GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

eLife

Volumn 2014, Issue 3, 2014, Pages

  Miller, Oliver H ^a   Yang, Lingling ^b   Wang, Chih Chieh ^a   Hargroder, Elizabeth A ^a   Zhang, Yihui ^b   Delpire, Eric ^c   Hall, Benjamin J ^a,b,d  

^a TULANE UNIVERSITY   (United States)

^b Tulane University   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IFENPRODIL; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RHEB PROTEIN; ANTIDEPRESSANT AGENT; GLUTAMIC ACID; NR2B NMDA RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DEPRESSION; EXCITATORY POSTSYNAPTIC POTENTIAL; FORCED SWIM TEST; GLUN2B SUBUNIT; LOCOMOTION; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TAIL SUSPENSION TEST; WESTERN BLOTTING; ANIMAL; BRAIN CORTEX; DRUG EFFECTS; GENE INACTIVATION; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; SYNAPSE;

MUS;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; DEPRESSION; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE KNOCKOUT TECHNIQUES; GLUTAMIC ACID; KETAMINE; MICE, KNOCKOUT; NEURONS; PREFRONTAL CORTEX; PROTEIN BIOSYNTHESIS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84920270347     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.03581     Document Type: Article

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