Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

Biological Psychiatry

Volumn 69, Issue 8, 2011, Pages 754-761

  Li, Nanxin ^a   Liu, Rong Jian ^a   Dwyer, Jason M ^a   Banasr, Mounira ^a   Lee, Boyoung ^b   Son, Hyeon ^c   Li, Xiao Yuan ^a   Aghajanian, George ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Korea Institute of Science and Technology   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Antidepressant; depression; ketamine; rapamycin; spines; synaptogenesis

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; CELL PROTEIN; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BONE DENSITY; BRAIN REGION; CHRONIC STRESS; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENVIRONMENTAL EXPOSURE; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMUNOBLOTTING; MALE; NEUROCHEMISTRY; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PYRAMIDAL NERVE CELL; RAT; SYNAPSE; SYNAPTOGENESIS;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CHOICE BEHAVIOR; DENDRITIC SPINES; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; KETAMINE; NEURONS; PHENOLS; PIPERIDINES; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SIROLIMUS; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 79953166373     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.12.015     Document Type: Article

References (48)

1. R.C. Kessler, P. Berglund, O. Demler, R. Jin, D. Koretz, and K.R. Merikangas The epidemiology of major depressive disorder: Results from the national comorbidity Survey Replication (NCS-R) JAMA 289 2003 3095 3105 (Pubitemid 37432885)
2. M.H. Trivedi, A.J. Rush, S.R. Wisniewski, A.A. Nierenberg, D. Warden, and L. Ritz Evaluation of outcomes with citalopram for depression using measurement-based care in STAR (*)D: Implications for clinical practice Am J Psychiatry 163 2006 28 40 (Pubitemid 43050100)
3. R.M. Berman, A. Cappiello, A. Anand, D.A. Oren, G.R. Heninger, D.S. Charney, and J.H. Krystal Antidepressant effects of ketamine in depressed patients Biol Psychiatry 47 2000 351 354 (Pubitemid 30109248)
4. C.A. Zarate Jr, J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, and D.A. Luckenbaugh A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression Arch Gen Psychiatry 63 2006 856 864 (Pubitemid 44188478)
5. M. Liebrenz, A. Borgeat, R. Leisinger, and R. Stohler Intravenous ketamine therapy in a patient with a treatment-resistant major depression Swiss Med Wkly 137 2007 234 236 (Pubitemid 46814243)
6. A. Yilmaz, D. Schulz, A. Aksoy, and R. Canbeyli Prolonged effect of an anesthetic dose of ketamine on behavioral despair Pharmacol Biochem Behav 71 2002 341 344
7. S. Maeng, C.A. Zarate Jr, J. Du, R.J. Schloesser, J. McCammon, G. Chen, and H.K. Manji Cellular mechanisms underlying the antidepressant effects of ketamine: Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors Biol Psychiatry 63 2008 349 352 (Pubitemid 351146651)
8. L.S. Garcia, C.M. Comim, S.S. Valvassori, G.Z. Reus, L.M. Barbosa, and A.C. Andreazza Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus Prog Neuropsychopharmacol Biol Psychiatry 32 2008 140 144
9. P. Popik, T. Kos, M. Sowa-Kucma, and G. Nowak Lack of persistent effects of ketamine in rodent models of depression Psychopharmacology (Berl) 198 2008 421 430
10. E. Engin, D. Treit, and C.T. Dickson Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models Neuroscience 161 2009 359 369
11. H.D. Schmidt, and R.S. Duman The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior Behav Pharmacol 18 2007 391 418 (Pubitemid 47356367)
12. P. Willner Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS Neuropsychobiology 52 2005 90 110 (Pubitemid 41160326)
13. R.J. Liu, and G.K. Aghajanian Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy Proc Natl Acad Sci U S A 105 2008 359 364
14. G. Rajkowska, J.J. Miguel-Hidalgo, J. Wei, G. Dilley, S.D. Pittman, and H.Y. Meltzer Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression Biol Psychiatry 45 1999 1085 1098 (Pubitemid 29236550)
15. C. Liston, M.M. Miller, D.S. Goldwater, J.J. Radley, A.B. Rocher, and P.R. Hof Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting J Neurosci 26 2006 7870 7874 (Pubitemid 44315156)
16. J.J. Radley, A.B. Rocher, W.G. Janssen, P.R. Hof, B.S. McEwen, and J.H. Morrison Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress Exp Neurol 196 2005 199 203 (Pubitemid 41416662)
17. J.J. Radley, and J.H. Morrison Repeated stress and structural plasticity in the brain Ageing Res Rev 4 2005 271 287 (Pubitemid 41111982)
18. J.J. Radley, A.B. Rocher, M. Miller, W.G. Janssen, C. Liston, and P.R. Hof Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex Cereb Cortex 16 2006 313 320 (Pubitemid 43209205)
19. D.S. Goldwater, C. Pavlides, R.G. Hunter, E.B. Bloss, P.R. Hof, B.S. McEwen, and J.H. Morrison Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery Neuroscience 164 2009 798 808
