Epigenetic mechanisms of depression

JAMA Psychiatry

Volumn 71, Issue 4, 2014, Pages 454-456

  Nestler, Eric J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA METHYLTRANSFERASE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE;

CHROMATIN STRUCTURE; DEPRESSION; DNA METHYLATION; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; INHERITANCE; INTRACELLULAR SIGNALING; LIFE EVENT; LIFE STRESS; NONHUMAN; NUCLEOSOME; PROTEIN PROCESSING; REVIEW; SOCIAL STRESS; SYNAPTIC TRANSMISSION;

ANIMALS; AROUSAL; BRAIN; DEPRESSIVE DISORDER; EPIGENESIS, GENETIC; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; RESILIENCE, PSYCHOLOGICAL; RISK FACTORS; STRESS, PSYCHOLOGICAL;

EID: 84898645098     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2013.4291     Document Type: Review

References (10)

1. Vialou V, Feng J, Robison AJ, Nestler EJ. Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol. 2013; 53: 59-87.
2. Covington HE III, Maze I, LaPlant QC, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009; 29 (37): 11451-11460.
3. Covington HE III, Maze I, Sun H, et al. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. 2011; 71 (4): 656-670.
4. Hunter RG, McCarthy KJ, Milne TA, Pfaff DW, McEwen BS. Regulation of hippocampal H3 histone methylation by acute and chronic stress. Proc Natl Acad Sci U S A. 2009; 106 (49): 20912-20917.
5. Tsankova NM, Berton O, RenthalW, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006; 9 (4): 519-525.
6. Wilkinson MB, Xiao GH, Kumar A, et al. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci. 2009; 29 (24): 7820-7832.
7. Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004; 7 (8): 847-854.
8. Jiang Y, Jakovcevski M, Bharadwaj R, et al. Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci. 2010; 30 (21): 7152-7167.
9. Franklin TB, Russig H, Weiss IC, et al. Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry. 2010; 68 (5): 408-415.
10. Dietz DM, Laplant Q, Watts EL, et al. Paternal transmission of stress-induced pathologies. Biol Psychiatry. 2011; 70 (5): 408-414.