-
1
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64(6):1057-1068.
-
(1991)
Cell
, vol.64
, Issue.6
, pp. 1057-1068
-
-
Vu, T.K.1
Hung, D.T.2
Wheaton, V.I.3
Coughlin, S.R.4
-
2
-
-
0035952643
-
Protease activated receptors: Theme and variations
-
O'Brien PJ, Molino M, Kahn M, Brass LF. Protease activated receptors: theme and variations. Oncogene. 2001;20(13):1570-1581.
-
(2001)
Oncogene
, vol.20
, Issue.13
, pp. 1570-1581
-
-
O'Brien, P.J.1
Molino, M.2
Kahn, M.3
Brass, L.F.4
-
3
-
-
0030979972
-
Proteaseactivated receptor 3 is a second thrombin receptor in humans
-
Ishihara H, Connolly AJ, Zeng D, et al. Proteaseactivated receptor 3 is a second thrombin receptor in humans. Nature. 1997;386(6624):502-506.
-
(1997)
Nature
, vol.386
, Issue.6624
, pp. 502-506
-
-
Ishihara, H.1
Connolly, A.J.2
Zeng, D.3
-
4
-
-
0032514474
-
A dual thrombin receptor system for platelet activation
-
Kahn ML, Zheng YW, Huang W, et al. A dual thrombin receptor system for platelet activation. Nature. 1998;394(6694):690-694.
-
(1998)
Nature
, vol.394
, Issue.6694
, pp. 690-694
-
-
Kahn, M.L.1
Zheng, Y.W.2
Huang, W.3
-
5
-
-
0032499696
-
Cloning and characterization of human proteaseactivated receptor 4
-
Xu WF, Andersen H, Whitmore TE, et al. Cloning and characterization of human proteaseactivated receptor 4. Proc Natl Acad Sci USA. 1998;95(12):6642-6646.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.12
, pp. 6642-6646
-
-
Xu, W.F.1
Andersen, H.2
Whitmore, T.E.3
-
6
-
-
0029113121
-
Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
-
Nystedt S, Emilsson K, Larsson AK, Strömbeck B, Sundelin J. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem. 1995;232(1):84-89.
-
(1995)
Eur J Biochem.
, vol.232
, Issue.1
, pp. 84-89
-
-
Nystedt, S.1
Emilsson, K.2
Larsson, A.K.3
Strömbeck, B.4
Sundelin, J.5
-
8
-
-
84888178878
-
Cofactoring and dimerization of proteinase-activated receptors
-
Lin H, Liu AP, Smith TH, Trejo J. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013;65(4):1198-1213.
-
(2013)
Pharmacol Rev.
, vol.65
, Issue.4
, pp. 1198-1213
-
-
Lin, H.1
Liu, A.P.2
Smith, T.H.3
Trejo, J.4
-
9
-
-
84929377699
-
Activated protein C: Biased for translation
-
Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 2015;125(19):2898-2907.
-
(2015)
Blood
, vol.125
, Issue.19
, pp. 2898-2907
-
-
Griffin, J.H.1
Zlokovic, B.V.2
Mosnier, L.O.3
-
10
-
-
0028283850
-
Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface
-
Gerszten RE, Chen J, Ishii M, et al. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature. 1994;368(6472):648-651.
-
(1994)
Nature
, vol.368
, Issue.6472
, pp. 648-651
-
-
Gerszten, R.E.1
Chen, J.2
Ishii, M.3
-
11
-
-
0033613183
-
How the protease thrombin talks to cells
-
Coughlin SR. How the protease thrombin talks to cells. Proc Natl Acad Sci USA. 1999;96(20):11023-11027.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.20
, pp. 11023-11027
-
-
Coughlin, S.R.1
-
12
-
-
65949091143
-
Proteases display biased agonism at protease-activated receptors: Location matters!
-
Russo A, Soh UJ, Trejo J. Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009;9(2):87-96.
-
(2009)
Mol Interv.
, vol.9
, Issue.2
, pp. 87-96
-
-
Russo, A.1
Soh, U.J.2
Trejo, J.3
-
13
-
-
84895156496
-
Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease
-
Hollenberg MD, Mihara K, Polley D, et al. Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. Br J Pharmacol. 2014;171(5):1180-1194.
-
(2014)
Br J Pharmacol.
, vol.171
, Issue.5
, pp. 1180-1194
-
-
Hollenberg, M.D.1
Mihara, K.2
Polley, D.3
-
14
-
-
17644371341
-
Exosite-driven substrate specificity and function in coagulation
-
Krishnaswamy S. Exosite-driven substrate specificity and function in coagulation. J Thromb Haemost. 2005;3(1):54-67.
-
(2005)
J Thromb Haemost.
, vol.3
, Issue.1
, pp. 54-67
-
-
Krishnaswamy, S.1
-
15
-
-
77956544191
-
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states
-
Kamath P, Huntington JA, Krishnaswamy S. Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states. J Biol Chem. 2010;285(37):28651-28658.
-
(2010)
J Biol Chem.
, vol.285
, Issue.37
, pp. 28651-28658
-
-
Kamath, P.1
Huntington, J.A.2
Krishnaswamy, S.3
-
16
-
-
0026003287
-
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity
-
Liu LW, Vu TK, Esmon CT, Coughlin SR. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem. 1991;266(26):16977-16980.
-
(1991)
J Biol Chem.
, vol.266
, Issue.26
, pp. 16977-16980
-
-
Liu, L.W.1
Vu, T.K.2
Esmon, C.T.3
Coughlin, S.R.4
-
17
-
-
0034731322
-
Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage
-
Jacques SL, LeMasurier M, Sheridan PJ, Seeley SK, Kuliopulos A. Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage. J Biol Chem. 2000;275(52):40671-40678.
-
(2000)
J Biol Chem.