20. J.J. Radley, A.B. Rocher, A. Rodriguez, D.B. Ehlenberger, M. Dammann, and B.S. McEwen Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex J Comp Neurol 507 2008 1141 1150 (Pubitemid 351214235)
21. Y.I. Sheline, P.W. Wang, M.H. Gado, J.G. Csernansky, and M.W. Vannier Hippocampal atrophy in recurrent major depression Proc Natl Acad Sci U S A 93 1996 3908 3913 (Pubitemid 26144221)
22. P. Videbech, and B. Ravnkilde Hippocampal volume and depression: A meta-analysis of MRI studies Am J Psychiatry 161 2004 1957 1966 (Pubitemid 39441394)
23. J.D. Bremner, M. Vythilingam, E. Vermetten, A. Nazeer, J. Adil, and S. Khan Reduced volume of orbitofrontal cortex in major depression Biol Psychiatry 51 2002 273 279 (Pubitemid 34214992)
24. W.C. Drevets, J.L. Price, J.R. Simpson Jr, R.D. Todd, T. Reich, M. Vannier, and M.E. Raichle Subgenual prefrontal cortex abnormalities in mood disorders Nature 386 1997 824 827 (Pubitemid 27181254)
25. N. Li, B. Lee, R.J. Liu, M. Banasr, J.M. Dwyer, and M. Iwata mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists Science 329 2010 959 964
26. C.A. Hoeffer, and E. Klann mTOR signaling: At the crossroads of plasticity, memory and disease Trends Neurosci 33 2010 67 75
27. M. Banasr, G.W. Valentine, X.Y. Li, S.L. Gourley, J.R. Taylor, and R.S. Duman Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat Biol Psychiatry 62 2007 496 504 (Pubitemid 47284039)
28. M. Banasr, and R.S. Duman Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors Biol Psychiatry 64 2008 863 870
29. D. Cota, K. Proulx, K.A. Smith, S.C. Kozma, G. Thomas, S.C. Woods, and R.J. Seeley Hypothalamic mTOR signaling regulates food intake Science 312 2006 927 930 (Pubitemid 43727328)
30. P. Willner Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation Psychopharmacology (Berl) 134 1997 319 329 (Pubitemid 28023396)
31. J.L. Warner-Schmidt, and R.S. Duman VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants Proc Natl Acad Sci U S A 104 2007 4647 4652 (Pubitemid 47186279)
32. M. Joels, H. Karst, D. Alfarez, V.M. Heine, Y. Qin, and E. van Riel Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus Stress 7 2004 221 231 (Pubitemid 40591422)
33. R. Machado-Vieira, G. Salvadore, L.A. Ibrahim, N. Diaz-Granados, and C.A. Zarate Jr Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders Curr Pharm Des 15 2009 1595 1611
34. S.H. Preskorn, B. Baker, S. Kolluri, F.S. Menniti, M. Krams, and J.W. Landen An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-d-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder J Clin Psychopharmacol 28 2008 631 637
35. C.A. Zarate Jr, J.B. Singh, J.A. Quiroz, G. De Jesus, K.K. Denicoff, and D.A. Luckenbaugh A double-blind, placebo-controlled study of memantine in the treatment of major depression Am J Psychiatry 163 2006 153 155 (Pubitemid 43050119)
36. J.H. Krystal Ketamine and the potential role for rapid-acting antidepressant medications Swiss Med Wkly 137 2007 215 216 (Pubitemid 46814239)
37. M. Banasr, G.M. Chowdhury, R. Terwilliger, S.S. Newton, R.S. Duman, K.L. Behar, and G. Sanacora Glial pathology in an animal model of depression: Reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole Mol Psychiatry 15 2008 501 511
38. L.S. Garcia, C.M. Comim, S.S. Valvassori, G.Z. Reus, L. Stertz, and F. Kapczinski Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats Prog Neuropsychopharmacol Biol Psychiatry 33 2009 450 455
39. C. Cleary, J.A. Linde, K.M. Hiscock, I. Hadas, R.H. Belmaker, and G. Agam Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders Brain Res Bull 76 2008 469 473
40. P.C. Yang, C.H. Yang, C.C. Huang, and K.S. Hsu Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity J Biol Chem 283 2008 2631 2643
41. S.L. Gourley, F.J. Wu, and J.R. Taylor Corticosterone regulates pERK1/2 map kinase in a chronic depression model Ann N Y Acad Sci 1148 2008 509 514
42. S.L. Gourley, F.J. Wu, D.D. Kiraly, J.E. Ploski, A.T. Kedves, R.S. Duman, and J.R. Taylor Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression Biol Psychiatry 63 2008 353 359
43. X. Qi, W. Lin, J. Li, H. Li, W. Wang, D. Wang, and M. Sun Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress Neurobiol Dis 31 2008 278 285
44. X. Qi, W. Lin, J. Li, Y. Pan, and W. Wang The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress Behav Brain Res 175 2006 233 240 (Pubitemid 44750226)
45. A. Polter, E. Beurel, S. Yang, R. Garner, L. Song, and C.A. Miller Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Neuropsychopharmacology 35 2010 1761 1774
46. A. Soetanto, R.S. Wilson, K. Talbot, A. Un, J.A. Schneider, and M. Sobiesk Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans Arch Gen Psychiatry 67 2010 448 457
47. E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25 (Pubitemid 34270695)
48. R.S. Duman Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: Stress and depression Dialogues Clin Neurosci 11 2009 239 255