Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

Nature Communications

Volumn 7, Issue , 2016, Pages

  Li, Yanran ^a   Smolke, Christina D ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLTRANSFERASE; CARBOXYLESTERASE; COCLAURINE N METHYLTRANSFERASE; CYTOCHROME P450; CYTOCHROME P450 719A21; CYTOCHROME P450 82X1; CYTOCHROME P450 82X2; CYTOCHROME P450 82Y1; NARCOTOLINE; NARCOTOLINE 4' O METHYLTRANSFERASE; NOSCAPINE; O METHYLTRANSFERASE; PROTOBERBERINE; SECOBERBERINE; TETRAHYDROPAPAVEROLINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BERBERINE DERIVATIVE; METHYLTRANSFERASE; PLANT PROTEIN;

ALKALOID; DRUG; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; HOST; YEAST;

ARTICLE; BIOSYNTHESIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE CLUSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SACCHAROMYCES CEREVISIAE; SIZE EXCLUSION CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; TEMPERATURE; WESTERN BLOTTING; YEAST; BIOENGINEERING; DRUG DEVELOPMENT; GENETICS; METABOLISM; MULTIGENE FAMILY; PAPAVER; PROCEDURES;

PAPAVER SOMNIFERUM; SACCHAROMYCES CEREVISIAE;

ANTINEOPLASTIC AGENTS; BERBERINE ALKALOIDS; BIOENGINEERING; BIOSYNTHETIC PATHWAYS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; METHYLTRANSFERASES; MULTIGENE FAMILY; NOSCAPINE; PAPAVER; PLANT PROTEINS; SACCHAROMYCES CEREVISIAE; TETRAHYDROPAPAVEROLINE;

EID: 84977472256     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12137     Document Type: Article

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