, vol.275
, Issue.52
, pp. 40671-40678
-
-
Jacques, S.L.1
LeMasurier, M.2
Sheridan, P.J.3
Seeley, S.K.4
Kuliopulos, A.5
-
18
-
-
34547108343
-
Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
-
Nieman MT, Schmaier AH. Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site. Biochemistry. 2007;46(29):8603-8610.
-
(2007)
Biochemistry
, vol.46
, Issue.29
, pp. 8603-8610
-
-
Nieman, M.T.1
Schmaier, A.H.2
-
19
-
-
57649115436
-
Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1
-
Nieman MT. Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1. Biochemistry. 2008;47(50):13279-13286.
-
(2008)
Biochemistry
, vol.47
, Issue.50
, pp. 13279-13286
-
-
Nieman, M.T.1
-
20
-
-
0344925961
-
Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage
-
Jacques SL, Kuliopulos A. Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. Biochem J. 2003;376(Pt 3):733-740.
-
(2003)
Biochem J
, vol.376
, pp. 733-740
-
-
Jacques, S.L.1
Kuliopulos, A.2
-
21
-
-
34547466613
-
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
-
Bah A, Chen Z, Bush-Pelc LA, Mathews FS, Di Cera E. Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci USA. 2007;104(28):11603-11608.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.28
, pp. 11603-11608
-
-
Bah, A.1
Chen, Z.2
Bush-Pelc, L.A.3
Mathews, F.S.4
Di Cera, E.5
-
22
-
-
0034611727
-
PAR3 is a cofactor for PAR4 activation by thrombin
-
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000;404(6778):609-613.
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 609-613
-
-
Nakanishi-Matsui, M.1
Zheng, Y.W.2
Sulciner, D.J.3
Weiss, E.J.4
Ludeman, M.J.5
Coughlin, S.R.6
-
23
-
-
33645507738
-
Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis
-
Leger AJ, Jacques SL, Badar J, et al. Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis. Circulation. 2006;113(9):1244-1254.
-
(2006)
Circulation
, vol.113
, Issue.9
, pp. 1244-1254
-
-
Leger, A.J.1
Jacques, S.L.2
Badar, J.3
-
24
-
-
84857783253
-
Mechanisms of platelet activation by thrombin: A short history
-
De Candia E. Mechanisms of platelet activation by thrombin: a short history. Thromb Res. 2012;129(3):250-256.
-
(2012)
Thromb Res.
, vol.129
, Issue.3
, pp. 250-256
-
-
De Candia, E.1
-
25
-
-
0035895962
-
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
-
De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem. 2001;276(7):4692-4698.
-
(2001)
J Biol Chem.
, vol.276
, Issue.7
, pp. 4692-4698
-
-
De Candia, E.1
Hall, S.W.2
Rutella, S.3
Landolfi, R.4
Andrews, R.K.5
De Cristofaro, R.6
-
26
-
-
0142228243
-
Thrombin-induced platelet PAR4 activation: Role of glycoprotein Ib and ADP
-
Adam F, Verbeuren TJ, Fauchère JL, Guillin MC, Jandrot-Perrus M. Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. J Thromb Haemost. 2003;1(4):798-804.
-
(2003)
J Thromb Haemost.
, vol.1
, Issue.4
, pp. 798-804
-
-
Adam, F.1
Verbeuren, T.J.2
Fauchère, J.L.3
Guillin, M.C.4
Jandrot-Perrus, M.5
-
27
-
-
84958084789
-
Signalingmediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
-
Estevez B, Kim K, Delaney MK, et al. Signalingmediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood. 2016;127(5):626-636.
-
(2016)
Blood
, vol.127
, Issue.5
, pp. 626-636
-
-
Estevez, B.1
Kim, K.2
Delaney, M.K.3
-
28
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296(5574):1880-1882.
-
(2002)
Science
, vol.296
, Issue.5574
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Mueller, B.M.4
Ruf, W.5
-
29
-
-
77956372381
-
Activated protein C targets CD81 dendritic cells to reduce the mortality of endotoxemia in mice
-
Kerschen E, Hernandez I, Zogg M, et al. Activated protein C targets CD81 dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest. 2010;120(9):3167-3178.
-
(2010)
J Clin Invest
, vol.120
, Issue.9
, pp. 3167-3178
-
-
Kerschen, E.1
Hernandez, I.2
Zogg, M.3
-
30
-
-
34948866150
-
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C
-
Kerschen EJ, Fernandez JA, Cooley BC, et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med. 2007;204(10):2439-2448.
-
(2007)
J Exp Med
, vol.204
, Issue.10
, pp. 2439-2448
-
-
Kerschen, E.J.1
Fernandez, J.A.2
Cooley, B.C.3
-
31
-
-
34147119744
-
The cytoprotective protein C pathway
-
Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007;109(8):3161-3172.
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3161-3172
-
-
Mosnier, L.O.1
Zlokovic, B.V.2
Griffin, J.H.3
-
32
-
-
16844383361
-
PAR1 cleavage and signaling in response to activated protein C and thrombin
-
Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005;280(13):13122-13128.
-
(2005)
J Biol Chem.
, vol.280
, Issue.13
, pp. 13122-13128
-
-
Ludeman, M.J.1
Kataoka, H.2
Srinivasan, Y.3
Esmon, N.L.4
Esmon, C.T.5
Coughlin, S.R.6
-
33
-
-
21244502159
-
Protease-activated receptor-1 signaling by activated protein C in cytokineperturbed endothelial cells is distinct from thrombin signaling
-
Riewald M, Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokineperturbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005;280(20):19808-19814.
-
(2005)
J Biol Chem.
, vol.280
, Issue.20
, pp. 19808-19814
-
-
Riewald, M.1
Ruf, W.2
-
34
-
-
29244436695
-
Proteaseactivated receptors-1 and -2 can mediate endothelial barrier protection: Role in factor Xa signaling
-
Feistritzer C, Lenta R, Riewald M. Proteaseactivated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling. J Thromb Haemost. 2005;3(12):2798-2805.
