메뉴 건너뛰기




Volumn 67, Issue 1, 2015, Pages 56-62

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics

Author keywords

Anticancer agents; Microtubule; Noscapine; Noscapinoids; Tubulin

Indexed keywords

ALPHA TUBULIN; AMINO NOSCAPINE; ANTINEOPLASTIC AGENT; AZIDO NOSCAPINE; BENZOFURANONE DERIVATIVE; BETA TUBULIN; BROMO NOSCAPINE; COLCHICINE; HALOGENATED NOSCAPINOID DERIVATIVE; NOSCAPINE DERIVATIVE; NOSCAPINOID DERIVATIVE; UNCLASSIFIED DRUG; NOSCAPINE; TUBULIN;

EID: 84908539510     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2014.09.003     Document Type: Review
Times cited : (39)

References (42)
  • 1
    • 0032605897 scopus 로고    scopus 로고
    • Pierre-jean robiquet
    • Warolin C. Pierre-Jean Robiquet. Rev Hist Pharm (Paris) 1999; 47(321):97-110.
    • (1999) Rev Hist Pharm (Paris) , vol.47 , Issue.321 , pp. 97-110
    • Warolin, C.1
  • 5
    • 77955283527 scopus 로고    scopus 로고
    • Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by emin oroudjev
    • Yenjerla M, Lopus M, Wilson L Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by Emin Oroudjev. Method Cell Biol 2010; 95: 189-206.
    • (2010) Method Cell Biol , vol.95 , pp. 189-206
    • Yenjerla, M.1    Lopus, M.2    Wilson, L.3
  • 6
    • 84862580438 scopus 로고    scopus 로고
    • Tubulins as therapeutic targets in cancer: From bench to bedside
    • Katsetos CD, Dráber P. Tubulins as therapeutic targets in cancer: from bench to bedside. Curr Pharm Des 2012; 18(19):2778-92.
    • (2012) Curr Pharm Des , vol.18 , Issue.19 , pp. 2778-2792
    • Katsetos, C.D.1    Dráber, P.2
  • 7
    • 77957374075 scopus 로고    scopus 로고
    • Microtubule-binding agents: A dynamic field of cancer therapeutics
    • Dumontet C, Jordan MA Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov 2010; 9(10):790-803.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.10 , pp. 790-803
    • Dumontet, C.1    Jordan, M.A.2
  • 8
    • 77958043944 scopus 로고    scopus 로고
    • Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules
    • Lopus M, Oroudjev E, Wilson L., Wilhelm S, Widdison W, Chari R., et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther 2010; 9(10):2689-99.
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2689-2699
    • Lopus, M.1    Oroudjev, E.2    Wilson, L.3    Wilhelm, S.4    Widdison, W.5    Chari, R.6
  • 9
    • 84900358913 scopus 로고    scopus 로고
    • The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation
    • Risinger AL, Riffle SM, Lopus M, Jordan M.A., Wilson L., Mooberry SL. The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation. Mol Cancer 2014; 13:41.
    • (2014) Mol Cancer , vol.13 , pp. 41
    • Risinger, A.L.1    Riffle, S.M.2    Lopus, M.3    Jordan, M.A.4    Wilson, L.5    Mooberry, S.L.6
  • 10
    • 84859612289 scopus 로고    scopus 로고
    • Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends
    • Lopus M, Manatschal C, Buey R.M., Bjelic S., Miller HP, Steinmetz MO, et al. Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends. Biochemistry 2012; 51(14):3021-30.
    • (2012) Biochemistry , vol.51 , Issue.14 , pp. 3021-3030
    • Lopus, M.1    Manatschal, C.2    Buey, R.M.3    Bjelic, S.4    Miller, H.P.5    Steinmetz, M.O.6
  • 11
    • 33644862731 scopus 로고    scopus 로고
    • Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro
    • Manna T, Thrower D, Miller H.P., Curmi P., Wilson L. Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro. J Biol Chem 2006; 281(4):2071-8.
    • (2006) J Biol Chem , vol.281 , Issue.4 , pp. 2071-2078
    • Manna, T.1    Thrower, D.2    Miller, H.P.3    Curmi, P.4    Wilson, L.5
  • 12
    • 79953011986 scopus 로고    scopus 로고
    • A molecular and structural mechanism for G protein-mediated microtubule destabilization
    • Dave RH, Saengsawang W, Lopus M., Dave S, Wilson L, Rasenick MM A molecular and structural mechanism for G protein-mediated microtubule destabilization. J Biol Chem 2011; 286(6):4319-28.
    • (2011) J Biol Chem , vol.286 , Issue.6 , pp. 4319-4328
