D.G. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 1996, 270:E299-E304.
    • (1996) Am J Physiol , vol.270 , pp. E299-E304
    • Winder, W.W.1    Hardie, D.G.2
  • 71
    • 0033949848 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    • Winder W.W., Holmes B.F., Rubink D.S., Jensen E.B., Chen M., Holloszy J.O. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol 2000, 88:2219-2226.
    • (2000) J Appl Physiol , vol.88 , pp. 2219-2226
    • Winder, W.W.1    Holmes, B.F.2    Rubink, D.S.3    Jensen, E.B.4    Chen, M.5    Holloszy, J.O.6
  • 72
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 73
    • 41549109753 scopus 로고    scopus 로고
    • AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
    • Thomson D.M., Fick C.A., Gordon S.E. AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions. J Appl Physiol 2008, 104:625-632.
    • (2008) J Appl Physiol , vol.104 , pp. 625-632
    • Thomson, D.M.1    Fick, C.A.2    Gordon, S.E.3
  • 74
    • 68549106237 scopus 로고    scopus 로고
    • Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy
    • Mounier R., Lantier L., Leclerc J., Sotiropoulos A., Pende M., Daegelen D., et al. Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy. FASEB J 2009, 23:2264-2273.
    • (2009) FASEB J , vol.23 , pp. 2264-2273
    • Mounier, R.1    Lantier, L.2    Leclerc, J.3    Sotiropoulos, A.4    Pende, M.5    Daegelen, D.6
  • 75
    • 84901058223 scopus 로고    scopus 로고
    • Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men
    • Lundberg T.R., Fernandez-Gonzalo R., Tesch P.A. Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men. J Appl Physiol (1985) 2014, 116:611-620.
    • (2014) J Appl Physiol (1985) , vol.116 , pp. 611-620
    • Lundberg, T.R.1    Fernandez-Gonzalo, R.2    Tesch, P.A.3
  • 76
    • 70449635645 scopus 로고    scopus 로고
    • Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
    • Coffey V.G., Jemiolo B., Edge J., Garnham A.P., Trappe S.W., Hawley J.A. Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. Am J Physiol Regulat Integr Comp Physiol 2009, 297:R1441-R1451.
    • (2009) Am J Physiol Regulat Integr Comp Physiol , vol.297 , pp. R1441-R1451
    • Coffey, V.G.1    Jemiolo, B.2    Edge, J.3    Garnham, A.P.4    Trappe, S.W.5    Hawley, J.A.6
  • 77
    • 84879574211 scopus 로고    scopus 로고
    • Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle
    • Apro W., Wang L., Ponten M., Blomstrand E., Sahlin K. Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle. Am J Physiol Endocrinol Metab 2013, 305:E22-E32.
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E22-E32
    • Apro, W.1    Wang, L.2    Ponten, M.3    Blomstrand, E.4    Sahlin, K.5
  • 78
    • 0019186535 scopus 로고
    • Interference of strength development by simultaneously training for strength and endurance
    • Hickson R.C. Interference of strength development by simultaneously training for strength and endurance. Eur J Appl Physiol Occup Physiol 1980, 45:255-263.
    • (1980) Eur J Appl Physiol Occup Physiol , vol.45 , pp. 255-263
    • Hickson, R.C.1
  • 79
    • 0028914150 scopus 로고
    • Compatibility of high-intensity strength and endurance training on hormonal and skeletal muscle adaptations
    • Kraemer W.J., Patton J.F., Gordon S.E., Harman E.A., Deschenes M.R., Reynolds K., et al. Compatibility of high-intensity strength and endurance training on hormonal and skeletal muscle adaptations. J Appl Physiol (1985) 1995, 78:976-989.
    • (1995) J Appl Physiol (1985) , vol.78 , pp. 976-989
    • Kraemer, W.J.1    Patton, J.F.2    Gordon, S.E.3    Harman, E.A.4    Deschenes, M.R.5    Reynolds, K.6
  • 81
    • 0018144643 scopus 로고
    • Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning
    • Ehsani A.A., Hagberg J.M., Hickson R.C. Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning. Am J Cardiol 1978, 42:52-56.
    • (1978) Am J Cardiol , vol.42 , pp. 52-56
    • Ehsani, A.A.1    Hagberg, J.M.2    Hickson, R.C.3
  • 84
    • 0030422815 scopus 로고    scopus 로고
    • Athlete's heart: a meta-analysis of the echocardiographic experience
    • Fagard R.H. Athlete's heart: a meta-analysis of the echocardiographic experience. Int J Sports Med 1996, 17(Suppl. 3):S140-S144.