-
(2005)
J Thromb Haemost.
, vol.3
, Issue.12
, pp. 2798-2805
-
-
Feistritzer, C.1
Lenta, R.2
Riewald, M.3
-
35
-
-
17044427680
-
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
-
Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood. 2005;105(8):3178-3184.
-
(2005)
Blood
, vol.105
, Issue.8
, pp. 3178-3184
-
-
Feistritzer, C.1
Riewald, M.2
-
36
-
-
84055182505
-
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through b-arrestin and dishevelled-2 scaffolds
-
Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through b-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA. 2011;108(50):E1372-E1380.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.50
, pp. E1372-E1380
-
-
Soh, U.J.1
Trejo, J.2
-
37
-
-
65549087489
-
Caveolae are required for protease-selective signaling by protease-activated receptor-1
-
Russo A, Soh UJ, Paing MM, Arora P, Trejo J. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci USA. 2009;106(15):6393-6397.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.15
, pp. 6393-6397
-
-
Russo, A.1
Soh, U.J.2
Paing, M.M.3
Arora, P.4
Trejo, J.5
-
38
-
-
37049012509
-
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
-
Bae JS, Yang L, Manithody C, Rezaie AR. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood. 2007;110(12):3909-3916.
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 3909-3916
-
-
Bae, J.S.1
Yang, L.2
Manithody, C.3
Rezaie, A.R.4
-
39
-
-
43749120051
-
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
-
Bae JS, Yang L, Rezaie AR. Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells. J Thromb Haemost. 2008;6(6):954-961.
-
(2008)
J Thromb Haemost.
, vol.6
, Issue.6
, pp. 954-961
-
-
Bae, J.S.1
Yang, L.2
Rezaie, A.R.3
-
40
-
-
4444331574
-
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
-
Mosnier LO, Gale AJ, Yegneswaran S, Griffin JH. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood. 2004;104(6):1740-1744.
-
(2004)
Blood
, vol.104
, Issue.6
, pp. 1740-1744
-
-
Mosnier, L.O.1
Gale, A.J.2
Yegneswaran, S.3
Griffin, J.H.4
-
41
-
-
36349014743
-
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions
-
Mosnier LO, Yang XV, Griffin JH. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007;282(45):33022-33033.
-
(2007)
J Biol Chem.
, vol.282
, Issue.45
, pp. 33022-33033
-
-
Mosnier, L.O.1
Yang, X.V.2
Griffin, J.H.3
-
42
-
-
84871584695
-
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
-
Mosnier LO, Sinha RK, Burnier L, Bouwens EA, Griffin JH. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood. 2012;120(26):5237-5246.
-
(2012)
Blood
, vol.120
, Issue.26
, pp. 5237-5246
-
-
Mosnier, L.O.1
Sinha, R.K.2
Burnier, L.3
Bouwens, E.A.4
Griffin, J.H.5
-
43
-
-
84865210286
-
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
-
Schuepbach RA, Madon J, Ender M, Galli P, Riewald M. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost. 2012;10(8):1675-1684.
-
(2012)
J Thromb Haemost.
, vol.10
, Issue.8
, pp. 1675-1684
-
-
Schuepbach, R.A.1
Madon, J.2
Ender, M.3
Galli, P.4
Riewald, M.5
-
44
-
-
84914155968
-
Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity
-
Stavenuiter F, Mosnier LO. Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity. Blood. 2014;124(23):3480-3489.
-
(2014)
Blood
, vol.124
, Issue.23
, pp. 3480-3489
-
-
Stavenuiter, F.1
Mosnier, L.O.2
-
45
-
-
0032864538
-
Matrix metalloproteinase inhibition. From the Jurassic to the third millennium
-
Woessner JF Jr. Matrix metalloproteinase inhibition. From the Jurassic to the third millennium. Ann NYAcad Sci. 1999;878:388-403.
-
(1999)
Ann N Y Acad Sci.
, vol.878
, pp. 388-403
-
-
Woessner, J.F.1
-
46
-
-
84872461768
-
Matrix metalloproteases and PAR1 activation
-
Austin KM, Covic L, Kuliopulos A. Matrix metalloproteases and PAR1 activation. Blood. 2013;121(3):431-439.
-
(2013)
Blood
, vol.121
, Issue.3
, pp. 431-439
-
-
Austin, K.M.1
Covic, L.2
Kuliopulos, A.3
-
47
-
-
64249129547
-
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
-
Trivedi V, Boire A, Tchernychev B, et al. Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Cell. 2009;137(2):332-343.
-
(2009)
Cell
, vol.137
, Issue.2
, pp. 332-343
-
-
Trivedi, V.1
Boire, A.2
Tchernychev, B.3
-
48
-
-
84862583259
-
B-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells
-
Jaffr É F, Friedman AE, Hu Z, Mackman N, Blaxall BC. b-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation. 2012;125(24):2993-3003.
-
(2012)
Circulation
, vol.125
, Issue.24
, pp. 2993-3003
-
-
É, J.F.1
Friedman, A.E.2
Hu, Z.3
Mackman, N.4
Blaxall, B.C.5
-
49
-
-
33845903110
-
Functional selectivity and classical concepts of quantitative pharmacology
-
Urban JD, Clarke WP, Von Zastrow M, et al. Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther. 2007;320(1):1-13.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, Issue.1
, pp. 1-13
-
-
Urban, J.D.1
Clarke, W.P.2
Von Zastrow, M.3
-
50
-
-
0035816704
-
Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
-
Ghanouni P, Gryczynski Z, Steenhuis JJ, et al. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. J Biol Chem. 2001;276(27):24433-24436.
-
(2001)
J Biol Chem.
