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Volumn 65, Issue 4, 2013, Pages 1198-1213

Cofactoring and dimerization of proteinase-activated receptors

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BETA ARRESTIN; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; HETERODIMER; HIRULOG; HOMODIMER; LIGAND; MELATONIN 2 RECEPTOR; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; THROMBIN RECEPTOR; VORAPAXAR;

EID: 84888178878     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.111.004747     Document Type: Review
Times cited : (87)

References (94)
  • 1
    • 53149113005 scopus 로고    scopus 로고
    • An escort for GPCRs: Implications for regulation of receptor density at the cell surface
    • Achour L, Labbé-Jullié C, Scott MG, and Marullo S (2008) An escort for GPCRs: implications for regulation of receptor density at the cell surface. Trends Pharmacol Sci 29:528-535.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 528-535
    • Achour, L.1    Labbé-Jullié, C.2    Scott, M.G.3    Marullo, S.4
  • 5
    • 84873557748 scopus 로고    scopus 로고
    • Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets
    • Arachiche A, de la Fuente M, and Nieman MT (2013) Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets. PLoS ONE 8:e55740.
    • (2013) PLoS ONE , vol.8
    • Arachiche, A.1    de la Fuente, M.2    Nieman, M.T.3
  • 6
    • 34247388037 scopus 로고    scopus 로고
    • Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer
    • Arora P, Ricks TK, and Trejo J (2007) Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci 120:921-928.
    • (2007) J Cell Sci , vol.120 , pp. 921-928
    • Arora, P.1    Ricks, T.K.2    Trejo, J.3
  • 7
    • 84872461768 scopus 로고    scopus 로고
    • Matrix metalloproteases and PAR1 activation
    • Austin KM, Covic L, and Kuliopulos A (2013) Matrix metalloproteases and PAR1 activation. Blood 121:431-439.
    • (2013) Blood , vol.121 , pp. 431-439
    • Austin, K.M.1    Covic, L.2    Kuliopulos, A.3
  • 8
    • 0037077208 scopus 로고    scopus 로고
    • Monitoring of ligand-independent dimerization and ligandinduced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
    • Ayoub MA, Couturier C, Lucas-Meunier E, Angers S, Fossier P, Bouvier M, and Jockers R (2002) Monitoring of ligand-independent dimerization and ligandinduced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem 277:21522-21528.
    • (2002) J Biol Chem , vol.277 , pp. 21522-21528
    • Ayoub, M.A.1    Couturier, C.2    Lucas-Meunier, E.3    Angers, S.4    Fossier, P.5    Bouvier, M.6    Jockers, R.7
  • 9
    • 34547466613 scopus 로고    scopus 로고
    • Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
    • Bah A, Chen Z, Bush-Pelc LA, Mathews FS, and Di Cera E (2007) Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci USA 104: 11603-11608.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11603-11608
    • Bah, A.1    Chen, Z.2    Bush-Pelc, L.A.3    Mathews, F.S.4    Di Cera, E.5
  • 12
    • 0035318509 scopus 로고    scopus 로고
    • Oligomerization of G-protein-coupled transmitter receptors
    • Bouvier M (2001) Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2:274-286.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 274-286
    • Bouvier, M.1
  • 15
    • 0344875553 scopus 로고    scopus 로고
    • Adenosine A2A-dopamine D2 receptor-receptor heteromerization: Qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
    • Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, and Woods AS, et al. (2003) Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278:46741-46749.
    • (2003) J Biol Chem , vol.278 , pp. 46741-46749
    • Canals, M.1    Marcellino, D.2    Fanelli, F.3    Ciruela, F.4    de Benedetti, P.5    Goldberg, S.R.6    Neve, K.7    Fuxe, K.8    Agnati, L.F.9    Woods, A.S.10
  • 16
    • 81755171483 scopus 로고    scopus 로고
    • Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation-and ubiquitination-dependent sorting signals
    • Chen B, Dores MR, Grimsey N, Canto I, Barker BL, and Trejo J (2011) Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation-and ubiquitination-dependent sorting signals. J Biol Chem 286:40760-40770.