    • Dave, R.H.1    Saengsawang, W.2    Lopus, M.3    Dave, S.4    Wilson, L.5    Rasenick, M.M.6
  • 13
    • 33749578369 scopus 로고    scopus 로고
    • 2-methox-yestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
    • Kamath K, Okouneva T, Larson G., Panda D, Wilson L, Jordan MA 2-Methox-yestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther 2006; 5(9):2225-33.
    • (2006) Mol Cancer Ther , vol.5 , Issue.9 , pp. 2225-2233
    • Kamath, K.1    Okouneva, T.2    Larson, G.3    Panda, D.4    Wilson, L.5    Jordan, M.A.6
  • 14
    • 0037106616 scopus 로고    scopus 로고
    • Attachment and tension in the spindle assembly checkpoint
    • Zhou J, Yao J, Joshi HC Attachment and tension in the spindle assembly checkpoint. J Cell Sci 2002; 115(18):3547-55.
    • (2002) J Cell Sci , vol.115 , Issue.18 , pp. 3547-3555
    • Zhou, J.1    Yao, J.2    Joshi, H.C.3
  • 15
  • 16
    • 53749106421 scopus 로고    scopus 로고
    • Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway
    • Newcomb EW, Lukyanov Y, Smirnova I, Schnee T, Zagzag D. Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway. Anticancer Drugs 2008; 19(6):553-63.
    • (2008) Anticancer Drugs , vol.19 , Issue.6 , pp. 553-563
    • Newcomb, E.W.1    Lukyanov, Y.2    Smirnova, I.3    Schnee, T.4    Zagzag, D.5
  • 17
    • 34248577475 scopus 로고    scopus 로고
    • P53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells
    • Aneja R, Ghaleb AM, Zhou J, Yang V.W., Joshi HC. p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. Cancer Res 2007; 67(8):3862-70.
    • (2007) Cancer Res , vol.67 , Issue.8 , pp. 3862-3870
    • Aneja, R.1    Ghaleb, A.M.2    Zhou, J.3    Yang, V.W.4    Joshi, H.C.5
  • 20
    • 34548574659 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent
    • Aneja R, Dhiman N, Idnani J., Awasthi A, Arora SK, Chandra R, et al Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent. Cancer Chemother Pharmacol 2007; 60(6):831-9.
    • (2007) Cancer Chemother Pharmacol , vol.60 , Issue.6 , pp. 831-839
    • Aneja, R.1    Dhiman, N.2    Idnani, J.3    Awasthi, A.4    Arora, S.K.5    Chandra, R.6
  • 21
    • 0033928547 scopus 로고    scopus 로고
    • Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses
    • Ke Y, Ye K, Grossniklaus H.E., Archer DR, Joshi HC, Kapp JA. Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer Immunol Immunother 2000; 49(4-5):217-25.
    • (2000) Cancer Immunol Immunother , vol.49 , Issue.4-5 , pp. 217-225
    • Ke, Y.1    Ye, K.2    Grossniklaus, H.E.3    Archer, D.R.4    Joshi, H.C.5    Kapp, J.A.6
  • 22
    • 0032539565 scopus 로고    scopus 로고
    • Opium alkaloid noscapine isan antitumor agent that arrests metaphase and induces apoptosis in dividing cells
    • Ye K, Ke Y, Keshava N., Shanks J, Kapp JA, Tekmal R.R., et al. Opium alkaloid noscapine isan antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proc Natl Acad Sci U S A 1998; 95(4):1601-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.4 , pp. 1601-1606
    • Ye, K.1    Ke, Y.2    Keshava, N.3    Shanks, J.4    Kapp, J.A.5    Tekmal, R.R.6
  • 23
    • 0037053409 scopus 로고    scopus 로고
    • Minor alteration of microtu-bule dynamics causes lossoftension across kinetochore pairs and activates the spindle checkpoint
    • Zhou J, Panda D, Landen J.W., Wilson L., Joshi HC. Minor alteration of microtu-bule dynamics causes lossoftension across kinetochore pairs and activates the spindle checkpoint. J Biol Chem 2002; 277(19):17200-08.
    • (2002) J Biol Chem , vol.277 , Issue.19 , pp. 17200-17208
    • Zhou, J.1    Panda, D.2    Landen, J.W.3    Wilson, L.4    Joshi, H.C.5
  • 24
    • 33745168689 scopus 로고    scopus 로고
    • Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and tcell lymphoma
    • Aneja R, Vangapandu SN, Lopus M, Chandra R, Panda D, et al. Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and Tcell lymphoma. Mol Pharmacol 2006; 69(6):1801-9.
    • (2006) Mol Pharmacol , vol.69 , Issue.6 , pp. 1801-1809
