Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape

Nature Methods

Volumn 12, Issue 9, 2015, Pages 845-851

  Alsteens, David ^a   Pfreundschuh, Moritz ^a   Zhang, Cheng ^b,d   Spoerri, Patrizia M ^a   Coughlin, Shaun R ^c   Kobilka, Brian K ^b   Müller, Daniel J ^a  

^a ETH ZURICH   (Switzerland)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; VORAPAXAR; LIGAND; LIPID BILAYER; PROTEIN BINDING;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DISSOCIATION; HUMAN; LIGAND BINDING; PLATELET AGGREGATION ASSAY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; VELOCITY; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; ENERGY TRANSFER; KINETICS; LIPID BILAYER; MECHANICAL STRESS; MOLECULAR IMAGING; PROCEDURES;

BINDING SITES; COMPUTER SIMULATION; ENERGY TRANSFER; HUMANS; KINETICS; LIGANDS; LIPID BILAYERS; MICROSCOPY, ATOMIC FORCE; MODELS, CHEMICAL; MOLECULAR IMAGING; PROTEIN BINDING; RECEPTOR, PAR-1; STRESS, MECHANICAL;

EID: 84940504317     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.3479     Document Type: Article

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