De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast

Metabolic Engineering

Volumn 31, Issue , 2015, Pages 74-83

  Trenchard, Isis J ^a   Siddiqui, Michael S ^a   Thodey, Kate ^a   Smolke, Christina D ^a  

^a Stanford University   (United States)

Author keywords

Plant alkaloids; Synthetic biology; Yeast

Indexed keywords

ALKALOIDS; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL COMPOUNDS; DRUG PRODUCTS; ENZYMES; MAMMALS; METABOLITES; MOLECULES; PLANTS (BOTANY);

BENZYLISOQUINOLINE ALKALOIDS; CENTRAL METABOLISMS; CULTURE CONDITIONS; MICROBIAL BIOSYNTHESIS; PLANT ALKALOIDS; SYNTHETIC BIOLOGY; TETRAHYDROBIOPTERIN; TYROSINE HYDROXYLASE;

YEAST;

3' HYDROXY N METHYLCOCLAURINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; COCLAURINE; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; DOPAMINE; ENZYME VARIANT; LEVODOPA; METHYLTRANSFERASE; MUTANT PROTEIN; N METHYLCOCLAURINE; NORCOCLAURINE; NORCOCLAURINE SYNTHASE; RETICULINE; SYNTHETASE; TETRAHYDROBIOPTERIN; TYROSINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; BENZYLISOQUINOLINE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; BIOTECHNOLOGICAL PRODUCTION; CONTROLLED STUDY; DNA MODIFICATION; FUNGAL CELL CULTURE; FUNGAL METABOLISM; FUNGAL STRAIN; FUNGUS GROWTH; GENOTYPE; METABOLIC ENGINEERING; METABOLIC REGULATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SACCHAROMYCES CEREVISIAE; METABOLISM;

BACTERIA (MICROORGANISMS); MAMMALIA; SACCHAROMYCES CEREVISIAE;

BENZYLISOQUINOLINES; METABOLIC ENGINEERING; SACCHAROMYCES CEREVISIAE;

EID: 84938063531     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.06.010     Document Type: Article

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