    • (2011) J Biol Chem , vol.286 , pp. 40760-40770
    • Chen, B.1    Dores, M.R.2    Grimsey, N.3    Canto, I.4    Barker, B.L.5    Trejo, J.6
  • 17
    • 1642368761 scopus 로고    scopus 로고
    • Termination of protease-activated receptor-1 signaling by b-arrestins is independent of receptor phosphorylation
    • Chen CH, Paing MM, and Trejo J (2004) Termination of protease-activated receptor-1 signaling by b-arrestins is independent of receptor phosphorylation. J Biol Chem 279:10020-10031.
    • (2004) J Biol Chem , vol.279 , pp. 10020-10031
    • Chen, C.H.1    Paing, M.M.2    Trejo, J.3
  • 18
    • 0028364862 scopus 로고
    • Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
    • Chen J, Ishii M, Wang L, Ishii K, and Coughlin SR (1994) Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem 269: 16041-16045.
    • (1994) J Biol Chem , vol.269 , pp. 16041-16045
    • Chen, J.1    Ishii, M.2    Wang, L.3    Ishii, K.4    Coughlin, S.R.5
  • 19
    • 0028031081 scopus 로고
    • Protease-activated receptors start a family
    • Coughlin SR (1994) Protease-activated receptors start a family. Proc Natl Acad Sci USA 91:9200-9202.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9200-9202
    • Coughlin, S.R.1
  • 20
    • 0033613183 scopus 로고    scopus 로고
    • How the protease thrombin talks to cells
    • Coughlin SR (1999) How the protease thrombin talks to cells. Proc Natl Acad Sci USA 96:11023-11027.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11023-11027
    • Coughlin, S.R.1
  • 21
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800-1814.
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 22
    • 38549167408 scopus 로고    scopus 로고
    • Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer
    • Coulon V, Audet M, Homburger V, Bockaert J, Fagni L, Bouvier M, and Perroy J (2008) Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer. Biophys J 94:1001-1009.
    • (2008) Biophys J , vol.94 , pp. 1001-1009
    • Coulon, V.1    Audet, M.2    Homburger, V.3    Bockaert, J.4    Fagni, L.5    Bouvier, M.6    Perroy, J.7
  • 23
    • 0034625055 scopus 로고    scopus 로고
    • Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
    • Covic L, Gresser AL, and Kuliopulos A (2000) Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets. Biochemistry 39: 5458-5467.
    • (2000) Biochemistry , vol.39 , pp. 5458-5467
    • Covic, L.1    Gresser, A.L.2    Kuliopulos, A.3
  • 25
    • 84858986564 scopus 로고    scopus 로고
    • Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4
    • de la Fuente M, Noble DN, Verma S, and Nieman MT (2012) Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4. J Biol Chem 287:10414-10423.
    • (2012) J Biol Chem , vol.287 , pp. 10414-10423
    • de la Fuente, M.1    Noble, D.N.2    Verma, S.3    Nieman, M.T.4
  • 26
    • 0034689003 scopus 로고    scopus 로고
    • β-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
    • De Fea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, and Bunnett NW (2000) b-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148:1267-1281.
    • (2000) J Cell Biol , vol.148 , pp. 1267-1281
    • De Fea, K.A.1    Zalevsky, J.2    Thoma, M.S.3    Déry, O.4    Mullins, R.D.5    Bunnett, N.W.6
  • 28
    • 84873044382 scopus 로고    scopus 로고
    • Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells
    • Ejendal KF, Conley JM, Hu CD, and Watts VJ (2013) Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells. Methods Enzymol 521:259-279.
