P85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 1192-1197

  Winnay, Jonathon N ^a   Dirice, Ercument ^a   Liew, Chong Wee ^b   Kulkarni, Rohit N ^a   Kahn, C Ronald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE REGULATORY SUBUNIT P85 ALPHA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; UNFOLDED PROTEIN RESPONSE;

ALLELES; ANIMALS; APOPTOSIS; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; GLUCOSE; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; OXIDATIVE STRESS; PANCREAS; PHENOTYPE; PROTEIN DENATURATION; PROTEIN FOLDING; TIME FACTORS;

EID: 84892941002     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322564111     Document Type: Article

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