, vol.276
, Issue.27
, pp. 24433-24436
-
-
Ghanouni, P.1
Gryczynski, Z.2
Steenhuis, J.J.3
-
51
-
-
0345791508
-
Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states
-
Swaminath G, Xiang Y, Lee TW, Steenhuis J, Parnot C, Kobilka BK. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem. 2004;279(1):686-691.
-
(2004)
J Biol Chem.
, vol.279
, Issue.1
, pp. 686-691
-
-
Swaminath, G.1
Xiang, Y.2
Lee, T.W.3
Steenhuis, J.4
Parnot, C.5
Kobilka, B.K.6
-
52
-
-
84925359034
-
Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
-
Aisiku O, Peters CG, De Ceunynck K, et al. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015;125(12):1976-1985.
-
(2015)
Blood
, vol.125
, Issue.12
, pp. 1976-1985
-
-
Aisiku, O.1
Peters, C.G.2
De Ceunynck, K.3
-
53
-
-
79952600213
-
Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1
-
Dowal L, Sim DS, Dilks JR, et al. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. Proc Natl Acad Sci USA. 2011;108(7):2951-2956.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.7
, pp. 2951-2956
-
-
Dowal, L.1
Sim, D.S.2
Dilks, J.R.3
-
54
-
-
84936818543
-
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias
-
Soto AG, Smith TH, Chen B, et al. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci USA. 2015;112(27):E3600-E3608.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, Issue.27
, pp. E3600-E3608
-
-
Soto, A.G.1
Smith, T.H.2
Chen, B.3
-
55
-
-
77956635542
-
Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1
-
Ayoub MA, Trinquet E, Pfleger KD, Pin JP. Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. FASEB J. 2010;24(9):3522-3535.
-
(2010)
FASEB J
, vol.24
, Issue.9
, pp. 3522-3535
-
-
Ayoub, M.A.1
Trinquet, E.2
Pfleger, K.D.3
Pin, J.P.4
-
56
-
-
84874411194
-
Receptor-G protein interaction studied by bioluminescence resonance energy transfer: Lessons from protease-activated receptor 1
-
Ayoub MA, Al-Senaidy A, Pin JP. Receptor-G protein interaction studied by bioluminescence resonance energy transfer: lessons from protease-activated receptor 1. Front Endocrinol (Lausanne). 2012;3:82.
-
(2012)
Front Endocrinol (Lausanne)
, vol.3
, pp. 82
-
-
Ayoub, M.A.1
Al-Senaidy, A.2
Pin, J.P.3
-
57
-
-
84892189154
-
Interaction of proteaseactivated receptor 2 with G proteins and b-arrestin 1 studied by bioluminescence resonance energy transfer
-
Ayoub MA, Pin JP. Interaction of proteaseactivated receptor 2 with G proteins and b-arrestin 1 studied by bioluminescence resonance energy transfer. Front Endocrinol (Lausanne). 2013;4:196.
-
(2013)
Front Endocrinol (Lausanne)
, vol.4
, pp. 196
-
-
Ayoub, M.A.1
Pin, J.P.2
-
58
-
-
34250666273
-
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
-
Whorton MR, Bokoch MP, Rasmussen SG, et al. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci USA. 2007;104(18):7682-7687.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.18
, pp. 7682-7687
-
-
Whorton, M.R.1
Bokoch, M.P.2
Rasmussen, S.G.3
-
59
-
-
42949164679
-
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer
-
Whorton MR, Jastrzebska B, Park PS, et al. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008;283(7):4387-4394.
-
(2008)
J Biol Chem.
, vol.283
, Issue.7
, pp. 4387-4394
-
-
Whorton, M.R.1
Jastrzebska, B.2
Park, P.S.3
-
60
-
-
10844255797
-
Oligomerization of G protein-coupled receptors: Past, present, and future
-
Park PS, Filipek S, Wells JW, Palczewski K. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry. 2004;43(50):15643-15656.
-
(2004)
Biochemistry
, vol.43
, Issue.50
, pp. 15643-15656
-
-
Park, P.S.1
Filipek, S.2
Wells, J.W.3
Palczewski, K.4
-
61
-
-
77958152523
-
Class A GPCR heterodimers: Evidence from binding studies
-
Birdsall NJ. Class A GPCR heterodimers: evidence from binding studies. Trends Pharmacol Sci. 2010;31(11):499-508.
-
(2010)
Trends Pharmacol Sci.
, vol.31
, Issue.11
, pp. 499-508
-
-
Birdsall, N.J.1
-
62
-
-
84939812854
-
G proteincoupled receptor multimers: A question still open despite the use of novel approaches
-
Vischer HF, Castro M, Pin JPG. G proteincoupled receptor multimers: a question still open despite the use of novel approaches. Mol Pharmacol. 2015;88(3):561-571.
-
(2015)
Mol Pharmacol.
, vol.88
, Issue.3
, pp. 561-571
-
-
Vischer, H.F.1
Castro, M.2
Pin, J.P.G.3
-
63
-
-
84902257361
-
Rebuttal from Michel Bouvier and Terence E. Hébert
-
Bouvier M, Hébert TE. Rebuttal from Michel Bouvier and Terence E. Hébert. J Physiol. 2014;592(12):2447.
-
(2014)
J Physiol.
, vol.592
, Issue.12
, pp. 2447
-
-
Bouvier, M.1
Hébert, T.E.2
-
64
-
-
84902263973
-
CrossTalk proposal: Weighing the evidence for class A GPCR dimers, the evidence favours dimers
-
Bouvier M, Hébert TE. CrossTalk proposal: weighing the evidence for class A GPCR dimers, the evidence favours dimers. J Physiol. 2014;592(12):2439-2441.
-
(2014)
J Physiol.
, vol.592
, Issue.12
, pp. 2439-2441
-
-
Bouvier, M.1
Hébert, T.E.2
-
65
-
-
84929093528
-
BRET evidence that b2 adrenergic receptors do not oligomerize in cells
-
Lan TH, Liu Q, Li C, Wu G, Steyaert J, Lambert NA. BRET evidence that b2 adrenergic receptors do not oligomerize in cells. Sci Rep. 2015;5:10166.