    • (2013) Methods Enzymol , vol.521 , pp. 259-279
    • Ejendal, K.F.1    Conley, J.M.2    Hu, C.D.3    Watts, V.J.4
  • 29
    • 29244436695 scopus 로고    scopus 로고
    • Protease-activated receptors-1 and-2 can mediate endothelial barrier protection: Role in factor Xa signaling
    • Feistritzer C, Lenta R, and Riewald M (2005) Protease-activated receptors-1 and-2 can mediate endothelial barrier protection: role in factor Xa signaling. J Thromb Haemost 3:2798-2805.
    • (2005) J Thromb Haemost , vol.3 , pp. 2798-2805
    • Feistritzer, C.1    Lenta, R.2    Riewald, M.3
  • 30
    • 66849132354 scopus 로고    scopus 로고
    • Instability of a class a G protein-coupled receptor oligomer interface
    • Fonseca JM and Lambert NA (2009) Instability of a class a G protein-coupled receptor oligomer interface. Mol Pharmacol 75:1296-1299.
    • (2009) Mol Pharmacol , vol.75 , pp. 1296-1299
    • Fonseca, J.M.1    Lambert, N.A.2
  • 31
    • 0035979691 scopus 로고    scopus 로고
    • A role for thrombin receptor signaling in endothelial cells during embryonic development
    • Griffin CT, Srinivasan Y, Zheng Y-W, Huang W, and Coughlin SR (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293:1666-1670.
    • (2001) Science , vol.293 , pp. 1666-1670
    • Griffin, C.T.1    Srinivasan, Y.2    Zheng, Y.-W.3    Huang, W.4    Coughlin, S.R.5
  • 32
    • 44449087996 scopus 로고    scopus 로고
    • Monitoring proteinprotein interactions in living cells by bioluminescence resonance energy transfer (BRET)
    • Unit 5.23
    • Hamdan FF, Percherancier Y, Breton B, and Bouvier M (2006) Monitoring proteinprotein interactions in living cells by bioluminescence resonance energy transfer (BRET). Curr Protoc Neurosci Chapter 5:Unit 5.23.
    • (2006) Curr Protoc Neurosci Chapter 5
    • Hamdan, F.F.1    Percherancier, Y.2    Breton, B.3    Bouvier, M.4
  • 33
    • 33748745670 scopus 로고    scopus 로고
    • PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
    • Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, and Hamm HE (2006) PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem 281:26665-26674.
    • (2006) J Biol Chem , vol.281 , pp. 26665-26674
    • Holinstat, M.1    Voss, B.2    Bilodeau, M.L.3    McLaughlin, J.N.4    Cleator, J.5    Hamm, H.E.6
  • 34
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS and Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 35
    • 84876197291 scopus 로고    scopus 로고
    • Crystal structure of oligomeric b1-adrenergic G protein-coupled receptors in ligand-free basal state
    • Huang J, Chen S, Zhang JJ, and Huang XY (2013) Crystal structure of oligomeric b1-adrenergic G protein-coupled receptors in ligand-free basal state. Nat Struct Mol Biol 20:419-425.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 419-425
    • Huang, J.1    Chen, S.2    Zhang, J.J.3    Huang, X.Y.4
  • 37
    • 0032101592 scopus 로고    scopus 로고
    • Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin
    • Ishihara H, Zeng D, Connolly AJ, Tam C, and Coughlin SR (1998) Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood 91:4152-4157.
    • (1998) Blood , vol.91 , pp. 4152-4157
    • Ishihara, H.1    Zeng, D.2    Connolly, A.J.3    Tam, C.4    Coughlin, S.R.5
  • 38
    • 0344925961 scopus 로고    scopus 로고
    • Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage
    • Jacques SL and Kuliopulos A (2003) Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. Biochem J 376:733-740.
    • (2003) Biochem J , vol.376 , pp. 733-740
    • Jacques, S.L.1    Kuliopulos, A.2
  • 39
    • 0034731322 scopus 로고    scopus 로고
    • Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage
    • Jacques SL, LeMasurier M, Sheridan PJ, Seeley SK, and Kuliopulos A (2000) Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage. J Biol Chem 275:40671-40678.
