Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states

Journal of Biological Chemistry

Volumn 285, Issue 37, 2010, Pages 28651-28658

  Kamath, Parvathi ^a   Huntington, James A ^b   Krishnaswamy, Sriram ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; BIOACTIVITY; COAGULATION; SODIUM; THERMODYNAMICS;

ACTIVATION PEPTIDE; ACTIVE SITE; ANION-BINDING; BLOOD COAGULATION; COFACTORS; EXOSITES; INTERCONVERSIONS; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; PROTEOLYTIC ACTIVITIES; THERMODYNAMIC DIFFERENCES; THERMODYNAMIC FRAMEWORK; THERMODYNAMIC LINKAGES; THROMBIN ALLOSTERY; X-RAY STRUCTURE; ZYMOGEN ACTIVATION;

LIGANDS;

ENZYME PRECURSOR; PROTEINASE; SODIUM ION; THROMBIN; LIGAND; PEPTIDE; PROTHROMBIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; PRIORITY JOURNAL; REGULATORY MECHANISM; THERMODYNAMICS; BLOOD CLOTTING; CALORIMETRY; CELL LINE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BLOOD COAGULATION; CALORIMETRY; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MUTATION; PEPTIDES; PROTHROMBIN; THROMBIN;

EID: 77956544191     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.154914     Document Type: Article

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