N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages E3600-E3608

  Soto, Antonio G ^a,b   Smith, Thomas H ^a,b   Chen, Buxin ^a   Bhattacharya, Supriyo ^c   Cordova, Isabel Canto ^a,b   Kenakin, Terry ^d   Vaidehi, Nagarajan ^c   Trejo, JoAnn ^a   Lefkowitz, Robert J ^e  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Arrestin; Endothelial; GPCR; RhoA; Thrombin

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; SMALL INTERFERING RNA; TUNICAMYCIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEIN BINDING; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBIN; THYMIDINE;

ARTICLE; CELL PROLIFERATION; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; EXTRACELLULAR LOOP 2; EXTRACELLULAR MATRIX; FEMALE; GLYCOPROTEIN SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; WILD TYPE; ALGORITHM; ANIMAL; BINDING SITE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; FIBROBLAST; GENETICS; GLYCOSYLATION; HELA CELL LINE; IMMUNOBLOTTING; KNOCKOUT MOUSE; METABOLISM; MUTATION; RNA INTERFERENCE;

ALGORITHMS; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; FIBROBLASTS; GLYCOSYLATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HELA CELLS; HUMANS; IMMUNOBLOTTING; MICE, KNOCKOUT; MUTATION; PROTEIN BINDING; RECEPTOR, PAR-1; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; THROMBIN; THYMIDINE;

EID: 84936818543     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508838112     Document Type: Article

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