    • (2000) J Biol Chem , vol.275 , pp. 40671-40678
    • Jacques, S.L.1    LeMasurier, M.2    Sheridan, P.J.3    Seeley, S.K.4    Kuliopulos, A.5
  • 43
    • 38449083544 scopus 로고    scopus 로고
    • Dual regulation of endothelial junctional permeability
    • Komarova YA, Mehta D, and Malik AB (2007) Dual regulation of endothelial junctional permeability. Sci STKE 2007:re8.
    • (2007) Sci STKE , vol.2007
    • Komarova, Y.A.1    Mehta, D.2    Malik, A.B.3
  • 46
    • 84876578107 scopus 로고    scopus 로고
    • Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits b-arrestin-mediated endosomal signaling
    • Lin H and Trejo J (2013) Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits b-arrestin-mediated endosomal signaling. J Biol Chem 288: 11203-11215.
    • (2013) J Biol Chem , vol.288 , pp. 11203-11215
    • Lin, H.1    Trejo, J.2
  • 47
    • 84858203893 scopus 로고    scopus 로고
    • Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling
    • Lohse MJ, Nuber S, and Hoffmann C (2012) Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacol Rev 64:299-336.
    • (2012) Pharmacol Rev , vol.64 , pp. 299-336
    • Lohse, M.J.1    Nuber, S.2    Hoffmann, C.3
  • 51
    • 34248374907 scopus 로고    scopus 로고
    • Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
    • McLaughlin JN, Patterson MM, and Malik AB (2007) Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Proc Natl Acad Sci USA 104:5662-5667.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5662-5667
    • McLaughlin, J.N.1    Patterson, M.M.2    Malik, A.B.3
  • 54
    • 84871584695 scopus 로고    scopus 로고
    • Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
    • Mosnier LO, Sinha RK, Burnier L, Bouwens EA, and Griffin JH (2012) Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood 120:5237-5246.
    • (2012) Blood , vol.120 , pp. 5237-5246
    • Mosnier, L.O.1    Sinha, R.K.2    Burnier, L.3    Bouwens, E.A.4    Griffin, J.H.5
  • 55
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Zlokovic BV, and Griffin JH (2007) The cytoprotective protein C pathway. Blood 109:3161-3172.
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 58
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
    • Nystedt S, Ramakrishnan V, and Sundelin J (1996) The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 271:14910-14915.
    • (1996) J Biol Chem , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 59
    • 0035952643 scopus 로고    scopus 로고
    • Protease activated receptors: Theme and variations
    • O'Brien PJ, Molino M, Kahn M, and Brass LF (2001) Protease activated receptors: theme and variations. Oncogene 20:1570-1581.
    • (2001) Oncogene , vol.20 , pp. 1570-1581
    • O'Brien, P.J.1    Molino, M.2    Kahn, M.3    Brass, L.F.4
  • 60
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombincleaved PAR1
    • O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, Woulfe DS, and Brass LF (2000) Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombincleaved PAR1. J Biol Chem 275:13502-13509.
    • (2000) J Biol Chem , vol.275 , pp. 13502-13509
    • O'Brien, P.J.1    Prevost, N.2    Molino, M.3    Hollinger, M.K.4    Woolkalis, M.J.5    Woulfe, D.S.6    Brass, L.F.7
  • 61
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S, Toombs CF, Hu YH, and Simon MI (1997) Defective platelet activation in G alpha(q)-deficient mice. Nature 389:183-186.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 62
    • 37549016836 scopus 로고    scopus 로고
    • Heterotrimeric G protein activation by G-proteincoupled receptors
    • Oldham WM and Hamm HE (2008) Heterotrimeric G protein activation by G-proteincoupled receptors. Nat Rev Mol Cell Biol 9:60-71.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 60-71
    • Oldham, W.M.1    Hamm, H.E.2
  • 63
    • 33644864081 scopus 로고    scopus 로고
    • Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization
    • Paing MM, Johnston CA, Siderovski DP, and Trejo J (2006) Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol 26:3231-3242.