-
(2015)
Sci Rep
, vol.5
, pp. 10166
-
-
Lan, T.H.1
Liu, Q.2
Li, C.3
Wu, G.4
Steyaert, J.5
Lambert, N.A.6
-
66
-
-
84902251729
-
Rebuttal from Nevin A. Lambert and Jonathan A. Javitch
-
Lambert NA, Javitch JA. Rebuttal from Nevin A. Lambert and Jonathan A. Javitch. J Physiol. 2014;592(12):2449.
-
(2014)
J Physiol.
, vol.592
, Issue.12
, pp. 2449
-
-
Lambert, N.A.1
Javitch, J.A.2
-
67
-
-
84902292100
-
CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out
-
Lambert NA, Javitch JA. CrossTalk opposing view: weighing the evidence for class A GPCR dimers, the jury is still out. J Physiol. 2014;592(12):2443-2445.
-
(2014)
J Physiol.
, vol.592
, Issue.12
, pp. 2443-2445
-
-
Lambert, N.A.1
Javitch, J.A.2
-
68
-
-
80053614132
-
Rhodopsin-transducin heteropentamer: Three-dimensional structure and biochemical characterization
-
Jastrzebska B, Ringler P, Lodowski DT, et al. Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011;176(3):387-394.
-
(2011)
J Struct Biol.
, vol.176
, Issue.3
, pp. 387-394
-
-
Jastrzebska, B.1
Ringler, P.2
Lodowski, D.T.3
-
69
-
-
84875725399
-
Asymmetry of the rhodopsin dimer in complex with transducin
-
Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J. 2013;27(4):1572-1584.
-
(2013)
FASEB J
, vol.27
, Issue.4
, pp. 1572-1584
-
-
Jastrzebska, B.1
Orban, T.2
Golczak, M.3
Engel, A.4
Palczewski, K.5
-
70
-
-
84886787864
-
Efficacy as an intrinsic property of the M (2) muscarinic receptor in its tetrameric state
-
Redka DS, Heerklotz H, Wells JW. Efficacy as an intrinsic property of the M (2) muscarinic receptor in its tetrameric state. Biochemistry. 2013;52(42):7405-7427.
-
(2013)
Biochemistry
, vol.52
, Issue.42
, pp. 7405-7427
-
-
Redka, D.S.1
Heerklotz, H.2
Wells, J.W.3
-
71
-
-
79551711208
-
Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging
-
Kasai RS, Suzuki KG, Prossnitz ER, et al. Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol. 2011;192(3):463-480.
-
(2011)
J Cell Biol.
, vol.192
, Issue.3
, pp. 463-480
-
-
Kasai, R.S.1
Suzuki, K.G.2
Prossnitz, E.R.3
-
72
-
-
84929377388
-
Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis
-
Ward RJ, Pediani JD, Godin AG, Milligan G. Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. J Biol Chem. 2015;290(20):12844-12857.
-
(2015)
J Biol Chem.
, vol.290
, Issue.20
, pp. 12844-12857
-
-
Ward, R.J.1
Pediani, J.D.2
Godin, A.G.3
Milligan, G.4
-
73
-
-
84877737677
-
The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane
-
Patowary S, Alvarez-Curto E, Xu TR, et al. The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane. Biochem J. 2013;452(2):303-312.
-
(2013)
Biochem J
, vol.452
, Issue.2
, pp. 303-312
-
-
Patowary, S.1
Alvarez-Curto, E.2
Xu, T.R.3
-
74
-
-
84931288404
-
The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor
-
Liste MJ, Caltabiano G, Ward RJ, Alvarez-Curto E, Marsango S, Milligan G. The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor. Mol Pharmacol. 2015;87(6):936-953.
-
(2015)
Mol Pharmacol.
, vol.87
, Issue.6
, pp. 936-953
-
-
Liste, M.J.1
Caltabiano, G.2
Ward, R.J.3
Alvarez-Curto, E.4
Marsango, S.5
Milligan, G.6
-
75
-
-
34248374907
-
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
-
McLaughlin JN, Patterson MM, Malik AB. Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Proc Natl Acad Sci USA. 2007;104(13):5662-5667.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.13
, pp. 5662-5667
-
-
McLaughlin, J.N.1
Patterson, M.M.2
Malik, A.B.3
-
76
-
-
84901455907
-
The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation
-
Khan A, Li D, Ibrahim S, Smyth E, Woulfe DS. The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation. Mol Pharmacol. 2014;86(1):1-11.
-
(2014)
Mol Pharmacol.
, vol.86
, Issue.1
, pp. 1-11
-
-
Khan, A.1
Li, D.2
Ibrahim, S.3
Smyth, E.4
Woulfe, D.S.5
-
77
-
-
79952783713
-
Arrestin-2 differentially regulates PAR4 and ADP receptor signaling in platelets
-
Li D, D'Angelo L, Chavez M, Woulfe DS. Arrestin-2 differentially regulates PAR4 and ADP receptor signaling in platelets. J Biol Chem. 2011;286(5):3805-3814.
-
(2011)
J Biol Chem.
, vol.286
, Issue.5
, pp. 3805-3814
-
-
Li, D.1
D'Angelo, L.2
Chavez, M.3
Woulfe, D.S.4
-
78
-
-
84887491969
-
Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by a-thrombin
-
Arachiche A, Mumaw MM, De La Fuente M, Nieman MT. Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by a-thrombin. J Biol Chem. 2013;288(45):32553-32562.
-
(2013)
J Biol Chem.