    • Aneja, R.1    Vangapandu, S.N.2    Lopus, M.3    Chandra, R.4    Panda, D.5
  • 25
    • 80053480531 scopus 로고    scopus 로고
    • Rational design of novel anti-microtubule agent (9-azido-noscapine) from quantitative structure activity relationship (QSAR) evaluation of noscapinoids
    • Santoshi S, Naik PK, Joshi HC Rational design of novel anti-microtubule agent (9-azido-noscapine) from quantitative structure activity relationship (QSAR) evaluation of noscapinoids. J Biomol Screen 2011; 16(9):1047-58.
    • (2011) J Biomol Screen , vol.16 , Issue.9 , pp. 1047-1058
    • Santoshi, S.1    Naik, P.K.2    Joshi, H.C.3
  • 26
    • 80051703052 scopus 로고    scopus 로고
    • Rational design, synthesis and biological evaluations of amino-noscapine: A high affinity tubulin-binding noscapinoid
    • Naik PK, Chatterji BP, Vangapandu S.N., Aneja R., Chandra R, Kanteveri S, et al Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid. J Comput Aided Mol Des 2011; 25(5):443-54.
    • (2011) J Comput Aided Mol Des , vol.25 , Issue.5 , pp. 443-454
    • Naik, P.K.1    Chatterji, B.P.2    Vangapandu, S.N.3    Aneja, R.4    Chandra, R.5    Kanteveri, S.6
  • 27
    • 33745933637 scopus 로고    scopus 로고
    • Synthesis of microtubule-interfering halogenated noscapine analogues that perturb mitosis incancer cells followed by cell death
    • Aneja R, Vangapandu SN, Lopus M, Viswesarappa V.G., Dhiman N., Verma A, et al. Synthesis of microtubule-interfering halogenated noscapine analogues that perturb mitosis incancer cells followed by cell death. Biochem Pharmacol 2006; 72(4):415-26.
    • (2006) Biochem Pharmacol , vol.72 , Issue.4 , pp. 415-426
    • Aneja, R.1    Vangapandu, S.N.2    Lopus, M.3    Viswesarappa, V.G.4    Dhiman, N.5    Verma, A.6
  • 28
    • 33750499732 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog
    • Aneja R, Vangapandu SN, Joshi HC Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog. Biorg Med Chem 2006; 14: 8352-8.
    • (2006) Biorg Med Chem , vol.14 , pp. 8352-8358
    • Aneja, R.1    Vangapandu, S.N.2    Joshi, H.C.3
  • 29
    • 79958092061 scopus 로고    scopus 로고
    • Benzofuranone ring substituted noscapine analogs: Synthesis and biological evaluation
    • Mishra RC, Karna P, Gundala S.R., Pannu V., Stanton RA, Gupta KK, et al. Benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation. Biochem Pharmacol 2011; 82(8):110-21.
    • (2011) Biochem Pharmacol , vol.82 , Issue.8 , pp. 110-121
    • Mishra, R.C.1    Karna, P.2    Gundala, S.R.3    Pannu, V.4    Stanton, R.A.5    Gupta, K.K.6
  • 30
    • 84893568990 scopus 로고    scopus 로고
    • Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents
    • Manchukonda NK, Naik PK, Santoshi S, Lopus M., Joseph S, Sridhar B, et al Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents. PLOS ONE 2013; 8:e77970.
    • (2013) PLOS ONE , vol.8
    • Manchukonda, N.K.1    Naik, P.K.2    Santoshi, S.3    Lopus, M.4    Joseph, S.5    Sridhar, B.6
  • 31
    • 0037379660 scopus 로고    scopus 로고
    • Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation
    • Zhou J, Gupta K, Aggarwal S., Aneja R, Chandra R, Panda D., et al. Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation. Mol Pharmacol 2003; 63(4):799-807.
    • (2003) Mol Pharmacol , vol.63 , Issue.4 , pp. 799-807
    • Zhou, J.1    Gupta, K.2    Aggarwal, S.3    Aneja, R.4    Chandra, R.5    Panda, D.6
  • 32
    • 33644780790 scopus 로고    scopus 로고
    • Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicro-tubule agent, EM011
    • Aneja R, Zhou J, Vangapandu SN, Zhou B, Chandra R, Joshi HC. Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicro-tubule agent, EM011. Blood 2006; 107(6):2486-92.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2486-2492
    • Aneja, R.1    Zhou, J.2    Vangapandu, S.N.3    Zhou, B.4    Chandra, R.5    Joshi, H.C.6
  • 33
    • 8844273265 scopus 로고    scopus 로고
