Cognitive and neuroprotective effects of chlorogenic acid

Nutritional Neuroscience

Volumn 20, Issue 1, 2017, Pages 32-39

  Heitman, Erin ^a   Ingram, Donald K ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Alzheimer's disease; Antioxidant; Chlorogenic acid; Cognition; Memory; Neurodegeneration; Neuroprotection; Parkinson's disease

Indexed keywords

ANTIOXIDANT; ANXIOLYTIC AGENT; GLUTAMIC ACID; GLUTATHIONE; NEOCHLOROGENIC ACID; POLYPHENOL; CHLOROGENIC ACID; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; CHEMICAL STRESS; CHRONOPHARMACOKINETICS; COGNITION; DEPRESSED BLOOD PRESSURE; FOOD INTAKE; HEART PROTECTION; HUMAN; HYPERALGESIA; INSULIN RESISTANCE; LIPID PEROXIDATION; MEMORY; NERVE CELL CULTURE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NUTRITION; OXIDATIVE STRESS; PARKINSON DISEASE; PRECLINICAL STUDY; PRIORITY JOURNAL; RETINA GANGLION CELL; REVIEW; SENSORIMOTOR FUNCTION; WEIGHT REDUCTION; ANIMAL; COGNITIVE DYSFUNCTION; DIETARY SUPPLEMENT; NEURODEGENERATIVE DISEASES; NEUROTOXICITY SYNDROMES;

ANIMALS; ANTIOXIDANTS; CHLOROGENIC ACID; COGNITION; COGNITIVE DYSFUNCTION; DIETARY SUPPLEMENTS; HUMANS; NEURODEGENERATIVE DISEASES; NEUROPROTECTION; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; NOOTROPIC AGENTS; OXIDATIVE STRESS;

EID: 84978512172     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830514Y.0000000146     Document Type: Review

References (65)