    • (2006) Mol Cell Biol , vol.26 , pp. 3231-3242
    • Paing, M.M.1    Johnston, C.A.2    Siderovski, D.P.3    Trejo, J.4
  • 65
  • 66
    • 0345803929 scopus 로고    scopus 로고
    • Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    • Pfeiffer M, Kirscht S, Stumm R, Koch T, Wu D, Laugsch M, Schröder H, Höllt V, and Schulz S (2003) Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization. J Biol Chem 278:51630-51637.
    • (2003) J Biol Chem , vol.278 , pp. 51630-51637
    • Pfeiffer, M.1    Kirscht, S.2    Stumm, R.3    Koch, T.4    Wu, D.5    Laugsch, M.6    Schröder, H.7    Höllt, V.8    Schulz, S.9
  • 67
    • 33747312516 scopus 로고    scopus 로고
    • Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells
    • Pfleger KD, Dromey JR, Dalrymple MB, Lim EM, Thomas WG, and Eidne KA (2006) Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells. Cell Signal 18:1664-1670.
    • (2006) Cell Signal , vol.18 , pp. 1664-1670
    • Pfleger, K.D.1    Dromey, J.R.2    Dalrymple, M.B.3    Lim, E.M.4    Thomas, W.G.5    Eidne, K.A.6
  • 68
    • 0038662595 scopus 로고    scopus 로고
    • Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
    • Pin JP, Galvez T, and Prézeau L (2003) Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol Ther 98:325-354.
    • (2003) Pharmacol Ther , vol.98 , pp. 325-354
    • Pin, J.P.1    Galvez, T.2    Prézeau, L.3
  • 69
  • 70
    • 71749108834 scopus 로고    scopus 로고
    • Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization
    • Ricks TK and Trejo J (2009) Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem 284: 34444-34457.
    • (2009) J Biol Chem , vol.284 , pp. 34444-34457
    • Ricks, T.K.1    Trejo, J.2
  • 71
    • 79551485761 scopus 로고    scopus 로고
    • Exploring a role for heteromerization in GPCR signalling specificity
    • Rozenfeld R and Devi LA (2011) Exploring a role for heteromerization in GPCR signalling specificity. Biochem J 433:11-18.
    • (2011) Biochem J , vol.433 , pp. 11-18
    • Rozenfeld, R.1    Devi, L.A.2
  • 72
    • 65549087489 scopus 로고    scopus 로고
    • Caveolae are required for protease-selective signaling by protease-activated receptor-1
    • Russo A, Soh UJ, Paing MM, Arora P, and Trejo J (2009) Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci USA 106:6393-6397.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6393-6397
    • Russo, A.1    Soh, U.J.2    Paing, M.M.3    Arora, P.4    Trejo, J.5
  • 74
    • 4043125390 scopus 로고    scopus 로고
    • Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting
    • Salahpour A, Angers S, Mercier JF, Lagacé M, Marullo S, and Bouvier M (2004) Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. J Biol Chem 279:33390-33397.
    • (2004) J Biol Chem , vol.279 , pp. 33390-33397
    • Salahpour, A.1    Angers, S.2    Mercier, J.F.3    Lagacé, M.4    Marullo, S.5    Bouvier, M.6
  • 76
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Sambrano GR, Weiss EJ, Zheng YW, Huang W, and Coughlin SR (2001) Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 413:74-78.
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 77
    • 0026629249 scopus 로고
    • Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
    • Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, and Coughlin SR (1992) Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem 267:13146-13149.
    • (1992) J Biol Chem , vol.267 , pp. 13146-13149
    • Scarborough, R.M.1    Naughton, M.A.2    Teng, W.3    Hung, D.T.4    Rose, J.5    Vu, T.K.6    Wheaton, V.I.7    Turck, C.W.8    Coughlin, S.R.9
  • 78
    • 0344668870 scopus 로고    scopus 로고
    • Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding
    • Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, and Kuliopulos A (2003) Structural basis for thrombin activation of a protease-activated receptor: inhibition of intramolecular liganding. Chem Biol 10:1033-1041.