    • Enhancement ofpaclitaxel-induced microtubule stabilization, mitotic arrest, and apoptosis by the microtubule-targeting agent EM012
    • Zhou J, Liu M, Aneja R, Chandra R, Joshi HC. Enhancement ofpaclitaxel-induced microtubule stabilization, mitotic arrest, and apoptosis by the microtubule-targeting agent EM012. Biochem Pharmacol 2004; 68(12):2435-41.
    • (2004) Biochem Pharmacol , vol.68 , Issue.12 , pp. 2435-2441
    • Zhou, J.1    Liu, M.2    Aneja, R.3    Chandra, R.4    Joshi, H.C.5
  • 34
    • 17644390209 scopus 로고    scopus 로고
    • EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice
    • Zhou J, Liu M, Luthra R, Jones J, Aneja R, Chandra R, et al. EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice. Cancer Chemother Pharmacol 2005; 55(5):461-5.
    • (2005) Cancer Chemother Pharmacol , vol.55 , Issue.5 , pp. 461-465
    • Zhou, J.1    Liu, M.2    Luthra, R.3    Jones, J.4    Aneja, R.5    Chandra, R.6
  • 36
    • 79957667944 scopus 로고    scopus 로고
    • Antibody-DM1 conjugates as cancer therapeutics
    • Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett 2011; 307(2):113-8.
    • (2011) Cancer Lett , vol.307 , Issue.2 , pp. 113-118
    • Lopus, M.1
  • 37
    • 77958059151 scopus 로고    scopus 로고
    • Maytansinoid-antibody conjugates induce mitotic arrest by suppressing mi-crotubule dynamic instability
    • Oroudjev E, Lopus M, Wilson L., Audette C, Provenzano C, Erickson H., et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing mi-crotubule dynamic instability. Mol Cancer Ther 2010; 9(10):2700-13.
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2700-2713
    • Oroudjev, E.1    Lopus, M.2    Wilson, L.3    Audette, C.4    Provenzano, C.5    Erickson, H.6
  • 38
    • 84884672557 scopus 로고    scopus 로고
    • Mechanism of mitotic arrest induced by dolast at in 15 involves loss of tension across kinetochore pairs
    • Lopus M. Mechanism of mitotic arrest induced by dolast at in 15 involves loss of tension across kinetochore pairs. Mol Cell Biochem 2013; 382(1-2):93-102.
    • (2013) Mol Cell Biochem , vol.382 , Issue.1-2 , pp. 93-102
    • Lopus, M.1
  • 39
    • 84866368751 scopus 로고    scopus 로고
    • Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates
    • Gianolio DA, Rouleau C, Bauta W.E., Lovett D., Cantrell Jr WR, Recio III A, et al. Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates. Cancer Chemother Pharmacol 2012; 70(3):439-49.
    • (2012) Cancer Chemother Pharmacol , vol.70 , Issue.3 , pp. 439-449
    • Gianolio, D.A.1    Rouleau, C.2    Bauta, W.E.3    Lovett, D.4    Cantrell, W.R.5    Recio, A.6
  • 40
    • 84870434926 scopus 로고    scopus 로고
    • Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells
    • Chandra R, Madan J, Singh P., Chandra A, Kumar P, Tomar V, et al. Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells. Curr Drug Metab 2012; 13(10):1476-83.
    • (2012) Curr Drug Metab , vol.13 , Issue.10 , pp. 1476-1483
    • Chandra, R.1    Madan, J.2    Singh, P.3    Chandra, A.4    Kumar, P.5    Tomar, V.6
  • 41
    • 84901608239 scopus 로고    scopus 로고
    • Enhanced noscapine delivery using estrogen-receptor-targeted nanoparticles for breast cancer therapy
    • PMID: 24642711
    • Madan J, Gundala SR, Kasetti Y, Bharatam P.V., Aneja R, Katyal A, et al. Enhanced noscapine delivery using estrogen-receptor-targeted nanoparticles for breast cancer therapy. Anticancer Drugs 2014; 25(6):704-16. PMID: 24642711.
    • (2014) Anticancer Drugs , vol.25 , Issue.6 , pp. 704-716
    • Madan, J.1    Gundala, S.R.2    Kasetti, Y.3    Bharatam, P.V.4    Aneja, R.5    Katyal, A.6
  • 42
    • 84862776774 scopus 로고    scopus 로고
    • Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity
    • Sun X, Li D, Yang Y., Ren Y, Li J, Wang Z., et al. Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity. J Pathol 2012; 226(4):666-73.
    • (2012) J Pathol , vol.226 , Issue.4 , pp. 666-673
    • Sun, X.1    Li, D.2    Yang, Y.3    Ren, Y.4    Li, J.5    Wang, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.