    • (1996) Int J Sports Med , vol.17 , pp. S140-S144
    • Fagard, R.H.1
  • 85
    • 0142027759 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    • McMullen J.R., Shioi T., Zhang L., Tarnavski O., Sherwood M.C., Kang P.M., et al. Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci U S A 2003, 100:12355-12360.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12355-12360
    • McMullen, J.R.1    Shioi, T.2    Zhang, L.3    Tarnavski, O.4    Sherwood, M.C.5    Kang, P.M.6
  • 88
    • 0035827723 scopus 로고    scopus 로고
    • Integrins and the myocardium
    • Ross R.S., Borg T.K. Integrins and the myocardium. Circ Res 2001, 88:1112-1119.
    • (2001) Circ Res , vol.88 , pp. 1112-1119
    • Ross, R.S.1    Borg, T.K.2
  • 89
    • 71149097258 scopus 로고    scopus 로고
    • The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions
    • Fukuda K., Gupta S., Chen K., Wu C., Qin J. The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell 2009, 36:819-830.
    • (2009) Mol Cell , vol.36 , pp. 819-830
    • Fukuda, K.1    Gupta, S.2    Chen, K.3    Wu, C.4    Qin, J.5
  • 90
    • 84880558437 scopus 로고    scopus 로고
    • ILK: a pseudokinase with a unique function in the integrin-actin linkage
    • Ghatak S., Morgner J., Wickstrom S.A. ILK: a pseudokinase with a unique function in the integrin-actin linkage. Biochem Soc Trans 2013, 41:995-1001.
    • (2013) Biochem Soc Trans , vol.41 , pp. 995-1001
    • Ghatak, S.1    Morgner, J.2    Wickstrom, S.A.3
  • 91
    • 0037236642 scopus 로고    scopus 로고
    • Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
    • Brancaccio M., Fratta L., Notte A., Hirsch E., Poulet R., Guazzone S., et al. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 2003, 9:68-75.
    • (2003) Nat Med , vol.9 , pp. 68-75
    • Brancaccio, M.1    Fratta, L.2    Notte, A.3    Hirsch, E.4    Poulet, R.5    Guazzone, S.6
  • 92
    • 40949083412 scopus 로고    scopus 로고
    • Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
    • McDonald P.C., Oloumi A., Mills J., Dobreva I., Maidan M., Gray V., et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008, 68:1618-1624.
    • (2008) Cancer Res , vol.68 , pp. 1618-1624
    • McDonald, P.C.1    Oloumi, A.2    Mills, J.3    Dobreva, I.4    Maidan, M.5    Gray, V.6
  • 93
    • 20344399430 scopus 로고    scopus 로고
    • Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload
    • De Acetis M., Notte A., Accornero F., Selvetella G., Brancaccio M., Vecchione C., et al. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 2005, 96:1087-1094.
    • (2005) Circ Res , vol.96 , pp. 1087-1094
    • De Acetis, M.1    Notte, A.2    Accornero, F.3    Selvetella, G.4    Brancaccio, M.5    Vecchione, C.6
  • 94
    • 0035108354 scopus 로고    scopus 로고
    • Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance
    • Keller R.S., Shai S.Y., Babbitt C.J., Pham C.G., Solaro R.J., Valencik M.L., et al. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol 2001, 158:1079-1090.
    • (2001) Am J Pathol , vol.158 , pp. 1079-1090
    • Keller, R.S.1    Shai, S.Y.2    Babbitt, C.J.3    Pham, C.G.4    Solaro, R.J.5    Valencik, M.L.6
  • 95
    • 0036695847 scopus 로고    scopus 로고
    • A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes
    • Valencik M.L., Keller R.S., Loftus J.C., McDonald J.A. A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes. J Card Fail 2002, 8:262-272.
    • (2002) J Card Fail , vol.8 , pp. 262-272
    • Valencik, M.L.1    Keller, R.S.2    Loftus, J.C.3    McDonald, J.A.4
  • 96
    • 33748250034 scopus 로고    scopus 로고
    • Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart
    • Bendig G., Grimmler M., Huttner I.G., Wessels G., Dahme T., Just S., et al. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev 2006, 20:2361-2372.
    • (2006) Genes Dev , vol.20 , pp. 2361-2372
    • Bendig, G.1    Grimmler, M.2    Huttner, I.G.3    Wessels, G.4    Dahme, T.5    Just, S.6
  • 97
    • 0035875975 scopus 로고    scopus 로고
    • Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts
    • Shen T.L., Guan J.L. Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett 2001, 499:176-181.