    • (2003) Chem Biol , vol.10 , pp. 1033-1041
    • Seeley, S.1    Covic, L.2    Jacques, S.L.3    Sudmeier, J.4    Baleja, J.D.5    Kuliopulos, A.6
  • 80
    • 0030478939 scopus 로고    scopus 로고
    • Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonisttriggered versus tonic internalization and intracellular localization
    • Shapiro MJ, Trejo J, Zeng D, and Coughlin SR (1996) Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonisttriggered versus tonic internalization and intracellular localization. J Biol Chem 271:32874-32880.
    • (1996) J Biol Chem , vol.271 , pp. 32874-32880
    • Shapiro, M.J.1    Trejo, J.2    Zeng, D.3    Coughlin, S.R.4
  • 81
    • 0034682810 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
    • Shapiro MJ, Weiss EJ, Faruqi TR, and Coughlin SR (2000) Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem 275:25216-25221.
    • (2000) J Biol Chem , vol.275 , pp. 25216-25221
    • Shapiro, M.J.1    Weiss, E.J.2    Faruqi, T.R.3    Coughlin, S.R.4
  • 82
    • 3543121913 scopus 로고    scopus 로고
    • Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
    • Shi X, Gangadharan B, Brass LF, Ruf W, and Mueller BM (2004) Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2:395-402.
    • (2004) Mol Cancer Res , vol.2 , pp. 395-402
    • Shi, X.1    Gangadharan, B.2    Brass, L.F.3    Ruf, W.4    Mueller, B.M.5
  • 83
    • 77951684623 scopus 로고    scopus 로고
    • Signal transduction by proteaseactivated receptors
    • Soh UJ, Dores MR, Chen B, and Trejo J (2010) Signal transduction by proteaseactivated receptors. Br J Pharmacol 160:191-203.
    • (2010) Br J Pharmacol , vol.160 , pp. 191-203
    • Soh, U.J.1    Dores, M.R.2    Chen, B.3    Trejo, J.4
  • 84
    • 84055182505 scopus 로고    scopus 로고
    • Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through b-arrestin and dishevelled-2 scaffolds
    • Soh UJ and Trejo J (2011) Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through b-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci USA 108:E1372-E1380.
    • (2011) Proc Natl Acad Sci USA , vol.108
    • Soh, U.J.1    Trejo, J.2
  • 85
    • 77953301324 scopus 로고    scopus 로고
    • N-Linked glycosylation of protease-activated receptor-1 second extracellular loop: A critical determinant for ligand-induced receptor activation and internalization
    • Soto AG and Trejo J (2010) N-Linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem 285:18781-18793.
    • (2010) J Biol Chem , vol.285 , pp. 18781-18793
    • Soto, A.G.1    Trejo, J.2
  • 86
    • 11244328357 scopus 로고    scopus 로고
    • Multiple independent functions of arrestins in the regulation of proteaseactivated receptor-2 signaling and trafficking
    • Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, and Trejo J (2005) Multiple independent functions of arrestins in the regulation of proteaseactivated receptor-2 signaling and trafficking. Mol Pharmacol 67:78-87.
    • (2005) Mol Pharmacol , vol.67 , pp. 78-87
    • Stalheim, L.1    Ding, Y.2    Gullapalli, A.3    Paing, M.M.4    Wolfe, B.L.5    Morris, D.R.6    Trejo, J.7
  • 88
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TK, Hung DT, Wheaton VI, and Coughlin SR (1991a) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 90
    • 34250666273 scopus 로고    scopus 로고
    • A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
    • Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, and Sunahara RK (2007) A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci USA 104:7682-7687.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7682-7687
    • Whorton, M.R.1    Bokoch, M.P.2    Rasmussen, S.G.3    Huang, B.4    Zare, R.N.5    Kobilka, B.6    Sunahara, R.K.7


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