SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway

International Journal of Neuropsychopharmacology

Volumn 18, Issue 6, 2015, Pages 1-13

  Jiang, Bo ^a   Wang, Fang ^a,b,c,d   Yang, Si ^a   Fang, Peng ^a   Deng, Zhi Fang ^a   Xiao, Jun Li ^a   Hu, Zhuang Li ^b,c   Chen, Jian Guo ^a,b,c,d  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Brain derived neurotrophic factor; Chronic social defeat stress; Depression; SKF83959

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; DOPAMINE 5 RECEPTOR; FLUOXETINE; INOSITOL PHOSPHATE; INOSITOL PHOSPHATE 3; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHINS 4; PHOSPHOLIPASE C; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ANTIDEPRESSANT AGENT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CAMK2A PROTEIN, MOUSE; DOPAMINE RECEPTOR STIMULATING AGENT; INOSITOL 1,4,5 TRISPHOSPHATE; MEMBRANE PROTEIN; NTRK2 PROTEIN, MOUSE; PROTEIN TYROSINE KINASE; SK&F 83959;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DENDRITIC SPINE; DENTATE GYRUS; DEPRESSION; DRUG MECHANISM; FORCED SWIM TEST; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; SOCIAL INTERACTION TEST; SUCROSE PREFERENCE TEST; TAIL SUSPENSION TEST; TRANSIENT EXPRESSION; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CHRONIC DISEASE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; HIPPOCAMPUS; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGY; RNA INTERFERENCE; SOCIAL BEHAVIOR;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CHRONIC DISEASE; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HIPPOCAMPUS; INOSITOL 1,4,5-TRISPHOSPHATE; MALE; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; PROTEIN-TYROSINE KINASES; RECEPTORS, DOPAMINE D5; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; STRESS, PSYCHOLOGICAL; TYPE C PHOSPHOLIPASES;

EID: 84939128522     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyu096     Document Type: Article

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