    • (2001) FEBS Lett , vol.499 , pp. 176-181
    • Shen, T.L.1    Guan, J.L.2
  • 98
    • 58149092317 scopus 로고    scopus 로고
    • Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection
    • Del Re D.P., Miyamoto S., Brown J.H. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem 2008, 283:35622-35629.
    • (2008) J Biol Chem , vol.283 , pp. 35622-35629
    • Del Re, D.P.1    Miyamoto, S.2    Brown, J.H.3
  • 99
    • 0034533580 scopus 로고    scopus 로고
    • Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway
    • Pham C.G., Harpf A.E., Keller R.S., Vu H.T., Shai S.Y., Loftus J.C., et al. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am J Physiol Heart Circ Physiol 2000, 279:H2916-H2926.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279 , pp. H2916-H2926
    • Pham, C.G.1    Harpf, A.E.2    Keller, R.S.3    Vu, H.T.4    Shai, S.Y.5    Loftus, J.C.6
  • 100
    • 0034383952 scopus 로고    scopus 로고
    • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    • Bueno O.F., De Windt L.J., Tymitz K.M., Witt S.A., Kimball T.R., Klevitsky R., et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 2000, 19:6341-6350.
    • (2000) EMBO J , vol.19 , pp. 6341-6350
    • Bueno, O.F.1    De Windt, L.J.2    Tymitz, K.M.3    Witt, S.A.4    Kimball, T.R.5    Klevitsky, R.6
  • 101
    • 10744223902 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110alpha) pathway
    • McMullen J.R., Shioi T., Huang W.Y., Zhang L., Tarnavski O., Bisping E., et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110alpha) pathway. J Biol Chem 2004, 279:4782-4793.
    • (2004) J Biol Chem , vol.279 , pp. 4782-4793
    • McMullen, J.R.1    Shioi, T.2    Huang, W.Y.3    Zhang, L.4    Tarnavski, O.5    Bisping, E.6
  • 102
    • 28844477847 scopus 로고    scopus 로고
    • Effect of training on GH and IGF-1 responses to a submaximal exercise in football players
    • Mejri S., Bchir F., Ben Rayana M.C., Ben Hamida J., Ben Slama C. Effect of training on GH and IGF-1 responses to a submaximal exercise in football players. Eur J Appl Physiol 2005, 95:496-503.
    • (2005) Eur J Appl Physiol , vol.95 , pp. 496-503
    • Mejri, S.1    Bchir, F.2    Ben Rayana, M.C.3    Ben Hamida, J.4    Ben Slama, C.5
  • 103
    • 0029040848 scopus 로고
    • Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice
    • Coleman M.E., DeMayo F., Yin K.C., Lee H.M., Geske R., Montgomery C., et al. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 1995, 270:12109-12116.
    • (1995) J Biol Chem , vol.270 , pp. 12109-12116
    • Coleman, M.E.1    DeMayo, F.2    Yin, K.C.3    Lee, H.M.4    Geske, R.5    Montgomery, C.6
  • 105
    • 37349085478 scopus 로고    scopus 로고
    • Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
    • Kemi O.J., Ceci M., Wisloff U., Grimaldi S., Gallo P., Smith G.L., et al. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol 2008, 214:316-321.
    • (2008) J Cell Physiol , vol.214 , pp. 316-321
    • Kemi, O.J.1    Ceci, M.2    Wisloff, U.3    Grimaldi, S.4    Gallo, P.5    Smith, G.L.6
  • 106
    • 0038133269 scopus 로고    scopus 로고
    • Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
    • Brown J., Cooper-Kuhn C.M., Kempermann G., Van Praag H., Winkler J., Gage F.H., et al. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 2003, 17:2042-2046.
    • (2003) Eur J Neurosci , vol.17 , pp. 2042-2046
    • Brown, J.1    Cooper-Kuhn, C.M.2    Kempermann, G.3    Van Praag, H.4    Winkler, J.5    Gage, F.H.6
  • 107
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999, 2:266-270.
    • (1999) Nat Neurosci , vol.2 , pp. 266-270
    • van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 109
    • 77957342026 scopus 로고    scopus 로고
    • A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children
    • Chaddock L., Erickson K.I., Prakash R.S., Kim J.S., Voss M.W., Vanpatter M., et al. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res 2010, 1358:172-183.
    • (2010) Brain Res , vol.1358 , pp. 172-183
    • Chaddock, L.1    Erickson, K.I.2    Prakash, R.S.3    Kim, J.S.4    Voss, M.W.5    Vanpatter, M.6
  • 112
    • 0010330438 scopus 로고    scopus 로고
    • Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
    • Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C.W. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996, 726:49-56.