1. Clifford MN. Chlorogenic acids and other cinnamates–nature, occurrence and dietary burden. J Sci Food Agric 1999;79:362–72. doi:10.1002/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D
2. Ito H, Sun XL, Watanabe M, Okamoto M, Hatano T. Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells. Biosci Biotechnol Biochem 2008;72:885–8. doi:10.1271/bbb.70670
3. ®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytothérapie 2006;4:1–4. doi:10.1007/s10298-006-0181-7
4. Vinson JA, Burnham Br, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2012;5:21–7. doi:10.2147/DMSO.S27665
5. Cropley V, Croft R, Silber B, Neale C, Scholey A, Stough C, et al. Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study. Psychopharm 2012;219:737–49. doi:10.1007/s00213-011-2395-0
6. Han J, Miyamae Y, Shigemori H, Isoda H. Neuroprotective effect of 3,5-di-o-caffeoylquinic acid on SH-SY5Y cells and senescense-accelerated-prone mice 8 through the up-regulation of phosphoglycertate kinase 1. Neuroscience 2010;169:1039–45. doi:10.1016/j.neuroscience.2010.05.049
7. Kwon SH, Lee HK, Kim JA, Hone SI, Kim HC, Jo TH, et al. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol 2010;649:210–7. doi:10.1016/j.ejphar.2010.09.001
8. Mubarak A, Bondonno CP, Liu AH, Considine MJ, Rich L, Mas E, et al. Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers:a randomized trial. J Agric Food Chem 2012;60:9130–6. doi:10.1021/jf303440j
9. Namba T, Matsuse T. A historical study of coffee in Japanese and Asian countries:focusing the medicinal uses in Asian traditional medicines. J Jpn Hist Pharm 2002;37:65–75.
10. Belkaid A, Currie JC, Desgagnés J, Annabi B. The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Cancer Res Int 2006;6:7.
11. Tanaka T, Kojima T, Kawamori T, Wang A, Suzui M, Okamoto K, et al. Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis 1993;14:1321–5. doi:10.1093/carcin/14.7.1321
12. Xu R, Kang Q, Ren J, Li Z, Xu X. Antitumor molecular mechanism of chlorogenic acid on inducting genes GSK-3β and APC and inhibiting gene β-catenin. J Anal Methods Chem 2013;2013:1–7.
13. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 1999;59:2347–52.
14. Ho L, Verghese M, Wang J, Zhao W, Chen F, Knable LA, et al. Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutr Neurosci 2012;15:37–45. doi:10.1179/1476830511Y.0000000027
15. Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R. Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 2007;262:77–84. doi:10.1016/j.jns.2007.06.028
16. Bagdas D, Cinklic N, Ozboluk HY, Ozyigit MO, Gurun MS. Antihyperalgesic activity of chlorogenic acid and in experimental neuropathic pain. J Nat Med 2013;67:698–704. doi:10.1007/s11418-012-0726-z
17. Bai X, Zhang H, Ren S. Antioxidant activity and HPLC analysis of polyphenol-enriched extracts from industrial apple pomace. J Sci Food Agric 2013;93(10):2502–6. doi:10.1002/jsfa.6066
18. Jakobek L, Šeruga M, Voća S, Šindrak Z, Dobričević N. Flavonol and phenolic acid composition of sweet cherries (cv. Lapins) produced on six different vegetative rootstocks. Sci Hortic 2009;123:23–8. doi:10.1016/j.scienta.2009.07.012
19. Kim DO, Heo HJ, Kim YJ, Yang HS, Lee CY. Sweet and sour cherry phenolics and their protective effects on neuronal cells. J Agric Food Chem 2005;53:9921–7. doi:10.1021/jf0518599
20. Kim DO, Jeong SW, Lee CY. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem 2003;81:321–6. doi:10.1016/S0308-8146(02)00423-5
21. Jakobek L, Seruga M. Influence of anthocyanins, flavonols and phenolic acids on the antiradical activity of berries and small fruits. Int J Food Prop 2012;15:122–33. doi:10.1080/10942911003754684
22. Erdogan S, Erdemoglu S. Evaluation of polyphenol contents in differently processed apricots using accelerated solvent extraction followed by high-performance liquid chromatography–diode array detector. Int J Food Sci Nutr 2011;62(7):729–39. doi:10.3109/09637486.2011.573469
23. Davies JN, Graeme EH. The constituents of tomato fruit the influence of environment, nutrition, and genotype. Crit Rev Food Sci Nutr 1981;15:205–80. doi:10.1080/10408398109527317
24. Slimestad R, Verheul MJ. Content of chalconaringenin and chlorogenic acid in cherry tomatoes is strongly reduced during postharvest ripening. J Agric Food Chem 2005;53(18):7251–6. doi:10.1021/jf050737d
25. Im HW, Suh BS, Lee SU, Kozukue N, Ohnisi-Kameyama M, Levin CE, et al. Analysis of phenolic compounds by high-performance liquid chromatography and liquid chromatography/mass spectrometry in potato plant flowers, leaves, stems, and tubers and in home-processed potatoes. J Agric Food Chem 2008;56(9):3341–9. doi:10.1021/jf073476b
26. Lachman J, Hamouz K, Musilová J, Hejtmánková K, Kotíková Z, Pazderů K, et al. Effect of peeling and three cooking methods on the content of selected phytochemicals in potato tubers with various colour of flesh. Food Chem 2013;318(2–3):1189–97. doi:10.1016/j.foodchem.2012.11.114
27. Veljkovic JN, Pavlovic AN, Mitic SS, Tosic SB, Stojanovic GS, Kalicanin BM, et al. Evaluation of individual phenolic compounds and antioxidant properties of black, green, herbal and fruit tea infusions consumed in Serbia:spectrophotometrical and electrochemical approaches. J Food Nutr Res 2013;52:12–24.
28. Wang Y, Ho CT. Polyphenolic chemistry of tea and coffee:a century of progress. J Agric Food Chem 2009;57(18):8109–14. doi:10.1021/jf804025c
29. Hoelzl C, Knasmüller S, Wagner KH, Elbling L, Huber W, Kager N, et al. Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. Mol Nutr Food Res 2010;54:1722–33. doi:10.1002/mnfr.201000048
30. Peŕez-Jimeńez J, Fezeu L, Touvier M, Arnault N, Manach C, Hercberg S, et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 2011;93:1220–8. doi:10.3945/ajcn.110.007096
31. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans:glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr 2003;78:728–33.
