-
1
-
-
28544451327
-
Foundations for engineering biology
-
Endy, D. Foundations for engineering biology. Nature 438, 449-453 (2005).
-
(2005)
Nature
, vol.438
, pp. 449-453
-
-
Endy, D.1
-
2
-
-
23444461901
-
Advances in synthetic biology: On the path from prototypes to applications
-
McDaniel, R. & Weiss, R. Advances in synthetic biology: on the path from prototypes to applications. Curr. Opin. Biotechnol. 16, 476-483 (2005).
-
(2005)
Curr. Opin. Biotechnol
, vol.16
, pp. 476-483
-
-
McDaniel, R.1
Weiss, R.2
-
3
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro, D.K. et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440, 940-943 (2006).
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
-
4
-
-
0031905709
-
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
-
Kealey, J.T., Liu, L., Santi, D.V., Betlach, M.C. & Barr, P.J. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc. Natl. Acad. Sci. USA 95, 505-509 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 505-509
-
-
Kealey, J.T.1
Liu, L.2
Santi, D.V.3
Betlach, M.C.4
Barr, P.J.5
-
5
-
-
0037313962
-
Total biosynthesis of hydrocortisone from a simple carbon source in yeast
-
Szczebara, F.M. et al. Total biosynthesis of hydrocortisone from a simple carbon source in yeast. Nat. Biotechnol. 21, 143-149 (2003).
-
(2003)
Nat. Biotechnol
, vol.21
, pp. 143-149
-
-
Szczebara, F.M.1
-
6
-
-
0027472156
-
Antispasmodic activity of benzylisoquinoline alkaloids analogous to papaverine
-
Martin, M.L. et al. Antispasmodic activity of benzylisoquinoline alkaloids analogous to papaverine. Planta Med. 59, 63-67 (1993).
-
(1993)
Planta Med
, vol.59
, pp. 63-67
-
-
Martin, M.L.1
-
7
-
-
0032146194
-
Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice
-
Morais, L.C., Barbosa-Filho, J.M. & Almeida, R.N. Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice. J. Ethnopharmacol. 62, 57-61 (1998).
-
(1998)
J. Ethnopharmacol
, vol.62
, pp. 57-61
-
-
Morais, L.C.1
Barbosa-Filho, J.M.2
Almeida, R.N.3
-
8
-
-
0030913319
-
Norreticuline and reticuline as possible new agents for hair growth acceleration
-
Nakaoji, K., Nayeshiro, H. & Tanahashi, T. Norreticuline and reticuline as possible new agents for hair growth acceleration. Biol. Pharm. Bull. 20, 586-588 (1997).
-
(1997)
Biol. Pharm. Bull
, vol.20
, pp. 586-588
-
-
Nakaoji, K.1
Nayeshiro, H.2
Tanahashi, T.3
-
9
-
-
33746310059
-
Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine
-
Kemeny-Beke, A. et al. Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett. 237, 67-75 (2006).
-
(2006)
Cancer Lett
, vol.237
, pp. 67-75
-
-
Kemeny-Beke, A.1
-
10
-
-
0028938214
-
Structure-antioxidative activity relationships in benzylisoquinoline alkaloids
-
Cassels, B.K. et al. Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Pharmacol. Res. 31, 103-107 (1995).
-
(1995)
Pharmacol. Res
, vol.31
, pp. 103-107
-
-
Cassels, B.K.1
-
11
-
-
30644458311
-
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
-
Exley, R. et al. Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors. Br. J. Pharmacol. 146, 15-24 (2005).
-
(2005)
Br. J. Pharmacol
, vol.146
, pp. 15-24
-
-
Exley, R.1
-
12
-
-
20844441926
-
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids
-
Kashiwada, Y. et al. Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. Bioorg. Med. Chem. 13, 443-448 (2005).
-
(2005)
Bioorg. Med. Chem
, vol.13
, pp. 443-448
-
-
Kashiwada, Y.1
-
13
-
-
0036901923
-
Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases
-
Lai, J.H. Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol. Sin. 23, 1093-1101 (2002).
-
(2002)
Acta Pharmacol. Sin
, vol.23
, pp. 1093-1101
-
-
Lai, J.H.1
-
14
-
-
0036902138
-
Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action
-
Kwan, C.Y. & Achike, F.I. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action. Acta Pharmacol. Sin. 23, 1057-1068 (2002).
-
(2002)
Acta Pharmacol. Sin
, vol.23
, pp. 1057-1068
-
-
Kwan, C.Y.1
Achike, F.I.2
-
15
-
-
0030882744
-
Relationships between structure and vascular activity in a series of benzylisoquinolines
-
Chulia, S. et al. Relationships between structure and vascular activity in a series of benzylisoquinolines. Br. J. Pharmacol. 122, 409-416 (1997).