, vol.288
, Issue.45
, pp. 32553-32562
-
-
Arachiche, A.1
Mumaw, M.M.2
De La Fuente, M.3
Nieman, M.T.4
-
79
-
-
84873557748
-
Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets [published correction appears in PLoS One. 2013;8 (12)]
-
Arachiche A, De La Fuente M, Nieman MT. Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets [published correction appears in PLoS One. 2013;8 (12)]. PLoS One. 2013;8(2):e55740.
-
(2013)
PLoS One
, vol.8
, Issue.2
, pp. e55740
-
-
Arachiche, A.1
De La Fuente, M.2
Nieman, M.T.3
-
80
-
-
36448968578
-
Allosteric modulation of heterodimeric G-protein-coupled receptors
-
Milligan G, Smith NJ. Allosteric modulation of heterodimeric G-protein-coupled receptors. Trends Pharmacol Sci. 2007;28(12):615-620.
-
(2007)
Trends Pharmacol Sci.
, vol.28
, Issue.12
, pp. 615-620
-
-
Milligan, G.1
Smith, N.J.2
-
81
-
-
84886430553
-
Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of proteaseactivated receptor 3
-
Burnier L, Mosnier LO. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of proteaseactivated receptor 3. Blood. 2013;122(5):807-816.
-
(2013)
Blood
, vol.122
, Issue.5
, pp. 807-816
-
-
Burnier, L.1
Mosnier, L.O.2
-
82
-
-
0034608013
-
Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombincleaved PAR1
-
O'Brien PJ, Prevost N, Molino M, et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombincleaved PAR1. J Biol Chem. 2000;275(18):13502-13509.
-
(2000)
J Biol Chem.
, vol.275
, Issue.18
, pp. 13502-13509
-
-
O'Brien, P.J.1
Prevost, N.2
Molino, M.3
-
83
-
-
36249020418
-
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
-
Kaneider NC, Leger AJ, Agarwal A, et al. 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol. 2007;8(12):1303-1312.
-
(2007)
Nat Immunol.
, vol.8
, Issue.12
, pp. 1303-1312
-
-
Kaneider, N.C.1
Leger, A.J.2
Agarwal, A.3
-
84
-
-
84876578107
-
Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits b-arrestinmediated endosomal signaling
-
Lin H, Trejo J. Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits b-arrestinmediated endosomal signaling. J Biol Chem. 2013;288(16):11203-11215.
-
(2013)
J Biol Chem.
, vol.288
, Issue.16
, pp. 11203-11215
-
-
Lin, H.1
Trejo, J.2
-
85
-
-
31044453008
-
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
-
Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest. 2006;116(1):49-58.
-
(2006)
J Clin Invest
, vol.116
, Issue.1
, pp. 49-58
-
-
Parmar, K.M.1
Larman, H.B.2
Dai, G.3
-
86
-
-
79952188205
-
High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells
-
Dangwal S, Rauch BH, Gensch T, et al. High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2011;31(3):624-633.
-
(2011)
Arterioscler Thromb Vasc Biol.
, vol.31
, Issue.3
, pp. 624-633
-
-
Dangwal, S.1
Rauch, B.H.2
Gensch, T.3
-
87
-
-
84913570652
-
Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus
-
Pavic G, Grandoch M, Dangwal S, et al. Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus. Circulation. 2014;130(19):1700-1711.
-
(2014)
Circulation
, vol.130
, Issue.19
, pp. 1700-1711
-
-
Pavic, G.1
Grandoch, M.2
Dangwal, S.3
-
88
-
-
11244255408
-
Identification of a novel functional androgen response element within hPar1 promoter: Implications to prostate cancer progression
-
Salah Z, Maoz M, Cohen I, et al. Identification of a novel functional androgen response element within hPar1 promoter: implications to prostate cancer progression. FASEB J. 2005;19(1):62-72.
-
(2005)
FASEB J
, vol.19
, Issue.1
, pp. 62-72
-
-
Salah, Z.1
Maoz, M.2
Cohen, I.3
-
89
-
-
56649092823
-
P53 controls hPar1 function and expression
-
Salah Z, Haupt S, Maoz M, et al. p53 controls hPar1 function and expression. Oncogene. 2008;27(54):6866-6874.
-
(2008)
Oncogene
, vol.27
, Issue.54
, pp. 6866-6874
-
-
Salah, Z.1
Haupt, S.2
Maoz, M.3
-
90
-
-
0345306669
-
Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma
-
Tellez C, McCarty M, Ruiz M, Bar-Eli M. Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma. J Biol Chem. 2003;278(47):46632-46642.
-
(2003)
J Biol Chem.
, vol.278
, Issue.47
, pp. 46632-46642
-
-
Tellez, C.1
McCarty, M.2
Ruiz, M.3
Bar-Eli, M.4
-
91
-
-
79953706343
-
Tobacco-smoking-related differential DNA methylation: 27K discovery and replication
-
Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet. 2011;88(4):450-457.
-
(2011)
Am J Hum Genet
, vol.88
, Issue.4
, pp. 450-457
-
-
Breitling, L.P.1
Yang, R.2
Korn, B.3
Burwinkel, B.4
Brenner, H.5
-
92
-
-
84863509978
-
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
-
Wan ES, Qiu W, Baccarelli A, et al. Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet. 2012;21(13):3073-3082.
-
(2012)
Hum Mol Genet
, vol.21
, Issue.13
, pp. 3073-3082
-
-
Wan, E.S.1
Qiu, W.2
Baccarelli, A.3
-
93
-
-
84873476594
-
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking
-
Shenker NS, Polidoro S, Van Veldhoven K, et al. Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet. 2013;22(5):843-851.
-
(2013)
Hum Mol Genet
, vol.22
, Issue.5
, pp. 843-851
-
-
Shenker, N.S.1
Polidoro, S.2
Van Veldhoven, K.3
-
94
-
-
84882580222
-
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans
-
Sun YV, Smith AK, Conneely KN, et al. Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet. 2013;132(9):1027-1037.
