IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Takatani, Tomozumi ^a   Shirakawa, Jun ^a   Roe, Michael W ^b   Leech, Colin A ^b   Maier, Bernhard F ^c   Mirmira, Raghavendra G ^c   Kulkarni, Rohit N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; IRS2 PROTEIN, MOUSE; X BOX BINDING PROTEIN 1; XBP1 PROTEIN, MOUSE;

ANIMAL; APOPTOSIS; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DEFICIENCY; ENDOPLASMIC RETICULUM STRESS; GENE KNOCKOUT; GENETICS; METABOLISM; MOUSE; PANCREAS ISLET BETA CELL; PROTEIN STABILITY; PROTEIN SYNTHESIS;

ANIMALS; APOPTOSIS; CALCIUM; CELL NUCLEUS; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; GENE KNOCKOUT TECHNIQUES; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MICE; PROTEIN BIOSYNTHESIS; PROTEIN STABILITY; X-BOX BINDING PROTEIN 1;

EID: 84977262688     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28177     Document Type: Article

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