32. Schrader K, Kiehne A, Engelhardt UH, Maier HG. Determination of chlorogenic acids with lactones in roasted coffee. J Sci Food Agric 1999;71(3):392–8. doi:10.1002/(SICI)1097-0010(199607)71:3<392::AID-JSFA597>3.0.CO;2-X
33. Samanidou V, Tsagiannidis A, Sarakatsianos I. Simultaneous determination of polyphenols and major purine alkaloids in Greek Sideritis species, herbal extracts, green tea, black tea, and coffee by high-performance liquid chromatography-diode array detection. J Sep Sci 2012;35(4):608–15. doi:10.1002/jssc.201100894
34. Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357–66. doi:10.1002/ana.410380304
35. Huang FN, Zhang BL, Li WB, Cui X, Han ZT, Fang ZY. Effects of free radicals and amyloid beta protein on the currents of expressed rat receptors in Xenopus oocytes. Chin J Appl Physiol 2001;17:109–12.
36. Marksberry WR, Lovell MA. Damage to lipids, proteins, DNA and RNA in mild cognitive impairment. Arch Neurol 2007;64:954–6. doi:10.1001/archneur.64.7.954
37. Shen W, Qi R, Zhang J, Wang Z, Wang H, Hu C, et al. Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons. Brain Res Bull 2012;88:487–94. doi:10.1016/j.brainresbull.2012.04.010
38. Teraoka M, Nakaso K, Kusumoto C, Katano S, Tajima N, Yamashita A, et al. Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells. J Clin Biochem Nutr 2012;51:122–7. doi:10.3164/jcbn.D-11-00030
39. Chu YF, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, et al. Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem 2009;57:9801–8. doi:10.1021/jf902095z
40. Jang YJ, Kim J, Shim J, Kim CY, Jang JH, Lee KW, et al. Decaffeinated coffee prevents scopolamine-induced memory impairment in rats. Behav Brain Res 2013;245:113–9. doi:10.1016/j.bbr.2013.02.003
41. 2-induced apoptosis in primary cortical neurons. Neurochem Int 2012;60:466–74. doi:10.1016/j.neuint.2012.02.004
42. Nakajima Y, Shimazawa M, Mishima S, Hara H. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci 2007;80:370–7. doi:10.1016/j.lfs.2006.09.017
43. Cho ES, Jang YJ, Hwang MK, Kang NJ, Lee KW, Lee HJ. Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals. Mutat Res 2009;661:18–24. doi:10.1016/j.mrfmmm.2008.10.021
44. Oboh G, Agunloye OM, Akinyemi AJ, Ademiluyi AO, Adefegha SA. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer's disease and some pro-oxidant induced oxidative stress in rats' brain-in vitro. Neurochem Res 2013;38:413–9. doi:10.1007/s11064-012-0935-6
45. Arnold SE, Kumar A. Reversible dementias. Med Clin North Am 1993;77:215–30.
46. Orhan I, Sener B, Choudhary MI, Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol 2004;91:57–60. doi:10.1016/j.jep.2003.11.016
47. Mizuno Y, Hattori N, Kubo S, Sato S, Nishioka K, Hatano T, et al. Progress in the pathogenesis and genetics of Parkinson's disease. Philos Trans R Soc Lond B Biol Sci 2008;363:2215–27. doi:10.1098/rstb.2008.2273
48. Spillantini MG, Crowther RA, Jakes R, Masegawa M, Goedert M. α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 1998;95:6469–73. doi:10.1073/pnas.95.11.6469
49. Vardi N, Parlakpinar H, Ates B. Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats. J Chem Neuroanat 2012;43:43–7. doi:10.1016/j.jchemneu.2011.09.003
50. Yagi H, Katoh S, Akiguchi I, Takeda T. Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse:SAM-P/8 as an animal model of disturbances in recent memory. Brain Res 1988;474:86–93. doi:10.1016/0006-8993(88)90671-3
51. Ben-Barak J, Dudai Y. Scopolamine induces an increase in muscarinic receptor level in rat hippocampus. Brain Res 1980;193:309–13. doi:10.1016/0006-8993(80)90973-7
52. Fan Y, Hu J, Li J, Yang Z, Xin X, Wang J, et al. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett 2005;374:222–6. doi:10.1016/j.neulet.2004.10.063
53. Sakurai T, Kato T, Mori K, Takano E, Watabe S, Nabeshima T. Nefiracetam elevates extracellular acetylcholine level in the frontal cortex of rats with cerebral cholinergic dysfunctions:an in vivo microdialysis study. Neurosci Lett 1998;246:69–72. doi:10.1016/S0304-3940(98)00244-4
54. Beatty WW, Butters N, Janowsky DS. Patterns of memory failure after scopolamine treatment:implications for cholinergic hypotheses of dementia. Behav Neural Biol 1986;45:196–211. doi:10.1016/S0163-1047(86)90772-7
55. Kopelman MD, Corn TH. Cholinergic ‘blockade’ as a model for cholinergic depletion. A comparison of the memory deficits with those of Alzheimer-type dementia and the alcoholic Korsakoff syndrome. Brain 1988;111:1079–110. doi:10.1093/brain/111.5.1079
56. Tu Q, Tang X, Hu Z. Chlorogenic acid protection of neuronal nitric oxide synthase-positive neurons in the hippocampus of mice with impaired learning and memory. Neural Regen Res 2008;3(11):1218–21.
57. Böhme GA, Bon C, Lemaire M, Reibaud M, Piot O, Stutzmann JM, et al. Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc Natl Acad Sci USA 1993;90:9191–4. doi:10.1073/pnas.90.19.9191
58. Tu QY, Tang XQ, Liu ZQ. Effect of NOS positive neurons in rats with learning-remembering barrier. Bull Hunan Med Univ 2001;26:331–4.
59. Lee K, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, et al. Chlorogenic acid ameliorates brain damage and edema by inhibiting matrixmetalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. Eur J Pharm 2012;689:89–95. doi:10.1016/j.ejphar.2012.05.028
60. Hovatta L, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature 2005;438:662–6. doi:10.1038/nature04250
61. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243–55. doi:10.1016/S0278-6915(02)00096-0
62. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology 2005;179:813–25. doi:10.1007/s00213-004-2104-3
63. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007;35:900–8. doi:10.1177/147323000703500620
64. Gonthier MP, Verny MA, Besson C, Rémésy C, Scalbert A. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 2003;133:1853–9.
65. Gonthier MP, Remesy C, Scalbert A, Cheynier V, Souquet JM, Poutanen K, et al. Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro. Biomed Pharmacother 2006;60:536–40. doi:10.1016/j.biopha.2006.07.084