-
(2013)
Hum Genet
, vol.132
, Issue.9
, pp. 1027-1037
-
-
Sun, Y.V.1
Smith, A.K.2
Conneely, K.N.3
-
95
-
-
84866730439
-
Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease
-
Breitling LP, Salzmann K, Rothenbacher D, Burwinkel B, Brenner H. Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease. Eur Heart J. 2012;33(22):2841-2848.
-
(2012)
Eur Heart J
, vol.33
, Issue.22
, pp. 2841-2848
-
-
Breitling, L.P.1
Salzmann, K.2
Rothenbacher, D.3
Burwinkel, B.4
Brenner, H.5
-
96
-
-
84905668302
-
F2RL3 methylation in blood DNA is a strong predictor of mortality
-
Zhang Y, Yang R, Burwinkel B, et al. F2RL3 methylation in blood DNA is a strong predictor of mortality. Int J Epidemiol. 2014;43(4):1215-1225.
-
(2014)
Int J Epidemiol.
, vol.43
, Issue.4
, pp. 1215-1225
-
-
Zhang, Y.1
Yang, R.2
Burwinkel, B.3
-
97
-
-
84893387036
-
F2RL3 methylation as a biomarker of current and lifetime smoking exposures
-
Zhang Y, Yang R, Burwinkel B, Breitling LP, Brenner H. F2RL3 methylation as a biomarker of current and lifetime smoking exposures. Environ Health Perspect. 2014;122(2):131-137.
-
(2014)
Environ Health Perspect
, vol.122
, Issue.2
, pp. 131-137
-
-
Zhang, Y.1
Yang, R.2
Burwinkel, B.3
Breitling, L.P.4
Brenner, H.5
-
98
-
-
33646457838
-
Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation
-
Lin Z, Hamik A, Jain R, Kumar A, Jain MK. Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation. Arterioscler Thromb Vasc Biol. 2006;26(5):1185-1189.
-
(2006)
Arterioscler Thromb Vasc Biol.
, vol.26
, Issue.5
, pp. 1185-1189
-
-
Lin, Z.1
Hamik, A.2
Jain, R.3
Kumar, A.4
Jain, M.K.5
-
99
-
-
68949100635
-
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT
-
Rosenkranz AC, Rauch BH, Freidel K, Schrör K. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res. 2009;83(4):778-784.
-
(2009)
Cardiovasc Res.
, vol.83
, Issue.4
, pp. 778-784
-
-
Rosenkranz, A.C.1
Rauch, B.H.2
Freidel, K.3
Schrör, K.4
-
100
-
-
79960259343
-
Regulation of human vascular proteaseactivated receptor-3 through mRNA stabilization and the transcription factor nuclear factor of activated T cells (NFAT)
-
Rosenkranz AC, Rauch BH, Doller A, et al. Regulation of human vascular proteaseactivated receptor-3 through mRNA stabilization and the transcription factor nuclear factor of activated T cells (NFAT). Mol Pharmacol. 2011;80(2):337-344.
-
(2011)
Mol Pharmacol.
, vol.80
, Issue.2
, pp. 337-344
-
-
Rosenkranz, A.C.1
Rauch, B.H.2
Doller, A.3
-
101
-
-
0034671716
-
A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists
-
Compton SJ, Cairns JA, Palmer KJ, Al-Ani B, Hollenberg MD, Walls AF. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J Biol Chem. 2000;275(50):39207-39212.
-
(2000)
J Biol Chem.
, vol.275
, Issue.50
, pp. 39207-39212
-
-
Compton, S.J.1
Cairns, J.A.2
Palmer, K.J.3
Al-Ani, B.4
Hollenberg, M.D.5
Walls, A.F.6
-
102
-
-
84887913062
-
The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists
-
Ma JN, Burstein ES. The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists. J Pharmacol Exp Ther. 2013;347(3):697-704.
-
(2013)
J Pharmacol Exp Ther
, vol.347
, Issue.3
, pp. 697-704
-
-
Ma, J.N.1
Burstein, E.S.2
-
103
-
-
0037369218
-
An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN
-
Dupont A, Fontana P, Bachelot-Loza C, et al. An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN. Blood. 2003;101(5):1833-1840.
-
(2003)
Blood
, vol.101
, Issue.5
, pp. 1833-1840
-
-
Dupont, A.1
Fontana, P.2
Bachelot-Loza, C.3
-
104
-
-
84914680239
-
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
-
Edelstein LC, Simon LM, Lindsay CR, et al. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014;124(23):3450-3458.
-
(2014)
Blood
, vol.124
, Issue.23
, pp. 3450-3458
-
-
Edelstein, L.C.1
Simon, L.M.2
Lindsay, C.R.3
-
105
-
-
84889878234
-
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
-
Edelstein LC, Simon LM, Montoya RT, et al. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med. 2013;19(12):1609-1616.
-
(2013)
Nat Med
, vol.19
, Issue.12
, pp. 1609-1616
-
-
Edelstein, L.C.1
Simon, L.M.2
Montoya, R.T.3
-
106
-
-
84862954031
-
Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury
-
Muehlschlegel JD, Perry TE, Liu KY, et al. Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. Am J Hematol. 2012;87(2):161-166.
-
(2012)
Am J Hematol.
, vol.87
, Issue.2
, pp. 161-166
-
-
Muehlschlegel, J.D.1
Perry, T.E.2
Liu, K.Y.3
-
107
-
-
84944706227
-
Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention
-
Friedman EA, Texeira L, Delaney J, et al. Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention. J Thromb Thrombolysis. 2016;41(4):656-662.
-
(2016)
J Thromb Thrombolysis
, vol.41
, Issue.4
, pp. 656-662
-
-
Friedman, E.A.1
Texeira, L.2
Delaney, J.3
-
108
-
-
84858986564
-
Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4
-
De La Fuente M, Noble DN, Verma S, Nieman MT. Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4. J Biol Chem. 2012;287(13):10414-10423.