-
(1997)
Br. J. Pharmacol
, vol.122
, pp. 409-416
-
-
Chulia, S.1
-
16
-
-
33744954743
-
β-Phenylethylamines and the isoquinoline alkaloids
-
Bentley, K.W. β-Phenylethylamines and the isoquinoline alkaloids. Nat. Prod. Rep. 23, 444-463 (2006).
-
(2006)
Nat. Prod. Rep
, vol.23
, pp. 444-463
-
-
Bentley, K.W.1
-
17
-
-
0035780976
-
Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications
-
Facchini, P.J. Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52, 29-66 (2001).
-
(2001)
Annu. Rev. Plant Physiol. Plant Mol. Biol
, vol.52
, pp. 29-66
-
-
Facchini, P.J.1
-
18
-
-
34548313705
-
Metabolic engineering in isoquinoline alkaloid biosynthesis
-
Sato, F., Inui, T. & Takemura, T. Metabolic engineering in isoquinoline alkaloid biosynthesis. Curr. Pharm. Biotechnol. 8, 211-218 (2007).
-
(2007)
Curr. Pharm. Biotechnol
, vol.8
, pp. 211-218
-
-
Sato, F.1
Inui, T.2
Takemura, T.3
-
19
-
-
36849084099
-
Metabolic engineering of morphinan alkaloids by over-expression and RNAi suppression of salutaridinol 7-O-acetyltransferase in opium poppy
-
Allen, R.S. et al. Metabolic engineering of morphinan alkaloids by over-expression and RNAi suppression of salutaridinol 7-O-acetyltransferase in opium poppy. Plant Biotechnol. J. 6, 22-30 (2008).
-
(2008)
Plant Biotechnol. J
, vol.6
, pp. 22-30
-
-
Allen, R.S.1
-
20
-
-
11144352099
-
RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy
-
Allen, R.S. et al. RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy. Nat. Biotechnol. 22, 1559-1566 (2004).
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1559-1566
-
-
Allen, R.S.1
-
21
-
-
0035793046
-
Metabolic engineering of plant alkaloid biosynthesis
-
Sato, F. et al. Metabolic engineering of plant alkaloid biosynthesis. Proc. Natl. Acad. Sci. USA 98, 367-372 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 367-372
-
-
Sato, F.1
-
22
-
-
33947217953
-
Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism
-
Zulak, K.G. et al. Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism. Planta 225, 1085-1106 (2007).
-
(2007)
Planta
, vol.225
, pp. 1085-1106
-
-
Zulak, K.G.1
-
23
-
-
44949247292
-
Microbial production of plant benzylisoquinoline alkaloids
-
Minami, H. et al. Microbial production of plant benzylisoquinoline alkaloids. Proc. Natl. Acad. Sci. USA 105, 7393-7398 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7393-7398
-
-
Minami, H.1
-
24
-
-
33749241876
-
Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis
-
Ziegler, J. et al. Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis. Plant J. 48, 177-192 (2006).
-
(2006)
Plant J
, vol.48
, pp. 177-192
-
-
Ziegler, J.1
-
25
-
-
0028086426
-
Purification and characterization of S-adenosyl-L-methionine: Norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells
-
Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S. & Yamada, Y. Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 225, 125-131 (1994).
-
(1994)
Eur. J. Biochem
, vol.225
, pp. 125-131
-
-
Sato, F.1
Tsujita, T.2
Katagiri, Y.3
Yoshida, S.4
Yamada, Y.5
-
26
-
-
0347317979
-
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy
-
Ounaroon, A., Decker, G., Schmidt, J., Lottspeich, F. & Kutchan, T.M. (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. Plant J. 36, 808-819 (2003).
-
(2003)
Plant J
, vol.36
, pp. 808-819
-
-
Ounaroon, A.1
Decker, G.2
Schmidt, J.3
Lottspeich, F.4
Kutchan, T.M.5
-
27
-
-
33744955253
-
The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae
-
Hawkins, K.M. & Smolke, C.D. The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae. J. Biol. Chem. 281, 13485-13492 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 13485-13492
-
-
Hawkins, K.M.1
Smolke, C.D.2
-
28
-
-
33747376106
-
Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae
-
Nevoigt, E. et al. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 72, 5266-5273 (2006).
-
(2006)
Appl. Environ. Microbiol
, vol.72
, pp. 5266-5273
-
-
Nevoigt, E.1
-
29
-
-
0028785275
-
Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants
-
Kutchan, T.M. & Dittrich, H. Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. J. Biol. Chem. 270, 24475-24481 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 24475-24481
-
-
Kutchan, T.M.1
Dittrich, H.2
-
30
-
-
0034778031
-
Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant
-
Bird, D.A. & Facchini, P.J. Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta 213, 888-897 (2001).
-
(2001)
Planta
, vol.213
, pp. 888-897
-
-
Bird, D.A.1
Facchini, P.J.2
-
31
-
-
0141755310
-
Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells
-
Ikezawa, N. et al. Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. J. Biol. Chem. 278, 38557-38565 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 38557-38565
-
-
Ikezawa, N.1
-
32
-
-
2142751582
-
1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway
-
Hirata, K., Poeaknapo, C., Schmidt, J. & Zenk, M.H. 1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. Phytochemistry 65, 1039-1046 (2004).