    • (1996) Brain Res , vol.726 , pp. 49-56
    • Neeper, S.A.1    Gomez-Pinilla, F.2    Choi, J.3    Cotman, C.W.4
  • 114
    • 80053053528 scopus 로고    scopus 로고
    • Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
    • Griffin E.W., Mullally S., Foley C., Warmington S.A., O'Mara S.M., Kelly A.M. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011, 104:934-941.
    • (2011) Physiol Behav , vol.104 , pp. 934-941
    • Griffin, E.W.1    Mullally, S.2    Foley, C.3    Warmington, S.A.4    O'Mara, S.M.5    Kelly, A.M.6
  • 115
    • 84893021363 scopus 로고    scopus 로고
    • BDNF mediates adaptive brain and body responses to energetic challenges
    • Marosi K., Mattson M.P. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 2014, 25:89-98.
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 89-98
    • Marosi, K.1    Mattson, M.P.2
  • 116
    • 84880611557 scopus 로고    scopus 로고
    • Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats
    • Fang Z.H., Lee C.H., Seo M.K., Cho H., Lee J.G., Lee B.J., et al. Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats. Neurosci Res 2013, 76:187-194.
    • (2013) Neurosci Res , vol.76 , pp. 187-194
    • Fang, Z.H.1    Lee, C.H.2    Seo, M.K.3    Cho, H.4    Lee, J.G.5    Lee, B.J.6
  • 117
    • 18044394417 scopus 로고    scopus 로고
    • Exercise activates the phosphatidylinositol 3-kinase pathway
    • Chen M.J., Russo-Neustadt A.A. Exercise activates the phosphatidylinositol 3-kinase pathway. Brain Res Mol Brain Res 2005, 135:181-193.
    • (2005) Brain Res Mol Brain Res , vol.135 , pp. 181-193
    • Chen, M.J.1    Russo-Neustadt, A.A.2
  • 118
    • 7744224557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    • Takei N., Inamura N., Kawamura M., Namba H., Hara K., Yonezawa K., et al. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci 2004, 24:9760-9769.
    • (2004) J Neurosci , vol.24 , pp. 9760-9769
    • Takei, N.1    Inamura, N.2    Kawamura, M.3    Namba, H.4    Hara, K.5    Yonezawa, K.6
  • 119
    • 79952763934 scopus 로고    scopus 로고
    • Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
    • Stoica L., Zhu P.J., Huang W., Zhou H., Kozma S.C., Costa-Mattioli M. Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc Natl Acad Sci U S A 2011, 108:3791-3796.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3791-3796
    • Stoica, L.1    Zhu, P.J.2    Huang, W.3    Zhou, H.4    Kozma, S.C.5    Costa-Mattioli, M.6
  • 120
    • 84897401536 scopus 로고    scopus 로고
    • Treadmill exercise improves behavioral outcomes and spatial learning memory through up-regulation of reelin signaling pathway in autistic rats
    • Seo T.B., Cho H.S., Shin M.S., Kim C.J., Ji E.S., Baek S.S. Treadmill exercise improves behavioral outcomes and spatial learning memory through up-regulation of reelin signaling pathway in autistic rats. J Exerc Rehabil 2013, 9:220-229.
    • (2013) J Exerc Rehabil , vol.9 , pp. 220-229
    • Seo, T.B.1    Cho, H.S.2    Shin, M.S.3    Kim, C.J.4    Ji, E.S.5    Baek, S.S.6
  • 121
    • 35148880174 scopus 로고    scopus 로고
    • Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth
    • Jossin Y., Goffinet A.M. Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Mol Cell Biol 2007, 27:7113-7124.
    • (2007) Mol Cell Biol , vol.27 , pp. 7113-7124
    • Jossin, Y.1    Goffinet, A.M.2
  • 122
    • 85029464381 scopus 로고    scopus 로고
    • Reelin and regular exercise in the brain cortex of healthy adult rats
    • Hesari F., Sale E. Reelin and regular exercise in the brain cortex of healthy adult rats. J Anim Sci Adv 2013, (3):569-574.
    • (2013) J Anim Sci Adv , Issue.3 , pp. 569-574
    • Hesari, F.1    Sale, E.2
  • 124
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M., Sabatini D.M. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009, 19:R1046-R1052.
    • (2009) Curr Biol , vol.19 , pp. R1046-R1052
    • Laplante, M.1    Sabatini, D.M.2
  • 125
    • 17444415304 scopus 로고    scopus 로고
    • Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside
    • Reiter A.K., Bolster D.R., Crozier S.J., Kimball S.R., Jefferson L.S. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab 2005, 288:E980-E988.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E980-E988
    • Reiter, A.K.1    Bolster, D.R.2    Crozier, S.J.3    Kimball, S.R.4    Jefferson, L.S.5


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