-
(2012)
J Biol Chem.
, vol.287
, Issue.13
, pp. 10414-10423
-
-
De La Fuente, M.1
Noble, D.N.2
Verma, S.3
Nieman, M.T.4
-
109
-
-
34447636770
-
Heritability of platelet function in families with premature coronary artery disease
-
Bray PF, Mathias RA, Faraday N, et al. Heritability of platelet function in families with premature coronary artery disease. J Thromb Haemost. 2007;5(8):1617-1623.
-
(2007)
J Thromb Haemost.
, vol.5
, Issue.8
, pp. 1617-1623
-
-
Bray, P.F.1
Mathias, R.A.2
Faraday, N.3
-
110
-
-
84891760740
-
GPCRDB: An information system for G protein-coupled receptors
-
Database issue
-
Isberg V, Vroling B, Van Der Kant R, Li K, Vriend G, Gloriam D. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 2014;42(Database issue):D422-D425.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. D422-D425
-
-
Isberg, V.1
Vroling, B.2
Van Der Kant, R.3
Li, K.4
Vriend, G.5
Gloriam, D.6
-
111
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science. 2000;289(5480):739-745.
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
-
112
-
-
80053615320
-
The significance of G protein-coupled receptor crystallography for drug discovery
-
Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011;63(4):901-937.
-
(2011)
Pharmacol Rev.
, vol.63
, Issue.4
, pp. 901-937
-
-
Salon, J.A.1
Lodowski, D.T.2
Palczewski, K.3
-
113
-
-
84871411930
-
Highresolution crystal structure of human proteaseactivated receptor 1
-
Zhang C, Srinivasan Y, Arlow DH, et al. Highresolution crystal structure of human proteaseactivated receptor 1. Nature. 2012;492(7429):387-392.
-
(2012)
Nature
, vol.492
, Issue.7429
, pp. 387-392
-
-
Zhang, C.1
Srinivasan, Y.2
Arlow, D.H.3
-
114
-
-
84940504317
-
Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape
-
Alsteens D, Pfreundschuh M, Zhang C, et al. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015;12(9):845-851.
-
(2015)
Nat Methods
, vol.12
, Issue.9
, pp. 845-851
-
-
Alsteens, D.1
Pfreundschuh, M.2
Zhang, C.3
-
115
-
-
84877616712
-
A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4)
-
Padayatti PS, Wang L, Gupta S, et al. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 2013;12(5):1259-1271.
-
(2013)
Mol Cell Proteomics
, vol.12
, Issue.5
, pp. 1259-1271
-
-
Padayatti, P.S.1
Wang, L.2
Gupta, S.3
-
116
-
-
84861079526
-
Conformational dynamics of activation for the pentameric complex of dimeric G proteincoupled receptor and heterotrimeric G protein
-
Orban T, Jastrzebska B, Gupta S, et al. Conformational dynamics of activation for the pentameric complex of dimeric G proteincoupled receptor and heterotrimeric G protein. Structure. 2012;20(5):826-840.
-
(2012)
Structure
, vol.20
, Issue.5
, pp. 826-840
-
-
Orban, T.1
Jastrzebska, B.2
Gupta, S.3
-
117
-
-
83655177669
-
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
-
Tricoci P, Huang Z, Held C, et al; TRACER Investigators. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med. 2012;366(1):20-33.
-
(2012)
N Engl J Med
, vol.366
, Issue.1
, pp. 20-33
-
-
Tricoci, P.1
Huang, Z.2
Held, C.3
-
118
-
-
84859555815
-
Vorapaxar in the secondary prevention of atherothrombotic events
-
Morrow DA, Braunwald E, Bonaca MP, et al; TRA 2P-TIMI 50 Steering Committee and Investigators. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med. 2012;366(15):1404-1413.
-
(2012)
N Engl J Med
, vol.366
, Issue.15
, pp. 1404-1413
-
-
Morrow, D.A.1
Braunwald, E.2
Bonaca, M.P.3
-
119
-
-
84918586956
-
Overview of the 2014 food and drug administration cardiovascular and renal drugs advisory committee meeting about vorapaxar
-
Baker NC, Lipinski MJ, Lhermusier T, Waksman R. Overview of the 2014 food and drug administration cardiovascular and renal drugs advisory committee meeting about vorapaxar. Circulation. 2014;130(15):1287-1294.
-
(2014)
Circulation
, vol.130
, Issue.15
, pp. 1287-1294
-
-
Baker, N.C.1
Lipinski, M.J.2
Lhermusier, T.3
Waksman, R.4
-
120
-
-
84859760355
-
Turning receptors on and off with intracellular pepducins: New insights into G-protein-coupled receptor drug development
-
O'Callaghan K, Kuliopulos A, Covic L. Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development. J Biol Chem. 2012;287(16):12787-12796.
-
(2012)
J Biol Chem.
, vol.287
, Issue.16
, pp. 12787-12796
-
-
O'Callaghan, K.1
Kuliopulos, A.2
Covic, L.3
-
121
-
-
0242352636
-
Blocking receptors on the inside: Pepducin-based intervention of PAR signaling and thrombosis
-
Kuliopulos A, Covic L. Blocking receptors on the inside: pepducin-based intervention of PAR signaling and thrombosis. Life Sci. 2003;74(2-3):255-262.
-
(2003)
Life Sci.
, vol.74
, Issue.2-3
, pp. 255-262
-
-
Kuliopulos, A.1
Covic, L.2
-
122
-
-
84905679581
-
Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis
-
Mumaw MM, De La Fuente M, Noble DN, Nieman MT. Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis. J Thromb Haemost. 2014;12(8):1331-1341.
-
(2014)
J Thromb Haemost.
, vol.12
, Issue.8
, pp. 1331-1341
-
-
Mumaw, M.M.1
De La Fuente, M.2
Noble, D.N.3
Nieman, M.T.4
|