-
(2004)
Phytochemistry
, vol.65
, pp. 1039-1046
-
-
Hirata, K.1
Poeaknapo, C.2
Schmidt, J.3
Zenk, M.H.4
-
33
-
-
28244474541
-
Human white blood cells synthesize morphine: CYP2D6 modulation
-
Zhu, W., Cadet, P., Baggerman, G., Mantione, K.J. & Stefano, G.B. Human white blood cells synthesize morphine: CYP2D6 modulation. J. Immunol. 175, 7357-7362 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 7357-7362
-
-
Zhu, W.1
Cadet, P.2
Baggerman, G.3
Mantione, K.J.4
Stefano, G.B.5
-
34
-
-
42249097714
-
Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis
-
Liscombe, D.K. & Facchini, P.J. Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis. Curr. Opin. Biotechnol. 19, 173-180 (2008).
-
(2008)
Curr. Opin. Biotechnol
, vol.19
, pp. 173-180
-
-
Liscombe, D.K.1
Facchini, P.J.2
-
35
-
-
3242655621
-
Metabolic channeling in plants
-
Winkel, B.S. Metabolic channeling in plants. Annu. Rev. Plant Biol. 55, 85-107 (2004).
-
(2004)
Annu. Rev. Plant Biol
, vol.55
, pp. 85-107
-
-
Winkel, B.S.1
-
36
-
-
0004262043
-
-
3rd edn, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA
-
Sambrook, J. & Russell, D.W. Molecular Cloning 3rd edn. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2001).
-
(2001)
Molecular Cloning
-
-
Sambrook, J.1
Russell, D.W.2
-
37
-
-
0028977906
-
Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization
-
Gillam, E.M., Guo, Z., Martin, M.V., Jenkins, C.M. & Guengerich, F.P. Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization. Arch. Biochem. Biophys. 319, 540-550 (1995).
-
(1995)
Arch. Biochem. Biophys
, vol.319
, pp. 540-550
-
-
Gillam, E.M.1
Guo, Z.2
Martin, M.V.3
Jenkins, C.M.4
Guengerich, F.P.5
-
38
-
-
0030852872
-
Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5
-
Urban, P., Mignotte, C., Kazmaier, M., Delorme, F. & Pompon, D. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. J. Biol. Chem. 272, 19176-19186 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 19176-19186
-
-
Urban, P.1
Mignotte, C.2
Kazmaier, M.3
Delorme, F.4
Pompon, D.5
-
39
-
-
0027158167
-
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression
-
Mapoles, J., Berthou, F., Alexander, A., Simon, F. & Menez, J.F. Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression. Eur. J. Biochem. 214, 735-745 (1993).
-
(1993)
Eur. J. Biochem
, vol.214
, pp. 735-745
-
-
Mapoles, J.1
Berthou, F.2
Alexander, A.3
Simon, F.4
Menez, J.F.5
-
40
-
-
33644792045
-
Yeast transformation by the LiAc/SS Carrier DNA/PEG method
-
Gietz, R.D. & Woods, R.A. Yeast transformation by the LiAc/SS Carrier DNA/PEG method. Methods Mol. Biol. 313, 107-120 (2006).
-
(2006)
Methods Mol. Biol
, vol.313
, pp. 107-120
-
-
Gietz, R.D.1
Woods, R.A.2
-
41
-
-
0024977417
-
Elevated recombination rates in transcriptionally active DNA
-
Thomas, B.J. & Rothstein, R. Elevated recombination rates in transcriptionally active DNA. Cell 56, 619-630 (1989).
-
(1989)
Cell
, vol.56
, pp. 619-630
-
-
Thomas, B.J.1
Rothstein, R.2
-
42
-
-
0029994841
-
A new efficient gene disruption cassette for repeated use in budding yeast
-
Guldener, U., Heck, S., Fielder, T., Beinhauer, J. & Hegemann, J.H. A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 24, 2519-2524 (1996).
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 2519-2524
-
-
Guldener, U.1
Heck, S.2
Fielder, T.3
Beinhauer, J.4
Hegemann, J.H.5
-
43
-
-
44649092127
-
Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray-time of flight mass spectrometry with different background electrolytes
-
Chen, J. et al. Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray-time of flight mass spectrometry with different background electrolytes. Electrophoresis 29, 2135-2147 (2008).
-
(2008)
Electrophoresis
, vol.29
, pp. 2135-2147
-
-
Chen, J.1
-
44
-
-
0142257918
-
Electrospray tandem mass spectrometric investigations of morphinans
-
Raith, K. et al. Electrospray tandem mass spectrometric investigations of morphinans. J. Am. Soc. Mass Spectrom. 14, 1262-1269 (2003).
-
(2003)
J. Am. Soc. Mass Spectrom
, vol.14
, pp. 1262-1269
-
-
Raith, K.1
|