Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 7, 2011, Pages 2951-2956

  Dowal, Louisa ^a   Sim, Derek S ^a   Dilks, James R ^a   Blair, Price ^a   Beaudry, Sarah ^b   Denker, Bradley M ^b   Koukos, Georgios ^c   Kuliopulos, Athan ^c   Flaumenhaft, Robert ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemical genetics; Platelet signaling; Thrombin receptor; Thrombosis

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ANTICOAGULANT AGENT; CARRIER PROTEIN; G PROTEIN COUPLED RECEPTOR; JF 5; PROTEIN PAR1; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG ACTIVITY; IC 50; MALE; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN INTERACTION; SENSITIVITY ANALYSIS; THROMBOCYTE AGGREGATION; THROMBUS;

ALLOSTERIC REGULATION; ANIMALS; ANTITHROMBINS; CALCIUM; CELL LINE; DOGS; EPINEPHRINE; FLOW CYTOMETRY; LUCIFERASES; P-SELECTIN; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, PAR-1; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 79952600213     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1014863108     Document Type: Article

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